Beta Amyloid Peptide: Research Paper : Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease

Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease

Abstract

Background: The composite Unified Huntington's Disease Rating Scale (cUHDRS) is a multidimensional measure of progression in Huntington's disease (HD) being used as a primary outcome in clinical trials investigating potentially disease-modifying huntingtin-lowering therapies.

Objective: Evaluating volumetric and structural connectivity correlates of the cUHDRS.

Methods: One hundred and nineteen premanifest and 119 early-HD participants were included. Gray and white matter (WM) volumes were correlated with cUHDRS cross-sectionally and longitudinally using voxel-based morphometry. Correlations between baseline fractional anisotropy (FA); mean, radial, and axial diffusivity; and baseline cUHDRS were examined using tract-based spatial statistics.

Results: Worse performance in the cUHDRS over time correlated with longitudinal volume decreases in the occipito-parietal cortex and centrum semiovale, whereas lower baseline scores correlated with decreased volume in the basal ganglia and surrounding WM. Lower cUHDRS scores were also associated with reduced FA and increased diffusivity at baseline.

Conclusion: The cUHDRS correlates with imaging biomarkers and tracks atrophy progression in HD supporting its biological relevance. © 2021 International Parkinson and Movement Disorder Society.

Keywords: Huntington's disease; composite Unified Huntington's Disease Rating Scale; diffusion tensor imaging; voxel-based morphometry; clinical trials; longitudinal.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33471951/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.