The amyloid hypothesis is initially compelling because the gene for the amyloid beta precursor APP is located on chromosome 21, and patients with trisomy 21 - better known as Down syndrome - who thus have an extra gene copy almost universally exhibit AD-like disorders by 40 years of age. The traditional formulation of the amyloid hypothesis points to the cytotoxicity of mature aggregated amyloid fibrils, which are believed to be the toxic form of the protein responsible for disrupting the cell's calcium ion homeostasis and thus inducing apoptosis. This hypothesis is supported by the observation that higher levels of a variant of the beta amyloid protein known to form fibrils faster in vitro correlate with earlier onset and greater cognitive impairment in mouse models and with AD diagnosis in humans.However, mechanisms for the induced calcium influx, or proposals for alternative cytotoxic mechanisms, by mature fibrils are not obvious.
We have shortlisted some papers which we think will help you in your experiments. Here are those:
Lipsanen A, Hiltunen M, Jolkkonen J
Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats.
Pharmacol Biochem Behav. 2011 Sep;99(3):468-74.
PMID: 21557963
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21557963
Fodero-Tavoletti MT, Villemagne VL, Rowe CC, Masters CL, Barnham KJ, Cappai R
Amyloid-ß: The seeds of darkness.
Int J Biochem Cell Biol. 2011 Sep;43(9):1247-51.
PMID: 21601003
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21601003
Zall A, Kieser D, Höttecke N, Naumann EC, Thomaszewski B, Schneider K, Steinbacher DT, Schubenel R, Masur S, Baumann K, Schmidt B
NSAID-derived ?-secretase modulation requires an acidic moiety on the carbazole scaffold.
Bioorg Med Chem. 2011 Aug 15;19(16):4903-9.
PMID: 21763147
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21763147
Zanetti Polzi L, Amadei A, Aschi M, Daidone I
New Insight into the IR-Spectra/Structure Relationship in Amyloid Fibrils: A Theoretical Study on a Prion Peptide.
J Am Chem Soc. 2011 Aug 3;133(30):11414-7.
PMID: 21692535
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21692535
Supnet C, Bezprozvanny I
Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.
Sci China Life Sci. 2011 Aug;54(8):744-51.
PMID: 21786197
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21786197
[No authors listed]
The amyloid cascade hypothesis has misled the pharmaceutical industry.
Biochem Soc Trans. 2011 Aug 1;39(4):920-3.
PMID: 21787324
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21787324
Hara H, Mouri A, Yonemitsu Y, Nabeshima T, Tabira T
Mucosal immunotherapy in an Alzheimer mouse model by recombinant Sendai virus vector carrying Aß1-43/IL-10 cDNA.
Vaccine. 2011 Jul 29;
PMID: 21803105
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21803105
Sano M, Bell KL, Galasko D, Galvin JE, Thomas RG, van Dyck CH, Aisen PS
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease.
Neurology. 2011 Jul 27;
PMID: 21795660
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21795660
Cissé M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the j20 line of human amyloid precursor protein transgenic mice.
J Neurosci. 2011 Jul 20;31(29):10427-31.
PMID: 21775587
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21775587
van Norden AG, van Dijk EJ, de Laat KF, Scheltens P, Olderikkert MG, de Leeuw FE
Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction.
Biochim Biophys Acta. 2011 Jul 14;
PMID: 21777675
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21777675
Bedrosian TA, Herring KL, Weil ZM, Nelson RJ
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11686-91.
PMID: 21709248
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21709248
Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.
Nature. 2011 Jul 7;475(7354):96-100.
PMID: 21677644
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21677644
Choi BR, Lee SR, Han JS, Woo SK, Kim KM, Choi DH, Kwon KJ, Han SH, Shin CY, Lee J, Chung CS, Lee SR, Kim HY
Synergistic Memory Impairment Through the Interaction of Chronic Cerebral Hypoperfusion and Amlyloid Toxicity in a Rat Model.
Stroke. 2011 Jul 7;
PMID: 21737797
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21737797
Herholz K, Ebmeier K
Clinical amyloid imaging in Alzheimer's disease.
Lancet Neurol. 2011 Jul;10(7):667-70.
PMID: 21683932
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21683932
Vallabhajosula S
Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid.
Semin Nucl Med. 2011 Jul;41(4):283-99.
PMID: 21624562
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21624562
Spronk SA, Carlson HA
The role of tyrosine 71 in modulating the flap conformations of BACE1.
Proteins. 2011 Jul;79(7):2247-59.
PMID: 21590744
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21590744
Rodgers CC
Dental X-ray exposure and Alzheimer's disease: A hypothetical etiological association.
Med Hypotheses. 2011 Jul;77(1):29-34.
PMID: 21458164
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21458164
Devanand DP, Schupf N, Stern Y, Parsey R, Pelton GH, Mehta P, Mayeux R
Plasma A{beta} and PET PiB binding are inversely related in mild cognitive impairment.
Neurology. 2011 Jun 29;
PMID: 21715709
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21715709
Drew SC, Barnham KJ
The Heterogeneous Nature of Cu(2+) Interactions with Alzheimer's Amyloid-ß Peptide.
Acc Chem Res. 2011 Jun 29;
PMID: 21714485
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21714485
Nelson O, Supnet C, Tolia A, Horré K, De Strooper B, Bezprozvanny I
Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.
J Biol Chem. 2011 Jun 24;286(25):22339-47.
PMID: 21531718
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21531718
Diaz-de-Grenu LZ, Acosta-Cabronero J, Pereira JM, Pengas G, Williams GB, Nestor PJ
MRI detection of tissue pathology beyond atrophy in Alzheimer's disease: Introducing T2-VBM.
Neuroimage. 2011 Jun 15;56(4):1946-53.
PMID: 21473918
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21473918
Villemagne VL, Rowe CC
Amyloid imaging.
Int Psychogeriatr. 2011 Jun 10;:1-9.
PMID: 21729418
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21729418
Supnet C, Bezprozvanny I
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
Cell Calcium. 2011 Jun 8;
PMID: 21663966
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21663966
Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors.
Top Curr Chem. 2011 Jun 7;
PMID: 21647837
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21647837
Mannix R, Zhang J, Park J, Lee C, Whalen M
DETRIMENTAL EFFECT OF GENETIC INHIBITION OF ß-SITE APP CLEAVING ENZYME 1 ON FUNCTIONAL OUTCOME AFTER CONTROLLED CORTICAL IMPACT IN YOUNG ADULT MICE.
J Neurotrauma. 2011 Jun 3;
PMID: 21639727
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21639727
Cavedo E, Frisoni GB
The dynamic marker hypothesis of Alzheimer's disease and its implications for clinical imaging.
Q J Nucl Med Mol Imaging. 2011 Jun;55(3):237-49.
PMID: 21532538
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21532538
Morgan K
The three new pathways leading to Alzheimer's disease.
Neuropathol Appl Neurobiol. 2011 Jun;37(4):353-7.
PMID: 21486313
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21486313
Castellani RJ, Smith MA
Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.
J Pathol. 2011 Jun;224(2):147-52.
PMID: 21557219
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21557219
Lelos MJ, Thomas RS, Kidd EJ, Good MA
Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus- or action-outcome, associations in aged Tg2576 mice.
Behav Neurosci. 2011 Jun;125(3):412-25.
PMID: 21480689
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21480689
Lambert JC, Amouyel P
Genetics of Alzheimer's disease: new evidences for an old hypothesis?
Curr Opin Genet Dev. 2011 Jun;21(3):295-301.
PMID: 21371880
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21371880
Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E
Dissociation of ß-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates ß-amyloid-42 assembly.
J Neurosci Res. 2011 Jun;89(6):815-21.
PMID: 21394760
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21394760
Ku HL, Chi NF
Cerebral lobar microhemorrhages detection by high magnetic field susceptibility weighted image: A potential diagnostic neuroimage technique of Alzheimer's disease.
Med Hypotheses. 2011 Jun;76(6):840-2.
PMID: 21392891
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21392891
Zarazúa S, Bürger S, Delgado JM, Jiménez-Capdeville ME, Schliebs R
Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP.
Int J Dev Neurosci. 2011 Jun;29(4):389-96.
PMID: 21440049
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21440049
Paley EL
Tryptamine-Induced Tryptophanyl-tRNAtrp Deficiency in Neurodifferentiation and Neurodegeneration Interplay: Progenitor Activation with Neurite Growth Terminated in Alzheimer's Disease Neuronal Vesicularization and Fragmentation.
J Alzheimers Dis. 2011 May 31;
PMID: 21628792
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21628792
Rojo LE, Gaspar P, Maccioni RB
Molecular Targets in the Rational Design of AD Specific PET Tracers: Tau or Amyloid Aggregates?
Curr Alzheimer Res. 2011 May 23;
PMID: 21605040
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21605040
Konietzko U
AICD Nuclear Signaling and its Possible Contribution to Alzheimer's Disease.
Curr Alzheimer Res. 2011 May 23;
PMID: 21605035
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21605035
Copenhaver PF, Anekonda TS, Musashe D, Robinson KM, Ramaker JM, Swanson TL, Wadsworth TL, Kretzschmar D, Woltjer RL, Quinn JF
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Dis Model Mech. 2011 May 19;
PMID: 21596710
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21596710
Casula M, Steentjes K, Aronica E, van Geel BM, Troost D
Concomitant CNS pathology in a patient with amyotropic lateral sclerosis following poliomyelitis in childhood.
Clin Neuropathol. 2011 May-Jun;30(3):111-7.
PMID: 21545774
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21545774
Grasso G
The use of mass spectrometry to study amyloid-ß peptides.
Mass Spectrom Rev. 2011 May-Jun;30(3):347-65.
PMID: 21500241
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21500241
Fedrizzi L, Carafoli E
Ca(2+) dysfunction in neurodegenerative disorders: Alzheimer's disease.
Biofactors. 2011 May;37(3):189-96.
PMID: 21698698
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21698698
Belluti F, Bartolini M, Bottegoni G, Bisi A, Cavalli A, Andrisano V, Rampa A
Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Eur J Med Chem. 2011 May;46(5):1682-93.
PMID: 21397996
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21397996
Darocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T
Brain oligomeric ß-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
J Neuropathol Exp Neurol. 2011 May;70(5):360-76.
PMID: 21487307
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21487307
Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA
Targets for AD treatment: conflicting messages from ?-secretase inhibitors.
J Neurochem. 2011 May;117(3):359-74.
PMID: 21320126
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21320126
Nakayama K, Nagase H, Koh CS, Ohkawara T
?-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer's Disease.
Cell Mol Neurobiol. 2011 Apr 23;
PMID: 21516353
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21516353
Wallace RA, Dalton AJ
What can we learn from study of Alzheimer's disease in patients with Down syndrome for early-onset Alzheimer's disease in the general population?
Alzheimers Res Ther. 2011 Apr 19;3(2):13.
PMID: 21542885
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21542885
de Souza LC, Chupin M, Lamari F, Jardel C, Leclercq D, Colliot O, Lehéricy S, Dubois B, Sarazin M
CSF tau markers are correlated with hippocampal volume in Alzheimer's disease.
Neurobiol Aging. 2011 Apr 11;
PMID: 21489655
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21489655
Canepa E, Borghi R, Viña J, Traverso N, Gambini J, Domenicotti C, Marinari UM, Poli G, Pronzato MA, Ricciarelli R
Cholesterol and Amyloid-ß: Evidence for a Cross-Talk between Astrocytes and Neuronal Cells.
J Alzheimers Dis. 2011 Apr 11;
PMID: 21483097
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21483097
Elliott-Hunt CR, Holmes FE, Hartley DM, Perez S, Mufson EJ, Wynick D
Endogenous Galanin Protects Mouse Hippocampal Neurons Against Amyloid Toxicity in vitro via Activation of Galanin Receptor-2.
J Alzheimers Dis. 2011 Apr 6;
PMID: 21471641
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21471641
Kelley CM, Perez SE, Overk C, Wynick D, Mufson EJ
Effect of Neocortical and Hippocampal Amyloid Deposition upon Galaninergic and Cholinergic Neurites in AßPPswe/PS1?E9 Mice.
J Alzheimers Dis. 2011 Apr 6;
PMID: 21471639
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21471639
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D
Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Biochemistry. 2011 Apr 5;50(13):2456-63.
PMID: 21323366
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21323366
Zhang Y, Lee DH
Sink Hypothesis and Therapeutic Strategies for Attenuating A{beta} Levels.
Neuroscientist. 2011 Apr;17(2):163-73.
PMID: 21330304
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21330304
Hawkes CA, Härtig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.
Acta Neuropathol. 2011 Apr;121(4):431-43.
PMID: 21259015
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21259015
Müller T, Loosse C, Schrötter A, Schnabel A, Helling S, Egensperger R, Marcus K
The AICD Interacting Protein DAB1 is Up-Regulated in Alzheimer Frontal Cortex Brain Samples and Causes Deregulation of Proteins Involved in Gene Expression Changes.
Curr Alzheimer Res. 2011 Apr 1;
PMID: 21453247
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21453247
Saijo E, Scheff SW, Telling GC
Unaltered prion protein expression in Alzheimer disease patients.
Prion. 2011 Apr 1;5(2):109-16.
PMID: 21654203
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21654203
Vignini A, Sartini D, Morganti S, Nanetti L, Luzzi S, Provinciali L, Mazzanti L, Emanuelli M
Platelet amyloid precursor protein isoform expression in Alzheimer's disease: evidence for peripheral marker.
Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):529-34.
PMID: 21658330
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21658330
Araujo JA, Nobrega JN, Raymond R, Milgram NW
Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density.
Pharmacol Biochem Behav. 2011 Apr;98(2):203-9.
PMID: 21238475
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21238475
Maltsev AV, Bystryak S, Galzitskaya OV
The role of ß-amyloid peptide in neurodegenerative diseases.
Ageing Res Rev. 2011 Mar 23;
PMID: 21406255
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21406255
Jardanhazi-Kurutz D, Kummer MP, Terwel D, Vogel K, Thiele A, Heneka MT
Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in APP/PS1 transgenic mice.
Neuroscience. 2011 Mar 10;176:396-407.
PMID: 21129451
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21129451
Rozkalne A, Hyman BT, Spires-Jones TL
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.
Neurobiol Dis. 2011 Mar;41(3):650-4.
PMID: 21134458
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21134458
Ott S, Henkel AW, Henkel MK, Redzic ZB, Kornhuber J, Wiltfang J
Pre-aggregated Aß1-42 peptide increases tau aggregation and hyperphosphorylation after short-term application.
Mol Cell Biochem. 2011 Mar;349(1-2):169-77.
PMID: 21113648
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21113648
Cuevas E, Lantz SM, Tobón-Velasco JC, Newport GD, Wu Q, Virmani A, Ali SF, Santamaría A
On the in vivo early toxic properties of Aß(25-35) peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression.
Neurotoxicol Teratol. 2011 Mar-Apr;33(2):288-96.
PMID: 21216281
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21216281
Vargas T, Martinez-Garcia A, Antequera D, Vilella E, Clarimon J, Mateo I, Sanchez-Juan P, Rodriguez-Rodriguez E, Frank A, Rosich-Estrago M, Lleo A, Molina-Porcel L, Blesa R, Gomez-Isla T, Combarros O, Bermejo-Pareja F, Valdivieso F, Bullido MJ, Carro E
IGF-I gene variability is associated with an increased risk for AD.
Neurobiol Aging. 2011 Mar;32(3):556.e3-11.
PMID: 21176999
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21176999
Eikelenboom P, Veerhuis R, Exel EV, Hoozemans JJ, Rozemuller AJ, Van Gool WA
The Early Involvement of the Innate Immunity in the Pathogenesis of Late-OnsetAlzheimer's Disease: Neuropathological, Epidemiological and Genetic Evidence.
Curr Alzheimer Res. 2011 Mar 1;8(2):142-50.
PMID: 21345167
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21345167
Rahmadi A, Steiner N, Münch G
Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease.
Clin Chem Lab Med. 2011 Mar;49(3):385-91.
PMID: 21275816
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21275816
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
Copper(I) and copper(II) inhibit Aß peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.
Chemistry. 2011 Feb 25;17(9):2752-62.
PMID: 21274957
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21274957
Croce N, Dinallo V, Ricci V, Federici G, Caltagirone C, Bernardini S, Angelucci F
Neuroprotective Effect of Neuropeptide Y against Beta-Amyloid 25-35 Toxicity in SH-SY5Y Neuroblastoma Cells Is Associated with Increased Neurotrophin Production.
Neurodegener Dis. 2011 Feb 23;
PMID: 21346312
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21346312
Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA, Crowther DC
Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.
J Biol Chem. 2011 Feb 11;286(6):4248-56.
PMID: 21147772
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21147772
Petrlova J, Hong HS, Bricarello DA, Harishchandra G, Lorigan GA, Jin LW, Voss JC
A differential association of Apolipoprotein E isoforms with the amyloid-ß oligomer in solution.
Proteins. 2011 Feb;79(2):402-16.
PMID: 21069870
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21069870
Shah S, Federoff HJ
Therapeutic potential of vaccines for Alzheimer's disease.
Immunotherapy. 2011 Feb;3(2):287-98.
PMID: 21322764
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21322764
Cordonnier C, van der Flier WM
Brain microbleeds and Alzheimer's disease: innocent observation or key player?
Brain. 2011 Feb;134(Pt 2):335-44.
PMID: 21257651
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21257651
Wiley JC, Pettan-Brewer C, Ladiges WC
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.
Aging Cell. 2011 Jan 27;
PMID: 21272191
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21272191
Cerf E, Gustot A, Goormaghtigh E, Ruysschaert JM, Raussens V
High ability of apolipoprotein E4 to stabilize amyloid-{beta} peptide oligomers, the pathological entities responsible for Alzheimer's disease.
FASEB J. 2011 Jan 25;
PMID: 21266538
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21266538
Ji C, Song C, Zuo P
The Mechanism of Memory Impairment Induced by Aß Chronic Administration Involves Imbalance Between Cytokines and Neurotrophins in the Rat Hippocampus.
Curr Alzheimer Res. 2011 Jan 19;
PMID: 21244354
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21244354
Goguel V, Belair AL, Ayaz D, Lampin-Saint-Amaux A, Scaplehorn N, Hassan BA, Preat T
Drosophila amyloid precursor protein-like is required for long-term memory.
J Neurosci. 2011 Jan 19;31(3):1032-7.
PMID: 21248128
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21248128
Vannini P, Hedden T, Sullivan C, Ward A, Becker JA, Johnson KA, Sperling RA
Age and amyloid deposition are associated with functional alterations in posteromedial cortex during encoding and retrieval processes.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=113712
Nabi HA, Sajjad M, Dhindsa S, Erb D, Wack D, Chaudhuri A, Dubey S, Wisniewski S, Dandona P
Quantitative measurement of B amyloid plaques with C-11 PIB positron emission tomography of hypogonadal men with type 2 diabetes.
Human Amyloid Imaging 2011 Meeting Abstracts. 2011 Jan 15;
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=113754
Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C
Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.
Alzheimers Res Ther. 2011 Jan 6;3(1):1.
PMID: 21211070
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21211070
Ahmad E, Ahmad A, Singh S, Arshad M, Khan AH, Khan RH
A mechanistic approach for islet amyloid polypeptide aggregation to develop anti-amyloidogenic agents for type-2 diabetes.
Biochimie. 2011 Jan 5;
PMID: 21215287
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21215287
Puccio S, Chu J, Praticò D
Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.
PLoS One. 2011;6(1):e15163.
PMID: 21253592
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21253592
Wegiel J, Gong CX, Hwang YW
The role of DYRK1A in neurodegenerative diseases.
FEBS J. 2011 Jan;278(2):236-45.
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Marchesi VT
Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy.
FASEB J. 2011 Jan;25(1):5-13.
PMID: 21205781
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Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT
Plasma Amyloid-ß as a Function of Age, Level of Intellectual Disability, and Presence of Dementia in Down Syndrome.
J Alzheimers Dis. 2011 Jan 1;23(3):399-409.
PMID: 21116050
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21116050
Medina M
Recent developments in tau-based therapeutics for neurodegenerative diseases.
Recent Pat CNS Drug Discov. 2011 Jan;6(1):20-30.
PMID: 21118095
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21118095
Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
Neurobiol Aging. 2011 Jan;32(1):1-14.
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de la Torre JC
Three postulates to help identify the cause of Alzheimer's disease.
J Alzheimers Dis. 2011 Jan 1;24(4):657-68.
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Armstrong RA
The pathogenesis of Alzheimer's disease: a reevaluation of the "amyloid cascade hypothesis".
Int J Alzheimers Dis. 2011;2011:630865.
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Morgan D
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J Intern Med. 2011 Jan;269(1):54-63.
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Yanagisawa D, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I
Curcuminoid binds to amyloid-ß1-42 oligomer and fibril.
J Alzheimers Dis. 2011;24 Suppl 2:33-42.
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Pagani L, Eckert A
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Int J Alzheimers Dis. 2011;2011:925050.
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van der Hilst JC
Recent insights into the pathogenesis of type AA amyloidosis.
ScientificWorldJournal. 2011;11:641-50.
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Smach MA, Jacob N, Golmard JL, Charfeddine B, Lammouchi T, Ben Othman L, Dridi H, Bennamou S, Limem K
Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study.
Eur Neurol. 2011;65(5):270-8.
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Wostyn P, Van Dam D, Audenaert K, De Deyn PP
Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease.
Int J Alzheimers Dis. 2011;2011:617420.
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Ray B, Long JM, Sokol DK, Lahiri DK
Increased Secreted Amyloid Precursor Protein-a (sAPPa) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker.
PLoS One. 2011;6(6):e20405.
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Cižas P, Jekabsone A, Borutaite V, Morkuniene R
Prevention of Amyloid-Beta Oligomer-Induced Neuronal Death by EGTA, Estradiol, and Endocytosis Inhibitor.
Medicina (Kaunas). 2011;47(2):107-112.
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Marchetti C, Marie H
Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models?
Rev Neurosci. 2011;22(4):373-402.
PMID: 21732714
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21732714
Imbimbo BP, Giardina GA
?-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes.
Curr Top Med Chem. 2011;11(12):1555-70.
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Hoogerhout P, Kamphuis W, Brugghe HF, Sluijs JA, Timmermans HA, Westdijk J, Zomer G, Boog CJ, Hol EM, van den Dobbelsteen GP
A cyclic undecamer peptide mimics a turn in folded Alzheimer amyloid ß and elicits antibodies against oligomeric and fibrillar amyloid and plaques.
PLoS One. 2011;6(4):e19110.
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Hashimoto M, Hossain S
Neuroprotective and ameliorative actions of polyunsaturated fatty acids against neuronal diseases: beneficial effect of docosahexaenoic acid on cognitive decline in Alzheimer's disease.
J Pharmacol Sci. 2011;116(2):150-62.
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Saxena U
Bioenergetics breakdown in Alzheimer's disease: targets for new therapies.
Int J Physiol Pathophysiol Pharmacol. 2011;3(2):133-9.
PMID: 21760971
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Bailey JA, Ray B, Greig NH, Lahiri DK
Rivastigmine Lowers Aß and Increases sAPPa Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons.
PLoS One. 2011;6(7):e21954.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21799757
Berridge MJ
Calcium Signalling and Alzheimer's Disease.
Neurochem Res. 2010 Dec 24;
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Maiti P, Piacentini R, Ripoli C, Grassi C, Bitan G
Surprising toxicity and assembly behaviour of amyloid ß-protein oxidized to sulfone.
Biochem J. 2010 Dec 22;433(2):323-32.
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Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.
J Neurosci. 2010 Dec 15;30(50):17068-78.
PMID: 21159977
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21159977
Herrup K
Reimagining Alzheimer's disease--an age-based hypothesis.
J Neurosci. 2010 Dec 15;30(50):16755-62.
PMID: 21159946
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21159946
Goryacheva AV, Kruglov SV, Pshennikova MG, Smirin BV, Malyshev IY, Barskov IV, Viktorov IV, Downey HF, Manukhina EB
Adaptation to intermittent hypoxia restricts nitric oxide overproduction and prevents beta-amyloid toxicity in rat brain.
Nitric Oxide. 2010 Dec 15;23(4):289-99.
PMID: 20804853
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20804853
Habib LK, Lee MT, Yang J
Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.
J Biol Chem. 2010 Dec 10;285(50):38933-43.
PMID: 20923778
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Balducci C, Forloni G
APP Transgenic Mice: Their Use and Limitations.
Neuromolecular Med. 2010 Dec 9;
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21152995
Saxena U
Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here?
Expert Opin Ther Targets. 2010 Dec;14(12):1273-7.
PMID: 21058918
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Fan LY, Chiu MJ
Pharmacological treatment for Alzheimer's disease: current approaches and future strategies.
Acta Neurol Taiwan. 2010 Dec;19(4):228-45.
PMID: 21213151
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21213151
Shafrir Y, Durell S, Arispe N, Guy HR
Models of membrane-bound Alzheimer's Abeta peptide assemblies.
Proteins. 2010 Dec;78(16):3473-87.
PMID: 20939098
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20939098
Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain.
J Neurochem. 2010 Dec;115(5):1077-89.
PMID: 20854368
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20854368
Jomova K, Vondrakova D, Lawson M, Valko M
Metals, oxidative stress and neurodegenerative disorders.
Mol Cell Biochem. 2010 Dec;345(1-2):91-104.
PMID: 20730621
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20730621
Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL
Traumatic brain injury reduces soluble extracellular amyloid-ß in mice: a methodologically novel combined microdialysis-controlled cortical impact study.
Neurobiol Dis. 2010 Dec;40(3):555-64.
PMID: 20682338
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20682338
Petzold A, Verwey NA, Van Uffelen K, Blankenstein MA, Teunissen C
Batch prepared protein standards for cerebrospinal fluid (CSF) biomarkers for neurodegeneration.
J Neurosci Methods. 2010 Nov 30;193(2):296-9.
PMID: 20832428
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20832428
Tamayev R, Matsuda S, Fà M, Arancio O, D'Adamio L
Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits.
Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20822-7.
PMID: 21098268
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21098268
Humpel C
Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
Exp Gerontol. 2010 Nov 26;
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21112383
Grasso G
The use of mass spectrometry to study amyloid-ß peptides.
Mass Spectrom Rev. 2010 Nov 22;
PMID: 21104913
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21104913
Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.
J Neurosci. 2010 Nov 10;30(45):14946-54.
PMID: 21068297
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21068297
Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Neuropathology. 2010 Nov 9;
PMID: 21062360
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21062360
Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.
J Neurosci. 2010 Nov 3;30(44):14915-24.
PMID: 21048150
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21048150
Fritz G, Botelho HM, Morozova-Roche LA, Gomes CM
Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.
FEBS J. 2010 Nov;277(22):4578-90.
PMID: 20977662
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20977662
Dieckmann M, Dietrich MF, Herz J
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.
Biol Chem. 2010 Nov;391(11):1341-63.
PMID: 20868222
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20868222
Mairuae N, Hall Ii EC, Cheepsunthorn P, Lee SY, Connor JR
The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following ß-amyloid peptide exposure.
J Neurosci Res. 2010 Nov 1;88(14):3079-89.
PMID: 20734416
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20734416
Wang WX, Huang Q, Hu Y, Stromberg AJ, Nelson PT
Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter.
Acta Neuropathol. 2010 Oct 10;
PMID: 20936480
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20936480
Szego EM, Csorba A, Janáky T, Kékesi KA, Abrahám IM, Mórotz GM, Penke B, Palkovits M, Murvai U, Kellermayer MS, Kardos J, Juhász GD
Effects of Estrogen on Beta-Amyloid-Induced Cholinergic Cell Death in the Nucleus Basalis Magnocellularis.
Neuroendocrinology. 2010 Oct 8;
PMID: 20938166
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20938166
Miners JS, Morris S, Love S, Kehoe PG
Accumulation of Insoluble Amyloid-ß in Down's Syndrome is Associated with Increased BACE-1 and Neprilysin Activities.
J Alzheimers Dis. 2010 Oct 7;
PMID: 20930275
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20930275
Morohashi Y, Tomita T, Iwatsubo T
[Molecular targeted therapy in Alzheimer disease].
Nippon Rinsho. 2010 Oct;68(10):1906-10.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20954338
Pomara N, Sidtis JJ
Brain neurotoxic amyloid-beta peptides: their potential role in the pathophysiology of depression and as molecular therapeutic targets.
Br J Pharmacol. 2010 Oct;161(4):768-70.
PMID: 21105218
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21105218
Princz-Kranz FL, Mueggler T, Knobloch M, Nitsch RM, Rudin M
Vascular response to acetazolamide decreases as a function of age in the arcA beta mouse model of cerebral amyloidosis.
Neurobiol Dis. 2010 Oct;40(1):284-92.
PMID: 20600914
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20600914
Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S
Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
J Neurosci. 2010 Sep 29;30(39):13110-5.
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[ARF Recommends]
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Houeland G, Romani A, Marchetti C, Amato G, Capsoni S, Cattaneo A, Marie H
Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities.
J Neurosci. 2010 Sep 29;30(39):13089-94.
PMID: 20881126
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20881126
Tsartsalis S, Panagopoulos PK, Mironidou-Tzouveleki M
Non-Cholinergic Pharmacotherapy Approaches to Alzheimer's Disease: The Use of Non-Steroidal Anti-Inflammatory Drugs.
CNS Neurol Disord Drug Targets. 2010 Sep 29;
PMID: 20874697
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20874697
Du J, Murphy RM
Characterization of the interaction of ß-amyloid with transthyretin monomers and tetramers.
Biochemistry. 2010 Sep 28;49(38):8276-89.
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Swaab DF, Bao AM
(Re-)activation of neurons in aging and dementia: Lessons from the hypothalamus.
Exp Gerontol. 2010 Sep 15;
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20833237
Zempel H, Thies E, Mandelkow E, Mandelkow EM
Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines.
J Neurosci. 2010 Sep 8;30(36):11938-50.
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Nilsson KP, Joshi-Barr S, Winson O, Sigurdson CJ
Prion strain interactions are highly selective.
J Neurosci. 2010 Sep 8;30(36):12094-102.
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Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ
The role of STEP in Alzheimer disease.
Channels (Austin). 2010 Sep 6;4(5)
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Saraiva AM, Cardoso I, Pereira MC, Coelho MA, Saraiva MJ, Möhwald H, Brezesinski G
Controlling amyloid-beta peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles.
Chembiochem. 2010 Sep 3;11(13):1905-13.
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Creed MC, Milgram NW
Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications.
Age (Dordr). 2010 Sep;32(3):365-84.
PMID: 20640545
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Boche D, Denham N, Holmes C, Nicoll JA
Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis.
Acta Neuropathol. 2010 Sep;120(3):369-84.
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Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, Levine H, Murphy MP
Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle.
Neurobiol Dis. 2010 Sep;39(3):449-56.
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von Einem B, Schwanzar D, Rehn F, Beyer AS, Weber P, Wagner M, Schneckenburger H, von Arnim CA
The role of low-density receptor-related protein 1 (LRP1) as a competitive substrate of the amyloid precursor protein (APP) for BACE1.
Exp Neurol. 2010 Sep;225(1):85-93.
PMID: 20685197
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Bareiss S, Kim K, Lu Q
Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.
J Neurosci Res. 2010 Aug 15;88(11):2350-63.
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Odero GL, Oikawa K, Glazner KA, Schapansky J, Grossman D, Thiessen JD, Motnenko A, Ge N, Martin M, Glazner GW, Albensi BC
Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease.
Neuroscience. 2010 Aug 11;169(1):532-43.
PMID: 20399254
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20399254
Smith AM, Gibbons HM, Dragunow M
Valproic acid enhances microglial phagocytosis of amyloid-beta(1-42).
Neuroscience. 2010 Aug 11;169(1):505-15.
PMID: 20423723
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20423723
Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B
Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice.
Neuroscience. 2010 Aug 11;169(1):488-94.
PMID: 20433905
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20433905
Takashima A
Tau Aggregation is a Therapeutic Target for Alzheimer's Disease.
Curr Alzheimer Res. 2010 Aug 2;
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Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW, Alzheimer's Disease Neuroimaging Initiative
Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study.
Neurobiol Aging. 2010 Aug;31(8):1340-54.
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Lemieux SK, Smith-Bell CA, Wells JR, Ezerioha NM, Carpenter JS, Sparks DL, Schreurs BG
Neurovascular changes measured by time-of-flight MR angiography in cholesterol-fed rabbits with cortical amyloid beta-peptide accumulation.
J Magn Reson Imaging. 2010 Aug;32(2):306-14.
PMID: 20677255
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Gate D, Rezai-Zadeh K, Jodry D, Rentsendorj A, Town T
Macrophages in Alzheimer's disease: the blood-borne identity.
J Neural Transm. 2010 Aug;117(8):961-70.
PMID: 20517700
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Hussain I
APP transgenic mouse models and their use in drug discovery to evaluate amyloid- lowering therapeutics.
CNS Neurol Disord Drug Targets. 2010 Aug 1;9(4):395-402.
PMID: 20522015
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Heilig EA, Xia W, Shen J, Kelleher RJ
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
J Biol Chem. 2010 Jul 16;285(29):22350-9.
PMID: 20460383
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Pflanzner T, Janko MC, André-Dohmen B, Reuss S, Weggen S, Roebroek AJ, Kuhlmann CR, Pietrzik CU
LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier.
Neurobiol Aging. 2010 Jul 12;
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Capsoni S, Tiveron C, Vignone D, Amato G, Cattaneo A
Dissecting the involvement of tropomyosin-related kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration.
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12299-304.
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Zetzsche T, Rujescu D, Hardy J, Hampel H
Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease.
Expert Rev Mol Diagn. 2010 Jul;10(5):667-90.
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Spuch C, Antequera D, Portero A, Orive G, Hernández RM, Molina JA, Bermejo-Pareja F, Pedraz JL, Carro E
The effect of encapsulated VEGF-secreting cells on brain amyloid load and behavioral impairment in a mouse model of Alzheimer's disease.
Biomaterials. 2010 Jul;31(21):5608-18.
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Keene CD, Chang RC, Lopez-Yglesias AH, Shalloway BR, Sokal I, Li X, Reed PJ, Keene LM, Montine KS, Breyer RM, Rockhill JK, Montine TJ
Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow.
Am J Pathol. 2010 Jul;177(1):346-54.
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J Am Geriatr Soc. 2010 Jul;58(7):1318-21.
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The endocannabinoid system and amyloid-related diseases.
Exp Neurol. 2010 Jul;224(1):66-73.
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An Amyloid-Notch Hypothesis for Alzheimer's Disease.
Neuroscientist. 2010 Jun 30;
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Horiuchi M, Maezawa I, Itoh A, Wakayama K, Jin LW, Itoh T, Decarli C
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Neurobiol Aging. 2010 Jun 29;
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Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I
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J Neurosci. 2010 Jun 23;30(25):8566-80.
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Panza F, Frisardi V, Imbimbo BP, Capurso C, Logroscino G, Sancarlo D, Seripa D, Vendemiale G, Pilotto A, Solfrizzi V
gamma-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State.
CNS Neurosci Ther. 2010 Jun 16;
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Iemolo F, Cavallaro T, Rizzuto N
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Neurol Sci. 2010 Jun 15;
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Int Psychogeriatr. 2010 Jun;22(4):598-606.
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Mol Neurobiol. 2010 Jun;41(2-3):392-409.
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Keshet B, Yang IH, Good TA
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Biotechnol Bioeng. 2010 Jun 1;106(2):333-7.
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Gong G, O'Bryant SE
The Arsenic Exposure Hypothesis for Alzheimer Disease.
Alzheimer Dis Assoc Disord. 2010 May 13;
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Drugs Aging. 2010 May;27(5):351-65.
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Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM, Medical Research Council Cognitive Function and Ageing Study
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J Neurochem. 2010 May 1;113(3):761-71.
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J Neurochem. 2010 May 1;113(3):649-60.
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Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE
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J Neurochem. 2010 May 1;113(3):784-95.
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Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M
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Curr Protein Pept Sci. 2010 Apr 26;
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Curr Protein Pept Sci. 2010 Apr 26;
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Maye JE, Carmasin JS, Becker JA, Rentz DM, Sperling RA, Johnson KA
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Human Amyloid Imaging 2010 Meeting Abstracts. 2010 April 9;
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Daulatzai MA
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J Alzheimers Dis. 2010 Feb 17;
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Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT
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Ha S, Furukawa R, Fechheimer M
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Neurobiol Aging. 2010 Feb 2;
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Alzheimers Res Ther. 2010 Jan 22;2(1):1.
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J Alzheimers Dis. 2010 Jan 7;
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[ARF Recommends]
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Reis HJ, Mukhamedyarov MA, Rizvanov AA, Palotás A
A new story about an old guy: is Alzheimer's disease infectious?
Neurodegener Dis. 2010;7(4):272-8.
PMID: 20502038
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20502038
Schonrock N, Ke YD, Humphreys D, Staufenbiel M, Ittner LM, Preiss T, Götz J
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta.
PLoS One. 2010;5(6):e11070.
PMID: 20552018
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20552018
Jan A, Hartley DM, Lashuel HA
Preparation and characterization of toxic Abeta aggregates for structural and functional studies in Alzheimer's disease research.
Nat Protoc. 2010;5(6):1186-209.
PMID: 20539293
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20539293
Guglielmotto M, Giliberto L, Tamagno E, Tabaton M
Oxidative stress mediates the pathogenic effect of different Alzheimer's disease risk factors.
Front Aging Neurosci. 2010;2:3.
PMID: 20552043
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20552043
Hampel H
PL01-01 - Recent developments in the treatment of Alzheimer disease.
Eur Psychiatry. 2010;25S1:204.
PMID: 20569897
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20569897
Zeng Y, Zhao D, Xie CW
Neurotrophins enhance CaMKII activity and rescue amyloid-ß-induced deficits in hippocampal synaptic plasticity.
J Alzheimers Dis. 2010;21(3):823-31.
PMID: 20634586
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20634586
Bate C, Williams A
Amyloid-ß(1-4) inhibits amyloid-ß(1-42) induced activation of cytoplasmic phospholipase A2 and synapse degeneration.
J Alzheimers Dis. 2010;21(3):985-93.
PMID: 20634578
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20634578
Broersen K, Rousseau F, Schymkowitz J
The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
Alzheimers Res Ther. 2010;2(4):12.
PMID: 20642866
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20642866
Games D, Seubert P
The role of animal models in advancing amyloid-beta immunotherapy to the clinic.
Alzheimers Res Ther. 2010;2(4):22.
PMID: 20682084
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20682084
Kawahara M
Neurotoxicity of ß-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis.
Curr Pharm Des. 2010;16(25):2779-89.
PMID: 20698821
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20698821
Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM
Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.
Front Neural Circuits. 2010;4
PMID: 20725509
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20725509
Mancuso M, Orsucci D, LoGerfo A, Calsolaro V, Siciliano G
Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA.
Adv Exp Med Biol. 2010;685:34-44.
PMID: 20687493
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20687493
Jiménez JS
Protein-DNA interaction at the origin of neurological diseases: a hypothesis.
J Alzheimers Dis. 2010;22(2):375-91.
PMID: 20847445
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20847445
Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E
Changes in cognition and amyloid-ß processing with long term cholesterol reduction using atorvastatin in aged dogs.
J Alzheimers Dis. 2010;22(1):135-50.
PMID: 20847439
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20847439
Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX
Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
J Alzheimers Dis. 2010;22(2):393-9.
PMID: 20847431
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20847431
Candela P, Gosselet F, Saint-Pol J, Sevin E, Boucau MC, Boulanger E, Cecchelli R, Fenart L
Apical-to-basolateral transport of amyloid-ß peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein.
J Alzheimers Dis. 2010 Jan 1;22(3):849-59.
PMID: 20858979
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20858979
Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM
Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-ß resulting in neurodegeneration.
J Alzheimers Dis. 2010 Jan 1;22(3):959-70.
PMID: 20858958
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20858958
Jaworski T, Kügler S, Van Leuven F
Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease.
Int J Alzheimers Dis. 2010;2010
PMID: 20862366
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20862366
Hurko O, Boudonck K, Gonzales C, Hughes ZA, Jacobsen JS, Reinhart PH, Crowther D
Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice.
Int J Alzheimers Dis. 2010;2010:864625.
PMID: 20981353
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20981353
Sundelöf J, Sundström J, Hansson O, Eriksdotter-Jönhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L
Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls.
J Alzheimers Dis. 2010 Jan 1;22(4):1223-30.
PMID: 20930303
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20930303
Forette F, Hauw JJ
[Treatment of Alzheimer's Disease and Future Approaches.]
Therapie. 2010 9-10;65(5):429-437.
PMID: 21144478
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21144478
Drew SC, Masters CL, Barnham KJ
Alzheimer's Aß peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.
PLoS One. 2010;5(12):e15875.
PMID: 21209855
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=21209855
Feng Y, Yang SG, Du XT, Zhang X, Sun XX, Zhao M, Sun GY, Liu RT
Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity.
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1250-4.
PMID: 19878655
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19878655
Moore BD, Rangachari V, Tay WM, Milkovic NM, Rosenberry TL
Biophysical analyses of synthetic amyloid-beta(1-42) aggregates before and after covalent cross-linking. Implications for deducing the structure of endogenous amyloid-beta oligomers.
Biochemistry. 2009 Dec 15;48(49):11796-806.
PMID: 19916493
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19916493
Hunter S, Friedland RP, Brayne C
Time for a Change in the Research Paradigm for Alzheimer's Disease: The Value of a Chaotic Matrix Modeling Approach.
CNS Neurosci Ther. 2009 Dec 11;
PMID: 20002628
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20002628
Kim J, Castellano JM, Jiang H, Basak JM, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM
Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.
Neuron. 2009 Dec 10;64(5):632-44.
PMID: 20005821
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20005821
Roodveldt C, Bertoncini CW, Andersson A, van der Goot AT, Hsu ST, Fernández-Montesinos R, de Jong J, van Ham TJ, Nollen EA, Pozo D, Christodoulou J, Dobson CM
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/alpha-synuclein complex by Hip.
EMBO J. 2009 Dec 2;28(23):3758-70.
PMID: 19875982
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19875982
Dunstan DE, Hamilton-Brown P, Asimakis P, Ducker W, Bertolini J
Shear flow promotes amyloid-{beta} fibrilization.
Protein Eng Des Sel. 2009 Dec;22(12):741-6.
PMID: 19850675
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19850675
Jin T, Ito Y, Luan X, Dangaria S, Walker C, Allen M, Kulkarni A, Gibson C, Braatz R, Liao X, Diekwisch TG
Elongated polyproline motifs facilitate enamel evolution through matrix subunit compaction.
PLoS Biol. 2009 Dec;7(12):e1000262.
PMID: 20027208
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20027208
Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX
Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.
Eur J Neurosci. 2009 Dec;30(12):2271-83.
PMID: 20092570
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20092570
Mazzucchelli S, De Palma A, Riva M, D'Urzo A, Pozzi C, Pastori V, Comelli F, Fusi P, Vanoni M, Tortora P, Mauri P, Regonesi ME
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Int J Biochem Cell Biol. 2009 Dec;41(12):2485-92.
PMID: 19666135
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19666135
Frisardi V, Solfrizzi V, Imbimbo BP, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, Seripa D, Pilotto A, Capurso A, Panza F
Towards Disease-Modifying Treatment of Alzheimer's Disease: Drugs Targeting beta-Amyloid.
Curr Alzheimer Res. 2009 Nov 26;
PMID: 19939231
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19939231
Wasmer C, Schütz A, Loquet A, Buhtz C, Greenwald J, Riek R, Böckmann A, Meier BH
The molecular organization of the fungal prion HET-s in its amyloid form.
J Mol Biol. 2009 Nov 20;394(1):119-27.
PMID: 19748509
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19748509
Hermes M, Eichhoff G, Garaschuk O
Intracellular calcium signaling in Alzheimer's disease.
J Cell Mol Med. 2009 Nov 19;
PMID: 19929945
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19929945
Takechi R, Galloway S, Pallebage-Gamarallage MM, Lam V, Mamo JC
Dietary fats, cerebrovasculature integrity and Alzheimer's disease risk.
Prog Lipid Res. 2009 Nov 5;
PMID: 19896503
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19896503
Harris B, Pereira I, Parkin E
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
Brain Res. 2009 Nov 3;1296:203-15.
PMID: 19679113
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19679113
Squitti R, Zito G
Anti-copper Therapies in Alzheimer's Disease: New Concepts.
Recent Pat CNS Drug Discov. 2009 Nov 1;
PMID: 19594438
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19594438
Lin MS, Chen XB, Wang SS, Chang Y, Chen WY
Dynamic fluorescence imaging analysis to investigate the cholesterol recruitment in lipid monolayer during the interaction between beta-amyloid (1-40) and lipid monolayers.
Colloids Surf B Biointerfaces. 2009 Nov 1;74(1):59-66.
PMID: 19619991
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19619991
Origlia N, Arancio O, Domenici L, Yan SS
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
Expert Rev Neurother. 2009 Nov;9(11):1635-45.
PMID: 19903023
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19903023
Squitti R, Zito G
Anti-copper therapies in Alzheimer's disease: new concepts.
Recent Pat CNS Drug Discov. 2009 Nov;4(3):209-19.
PMID: 19891600
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19891600
Ablonczy Z, Prakasam A, Fant J, Fauq A, Crosson C, Sambamurti K
Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase.
J Biol Chem. 2009 Oct 30;284(44):30177-86.
PMID: 19723623
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19723623
Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW
Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.
Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18367-72.
PMID: 19837693
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19837693
Fernandez-Montesinos R, Torres M, Baglietto-Vargas D, Gutierrez A, Gozes I, Vitorica J, Pozo D
Activity-Dependent Neuroprotective Protein (ADNP) Expression in the Amyloid Precursor Protein/Presenilin 1 Mouse Model of Alzheimer's Disease.
J Mol Neurosci. 2009 Oct 21;
PMID: 19844808
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19844808
Landgren S, Palmér MS, Skoog I, Minthon L, Wallin A, Andreasen N, Zetterberg M, Blennow K, Zetterberg H
No Association of VEGF Polymorphims with Alzheimer's Disease.
Neuromolecular Med. 2009 Oct 20;
PMID: 19842071
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19842071
Blanc F, Poisbeau P, Sellal F, Tranchant C, de Seze J, André G
[Alzheimer disease, memory and estrogen.]
Rev Neurol (Paris). 2009 Oct 15;
PMID: 19836813
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19836813
Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
J Neurosci. 2009 Oct 14;29(41):13042-52.
PMID: 19828817
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19828817
Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT
A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
J Neurosci. 2009 Oct 7;29(40):12636-40.
PMID: 19812338
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19812338
Yang X, Sheng W, He Y, Cui J, Haidekker MA, Sun GY, Lee JC
Secretory phospholipase A2 Type III enhances {alpha}-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity.
J Lipid Res. 2009 Oct 5;
PMID: 19805624
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19805624
Mancuso M, Calsolaro V, Orsucci D, Siciliano G, Murri L
Is there a primary role of the mitochondrial genome in Alzheimer's disease?
J Bioenerg Biomembr. 2009 Oct 2;
PMID: 19798559
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19798559
Berridge MJ
Calcium hypothesis of Alzheimer's disease.
Pflugers Arch. 2009 Oct 1;
PMID: 19795132
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19795132
Schipper HM, Gupta A, Szarek WA
Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD.
Curr Alzheimer Res. 2009 Oct;6(5):424-30.
PMID: 19874266
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19874266
Schipper HM, Gupta A, Szarek WA
Suppression of Glial HO-1 Activitiy as a Potential Neurotherapeutic Intervention in AD.
Curr Alzheimer Res. 2009 Oct 1;
PMID: 19663798
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19663798
Streit WJ, Braak H, Xue QS, Bechmann I
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease.
Acta Neuropathol. 2009 Oct;118(4):475-85.
PMID: 19513731
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19513731
Bencherif M, Lippiello PM
Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer's etiopathology?
Med Hypotheses. 2009 Sep 30;
PMID: 19800174
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19800174
Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW
Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice.
Neuroscience. 2009 Sep 29;163(1):55-72.
PMID: 19500657
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19500657
Zerovnik E
Protein Conformational Pathology in Alzheimer's and other Neurodegenerative Diseases; New Targets for Therapy.
Curr Alzheimer Res. 2009 Sep 28;
PMID: 19860728
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19860728
Agnati FL, Guidolin D, Baluska F, Leo G, Barlow PW, Carone C, Genedani S
A New Hypothesis of Pathogenesis Based on the Divorce between Mitochondria and their Host Cells: Possible Relevances for the Alzheimer's Disease.
Curr Alzheimer Res. 2009 Sep 28;
PMID: 19860724
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19860724
Genedani S, Agnati LF, Leo G, Buzzega D, Maccari F, Carone C, Andreoli N, Filaferro M, Volpi N
beta-Amyloid Fibrillation and/or Hyperhomocysteinemia Modify Striatal Patterns of Hyaluronic Acid and Dermatan Sulfate: Possible Role in the Pathogenesis of Alzheimer's Disease.
Curr Alzheimer Res. 2009 Sep 28;
PMID: 19860722
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19860722
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16505-10.
PMID: 19805328
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19805328
Bartzokis G
Alzheimer's disease as homeostatic responses to age-related myelin breakdown.
Neurobiol Aging. 2009 Sep 21;
PMID: 19775776
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19775776
Cendron L, Trovato A, Seno F, Folli C, Alfieri B, Zanotti G, Berni R
Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
J Biol Chem. 2009 Sep 18;284(38):25832-41.
PMID: 19602727
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19602727
Kaminsky YG, Marlatt MW, Smith MA, Kosenko EA
Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: Evidence for Abeta(25-35).
Exp Neurol. 2009 Sep 12;
PMID: 19751725
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19751725
Pani A, Dessì S, Diaz G, La Colla P, Abete C, Mulas C, Angius F, Cannas MD, Orru CD, Cocco PL, Mandas A, Putzu P, Laurenzana A, Cellai C, Costanza AM, Bavazzano A, Mocali A, Paoletti F
Altered Cholesterol Ester Cycle in Skin Fibroblasts from Patients with Alzheimer's Disease.
J Alzheimers Dis. 2009 Sep 11;
PMID: 19749436
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19749436
Fuller S, Steele M, Münch G
Activated astroglia during chronic inflammation in Alzheimer's disease-Do they neglect their neurosupportive roles?
Mutat Res. 2009 Sep 11;
PMID: 19748514
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19748514
Tabaton M, Zhu X, Perry G, Smith MA, Giliberto L
Signaling effect of amyloid-beta(42) on the processing of AbetaPP.
Exp Neurol. 2009 Sep 9;
PMID: 19747481
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19747481
Bednar MM
Anti-amyloid antibody drugs in clinical testing for Alzheimer's disease.
IDrugs. 2009 Sep;12(9):566-75.
PMID: 19697276
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19697276
Fournier A, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N
Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.
Expert Rev Neurother. 2009 Sep;9(9):1413-31.
PMID: 19769454
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19769454
Wu TY, Chen CP
Dual action of memantine in Alzheimer disease: a hypothesis.
Taiwan J Obstet Gynecol. 2009 Sep;48(3):273-7.
PMID: 19797019
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19797019
Cohen AD, Ikonomovic MD, Abrahamson EE, Paljug WR, Dekosky ST, Lefterov IM, Koldamova RP, Shao L, Debnath ML, Mason NS, Mathis CA, Klunk WE
Anti-Amyloid Effects of Small Molecule Abeta-Binding Agents in PS1/APP Mice.
Lett Drug Des Discov. 2009 Sep;6(6):437.
PMID: 20119496
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20119496
Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
Beta-amyloid monomers are neuroprotective.
J Neurosci. 2009 Aug 26;29(34):10582-7.
PMID: 19710311
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19710311
Bublak P, Redel P, Sorg C, Kurz A, Förstl H, Müller HJ, Schneider WX, Finke K
Staged decline of visual processing capacity in mild cognitive impairment and Alzheimer's disease.
Neurobiol Aging. 2009 Aug 25;
PMID: 19713001
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19713001
Tanaka N, Goto YI, Akanuma J, Kato M, Kinoshita T, Yamashita F, Tanaka M, Asada T
Mitochondrial DNA variants in a Japanese population of patients with Alzheimer's disease.
Mitochondrion. 2009 Aug 22;
PMID: 19703591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19703591
Claasen AM, Guévremont D, Mason-Parker SE, Bourne K, Tate WP, Abraham WC, Williams JM
Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism.
Neurosci Lett. 2009 Aug 21;460(1):92-6.
PMID: 19463893
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19463893
Igbavboa U, Sun GY, Weisman GA, He Y, Wood WG
Amyloid beta-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes.
Neuroscience. 2009 Aug 18;162(2):328-38.
PMID: 19401218
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19401218
Grases F, Costa-Bauzà A, Prieto RM
A potential role for crystallization inhibitors in treatment of Alzheimer's disease.
Med Hypotheses. 2009 Aug 8;
PMID: 19666212
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19666212
Liu L, Hou J, Du J, Chumanov RS, Xu Q, Ge Y, Johnson JA, Murphy RM
Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity.
Protein Eng Des Sel. 2009 Aug;22(8):479-88.
PMID: 19549717
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19549717
Hardy J
The amyloid hypothesis for Alzheimer's disease: a critical reappraisal.
J Neurochem. 2009 Aug;110(4):1129-34.
PMID: 19457065
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19457065
Jagust W
Mapping brain beta-amyloid.
Curr Opin Neurol. 2009 Aug;22(4):356-61.
PMID: 19478666
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19478666
Grinberg LT, Rüb U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H, Brazilian Brain Bank Study Group
The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?
Neuropathol Appl Neurobiol. 2009 Aug;35(4):406-16.
PMID: 19508444
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19508444
Davis TJ, Soto-Ortega DD, Kotarek JA, Gonzalez-Velasquez FJ, Sivakumar K, Wu L, Wang Q, Moss MA
Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight.
Mol Pharmacol. 2009 Aug;76(2):405-13.
PMID: 19483107
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19483107
Agnati LF, Leo G, Genedani S, Piron L, Rivera A, Guidolin D, Fuxe K
Common key-signals in learning and neurodegeneration: focus on excito-amino acids, beta-amyloid peptides and alpha-synuclein.
J Neural Transm. 2009 Aug;116(8):953-74.
PMID: 19018448
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19018448
Sperling RA, Laviolette PS, O'keefe K, O'brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA
Amyloid deposition is associated with impaired default network function in older persons without dementia.
Neuron. 2009 Jul 30;63(2):178-88.
PMID: 19640477
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Hainsworth AH, Allsopp RC, Jim A, Potter JF, Lowe J, Talbot CJ, Prettyman RJ
Death-associated protein kinase (DAPK1) in cerebral cortex of late-onset Alzheimers Disease patients and aged controls.
Neuropathol Appl Neurobiol. 2009 Jul 14;
PMID: 19627511
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19627511
Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.
J Neurosci. 2009 Jul 8;29(27):8805-15.
PMID: 19587288
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19587288
Lin HC, Hsieh HM, Chen YH, Hu ML
S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters.
Neurotoxicology. 2009 Jul;30(4):622-7.
PMID: 19635394
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19635394
Zatta P, Drago D, Bolognin S, Sensi SL
Alzheimer's disease, metal ions and metal homeostatic therapy.
Trends Pharmacol Sci. 2009 Jul;30(7):346-55.
PMID: 19540003
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19540003
Kokjohn TA, Roher AE
Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions.
Alzheimers Dement. 2009 Jul;5(4):340-7.
PMID: 19560104
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Weih M, Krinninger M, Zimmermann R, Lewczuk P, Svitek J, Schaller G, Degirmenci U, Richter-Schmidinger T, Wiltfang J, Kuwert T, Kornhuber J, Schmidt D
[Sensitivity of neurochemical dementia diagnostics in CSF compared to 99mTc-SPECT in Alzheimer's dementia]
Fortschr Neurol Psychiatr. 2009 Jul;77(7):407-11.
PMID: 19582652
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19582652
Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR
Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease.
J Neuropathol Exp Neurol. 2009 Jul;68(7):774-84.
PMID: 19535994
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19535994
Capone R, Quiroz FG, Prangkio P, Saluja I, Sauer AM, Bautista MR, Turner RS, Yang J, Mayer M
Amyloid-beta-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy.
Neurotox Res. 2009 Jul;16(1):1-13.
PMID: 19526294
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19526294
Sultana R, Perluigi M, Butterfield DA
Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis.
Acta Neuropathol. 2009 Jul;118(1):131-50.
PMID: 19288120
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19288120
Shepherd C, McCann H, Halliday GM
Variations in the neuropathology of familial Alzheimer's disease.
Acta Neuropathol. 2009 Jul;118(1):37-52.
PMID: 19306098
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19306098
Arendt T
Synaptic degeneration in Alzheimer's disease.
Acta Neuropathol. 2009 Jul;118(1):167-79.
PMID: 19390859
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19390859
Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B
Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress.
ChemMedChem. 2009 Jul;4(7):1095-105.
PMID: 19396896
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19396896
Takashima A
Amyloid-beta, Tau, and Dementia.
J Alzheimers Dis. 2009 Jun 19;
PMID: 19542626
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19542626
de la Monte SM, Tong M
Mechanisms of Nitrosamine-Mediated Neurodegeneration: Potential Relevance to Sporadic Alzheimer's Disease.
J Alzheimers Dis. 2009 Jun 19;
PMID: 19542621
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19542621
Savioz A, Leuba G, Vallet PG, Walzer C
Contribution of neural networks to Alzheimer disease's progression.
Brain Res Bull. 2009 Jun 17;
PMID: 19539730
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19539730
Okura Y, Matsumoto Y
Recent advance in immunotherapies for Alzheimer's disease: With special reference to DNA vaccination.
Hum Vaccin. 2009 Jun 12;5(6)
PMID: 19221518
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19221518
Pimplikar SW
Reassessing the amyloid cascade hypothesis of Alzheimer's disease.
Int J Biochem Cell Biol. 2009 Jun;41(6):1261-8.
PMID: 19124085
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19124085
Sapra M, Kim KY
Anti-amyloid treatments in Alzheimer's disease.
Recent Pat CNS Drug Discov. 2009 Jun;4(2):143-8.
PMID: 19519562
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19519562
Funke SA, Birkmann E, Willbold D
Detection of Amyloid-beta aggregates in body fluids: a suitable method for early diagnosis of Alzheimer's disease?
Curr Alzheimer Res. 2009 Jun;6(3):285-9.
PMID: 19519310
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19519310
Rocchi A, Orsucci D, Tognoni G, Ceravolo R, Siciliano G
The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects.
Curr Alzheimer Res. 2009 Jun;6(3):224-37.
PMID: 19519304
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19519304
Sarell CJ, Syme CD, Rigby SE, Viles JH
Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form.
Biochemistry. 2009 May 26;48(20):4388-402.
PMID: 19338344
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19338344
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Münch G
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
Neurobiol Aging. 2009 May 21;
PMID: 19464758
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19464758
Kitazawa M, Vasilevko V, Cribbs DH, Laferla FM
Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model.
J Neurosci. 2009 May 13;29(19):6132-41.
PMID: 19439591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19439591
Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-Demotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA
Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance and Increases Brain Levels of Amyloid-beta Protein and Impairs Cognition.
J Alzheimers Dis. 2009 May 11;
PMID: 19433890
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19433890
Falzone TL, Stokin GB, Lillo C, Rodrigues EM, Westerman EL, Williams DS, Goldstein LS
Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.
J Neurosci. 2009 May 6;29(18):5758-67.
PMID: 19420244
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19420244
Shineman DW, Dain AS, Kim ML, Lee VM
Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.
Biochemistry. 2009 May 5;48(17):3787-94.
PMID: 19236051
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19236051
Kawahara M, Negishi-Kato M, Sadakane Y
Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.
Expert Rev Neurother. 2009 May;9(5):681-93.
PMID: 19402778
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19402778
Peters I, Igbavboa U, Schütt T, Haidari S, Hartig U, Rosello X, Böttner S, Copanaki E, Deller T, Kögel D, Wood WG, Müller WE, Eckert GP
The interaction of beta-amyloid protein with cellular membranes stimulates its own production.
Biochim Biophys Acta. 2009 May;1788(5):964-72.
PMID: 19366591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19366591
Ikonomovic MD, Wecker L, Abrahamson EE, Wuu J, Counts SE, Ginsberg SD, Mufson EJ, DeKosky ST
Cortical alpha7 nicotinic acetylcholine receptor and beta-amyloid levels in early Alzheimer disease.
Arch Neurol. 2009 May;66(5):646-51.
PMID: 19433665
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19433665
Koryakina A, Aeberhard J, Kiefer S, Hamburger M, Küenzi P
Regulation of secretases by all-trans-retinoic acid.
FEBS J. 2009 May;276(9):2645-55.
PMID: 19476501
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19476501
Takechi R, Galloway S, Pallebage-Gamarallage M, Wellington C, Johnsen R, Mamo JC
Three-dimensional colocalization analysis of plasma-derived apolipoprotein B with amyloid plaques in APP/PS1 transgenic mice.
Histochem Cell Biol. 2009 May;131(5):661-6.
PMID: 19225804
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19225804
Mormino EC, Kluth JT, Madison CM, Rabinovici GD, Baker SL, Miller BL, Koeppe RA, Mathis CA, Weiner MW, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.
Brain. 2009 May;132(Pt 5):1310-23.
PMID: 19042931
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Karlnoski RA, Rosenthal A, Kobayashi D, Pons J, Alamed J, Mercer M, Li Q, Gordon MN, Gottschall PE, Morgan D
Suppression of amyloid deposition leads to long-term reductions in Alzheimer's pathologies in Tg2576 mice.
J Neurosci. 2009 Apr 15;29(15):4964-71.
PMID: 19369565
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Vellas B, Black R, Thal LJ, Fox NC, Daniels M, McLennan G, Tompkins C, Leibman C, Pomfret M, Grundman M, AN1792 (QS-21)-251 Study Team
Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders.
Curr Alzheimer Res. 2009 Apr;6(2):144-51.
PMID: 19355849
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19355849
Palop JJ, Mucke L
Epilepsy and cognitive impairments in Alzheimer disease.
Arch Neurol. 2009 Apr;66(4):435-40.
PMID: 19204149
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19204149
Stante M, Minopoli G, Passaro F, Raia M, Vecchio LD, Russo T
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks.
Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5093-8.
PMID: 19282473
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Alper BJ, Schmidt WK
A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro.
J Neurosci Methods. 2009 Mar 30;178(1):40-5.
PMID: 19071160
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19071160
Di Carlo M
Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways.
Eur Biophys J. 2009 Mar 21;
PMID: 19305989
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19305989
Muresan V, Varvel NH, Lamb BT, Muresan Z
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
J Neurosci. 2009 Mar 18;29(11):3565-78.
PMID: 19295161
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Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7.
PMID: 19228947
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Stefani A, Sancesario G, Pierantozzi M, Leone G, Galati S, Hainsworth AH, Diomedi M
CSF biomarkers, impairment of cerebral hemodynamics and degree of cognitive decline in Alzheimer's and mixed dementia.
J Neurol Sci. 2009 Mar 9;
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19278690
Wilcock DM, Colton CA
Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice.
CNS Neurol Disord Drug Targets. 2009 Mar;8(1):50-64.
PMID: 19275636
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19275636
Shimohama S
Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models.
Biol Pharm Bull. 2009 Mar;32(3):332-6.
PMID: 19252273
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Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, Pasinetti GM
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.
Arch Neurol. 2009 Mar;66(3):352-61.
PMID: 19273754
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19273754
Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer R, Montine TJ, Craft S
Different patterns of cerebral injury in dementia with or without diabetes.
Arch Neurol. 2009 Mar;66(3):315-22.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19139294
Zhang JF, Qi JS, Qiao JT
Protein kinase C mediates amyloid beta-protein fragment 31-35-induced suppression of hippocampal late-phase long-term potentiation in vivo.
Neurobiol Learn Mem. 2009 Mar;91(3):226-34.
PMID: 19061963
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19061963
Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, Fischl B, Buckner RL
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.
Cereb Cortex. 2009 Mar;19(3):497-510.
PMID: 18632739
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Bennett S, Grant MM, Aldred S
Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology.
J Alzheimers Dis. 2009 Feb 16;
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19221412
Mandal PK, Fodale V
Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study.
Biochem Biophys Res Commun. 2009 Feb 13;379(3):716-20.
PMID: 19116131
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19116131
Guglielmotto M, Aragno M, Autelli R, Giliberto L, Novo E, Colombatto S, Danni O, Parola M, Smith MA, Perry G, Tamagno E, Tabaton M
The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha.
J Neurochem. 2009 Feb;108(4):1045-56.
PMID: 19196431
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19196431
Lee LL, Ha H, Chang YT, DeLisa MP
Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility.
Protein Sci. 2009 Feb;18(2):277-86.
PMID: 19177561
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19177561
Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.
Neurobiol Dis. 2009 Feb;33(2):213-20.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19028582
Choi SH, Bosetti F
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid.
Aging (Albany NY). 2009 Feb;1(2):234-44.
PMID: 20157512
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20157512
Corrêa DH, Ramos CH
Insights on the structure of amyloid fibrils from site-directed mutagenesis.
Protein Pept Lett. 2009;16(12):1519-25.
PMID: 20001915
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=20001915
Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H, Filipkowski RK, Kaczmarek L, Kügler S, Van Leuven F
AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
PLoS One. 2009;4(10):e7280.
PMID: 19794916
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19794916
Rabinovici GD, Jagust WJ
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo.
Behav Neurol. 2009;21(1):117-28.
PMID: 19847050
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19847050
Galloway S, Takechi R, Pallebage-Gamarallage MM, Dhaliwal SS, Mamo JC
Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine.
Lipids Health Dis. 2009;8:46.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19845970
Sohn JH, So JO, Hong HJ, Kim JW, Na DR, Kim M, Kim H, Nam E, Ha HJ, Kim YH, Mook-Jung I
Identification of autoantibody against beta-amyloid peptide in the serum of elderly.
Front Biosci. 2009;14:3879-83.
PMID: 19273318
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Jakob-Roetne R, Jacobsen H
Alzheimer's disease: from pathology to therapeutic approaches.
Angew Chem Int Ed Engl. 2009;48(17):3030-59.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19330877
Nimmrich V, Ebert U
Is Alzheimer's disease a result of presynaptic failure? Synaptic dysfunctions induced by oligomeric beta-amyloid.
Rev Neurosci. 2009;20(1):1-12.
PMID: 19526730
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19526730
Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, Harry GJ, Rice DC, Zawia NH, Lahiri DK
Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice.
J Alzheimers Dis. 2009;18(1):211-30.
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19584442
Panza F, Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, Capurso A, Imbimbo BP
Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.
Drugs Aging. 2009;26(7):537-55.
PMID: 19655822
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19655822
Anderson PJ, Watts HR, Jen S, Gentleman SM, Moncaster JA, Walsh DT, Jen LS
Differential effects of interleukin-1beta and S100B on amyloid precursor protein in rat retinal neurons.
Clin Ophthalmol. 2009;3:235-42.
PMID: 19668572
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Pirchl M, Humpel C
[Does acidosis in brain play a role in Alzheimer's disease?]
Neuropsychiatr. 2009;23(3):187-92.
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Solomon B
Immunotherapeutic strategies for Alzheimer's disease treatment.
ScientificWorldJournal. 2009;9:909-19.
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Mohandas E, Rajmohan V, Raghunath B
Neurobiology of Alzheimer's disease.
Indian J Psychiatry. 2009 Jan;51(1):55-61.
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Gatta LB, Vitali M, Verardi R, Arosio P, Finazzi D
Inhibition of heme synthesis alters Amyloid Precursor Protein processing.
J Neural Transm. 2009 Jan;116(1):79-88.
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Nelson PT, Braak H, Markesbery WR
Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship.
J Neuropathol Exp Neurol. 2009 Jan;68(1):1-14.
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Qin W, Ho L, Wang J, Peskind E, Pasinetti GM
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10.
PLoS ONE. 2009;4(1):e4183.
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Serretti A, Olgiati P, Politis A, Malitas P, Albani D, Dusi S, Polito L, De Mauro S, Zisaki A, Piperi C, Liappas I, Stamouli E, Mailis A, Atti AR, Morri M, Ujkaj M, Batelli S, Forloni G, Soldatos CR, Papadimitriou GN, De Ronchi D, Kalofoutis A
Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two Independent European samples.
J Alzheimers Dis. 2009 Jan;16(1):181-7.
PMID: 19158434
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Williams M
Progress in Alzheimer's disease drug discovery: an update.
Curr Opin Investig Drugs. 2009 Jan;10(1):23-34.
PMID: 19127484
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Minniti AN, Rebolledo DL, Grez PM, Fadic R, Aldunate R, Volitakis I, Cherny RA, Opazo C, Masters C, Bush AI, Inestrosa NC
Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification.
Mol Neurodegener. 2009;4(1):2.
PMID: 19126228
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19126228
Arimon M, Grimminger V, Sanz F, Lashuel HA
Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils.
J Mol Biol. 2008 Dec 31;384(5):1157-73.
PMID: 18851977
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18851977
Ricagno S, Colombo M, de Rosa M, Sangiovanni E, Giorgetti S, Raimondi S, Bellotti V, Bolognesi M
DE loop mutations affect beta2-microglobulin stability and amyloid aggregation.
Biochem Biophys Res Commun. 2008 Dec 5;377(1):146-50.
PMID: 18835253
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18835253
Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA
Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain.
Brain. 2008 Dec;131(Pt 12):3299-310.
PMID: 18953056
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18953056
Ohyagi Y
Intracellular amyloid beta-protein as a therapeutic target for treating Alzheimer's disease.
Curr Alzheimer Res. 2008 Dec;5(6):555-61.
PMID: 19075582
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19075582
Wilcock DM, Colton CA
Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.
J Alzheimers Dis. 2008 Dec;15(4):555-69.
PMID: 19096156
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19096156
T Cuenco K, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA, MIRAGE Study Group
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
Arch Neurol. 2008 Dec;65(12):1640-8.
PMID: 19064752
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19064752
Inoue S
In situ Abeta pores in AD brain are cylindrical assembly of Abeta protofilaments.
Amyloid. 2008 Dec;15(4):223-33.
PMID: 19065293
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19065293
Praticò D
Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows.
Ann N Y Acad Sci. 2008 Dec;1147:70-8.
PMID: 19076432
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19076432
Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T
Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
Curr Stem Cell Res Ther. 2008 Dec;3(4):288-302.
PMID: 19075758
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19075758
Staehelin HB
Neuronal protection by bioactive nutrients.
Int J Vitam Nutr Res. 2008 Dec;78(6):282-5.
PMID: 19685437
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19685437
Srivastava N, Averna M, Srivastava RA
Dietary cholesterol and estrogen administration elevate brain apolipoprotein E in mice by different mechanisms.
Indian J Biochem Biophys. 2008 Dec;45(6):410-5.
PMID: 19239128
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19239128
Conley YP, Mukherjee A, Kammerer C, Dekosky ST, Kamboh MI, Finegold DN, Ferrell RE
Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease.
Am J Med Genet B Neuropsychiatr Genet. 2008 Nov 26;
PMID: 19035514
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19035514
Dodson SE, Andersen OM, Karmali V, Fritz JJ, Cheng D, Peng J, Levey AI, Willnow TE, Lah JJ
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.
J Neurosci. 2008 Nov 26;28(48):12877-86.
PMID: 19036982
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19036982
Small SA, Duff K
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis.
Neuron. 2008 Nov 26;60(4):534-42.
PMID: 19038212
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19038212
Rivière C, Delaunay JC, Immel F, Cullin C, Monti JP
The Polyphenol Piceid Destabilizes Preformed Amyloid Fibrils and Oligomers In Vitro: Hypothesis on Possible Molecular Mechanisms.
Neurochem Res. 2008 Nov 23;
PMID: 19030989
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19030989
Yankner BA, Lu T
Amyloid beta -protein toxicity and the pathogenesis of Alzheimer's disease.
J Biol Chem. 2008 Nov 13;
PMID: 18957434
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18957434
Nadal RC, Rigby SE, Viles JH
Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals.
Biochemistry. 2008 Nov 4;47(44):11653-64.
PMID: 18847222
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18847222
Roe CM, Mintun MA, D'Angelo G, Xiong C, Grant EA, Morris JC
Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.
Arch Neurol. 2008 Nov;65(11):1467-71.
PMID: 19001165
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19001165
Bayer TA, Wirths O
[Alzheimer's disease. Molecular pathology, animal models, and current treatment]
Nervenarzt. 2008 Nov;79 Suppl 3:117-25; quiz 126-7.
PMID: 18820894
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18820894
Tan J, Mao G, Cui MZ, Kang SC, Lamb B, Wong BS, Sy MS, Xu X
Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.
J Neurochem. 2008 Nov;107(3):722-33.
PMID: 18752644
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18752644
Sambasivam D, Liu CW, Jayaraman M, Malar EJ, Rajadas J
Aggregation and conformational studies on a pentapeptide derivative.
Biochim Biophys Acta. 2008 Nov;1784(11):1659-67.
PMID: 18775521
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18775521
Pattison JS, Robbins J
Protein misfolding and cardiac disease: establishing cause and effect.
Autophagy. 2008 Nov-Dec;4(6):821-3.
PMID: 18612262
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18612262
Thinakaran G, Koo EH
Amyloid precursor protein trafficking, processing, and function.
J Biol Chem. 2008 Oct 31;283(44):29615-9.
PMID: 18650430
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18650430
Foster JK, Verdile G, Bates KA, Martins RN
Immunization in Alzheimer's disease: naïve hope or realistic clinical potential?
Mol Psychiatry. 2008 Oct 28;
PMID: 18957942
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18957942
Morgan D, Landreth G, Bickford P
The Promise and Perils of an Alzheimer Disease Vaccine: A Video Debate.
J Neuroimmune Pharmacol. 2008 Oct 23;
PMID: 18946741
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18946741
Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ
Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.
J Neurosci. 2008 Oct 8;28(41):10422-33.
PMID: 18842902
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18842902
Wan Y, Wang G, Chen SD
Genetic predisposition to inflammation: a new risk factor of Alzheimer's disease.
Neurosci Bull. 2008 Oct;24(5):314-22.
PMID: 18839025
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18839025
Bush AI
Drug development based on the metals hypothesis of Alzheimer's disease.
J Alzheimers Dis. 2008 Oct;15(2):223-40.
PMID: 18953111
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18953111
Mancuso M, Orsucci D, Siciliano G, Murri L
Mitochondria, mitochondrial DNA and Alzheimer's disease. What comes first?
Curr Alzheimer Res. 2008 Oct;5(5):457-68.
PMID: 18855587
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18855587
Goldsbury C, Whiteman IT, Jeong EV, Lim YA
Oxidative stress increases levels of endogenous amyloid-beta peptides secreted from primary chick brain neurons.
Aging Cell. 2008 Oct;7(5):771-5.
PMID: 18691184
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18691184
Brinton RD
Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease.
Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1504-11.
PMID: 18647624
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18647624
Pluta R, Amek MU
Brain ischemia and ischemic blood-brain barrier as etiological factors in sporadic Alzheimer's disease.
Neuropsychiatr Dis Treat. 2008 Oct;4(5):855-64.
PMID: 19183778
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19183778
Alisky JM
Intrathecal corticosteroids might slow Alzheimer's disease progression.
Neuropsychiatr Dis Treat. 2008 Oct;4(5):831-3.
PMID: 19183775
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19183775
Streltsov VA, Titmuss SJ, Epa VC, Barnham KJ, Masters CL, Varghese JN
The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.
Biophys J. 2008 Oct;95(7):3447-56.
PMID: 18599641
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18599641
Sugimoto H
The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis.
Chem Biol Interact. 2008 Sep 25;175(1-3):204-8.
PMID: 18577377
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18577377
Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Science. 2008 Sep 19;321(5896):1686-9.
PMID: 18802001
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18802001
Bates KA, Verdile G, Li QX, Ames D, Hudson P, Masters CL, Martins RN
Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests.
Mol Psychiatry. 2008 Sep 16;
PMID: 18794889
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18794889
Barrou Z, Lemaire A, Boddaert J, Verny M
[Diabetes mellitus and cognition: is there a link?]
Psychol Neuropsychiatr Vieil. 2008 Sep;6(3):189-98.
PMID: 18786878
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18786878
Gruschus JM
Do amyloid oligomers act as traps for misfolded proteins? A hypothesis.
Amyloid. 2008 Sep;15(3):160-5.
PMID: 18925454
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18925454
Chiang PK, Lam MA, Luo Y
The many faces of amyloid beta in Alzheimer's disease.
Curr Mol Med. 2008 Sep;8(6):580-4.
PMID: 18781964
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18781964
Takechi R, Galloway S, Pallebage-Gamarallage MM, Mamo JC
Chylomicron amyloid-beta in the aetiology of Alzheimer's disease.
Atheroscler Suppl. 2008 Sep;9(2):19-25.
PMID: 18640080
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18640080
Zhou J, Fonseca MI, Pisalyaput K, Tenner AJ
Complement C3 and C4 expression in C1q sufficient and deficient mouse models of Alzheimer's disease.
J Neurochem. 2008 Sep;106(5):2080-92.
PMID: 18624920
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18624920
Ceru S, Kokalj SJ, Rabzelj S, Skarabot M, Gutierrez-Aguirre I, Kopitar-Jerala N, Anderluh G, Turk D, Turk V, Zerovnik E
Size and morphology of toxic oligomers of amyloidogenic proteins: a case study of human stefin B.
Amyloid. 2008 Sep;15(3):147-59.
PMID: 18925453
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18925453
Stone J
What initiates the formation of senile plaques? The origin of Alzheimer-like dementias in capillary haemorrhages.
Med Hypotheses. 2008 Sep;71(3):347-59.
PMID: 18524497
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18524497
Selkoe DJ
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.
Behav Brain Res. 2008 Sep 1;192(1):106-13.
PMID: 18359102
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18359102
Jin SM, Cho HJ, Jung ES, Shim MY, Mook-Jung I
DNA damage-inducing agents elicit gamma-secretase activation mediated by oxidative stress.
Cell Death Differ. 2008 Sep;15(9):1375-84.
PMID: 18421302
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18421302
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Science. 2008 Aug 29;321(5893):1221-4.
PMID: 18755980
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18755980
Yeh HL, Tsai SJ
Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease.
Med Hypotheses. 2008 Aug 27;
PMID: 18760542
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18760542
Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, Roach AH, Cantone JL, Ford MJ, Drexler DM, Olson RE, Yang MG, Bergstrom CP, McElhone KE, Bronson JJ, Macor JE, Blat Y, Grafstrom RH, Stern AM, Seiffert DA, Zaczek R, Albright CF, Toyn JH
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
J Biol Chem. 2008 Aug 22;283(34):22992-3003.
PMID: 18574238
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18574238
Dezfulian M, Shokrgozar MA, Sardari S, Parivar K, Javadi G
Can phages cause Alzheimer's disease?
Med Hypotheses. 2008 Aug 11;
PMID: 18701222
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18701222
Villemagne VL, Fodero-Tavoletti MT, Pike KE, Cappai R, Masters CL, Rowe CC
The ART of loss: Abeta imaging in the evaluation of Alzheimer's disease and other dementias.
Mol Neurobiol. 2008 Aug;38(1):1-15.
PMID: 18690556
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18690556
Peri A, Serio M
Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.
Neuropsychiatr Dis Treat. 2008 Aug;4(4):817-824.
PMID: 19043524
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19043524
Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
J Pharmacol Exp Ther. 2008 Aug;326(2):502-13.
PMID: 18499745
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18499745
Cowan CB, Coté GL, Good TA
Development of photocrosslinked sialic acid containing polymers for use in Abeta toxicity attenuation.
Biomaterials. 2008 Aug-Sep;29(24-25):3408-14.
PMID: 18508118
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18508118
Patel JR, Brewer GJ
Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid.
J Neurosci Res. 2008 Aug 1;86(10):2303-13.
PMID: 18418902
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18418902
Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA
Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease.
J Nutr Biochem. 2008 Jul 3;
PMID: 18602817
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18602817
Bush AI, Tanzi RE
Therapeutics for Alzheimer's disease based on the metal hypothesis.
Neurotherapeutics. 2008 Jul;5(3):421-32.
PMID: 18625454
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18625454
Zlokovic BV
New therapeutic targets in the neurovascular pathway in Alzheimer's disease.
Neurotherapeutics. 2008 Jul;5(3):409-14.
PMID: 18625452
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18625452
Butters MA, Klunk WE, Mathis CA, Price JC, Ziolko SK, Hoge JA, Tsopelas ND, Lopresti BJ, Reynolds CF, DeKosky ST, Meltzer CC
Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B.
Alzheimer Dis Assoc Disord. 2008 Jul-Sep;22(3):261-8.
PMID: 18580591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18580591
Grimmer T, Perneczky R, Kurz A
[Current immune therapy for Alzheimer's disease.]
Nervenarzt. 2008 Jul;79(7):832-5.
PMID: 18542908
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18542908
Shelat PB, Chalimoniuk M, Wang JH, Strosznajder JB, Lee JC, Sun AY, Simonyi A, Sun GY
Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons.
J Neurochem. 2008 Jul;106(1):45-55.
PMID: 18346200
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18346200
Fernández JA, Rojo L, Kuljis RO, Maccioni RB
The damage signals hypothesis of Alzheimer's disease pathogenesis.
J Alzheimers Dis. 2008 Jul;14(3):329-33.
PMID: 18599959
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18599959
Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK
Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.
Neuron. 2008 Jun 26;58(6):871-83.
PMID: 18579078
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18579078
Jacobsen JS, Comery TA, Martone RL, Elokdah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzales C, Xu J, Zhou H, Atchison K, Wagner E, Zaleska MM, Das I, Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia M, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.
Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8754-9.
PMID: 18559859
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18559859
Pákáski M, Kálmán J
Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease.
Neurochem Int. 2008 Jun 17;
PMID: 18602955
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18602955
Resende R, Moreira PI, Proença T, Deshpande A, Busciglio J, Pereira C, Oliveira CR
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Free Radic Biol Med. 2008 Jun 15;44(12):2051-7.
PMID: 18423383
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18423383
Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, Younkin SG, Graff-Radford N, Dickson D, Rosenberry T, Golde TE
BRI2 (ITM2b) inhibits Abeta deposition in vivo.
J Neurosci. 2008 Jun 4;28(23):6030-6.
PMID: 18524908
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18524908
Lukiw WJ
Emerging amyloid beta (Ab) peptide modulators for the treatment of Alzheimer's disease (AD).
Expert Opin Emerg Drugs. 2008 Jun;13(2):255-71.
PMID: 18537520
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18537520
Kaminsky YG, Kosenko EA
Effects of amyloid-beta peptides on hydrogen peroxide-metabolizing enzymes in rat brain in vivo.
Free Radic Res. 2008 Jun;42(6):564-73.
PMID: 18569014
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18569014
van Marum RJ
Current and future therapy in Alzheimer's disease.
Fundam Clin Pharmacol. 2008 Jun;22(3):265-74.
PMID: 18485144
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18485144
Jayaraman M, Kannayiram G, Rajadas J
Amyloid toxicity in skeletal myoblasts: Implications for inclusion-body myositis.
Arch Biochem Biophys. 2008 Jun 1;474(1):15-21.
PMID: 18397759
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18397759
Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
Am J Pathol. 2008 Jun;172(6):1683-92.
PMID: 18467692
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18467692
Li M, Ager RR, Fraser DA, Tjokro NO, Tenner AJ
Development of a humanized C1q A chain knock-in mouse: assessment of antibody independent beta-amyloid induced complement activation.
Mol Immunol. 2008 Jun;45(11):3244-52.
PMID: 18400300
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18400300
Venugopal C, Demos CM, Rao KS, Pappolla MA, Sambamurti K
Beta-secretase: structure, function, and evolution.
CNS Neurol Disord Drug Targets. 2008 Jun;7(3):278-94.
PMID: 18673212
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18673212
Kerrigan TL, Atkinson L, Peers C, Pearson HA
Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein.
Neuroreport. 2008 May 28;19(8):839-43.
PMID: 18463498
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18463498
Barnham KJ, Kenche VB, Ciccotosto GD, Smith DP, Tew DJ, Liu X, Perez K, Cranston GA, Johanssen TJ, Volitakis I, Bush AI, Masters CL, White AR, Smith JP, Cherny RA, Cappai R
Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease.
Proc Natl Acad Sci U S A. 2008 May 13;105(19):6813-8.
PMID: 18463291
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18463291
Zaheer A, Zaheer S, Thangavel R, Wu Y, Sahu SK, Yang B
Glia maturation factor modulates beta-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage.
Brain Res. 2008 May 7;1208:192-203.
PMID: 18395194
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18395194
Marcello E, Epis R, Di Luca M
Amyloid flirting with synaptic failure: towards a comprehensive view of Alzheimer's disease pathogenesis.
Eur J Pharmacol. 2008 May 6;585(1):109-18.
PMID: 18377893
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18377893
Gellermann GP, Byrnes H, Striebinger A, Ullrich K, Mueller R, Hillen H, Barghorn S
A beta-globulomers are formed independently of the fibril pathway.
Neurobiol Dis. 2008 May;30(2):212-20.
PMID: 18353662
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18353662
Schaeffer EL, Gattaz WF
Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A(2) enzyme.
Psychopharmacology (Berl). 2008 May;198(1):1-27.
PMID: 18392810
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18392810
Solomon PR, Murphy CA
Early diagnosis and treatment of Alzheimer's disease.
Expert Rev Neurother. 2008 May;8(5):769-80.
PMID: 18457534
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18457534
András IE, Rha G, Huang W, Eum S, Couraud PO, Romero IA, Hennig B, Toborek M
Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells.
Mol Pharmacol. 2008 May;73(5):1424-33.
PMID: 18276775
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18276775
Allen PB, Chiu DT
Alzheimer's disease protein Abeta1-42 does not disrupt isolated synaptic vesicles.
Biochim Biophys Acta. 2008 May;1782(5):326-34.
PMID: 18339328
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18339328
Haataja L, Gurlo T, Huang CJ, Butler PC
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.
Endocr Rev. 2008 May;29(3):303-16.
PMID: 18314421
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18314421
Sugimoto H
[New approaches for the development of anti-Alzheimer's disease drugs based on the cholinergic hypothesis and amyloid hypothesis]
Nippon Yakurigaku Zasshi. 2008 May;131(5):338-40.
PMID: 18480562
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18480562
Korczyn AD
The amyloid cascade hypothesis.
Alzheimers Dement. 2008 May;4(3):176-8.
PMID: 18631966
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18631966
Shineman DW, Zhang B, Leight SN, Pratico D, Lee VM
Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice.
J Neurosci. 2008 Apr 30;28(18):4785-94.
PMID: 18448655
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18448655
Boyle PA, Wilson RS, Schneider JA, Bienias JL, Bennett DA
Processing resources reduce the effect of Alzheimer pathology on other cognitive systems.
Neurology. 2008 Apr 22;70(17):1534-42.
PMID: 18354077
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18354077
Engel MF, Khemtémourian L, Kleijer CC, Meeldijk HJ, Jacobs J, Verkleij AJ, de Kruijff B, Killian JA, Höppener JW
Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane.
Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6033-8.
PMID: 18408164
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18408164
Hampel H, Shen Y
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.
Scand J Clin Lab Invest. 2008 Apr 9;:1-5.
PMID: 18609117
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18609117
Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC
Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5585-90.
PMID: 18385378
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18385378
Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta.
J Neurosci. 2008 Apr 2;28(14):3555-66.
PMID: 18385314
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18385314
Okura Y, Matsumoto Y
DNA vaccine therapy for Alzheimer's disease: present status and future direction.
Rejuvenation Res. 2008 Apr;11(2):301-8.
PMID: 18442321
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18442321
Bertoni-Freddari C, Sensi SL, Giorgetti B, Balietti M, Di Stefano G, Canzoniero LM, Casoli T, Fattoretti P
Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease.
Rejuvenation Res. 2008 Apr;11(2):309-13.
PMID: 18328008
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18328008
Hoyer W, Grönwall C, Jonsson A, Ståhl S, Härd T
Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation.
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5099-104.
PMID: 18375754
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18375754
Solomon B
Immunological approaches for amyloid-beta clearance toward treatment for Alzheimer's disease.
Rejuvenation Res. 2008 Apr;11(2):349-57.
PMID: 18341423
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18341423
Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D'Anselmi F, Coluccia P, Calamandrei G, Scarpa S
B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice.
Mol Cell Neurosci. 2008 Apr;37(4):731-46.
PMID: 18243734
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18243734
Wiesehan K, Stöhr J, Nagel-Steger L, van Groen T, Riesner D, Willbold D
Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide.
Protein Eng Des Sel. 2008 Apr;21(4):241-6.
PMID: 18252750
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18252750
Goto Y, Niidome T, Hongo H, Akaike A, Kihara T, Sugimoto H
Impaired muscarinic regulation of excitatory synaptic transmission in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
Eur J Pharmacol. 2008 Mar 31;583(1):84-91.
PMID: 18282567
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18282567
Kim W, Hecht MH
Mutations enhance the aggregation propensity of the Alzheimer's A beta peptide.
J Mol Biol. 2008 Mar 21;377(2):565-74.
PMID: 18258258
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18258258
Niwa R, Zhou F, Li C, Slack FJ
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.
Dev Biol. 2008 Mar 15;315(2):418-25.
PMID: 18262516
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18262516
Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H
beta-Amyloid deposition in brains of subjects with diabetes.
Neuropathol Appl Neurobiol. 2008 Mar 10;
PMID: 18346114
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18346114
Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
Ann Neurol. 2008 Mar;63(3):377-87.
PMID: 18300294
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18300294
Salloway S, Mintzer J, Weiner MF, Cummings JL
Disease-modifying therapies in Alzheimer's disease.
Alzheimers Dement. 2008 Mar;4(2):65-79.
PMID: 18631951
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18631951
Stopa EG, Butala P, Salloway S, Johanson CE, Gonzalez L, Tavares R, Hovanesian V, Hulette CM, Vitek MP, Cohen RA
Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype.
Stroke. 2008 Mar;39(3):814-21.
PMID: 18258839
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18258839
Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Van Leuven F
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Am J Pathol. 2008 Mar;172(3):786-98.
PMID: 18258852
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18258852
Hooper C, Killick R, Lovestone S
The GSK3 hypothesis of Alzheimer's disease.
J Neurochem. 2008 Mar;104(6):1433-9.
PMID: 18088381
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18088381
Bojarski L, Herms J, Kuznicki J
Calcium dysregulation in Alzheimer's disease.
Neurochem Int. 2008 Mar-Apr;52(4-5):621-33.
PMID: 18035450
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18035450
Austen BM, Paleologou KE, Ali SA, Qureshi MM, Allsop D, El-Agnaf OM
Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.
Biochemistry. 2008 Feb 19;47(7):1984-92.
PMID: 18189413
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18189413
Lashley T, Revesz T, Plant G, Bandopadhyay R, Lees AJ, Frangione B, Wood NW, de Silva R, Ghiso J, Rostagno A, Holton JL
Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease.
Neuropathol Appl Neurobiol. 2008 Feb 13;
PMID: 18282158
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18282158
Haynes RL, Billiards SS, Borenstein NS, Volpe JJ, Kinney HC
Diffuse Axonal Injury in Periventricular Leukomalacia as Determined by Apoptotic Marker Fractin.
Pediatr Res. 2008 Feb 13;
PMID: 18277940
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18277940
Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature. 2008 Feb 7;451(7179):720-4.
PMID: 18256671
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18256671
Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR, Breitner JC, DeGroodt W, Mehta P, Craft S
Intranasal insulin improves cognition and modulates beta-amyloid in early AD.
Neurology. 2008 Feb 5;70(6):440-8.
PMID: 17942819
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17942819
Revuelta GJ, Rosso A, Lippa CF
Neuritic pathology as a correlate of synaptic loss in dementia with lewy bodies.
Am J Alzheimers Dis Other Demen. 2008 Feb-Mar;23(1):97-102.
PMID: 18276962
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18276962
[No authors listed]
The mechanisms of neurodegenerative processes and current pharmacotherapy of Alzheimer's disease.
Georgian Med News. 2008 Feb;(155):44-8.
PMID: 18401056
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18401056
Kawahara M
[Conformational change, pore formation and neurotoxicity of amyloidogenic proteins]
Rinsho Byori. 2008 Feb;56(2):130-6.
PMID: 18404827
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18404827
Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC
Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum.
Brain Res. 2008 Jan 23;1190:215-24.
PMID: 18083148
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18083148
Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP
Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.
J Neurosci Res. 2008 Jan 11;
PMID: 18189321
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18189321
Rojo LE, Fernández JA, Maccioni AA, Jimenez JM, Maccioni RB
Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease.
Arch Med Res. 2008 Jan;39(1):1-16.
PMID: 18067990
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18067990
Imbimbo BP
Therapeutic potential of gamma-secretase inhibitors and modulators.
Curr Top Med Chem. 2008;8(1):54-61.
PMID: 18220933
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18220933
Shrivastava-Ranjan P, Faundez V, Fang G, Rees H, Lah JJ, Levey AI, Kahn RA
Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.
Mol Biol Cell. 2008 Jan;19(1):51-64.
PMID: 17959829
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17959829
Klevay LM
Alzheimer's disease as copper deficiency.
Med Hypotheses. 2008;70(4):802-7.
PMID: 17928161
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17928161
Kemppainen NM, Aalto S, Karrasch M, Någren K, Savisto N, Oikonen V, Viitanen M, Parkkola R, Rinne JO
Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease.
Ann Neurol. 2008 Jan;63(1):112-8.
PMID: 18023012
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18023012
Das HK
Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease.
Front Biosci. 2008;13:822-32.
PMID: 17981591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17981591
Götz J, David D, Hoerndli F, Ke YD, Schonrock N, Wiesner A, Fath T, Bokhari L, Lim YA, Deters N, Ittner LM
Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response.
Neurodegener Dis. 2008;5(3-4):179-81.
PMID: 18322384
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18322384
García-Palomero E, Muñoz P, Usan P, Garcia P, Delgado E, De Austria C, Valenzuela R, Rubio L, Medina M, Martínez A
Potent beta-amyloid modulators.
Neurodegener Dis. 2008;5(3-4):153-6.
PMID: 18322376
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18322376
Nagai A, Terashima M, Sheikh AM, Notsu Y, Shimode K, Yamaguchi S, Kobayashi S, Kim SU, Masuda J
Involvement of cystatin C in pathophysiology of CNS diseases.
Front Biosci. 2008;13:3470-9.
PMID: 18508448
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18508448
Streit WJ, Miller KR, Lopes KO, Njie E
Microglial degeneration in the aging brain--bad news for neurons?
Front Biosci. 2008;13:3423-38.
PMID: 18508444
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18508444
Kummer MP, Heneka MT
PPARs in Alzheimer's Disease.
PPAR Res. 2008;2008:403896.
PMID: 18645613
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18645613
Wang DS, Dickson DW, Malter JS
Tissue transglutaminase, protein cross-linking and Alzheimer's disease: review and views.
Int J Clin Exp Pathol. 2008;1(1):5-18.
PMID: 18784819
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18784819
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA, Nicoletti F
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development.
Curr Med Chem. 2008;15(24):2420-32.
PMID: 18855671
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18855671
Nagai Y, Popiel HA
Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: exposed beta-sheet hypothesis.
Curr Pharm Des. 2008;14(30):3267-79.
PMID: 19075705
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19075705
Bajic VP, Spremo-Potparevic B, Zivkovic L, Djelic N, Smith MA
Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics?
Biosci Hypotheses. 2008;1(3):156-161.
PMID: 19122823
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19122823
Cashman JR, Ghirmai S, Abel KJ, Fiala M
Immune defects in Alzheimer's disease: new medications development.
BMC Neurosci. 2008;9 Suppl 2:S13.
PMID: 19090986
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=19090986
Cheon MS, Dierssen M, Kim SH, Lubec G
Protein expression of BACE1, BACE2 and APP in Down syndrome brains.
Amino Acids. 2007 Dec 29;
PMID: 18163181
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18163181
Tachida Y, Nakagawa K, Saito T, Saido TC, Honda T, Saito Y, Murayama S, Endo T, Sakaguchi G, Kato A, Kitazume S, Hashimoto Y
Interleukin-1beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production.
J Neurochem. 2007 Dec 19;
PMID: 18021299
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18021299
Crawford FC, Wood M, Ferguson S, Mathura VS, Faza B, Wilson S, Fan T, O'Steen B, Ait-Ghezala G, Hayes R, Mullan MJ
Genomic analysis of response to traumatic brain injury in a mouse model of Alzheimer's disease (APPsw).
Brain Res. 2007 Dec 14;1185:45-58.
PMID: 17961517
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17961517
Vasilevko V, Xu F, Previti ML, Van Nostrand WE, Cribbs DH
Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice.
J Neurosci. 2007 Dec 5;27(49):13376-83.
PMID: 18057195
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18057195
Torres-Aleman I
Targeting insulin-like growth factor-1 to treat Alzheimer's disease.
Expert Opin Ther Targets. 2007 Dec;11(12):1535-42.
PMID: 18020976
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18020976
Barrantes A, Rejas MT, Benítez MJ, Jiménez JS
Interaction between Alzheimer's Abeta1-42 peptide and DNA detected by surface plasmon resonance.
J Alzheimers Dis. 2007 Dec;12(4):345-55.
PMID: 18198421
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18198421
Nelson PT, Jicha GA, Schmitt FA, Liu H, Davis DG, Mendiondo MS, Abner EL, Markesbery WR
Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity.
J Neuropathol Exp Neurol. 2007 Dec;66(12):1136-46.
PMID: 18090922
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18090922
Mahley RW, Huang Y, Weisgraber KH
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Curr Alzheimer Res. 2007 Dec;4(5):537-40.
PMID: 18220516
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18220516
Talmard C, Bouzan A, Faller P
Zinc binding to amyloid-beta: isothermal titration calorimetry and Zn competition experiments with Zn sensors.
Biochemistry. 2007 Nov 27;46(47):13658-66.
PMID: 17983245
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17983245
Taniuchi N, Niidome T, Goto Y, Akaike A, Kihara T, Sugimoto H
Decreased proliferation of hippocampal progenitor cells in APPswe/PS1dE9 transgenic mice.
Neuroreport. 2007 Nov 19;18(17):1801-5.
PMID: 18090315
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18090315
Townsend M, Mehta T, Selkoe DJ
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
J Biol Chem. 2007 Nov 16;282(46):33305-12.
PMID: 17855343
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17855343
Levi O, Dolev I, Belinson H, Michaelson DM
Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation.
J Neurochem. 2007 Nov;103(3):1031-40.
PMID: 17666042
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17666042
Hawkes CA, McLaurin J
Immunotherapy as treatment for Alzheimer's disease.
Expert Rev Neurother. 2007 Nov;7(11):1535-48.
PMID: 17997702
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17997702
Dias WB, Hart GW
O-GlcNAc modification in diabetes and Alzheimer's disease.
Mol Biosyst. 2007 Nov;3(11):766-72.
PMID: 17940659
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17940659
Jiang ZJ, Richardson JS, Yu PH
The contribution of cerebral vascular semicarbazide-sensitive amine oxidase to cerebral amyloid angiopathy in Alzheimer's disease.
Neuropathol Appl Neurobiol. 2007 Oct 29;
PMID: 17971074
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17971074
Massone S, Argellati F, Passalacqua M, Armirotti A, Melone L, D'Abramo C, Marinari UM, Domenicotti C, Pronzato MA, Ricciarelli R
Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.
Biochem Biophys Res Commun. 2007 Oct 26;362(3):633-8.
PMID: 17727819
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17727819
Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB
Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.
Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16522-7.
PMID: 17940047
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17940047
Catania C, Sotiropoulos I, Silva R, Onofri C, Breen KC, Sousa N, Almeida OF
The amyloidogenic potential and behavioral correlates of stress.
Mol Psychiatry. 2007 Oct 2;
PMID: 17912249
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17912249
Mathis CA, Lopresti BJ, Klunk WE
Impact of amyloid imaging on drug development in Alzheimer's disease.
Nucl Med Biol. 2007 Oct;34(7):809-22.
PMID: 17921032
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17921032
Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA
Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment.
Arch Gen Psychiatry. 2007 Oct;64(10):1204-12.
PMID: 17909133
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17909133
Schulz B, Liebisch G, Grandl M, Werner T, Barlage S, Schmitz G
Beta-amyloid (Abeta40, Abeta42) binding to modified LDL accelerates macrophage foam cell formation.
Biochim Biophys Acta. 2007 Oct;1771(10):1335-44.
PMID: 17881287
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17881287
Li M, Chen L, Lee DH, Yu LC, Zhang Y
The role of intracellular amyloid beta in Alzheimer's disease.
Prog Neurobiol. 2007 Oct;83(3):131-9.
PMID: 17889422
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17889422
Seabrook GR, Ray WJ, Shearman M, Hutton M
Beyond amyloid: the next generation of Alzheimer's disease therapeutics.
Mol Interv. 2007 Oct;7(5):261-70.
PMID: 17932415
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17932415
Josephs KA, Whitwell JL, Ahmed Z, Shiung MM, Weigand SD, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Dickson DW, Jack CR
beta-amyloid burden is not associated with rates of brain atrophy.
Ann Neurol. 2007 Sep 25;
PMID: 17894374
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17894374
Ding JD, Lin J, Mace BE, Herrmann R, Sullivan P, Bowes Rickman C
Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: Anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model.
Vision Res. 2007 Sep 19;
PMID: 17888483
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17888483
Boelen E, Stassen FR, van der Ven AJ, Lemmens MA, Steinbusch HP, Bruggeman CA, Schmitz C, Steinbusch HW
Detection of amyloid beta aggregates in the brain of BALB/c mice after Chlamydia pneumoniae infection.
Acta Neuropathol. 2007 Sep;114(3):255-61.
PMID: 17581756
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17581756
Wiesehan K, Funke SA, Fries M, Willbold D
Purification of recombinantly expressed and cytotoxic human amyloid-beta peptide 1-42.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Sep 1;856(1-2):229-33.
PMID: 17606418
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17606418
Nelissen N, Vandenbulcke M, Fannes K, Verbruggen A, Peeters R, Dupont P, Van Laere K, Bormans G, Vandenberghe R
Abeta amyloid deposition in the language system and how the brain responds.
Brain. 2007 Aug;130(Pt 8):2055-69.
PMID: 17586869
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17586869
Lal R, Lin H, Quist AP
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
Biochim Biophys Acta. 2007 Aug;1768(8):1966-75.
PMID: 17553456
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17553456
Heneka MT, Landreth GE
PPARs in the brain.
Biochim Biophys Acta. 2007 Aug;1771(8):1031-45.
PMID: 17569578
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17569578
Lambert JC, Amouyel P
Genetic heterogeneity of Alzheimer's disease: complexity and advances.
Psychoneuroendocrinology. 2007 Aug;32 Suppl 1:S62-70.
PMID: 17659844
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17659844
Eckman CB, Eckman EA
An update on the amyloid hypothesis.
Neurol Clin. 2007 Aug;25(3):669-82, vi.
PMID: 17659184
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17659184
Oddo S, Caccamo A, Cheng D, Jouleh B, Torp R, LaFerla FM
Genetically augmenting tau levels does not modulate the onset or progression of Abeta pathology in transgenic mice.
J Neurochem. 2007 Aug;102(4):1053-63.
PMID: 17472708
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17472708
Arispe N, Diaz JC, Simakova O
Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers.
Biochim Biophys Acta. 2007 Aug;1768(8):1952-65.
PMID: 17490607
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17490607
Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J
Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin.
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12849-54.
PMID: 17652175
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17652175
Guilloreau L, Combalbert S, Sournia-Saquet A, Mazarguil H, Faller P
Redox chemistry of copper-amyloid-beta: the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state.
Chembiochem. 2007 Jul 23;8(11):1317-25.
PMID: 17577900
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17577900
Matsuyama S, Teraoka R, Mori H, Tomiyama T
Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice.
Neuroreport. 2007 Jul 2;18(10):1083-7.
PMID: 17558301
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17558301
Mare S, Penugonda S, Robinson SM, Dohgu S, Banks WA, Ercal N
Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma.
Peptides. 2007 Jul;28(7):1424-32.
PMID: 17580097
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17580097
Yang HQ, Pan J, Ba MW, Sun ZK, Ma GZ, Lu GQ, Xiao Q, Chen SD
New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity.
Eur J Neurosci. 2007 Jul;26(2):381-91.
PMID: 17650113
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17650113
Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
Am J Pathol. 2007 Jul;171(1):241-51.
PMID: 17591969
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17591969
Prodan CI, Ross ED, Vincent AS, Dale GL
Coated-platelets are higher in amnestic versus nonamnestic patients with mild cognitive impairment.
Alzheimer Dis Assoc Disord. 2007 Jul-Sep;21(3):259-61.
PMID: 17804959
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17804959
Gamerdinger M, Clement AB, Behl C
Cholesterol-Like Effects of Selective Cyclooxygenase Inhibitors and Fibrates on Cellular Membranes and Amyloid-beta Production.
Mol Pharmacol. 2007 Jul;72(1):141-51.
PMID: 17395689
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17395689
Klunk WE, Price JC, Mathis CA, Tsopelas ND, Lopresti BJ, Ziolko SK, Bi W, Hoge JA, Cohen AD, Ikonomovic MD, Saxton JA, Snitz BE, Pollen DA, Moonis M, Lippa CF, Swearer JM, Johnson KA, Rentz DM, Fischman AJ, Aizenstein HJ, Dekosky ST
Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.
J Neurosci. 2007 Jun 6;27(23):6174-84.
PMID: 17553989
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17553989
Muhs A, Hickman DT, Pihlgren M, Chuard N, Giriens V, Meerschman C, Van Der Auwera I, Van Leuven F, Sugawara M, Weingertner MC, Bechinger B, Greferath R, Kolonko N, Nagel-Steger L, Riesner D, Brady RO, Pfeifer A, Nicolau C
Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice.
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9810-5.
PMID: 17517595
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17517595
Lee HG, Zhu X, Castellani RJ, Nunomura A, Perry G, Smith MA
Amyloid-beta in Alzheimer disease: the null versus the alternate hypotheses.
J Pharmacol Exp Ther. 2007 Jun 1;321(3):823-9.
PMID: 17229880
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17229880
Sawaya MR, Sambashivan S, Nelson R, Ivanova MI, Sievers SA, Apostol MI, Thompson MJ, Balbirnie M, Wiltzius JJ, McFarlane HT, Madsen AØ, Riekel C, Eisenberg D
Atomic structures of amyloid cross-beta spines reveal varied steric zippers.
Nature. 2007 May 24;447(7143):453-7.
PMID: 17468747
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17468747
Ha C, Ryu J, Park CB
Metal ions differentially influence the aggregation and deposition of Alzheimer's beta-amyloid on a solid template.
Biochemistry. 2007 May 22;46(20):6118-25.
PMID: 17455909
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17455909
Del Giudice E, Facchinetti F, Nofrate V, Boccaccio P, Minelli T, Dam M, Leon A, Moschini G
Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma.
Neurosci Lett. 2007 May 11;418(1):9-12.
PMID: 17382472
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17382472
Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R, Taglialatela M, Di Renzo G, Annunziato L
Up-regulation and increased activity of KV3.4 channels and its accessory subunit MIRP2 induced by amyloid peptide is involved in apoptotic neuronal death.
Mol Pharmacol. 2007 May 10;
PMID: 17495071
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17495071
Mac Donald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL
Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury.
Exp Neurol. 2007 May;205(1):116-31.
PMID: 17368446
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17368446
Solomon B
Beta-amyloidbased immunotherapy as a treatment of Alzheimers disease.
Drugs Today (Barc). 2007 May;43(5):333-42.
PMID: 17724499
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17724499
González-Montalbán N, Villaverde A, Aris A
Amyloid-linked cellular toxicity triggered by bacterial inclusion bodies.
Biochem Biophys Res Commun. 2007 Apr 13;355(3):637-42.
PMID: 17307135
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17307135
Alisky JM
The coming problem of HIV-associated Alzheimer's disease.
Med Hypotheses. 2007 Apr 12;
PMID: 17433562
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17433562
Hemming ML, Selkoe DJ, Farris W
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease.
Neurobiol Dis. 2007 Apr;26(1):273-81.
PMID: 17321748
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17321748
Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, LaFerla FM, Mattson MP
Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease.
Neurobiol Dis. 2007 Apr;26(1):212-20.
PMID: 17306982
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17306982
Boscolo E, Folin M, Nico B, Grandi C, Mangieri D, Longo V, Scienza R, Zampieri P, Conconi MT, Parnigotto PP, Ribatti D
Beta amyloid angiogenic activity in vitro and in vivo.
Int J Mol Med. 2007 Apr;19(4):581-7.
PMID: 17334633
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17334633
Ferreira ST, Vieira MN, De Felice FG
Soluble protein oligomers as emerging toxins in alzheimer's and other amyloid diseases.
IUBMB Life. 2007 Apr-May;59(4-5):332-45.
PMID: 17505973
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17505973
Mikiciuk-Olasik E, Szymanski P, Zurek E
Diagnostics and therapy of Alzheimer's disease.
Indian J Exp Biol. 2007 Apr;45(4):315-25.
PMID: 17477302
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17477302
Sorrentino G, Bonavita V
Neurodegeneration and Alzheimer's disease: the lesson from tauopathies.
Neurol Sci. 2007 Apr;28(2):63-71.
PMID: 17464468
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17464468
Good MA, Hale G, Staal V
Impaired "episodic-like" object memory in adult APPswe transgenic mice.
Behav Neurosci. 2007 Apr;121(2):443-8.
PMID: 17469935
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17469935
Finch CE, Morgan TE
Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper.
Curr Alzheimer Res. 2007 Apr;4(2):185-9.
PMID: 17430245
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17430245
Deane R, Zlokovic BV
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.
Curr Alzheimer Res. 2007 Apr;4(2):191-7.
PMID: 17430246
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17430246
Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Mazur-Kolecka B, Imaki H, Wegiel J, Mehta PD, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Pirttilla T, Frey H, Lehtimäki T, Kivimäki T, Visser FE, Kamphorst W, Potempska A, Bolton D, Currie JR, Miller DL
Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration.
Acta Neuropathol (Berl). 2007 Apr;113(4):389-402.
PMID: 17237937
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17237937
von Bernhardi R, Ramírez G, Toro R, Eugenín J
Pro-inflammatory conditions promote neuronal damage mediated by Amyloid Precursor Protein and decrease its phagocytosis and degradation by microglial cells in culture.
Neurobiol Dis. 2007 Apr;26(1):153-64.
PMID: 17240154
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17240154
Calabrese MF, Miranker AD
Formation of a stable oligomer of beta-2 microglobulin requires only transient encounter with Cu(II).
J Mol Biol. 2007 Mar 16;367(1):1-7.
PMID: 17254602
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17254602
Park KH, Hallows JL, Chakrabarty P, Davies P, Vincent I
Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice.
J Neurosci. 2007 Mar 14;27(11):2969-78.
PMID: 17360920
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17360920
Garzon DJ, Fahnestock M
Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells.
J Neurosci. 2007 Mar 7;27(10):2628-35.
PMID: 17344400
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17344400
Schmitt HP
Profiling the culprit in Alzheimer's disease (AD): Bacterial toxic proteins - Will they be significant for the aetio-pathogenesis of AD and the transmissible spongiform encephalopathies?
Med Hypotheses. 2007 Mar 2;
PMID: 17337124
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17337124
Dogru-Abbasoglu S, Aykaç-Toker G, Hanagasi HA, Gürvit H, Emre M, Uysal M
The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease.
Neurol Sci. 2007 Mar;28(1):31-4.
PMID: 17385092
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17385092
Khalil Z, LoGiudice D, Khodr B, Maruff P, Masters C
Impaired peripheral endothelial microvascular responsiveness in Alzheimer's disease.
J Alzheimers Dis. 2007 Mar;11(1):25-32.
PMID: 17361032
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17361032
Genazzani AR, Pluchino N, Luisi S, Luisi M
Estrogen, cognition and female ageing.
Hum Reprod Update. 2007 Mar-Apr;13(2):175-87.
PMID: 17135285
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17135285
Magaki S, Yellon SM, Mueller C, Kirsch WM
Immunophenotypes in the circulation of patients with mild cognitive impairment.
J Psychiatr Res. 2007 Feb 22;
PMID: 17320906
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17320906
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.
Ann N Y Acad Sci. 2007 Feb;1097:40-50.
PMID: 17413008
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17413008
De Strooper B
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO Rep. 2007 Feb;8(2):141-6.
PMID: 17268505
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17268505
Wolfe MS
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO Rep. 2007 Feb;8(2):136-40.
PMID: 17268504
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17268504
Christensen DD
Alzheimer's disease: progress in the development of anti-amyloid disease-modifying therapies.
CNS Spectr. 2007 Feb;12(2):113-6, 119-23.
PMID: 17277711
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17277711
Yanagisawa K
Role of gangliosides in Alzheimer's disease.
Biochim Biophys Acta. 2007 Jan 28;
PMID: 17321494
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17321494
Patel BK, Liebman SW
"Prion-proof" for [PIN(+)]: Infection with In Vitro-made Amyloid Aggregates of Rnq1p-(132-405) Induces [PIN(+)].
J Mol Biol. 2007 Jan 19;365(3):773-82.
PMID: 17097676
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17097676
Reis K, Zharkovsky A, Bogdanovic N, Karelson E, Land T
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723).
Neuroscience. 2007 Jan 19;144(2):571-8.
PMID: 17101228
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17101228
Rivière C, Richard T, Quentin L, Krisa S, Mérillon JM, Monti JP
Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro.
Bioorg Med Chem. 2007 Jan 15;15(2):1160-7.
PMID: 17049256
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17049256
Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM
Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.
BMC Genet. 2007;8:3.
PMID: 17266761
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17266761
Thomas MP, Chartrand K, Reynolds A, Vitvitsky V, Banerjee R, Gendelman HE
Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease.
J Neurochem. 2007 Jan;100(2):503-19.
PMID: 17241161
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17241161
Haviv H, Wong DM, Silman I, Sussman JL
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Curr Top Med Chem. 2007;7(4):375-87.
PMID: 17305579
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17305579
Richardson SJ
Cell and molecular biology of transthyretin and thyroid hormones.
Int Rev Cytol. 2007;258:137-93.
PMID: 17338921
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17338921
Domingues SC, Henriques AG, Wu W, da Cruz e Silva EF, da Cruz e Silva OA
Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions.
Ann N Y Acad Sci. 2007 Jan;1096:184-95.
PMID: 17405930
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17405930
Höglund K, Blennow K
Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease.
CNS Drugs. 2007;21(6):449-62.
PMID: 17521225
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17521225
Rajendran L, Knobloch M, Geiger KD, Dienel S, Nitsch R, Simons K, Konietzko U
Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes.
Neurodegener Dis. 2007;4(2-3):164-70.
PMID: 17596711
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17596711
Venezia V, Nizzari M, Carlo P, Corsaro A, Florio T, Russo C
Amyloid precursor protein and presenilin involvement in cell signaling.
Neurodegener Dis. 2007;4(2-3):101-11.
PMID: 17596704
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17596704
Minopoli G, Passaro F, Aloia L, Carlomagno F, Melillo RM, Santoro M, Forzati F, Zambrano N, Russo T
Receptor- and non-receptor tyrosine kinases induce processing of the amyloid precursor protein: role of the low-density lipoprotein receptor-related protein.
Neurodegener Dis. 2007;4(2-3):94-100.
PMID: 17596703
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17596703
Christensen DD
Changing the course of Alzheimer's disease: anti-amyloid disease-modifying treatments on the horizon.
Prim Care Companion J Clin Psychiatry. 2007;9(1):32-41.
PMID: 17599166
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17599166
Van Broeck B, van Broeckhoven C, Kumar-Singh S
Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches.
Neurodegener Dis. 2007;4(5):349-65.
PMID: 17622778
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17622778
Munoz L, Ranaivo HR, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
J Neuroinflammation. 2007;4:21.
PMID: 17784957
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17784957
Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A
Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder?
Int Rev Neurobiol. 2007;82:235-46.
PMID: 17678964
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17678964
Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB, DeCarli C, Atwood LD, Wolf PA
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
BMC Med Genet. 2007;8 Suppl 1:S15.
PMID: 17903297
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17903297
Salkovic-Petrisic M, Hoyer S
Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach.
J Neural Transm Suppl. 2007;(72):217-33.
PMID: 17982898
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17982898
Shie FS, Woltjer RL
Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease.
Curr Med Chem. 2007;14(27):2865-71.
PMID: 18045132
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18045132
Prolo P, Chiappelli F, Grasso E, Rosso MG, Neagos N, Dovio A, Sartori ML, Perotti P, Fantò F, Civita M, Fiorucci A, Villanueva P, Angeli A
Aluminium blunts the proliferative response and increases apoptosis of cultured human cells: putative relationship to alzheimer's disease.
Bioinformation. 2007;2(1):24-7.
PMID: 18084647
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=18084647
Agnati LF, Genedani S, Leo G, Forni A, Woods AS, Filaferro M, Franco R, Fuxe K
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
J Neural Transm. 2007 Jan;114(1):21-31.
PMID: 16969627
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16969627
Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA
The relationship between cerebral Alzheimer's disease pathology and odour identification in old age.
J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):30-5.
PMID: 17012338
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17012338
Liu L, Murphy RM
Kinetics of Inhibition of beta-Amyloid Aggregation by Transthyretin.
Biochemistry. 2006 Dec 26;45(51):15702-9.
PMID: 17176092
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17176092
Misiti F, Sampaolese B, Mezzogori D, Orsini F, Pezzotti M, Giardina B, Clementi ME
Protective effect of rhubarb derivatives on amyloid beta (1-42) peptide-induced apoptosis in IMR-32 cells: a case of nutrigenomic.
Brain Res Bull. 2006 Dec 11;71(1-3):29-36.
PMID: 17113925
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17113925
Sadowski MJ, Pankiewicz J, Scholtzova H, Mehta PD, Prelli F, Quartermain D, Wisniewski T
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18787-92.
PMID: 17116874
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17116874
Schott JM, Kennedy J, Fox NC
New developments in mild cognitive impairment and Alzheimer's disease.
Curr Opin Neurol. 2006 Dec;19(6):552-8.
PMID: 17102693
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17102693
Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure.
J Gen Physiol. 2006 Dec;128(6):637-47.
PMID: 17101816
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17101816
van Oijen M, Soares HD, Koudstaal PJ, Hofman A, Breteler MM
Plasma amyloid-beta concentrations in Alzheimer's disease: an alternative hypothesis - Authors' reply.
Lancet Neurol. 2006 Dec;5(12):1002-3.
PMID: 17110280
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17110280
Oprisiu R, Serot JM, Godefroy O, Black SE, Fournier A
Plasma amyloid-beta concentrations in Alzheimer's disease: an alternative hypothesis.
Lancet Neurol. 2006 Dec;5(12):1001-2; author reply 1002-3.
PMID: 17110279
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17110279
Fullwood NJ, Hayashi Y, Allsop D
Plasma amyloid-beta concentrations in Alzheimer's disease: an alternative hypothesis.
Lancet Neurol. 2006 Dec;5(12):1000-1; author reply 1002-3.
PMID: 17110278
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17110278
Ansari MA, Joshi G, Huang Q, Opii WO, Abdul HM, Sultana R, Butterfield DA
In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders.
Free Radic Biol Med. 2006 Dec 1;41(11):1694-703.
PMID: 17145558
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17145558
Golde TE, Dickson D, Hutton M
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease.
Curr Alzheimer Res. 2006 Dec;3(5):421-30.
PMID: 17168641
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17168641
Zhao Y, Cui JG, Lukiw WJ
Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's disease.
Mol Neurobiol. 2006 Dec;34(3):181-92.
PMID: 17308351
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17308351
Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.
J Biol Chem. 2006 Nov 24;281(47):36180-6.
PMID: 17012232
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17012232
Van Broeck B, Vanhoutte G, Pirici D, Van Dam D, Wils H, Cuijt I, Vennekens K, Zabielski M, Michalik A, Theuns J, De Deyn PP, Van der Linden A, Van Broeckhoven C, Kumar-Singh S
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Neurobiol Aging. 2006 Nov 15;
PMID: 17112635
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17112635
Evans CG, Wisén S, Gestwicki JE
Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.
J Biol Chem. 2006 Nov 3;281(44):33182-91.
PMID: 16973602
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16973602
Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi K
Role of toll-like receptor signalling in Abeta uptake and clearance.
Brain. 2006 Nov 1;129(Pt 11):3006-19.
PMID: 16984903
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16984903
Turner RS
Alzheimer's disease.
Semin Neurol. 2006 Nov;26(5):499-506.
PMID: 17048151
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17048151
Dolev I, Michaelson DM
The nucleation growth and reversibility of Amyloid-beta deposition in vivo.
J Alzheimers Dis. 2006 Nov;10(2-3):291-301.
PMID: 17119294
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17119294
Atamna H
Heme binding to Amyloid-beta peptide: mechanistic role in Alzheimer's disease.
J Alzheimers Dis. 2006 Nov;10(2-3):255-66.
PMID: 17119291
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17119291
Small DH, Cappai R
Alois Alzheimer and Alzheimer's disease: a centennial perspective.
J Neurochem. 2006 Nov;99(3):708-10.
PMID: 17076655
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17076655
Copani A, Hoozemans JJ, Caraci F, Calafiore M, van Haastert ES, Veerhuis R, Rozemuller AJ, Aronica E, Sortino MA, Nicoletti F
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.
J Neurosci. 2006 Oct 25;26(43):10949-57.
PMID: 17065437
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17065437
Liu Q, Wu J
Neuronal nicotinic acetylcholine receptors serve as sensitive targets that mediate beta-amyloid neurotoxicity.
Acta Pharmacol Sin. 2006 Oct;27(10):1277-86.
PMID: 17007734
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17007734
Delacourte A
[From physiopathology to treatment of Alzheimer's disease]
Rev Neurol (Paris). 2006 Oct;162(10):909-12.
PMID: 17028557
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17028557
Muyllaert D, Terwel D, Borghgraef P, Devijver H, Dewachter I, Van Leuven F
Transgenic mouse models for Alzheimer's disease: the role of GSK-3B in combined amyloid and tau-pathology.
Rev Neurol (Paris). 2006 Oct;162(10):903-7.
PMID: 17028556
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17028556
Adriani W, Ognibene E, Heuland E, Ghirardi O, Caprioli A, Laviola G
Motor impulsivity in APP-SWE mice: a model of Alzheimer's disease.
Behav Pharmacol. 2006 Sep;17(5-6):525-33.
PMID: 16940774
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16940774
Siemers ER, Dean RA, Demattos R, May PC
New pathways in drug discovery for Alzheimer's disease.
Curr Neurol Neurosci Rep. 2006 Sep 1;6(5):372-8.
PMID: 16928346
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16928346
Lee HG, Zhu X, Nunomura A, Perry G, Smith MA
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!
Am J Pathol. 2006 Sep;169(3):738-9.
PMID: 16936250
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16936250
Duce JA, Smith DP, Blake RE, Crouch PJ, Li QX, Masters CL, Trounce IA
Linker histone H1 binds to disease associated amyloid-like fibrils.
J Mol Biol. 2006 Aug 18;361(3):493-505.
PMID: 16854430
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16854430
Baglioni S, Casamenti F, Bucciantini M, Luheshi LM, Taddei N, Chiti F, Dobson CM, Stefani M
Prefibrillar amyloid aggregates could be generic toxins in higher organisms.
J Neurosci. 2006 Aug 2;26(31):8160-7.
PMID: 16885229
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16885229
Ha C, Park CB
Ex situ atomic force microscopy analysis of beta-amyloid self-assembly and deposition on a synthetic template.
Langmuir. 2006 Aug 1;22(16):6977-85.
PMID: 16863248
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16863248
Obrenovich ME, Smith MA, Siedlak SL, Chen SG, de la Torre JC, Perry G, Aliev G
Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
Neurotox Res. 2006 Aug;10(1):43-56.
PMID: 17000469
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17000469
Istrin G, Bosis E, Solomon B
Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide.
J Neurosci Res. 2006 Aug 1;84(2):434-43.
PMID: 16767774
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16767774
Götz J, Ittner LM, Kins S
Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?
J Neurochem. 2006 Aug;98(4):993-1006.
PMID: 16787410
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16787410
Tamagno E, Bardini P, Guglielmotto M, Danni O, Tabaton M
The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression.
Free Radic Biol Med. 2006 Jul 15;41(2):202-12.
PMID: 16814100
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16814100
Squitti R, Barbati G, Rossi L, Ventriglia M, Dal Forno G, Cesaretti S, Moffa F, Caridi I, Cassetta E, Pasqualetti P, Calabrese L, Lupoi D, Rossini PM
Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF [beta]-amyloid, and h-tau.
Neurology. 2006 Jul 11;67(1):76-82.
PMID: 16832081
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16832081
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J
Synapse formation and function is modulated by the amyloid precursor protein.
J Neurosci. 2006 Jul 5;26(27):7212-21.
PMID: 16822978
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16822978
Helbecque N, Cottel D, Hermant X, Amouyel P
Impact of the matrix metalloproteinase MMP-3 on dementia.
Neurobiol Aging. 2006 Jul 3;
PMID: 16822591
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16822591
Boutte AM, Woltjer RL, Zimmerman LJ, Stamer SL, Montine KS, Manno MV, Cimino PJ, Liebler DC, Montine TJ
Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.
FASEB J. 2006 Jul;20(9):1473-83.
PMID: 16816122
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16816122
Thatcher GR, Bennett BM, Reynolds JN
NO chimeras as therapeutic agents in Alzheimer's disease.
Curr Alzheimer Res. 2006 Jul;3(3):237-45.
PMID: 16842101
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16842101
Fagan T, Kagan B, Corbin D, Hwang W, Glabe C, Nault L, Lal R, Teplow D, Albensi B, Sokolov Y
Alzheimer Research Forum Live Discussion: Now you see them, now you don't: The amyloid channel hypothesis.
J Alzheimers Dis. 2006 Jul;9(2):219-24.
PMID: 16873968
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16873968
Tabner BJ, Turnbull S, King JE, Benson FE, El-Agnaf OM, Allsop D
A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.
Free Radic Res. 2006 Jul;40(7):731-9.
PMID: 16984000
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16984000
Capsoni S, Cattaneo A
On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease.
Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):619-33.
PMID: 16944323
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16944323
Vasilevko V, Cribbs DH
Novel approaches for immunotherapeutic intervention in Alzheimer's disease.
Neurochem Int. 2006 Jul;49(2):113-26.
PMID: 16765487
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16765487
Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Traffic. 2006 Jul;7(7):873-88.
PMID: 16734669
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16734669
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Müller WE
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
Exp Gerontol. 2006 Jul;41(7):668-73.
PMID: 16677790
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16677790
Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E
Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice.
Neurobiol Aging. 2006 Jun 30;
PMID: 16815595
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16815595
Klajnert B, Cortijo-Arellano M, Cladera J, Bryszewska M
Influence of dendrimer's structure on its activity against amyloid fibril formation.
Biochem Biophys Res Commun. 2006 Jun 23;345(1):21-8.
PMID: 16674918
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16674918
Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
Altered localization of amyloid precursor protein under endoplasmic reticulum stress.
Biochem Biophys Res Commun. 2006 Jun 2;344(2):525-30.
PMID: 16630560
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16630560
Ono K, Hamaguchi T, Naiki H, Yamada M
Anti-amyloidogenic effects of antioxidants: implications for the prevention and therapeutics of Alzheimer's disease.
Biochim Biophys Acta. 2006 Jun;1762(6):575-86.
PMID: 16644188
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16644188
Paulsson JF, Andersson A, Westermark P, Westermark GT
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.
Diabetologia. 2006 Jun;49(6):1237-46.
PMID: 16570161
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16570161
Kitazawa M, Green KN, Caccamo A, LaFerla FM
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
Am J Pathol. 2006 Jun;168(6):1986-97.
PMID: 16723713
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16723713
Abdulkarim Y, Hameed Z
Is the LDL receptor involved in cortical amyloid protein clearance?
Neurochem Res. 2006 Jun;31(6):839-47.
PMID: 16841190
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16841190
Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L
Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.
J Neurosci. 2006 May 10;26(19):5167-79.
PMID: 16687508
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16687508
Mhatre M, Hensley K, Nguyen A, Grammas P
Chronic thrombin exposure results in an increase in apolipoprotein-E levels.
J Neurosci Res. 2006 May 8;
PMID: 16683250
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16683250
Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW
Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.
J Biol Chem. 2006 May 5;281(18):12809-16.
PMID: 16517603
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16517603
Yu MS, Suen KC, Kwok NS, So KF, Hugon J, Chuen-Chung Chang R
Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses.
Apoptosis. 2006 May;11(5):687-700.
PMID: 16532272
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16532272
Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.
Hum Mol Genet. 2006 May 1;15(9):1437-49.
PMID: 16551656
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16551656
Folin M, Baiguera S, Guidolin D, Di Liddo R, Grandi C, De Carlo E, Nussdorfer GG, Parnigotto PP
Apolipoprotein-E modulates the cytotoxic effect of beta-amyloid on rat brain endothelium in an isoform-dependent specific manner.
Int J Mol Med. 2006 May;17(5):821-6.
PMID: 16596266
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16596266
Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW
Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization.
Nat Chem Biol. 2006 May;2(5):249-53.
PMID: 16565714
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16565714
Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
J Neuropathol Exp Neurol. 2006 May;65(5):508-15.
PMID: 16772874
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16772874
Gil V, Nicolas O, Mingorance A, Ureña JM, Tang BL, Hirata T, Sáez-Valero J, Ferrer I, Soriano E, Del Río JA
Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease.
J Neuropathol Exp Neurol. 2006 May;65(5):433-44.
PMID: 16772867
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16772867
Lashuel HA, Lansbury PT
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
Q Rev Biophys. 2006 May;39(2):167-201.
PMID: 16978447
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16978447
Malisauskas M, Darinskas A, Zamotin VV, Gharibyan A, Kostanyan IA, Morozova-Roche LA
Intermediate amyloid oligomers of lysozyme: Is their cytotoxicity a particular case or general rule for amyloid?
Biochemistry (Mosc). 2006 May;71(5):505-12.
PMID: 16732728
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16732728
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Nature. 2006 Apr 27;440(7088):1208-12.
PMID: 16641999
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16641999
Floden AM, Combs CK
Beta-amyloid stimulates murine postnatal and adult microglia cultures in a unique manner.
J Neurosci. 2006 Apr 26;26(17):4644-8.
PMID: 16641245
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16641245
Cohen T, Frydman-Marom A, Rechter M, Gazit E
Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives.
Biochemistry. 2006 Apr 18;45(15):4727-35.
PMID: 16605241
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16605241
Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
J Physiol. 2006 Apr 15;572(Pt 2):477-92.
PMID: 16469784
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16469784
Wirths O, Weis J, Szczygielski J, Multhaup G, Bayer TA
Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease.
Acta Neuropathol (Berl). 2006 Apr 1;111(4):312-9.
PMID: 16520967
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16520967
Clementi ME, Pezzotti M, Orsini F, Sampaolese B, Mezzogori D, Grassi C, Giardina B, Misiti F
Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35.
Biochem Biophys Res Commun. 2006 Mar 31;342(1):206-13.
PMID: 16472763
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16472763
Pacheco-Quinto J, Rodriguez de Turco EB, Derosa S, Howard A, Cruz-Sanchez F, Sambamurti K, Refolo L, Petanceska S, Pappolla MA
Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
Neurobiol Dis. 2006 Mar 2;
PMID: 16516482
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16516482
Bales KR, Tzavara ET, Wu S, Wade MR, Bymaster FP, Paul SM, Nomikos GG
Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody.
J Clin Invest. 2006 Mar;116(3):825-32.
PMID: 16498501
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16498501
Boukhtouche F, Vodjdani G, Jarvis CI, Bakouche J, Staels B, Mallet J, Mariani J, Lemaigre-Dubreuil Y, Brugg B
Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis.
J Neurochem. 2006 Mar;96(6):1778-89.
PMID: 16539693
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16539693
Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA
Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
J Neurochem. 2006 Mar;96(5):1322-35.
PMID: 16478525
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16478525
Joshi G, Perluigi M, Sultana R, Agrippino R, Calabrese V, Butterfield DA
In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders.
Neurochem Int. 2006 Mar;48(4):318-27.
PMID: 16386335
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16386335
Disterhoft JF, Oh MM
Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease.
J Physiol Paris. 2006 Mar-May;99(2-3):180-92.
PMID: 16458491
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16458491
Walker DG, Link J, Lue LF, Dalsing-Hernandez JE, Boyes BE
Gene expression changes by amyloid {beta} peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.
J Leukoc Biol. 2006 Mar;79(3):596-610.
PMID: 16365156
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16365156
Fagan AM, Mintun MA, Mach RH, Lee SY, Dence CS, Shah AR, Larossa GN, Spinner ML, Klunk WE, Mathis CA, Dekosky ST, Morris JC, Holtzman DM
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans.
Ann Neurol. 2006 Mar;59(3):512-9.
PMID: 16372280
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Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.
J Alzheimers Dis. 2006 Mar;9(1):13-33.
PMID: 16627931
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16627931
Kim JR, Gibson TJ, Murphy RM
Predicting solvent and aggregation effects of peptides using group contribution calculations.
Biotechnol Prog. 2006 Mar-Apr;22(2):605-8.
PMID: 16599584
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16599584
Claassen JA, Jansen RW
Cholinergically mediated augmentation of cerebral perfusion in Alzheimer's disease and related cognitive disorders: the cholinergic-vascular hypothesis.
J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):267-71.
PMID: 16567376
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16567376
Manzano-Palomo S, De la Morena-Vicente MA, Barquero MS
[Neurotransmitters in Alzheimer's disease]
Rev Neurol. 2006 Mar 16-31;42(6):350-3.
PMID: 16575771
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16575771
de Leon MJ, Desanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Rusinek H, Li J, Tsui W, Saint Louis LA, Clark CM, Tarshish C, Li Y, Lair L, Javier E, Rich K, Lesbre P, Mosconi L, Reisberg B, Sadowski M, DeBernadis JF, Kerkman DJ, Hampel H, Wahlund LO, Davies P
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment.
Neurobiol Aging. 2006 Mar;27(3):394-401.
PMID: 16125823
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16125823
Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO
Mechanisms to explain the reverse perivascular transport of solutes out of the brain.
J Theor Biol. 2006 Feb 21;238(4):962-74.
PMID: 16112683
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16112683
Khan A, Dobson JP, Exley C
Redox cycling of iron by Abeta42.
Free Radic Biol Med. 2006 Feb 15;40(4):557-69.
PMID: 16458186
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16458186
Lee HG, Zhu X, Nunomura A, Perry G, Smith MA
Amyloid beta: the alternate hypothesis.
Curr Alzheimer Res. 2006 Feb;3(1):75-80.
PMID: 16472207
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16472207
Firuzi O, Praticò D
Coxibs and Alzheimer's disease: should they stay or should they go?
Ann Neurol. 2006 Feb;59(2):219-28.
PMID: 16402383
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16402383
Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.
J Clin Invest. 2006 Feb;116(2):378-85.
PMID: 16453022
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16453022
van de Nes JA, Konermann S, Nafe R, Swaab DF
beta-Protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients.
Acta Neuropathol (Berl). 2006 Feb;111(2):126-138.
PMID: 16456666
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16456666
Qiu WQ, Folstein MF
Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.
Neurobiol Aging. 2006 Feb;27(2):190-8.
PMID: 16399206
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16399206
de Groot NS, Aviles FX, Vendrell J, Ventura S
Mutagenesis of the central hydrophobic cluster in Abeta42 Alzheimer's peptide. Side-chain properties correlate with aggregation propensities.
FEBS J. 2006 Feb;273(3):658-68.
PMID: 16420488
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16420488
Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH
A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.
Curr Alzheimer Res. 2006 Feb;3(1):81-90.
PMID: 16472208
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16472208
Hardy J
Has the amyloid cascade hypothesis for Alzheimer's disease been proved?
Curr Alzheimer Res. 2006 Feb;3(1):71-3.
PMID: 16472206
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16472206
Kapková P, Alptüzün V, Frey P, Erciyas E, Holzgrabe U
Search for dual function inhibitors for Alzheimer's disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity.
Bioorg Med Chem. 2006 Jan 15;14(2):472-8.
PMID: 16198581
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16198581
Gobbi M, Colombo L, Morbin M, Mazzoleni G, Accardo E, Vanoni M, Del Favero E, Cantù L, Kirschner DA, Manzoni C, Beeg M, Ceci P, Ubezio P, Forloni G, Tagliavini F, Salmona M
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.
J Biol Chem. 2006 Jan 13;281(2):843-9.
PMID: 16286452
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16286452
Lazarov O, Peterson LD, Peterson DA, Sisodia SS
Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
J Neurosci. 2006 Jan 11;26(2):429-34.
PMID: 16407539
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16407539
Ralay Ranaivo H, Craft JM, Hu W, Guo L, Wing LK, Van Eldik LJ, Watterson DM
Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.
J Neurosci. 2006 Jan 11;26(2):662-70.
PMID: 16407564
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16407564
Lai SW, Yu MS, Yuen WH, Chang RC
Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn.
Neuropharmacology. 2006 Jan 4;
PMID: 16406021
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16406021
Bastianetto S, Yao ZX, Papadopoulos V, Quirion R
Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity.
Eur J Neurosci. 2006 Jan;23(1):55-64.
PMID: 16420415
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16420415
Perluigi M, Joshi G, Sultana R, Calabrese V, De Marco C, Coccia R, Butterfield DA
In vivo protection by the xanthate tricyclodecan-9-yl-xanthogenate against amyloid beta-peptide (1-42)-induced oxidative stress.
Neuroscience. 2006;138(4):1161-70.
PMID: 16427207
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16427207
Schmitt HP
epsilon-Glycation, APP and Abeta in ageing and Alzheimer disease: a hypothesis.
Med Hypotheses. 2006;66(5):898-906.
PMID: 16442744
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16442744
Geppert AM
[Alzheimer's disease and HSV-1 infection]
Neurol Neurochir Pol. 2006 Jan-Feb;40(1):57-61.
PMID: 16463223
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16463223
El Mouedden M, Vandermeeren M, Meert T, Mercken M
Reduction of Abeta levels in the Sprague Dawley rat after oral administration of the functional gamma-secretase inhibitor, DAPT: a novel non-transgenic model for Abeta production inhibitors.
Curr Pharm Des. 2006;12(6):671-6.
PMID: 16472156
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16472156
Armstrong RA
Plaques and tangles and the pathogenesis of Alzheimer's disease.
Folia Neuropathol. 2006;44(1):1-11.
PMID: 16565925
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16565925
Barten DM, Meredith JE, Zaczek R, Houston JG, Albright CF
Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.
Drugs R D. 2006;7(2):87-97.
PMID: 16542055
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16542055
Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A
C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
J Neurochem. 2006 Jan;96(1):218-27.
PMID: 16305624
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16305624
Quintana C, Bellefqih S, Laval JY, Guerquin-Kern JL, Wu TD, Avila J, Ferrer I, Arranz R, Patiño C
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.
J Struct Biol. 2006 Jan;153(1):42-54.
PMID: 16364657
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16364657
Feng Z, Qin C, Chang Y, Zhang JT
Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease.
Free Radic Biol Med. 2006 Jan 1;40(1):101-9.
PMID: 16337883
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16337883
Kammerman EM, Neumann DM, Ball MJ, Lukiw W, Hill JM
Senile plaques in Alzheimer's diseased brains: possible association of beta-amyloid with herpes simplex virus type 1 (HSV-1) L-particles.
Med Hypotheses. 2006;66(2):294-9.
PMID: 16242250
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16242250
Wenk GL
Neuropathologic changes in Alzheimer's disease: potential targets for treatment.
J Clin Psychiatry. 2006;67 Suppl 3:3-7; quiz 23.
PMID: 16649845
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16649845
Bate C, Kempster S, Last V, Williams A
Interferon-gamma increases neuronal death in response to amyloid-beta1-42.
J Neuroinflammation. 2006;3:7.
PMID: 16569229
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16569229
Sankaranarayanan S
Genetically modified mice models for Alzheimer's disease.
Curr Top Med Chem. 2006;6(6):609-27.
PMID: 16712495
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16712495
Catalano SM, Dodson EC, Henze DA, Joyce JG, Krafft GA, Kinney GG
The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.
Curr Top Med Chem. 2006;6(6):597-608.
PMID: 16712494
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16712494
John V
Human beta-secretase (BACE) and BACE inhibitors: progress report.
Curr Top Med Chem. 2006;6(6):569-78.
PMID: 16712492
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16712492
Bürklen TS, Schlattner U, Homayouni R, Gough K, Rak M, Szeghalmi A, Wallimann T
The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK-Inactivation, APP-CK Complexes and Focal Creatine Deposits.
J Biomed Biotechnol. 2006;2006(3):35936.
PMID: 17047305
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17047305
Senechal Y, Larmet Y, Dev KK
Unraveling in vivo functions of amyloid precursor protein: insights from knockout and knockdown studies.
Neurodegener Dis. 2006;3(3):134-47.
PMID: 16954700
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16954700
Colton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.
J Neuroinflammation. 2006;3:27.
PMID: 17005052
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17005052
Morgan D
Immunotherapy for Alzheimer's disease.
J Alzheimers Dis. 2006;9(3 Suppl):425-32.
PMID: 16914881
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914881
Tabaton M, Gambetti P
Soluble amyloid-beta in the brain: the scarlet pimpernel.
J Alzheimers Dis. 2006;9(3 Suppl):127-32.
PMID: 16914851
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914851
Solomon B
Alzheimer's disease immunotherapy: from in vitro amyloid immunomodulation to in vivo vaccination.
J Alzheimers Dis. 2006;9(3 Suppl):433-8.
PMID: 16914882
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914882
Goate A
Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease.
J Alzheimers Dis. 2006;9(3 Suppl):341-7.
PMID: 16914872
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914872
Selkoe DJ
Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise.
J Alzheimers Dis. 2006;9(3 Suppl):163-8.
PMID: 16914855
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914855
Hardy J
Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal.
J Alzheimers Dis. 2006;9(3 Suppl):151-3.
PMID: 16914853
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16914853
Höglund K, Wallin A, Blennow K
Effect of statins on beta-amyloid metabolism in humans: potential importance for the development of senile plaques in Alzheimer's disease.
Acta Neurol Scand Suppl. 2006;185:87-92.
PMID: 16866916
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16866916
Kayed R, Glabe CG
Conformation-dependent anti-amyloid oligomer antibodies.
Methods Enzymol. 2006;413:326-44.
PMID: 17046404
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17046404
Sciarretta KL, Gordon DJ, Meredith SC
Peptide-based inhibitors of amyloid assembly.
Methods Enzymol. 2006;413:273-312.
PMID: 17046402
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17046402
Muñoz-Torrero D, Camps P
Alzheimer drug design based on the amyloid hypothesis.
Curr Pharm Des. 2006;12(33):4281-2.
PMID: 17105427
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17105427
Díaz JC, Linnehan J, Pollard H, Arispe N
Histidines 13 and 14 in the Abeta sequence are targets for inhibition of Alzheimer's disease Abeta ion channel and cytotoxicity.
Biol Res. 2006;39(3):447-60.
PMID: 17106577
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17106577
Nguyen JT, Yamani A, Kiso Y
Views on amyloid hypothesis and secretase inhibitors for treating Alzheimer's disease: progress and problems.
Curr Pharm Des. 2006;12(33):4295-312.
PMID: 17105429
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17105429
DaSilva KA, Aubert I, McLaurin J
Vaccine development for Alzheimer's disease.
Curr Pharm Des. 2006;12(33):4283-93.
PMID: 17105428
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17105428
Ohno M
Genetic and pharmacological basis for therapeutic inhibition of beta- and gamma-secretases in mouse models of Alzheimer's memory deficits.
Rev Neurosci. 2006;17(4):429-54.
PMID: 17139843
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17139843
Wollmer MA, Nitsch RM, Hock C, Papassotiropoulos A
Genetic association study on colony-stimulating factor 1 in Alzheimer's disease.
Neurodegener Dis. 2006;3(6):334-7.
PMID: 17192722
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=17192722
de Chiara C, Menon RP, Dal Piaz F, Calder L, Pastore A
Polyglutamine is not all: the functional role of the AXH domain in the ataxin-1 protein.
J Mol Biol. 2005 Dec 9;354(4):883-93.
PMID: 16277991
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16277991
Apetri AC, Vanik DL, Surewicz WK
Polymorphism at residue 129 modulates the conformational conversion of the D178N variant of human prion protein 90-231.
Biochemistry. 2005 Dec 6;44(48):15880-8.
PMID: 16313190
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16313190
Hérard AS, Besret L, Dubois A, Dauguet J, Delzescaux T, Hantraye P, Bonvento G, Moya KL
siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo.
Neurobiol Aging. 2005 Dec 3;
PMID: 16337035
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16337035
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
J Biol Chem. 2005 Dec 2;280(48):40364-74.
PMID: 16183991
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16183991
Nakashima H, Ishihara T, Suguimoto P, Yokota O, Oshima E, Kugo A, Terada S, Hamamura T, Trojanowski JQ, Lee VM, Kuroda S
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.
Acta Neuropathol (Berl). 2005 Dec;110(6):547-56.
PMID: 16228182
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16228182
da Costa CA
Recent insights on the pro-apoptotic phenotype elicited by presenilin 2 and its caspase and presenilinase-derived fragments.
Curr Alzheimer Res. 2005 Dec;2(5):507-14.
PMID: 16375654
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16375654
Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease.
PLoS Med. 2005 Dec;2(12):e355.
PMID: 16279840
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Miida T, Takahashi A, Tanabe N, Ikeuchi T
Can statin therapy really reduce the risk of Alzheimer's disease and slow its progression?
Curr Opin Lipidol. 2005 Dec;16(6):619-23.
PMID: 16276238
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16276238
Ribé EM, Pérez M, Puig B, Gich I, Lim F, Cuadrado M, Sesma T, Catena S, Sánchez B, Nieto M, Gómez-Ramos P, Morán MA, Cabodevilla F, Samaranch L, Ortiz L, Pérez A, Ferrer I, Avila J, Gómez-Isla T
Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.
Neurobiol Dis. 2005 Dec;20(3):814-22.
PMID: 16125396
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Velliquette RA, O'Connor T, Vassar R
Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
J Neurosci. 2005 Nov 23;25(47):10874-83.
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Yagi H, Kusaka E, Hongo K, Mizobata T, Kawata Y
Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.
J Biol Chem. 2005 Nov 18;280(46):38609-16.
PMID: 16162499
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16162499
Hemming ML, Selkoe DJ
Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor.
J Biol Chem. 2005 Nov 11;280(45):37644-50.
PMID: 16154999
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Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J
Active immunization trial in Abeta(42)-injected P301L tau transgenic mice.
Neurobiol Dis. 2005 Nov 10;
PMID: 16289870
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16289870
Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, Fuortes M, Lin M, Ehrt S, Kwon NS, Chen J, Vodovotz Y, Kipiani K, Beal MF
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
J Exp Med. 2005 Nov 7;202(9):1163-9.
PMID: 16260491
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16260491
Clementi ME, Misiti F
Substitution of methionine 35 inhibits apoptotic effects of Abeta(31-35) and Abeta(25-35) fragments of amyloid-beta protein in PC12 cells.
Med Sci Monit. 2005 Nov;11(11):BR381-5.
PMID: 16258386
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16258386
Beher D, Graham SL
Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease.
Expert Opin Investig Drugs. 2005 Nov;14(11):1385-409.
PMID: 16255678
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16255678
Whalen BM, Selkoe DJ, Hartley DM
Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration.
Neurobiol Dis. 2005 Nov;20(2):254-66.
PMID: 16242634
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16242634
Rosenberg RN
Translational research on the way to effective therapy for Alzheimer disease.
Arch Gen Psychiatry. 2005 Nov;62(11):1186-92.
PMID: 16275806
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16275806
Woltjer RL, Cimino PJ, Boutté AM, Schantz AM, Montine KS, Larson EB, Bird T, Quinn JF, Zhang J, Montine TJ
Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease.
FASEB J. 2005 Nov;19(13):1923-5.
PMID: 16129700
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16129700
Tabner BJ, El-Agnaf OM, Turnbull S, German MJ, Paleologou KE, Hayashi Y, Cooper LJ, Fullwood NJ, Allsop D
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.
J Biol Chem. 2005 Oct 28;280(43):35789-92.
PMID: 16141213
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16141213
Buttini M, Masliah E, Barbour R, Grajeda H, Motter R, Johnson-Wood K, Khan K, Seubert P, Freedman S, Schenk D, Games D
Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.
J Neurosci. 2005 Oct 5;25(40):9096-101.
PMID: 16207868
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16207868
Pak T, Cadet P, Mantione KJ, Stefano GB
Morphine via nitric oxide modulates beta-amyloid metabolism: a novel protective mechanism for Alzheimer's disease.
Med Sci Monit. 2005 Oct;11(10):BR357-66.
PMID: 16192893
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16192893
Humpel C, Marksteiner J
Cerebrovascular damage as a cause for Alzheimer's disease.
Curr Neurovasc Res. 2005 Oct;2(4):341-7.
PMID: 16181125
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16181125
McGeer EG, McGeer PL
Abeta immunotherapy and other means to remove amyloid.
Curr Drug Targets CNS Neurol Disord. 2005 Oct;4(5):569-73.
PMID: 16266289
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16266289
Jacobsen JS, Reinhart P, Pangalos MN
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease.
NeuroRx. 2005 Oct;2(4):612-26.
PMID: 16489369
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16489369
Stratman NC, Castle CK, Taylor BM, Epps DE, Melchior GW, Carter DB
Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide.
Chem Phys Lipids. 2005 Oct;137(1-2):52-61.
PMID: 16140289
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16140289
Lashuel HA
Membrane permeabilization: a common mechanism in protein-misfolding diseases.
Sci Aging Knowledge Environ. 2005 Sep 21;2005(38):pe28.
PMID: 16186179
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16186179
Yamamoto N, Yokoseki T, Shibata M, Yamaguchi H, Yanagisawa K
Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody.
Biochem Biophys Res Commun. 2005 Sep 16;335(1):45-7.
PMID: 16051187
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16051187
Myllykangas L, Wavrant-De Vrièze F, Polvikoski T, Notkola IL, Sulkava R, Niinistö L, Edland SD, Arepalli S, Adighibe O, Compton D, Hardy J, Haltia M, Tienari PJ
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
J Neurol Sci. 2005 Sep 15;236(1-2):17-24.
PMID: 16023140
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16023140
Nguyen TV, Yao M, Pike CJ
Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection.
J Neurochem. 2005 Sep;94(6):1639-51.
PMID: 16011741
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16011741
Bennett DA, Schneider JA, Wilson RS, Bienias JL, Berry-Kravis E, Arnold SE
Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people.
J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1194-9.
PMID: 16107349
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16107349
Carrotta R, Manno M, Bulone D, Martorana V, San Biagio PL
Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
J Biol Chem. 2005 Aug 26;280(34):30001-8.
PMID: 15985437
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15985437
Craft JM, Watterson DM, Marks A, Van Eldik LJ
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.
Glia. 2005 Aug 15;51(3):209-16.
PMID: 15810011
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15810011
Lane RM, Potkin SG, Enz A
Targeting acetylcholinesterase and butyrylcholinesterase in dementia.
Int J Neuropsychopharmacol. 2005 Aug 5;:1-24.
PMID: 16083515
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16083515
Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.
Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):383-403.
PMID: 16101556
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16101556
Pangalos MN, Jacobsen SJ, Reinhart PH
Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide.
Biochem Soc Trans. 2005 Aug;33(Pt 4):553-8.
PMID: 16042543
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16042543
Walker DG, Lue LF
Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases.
J Neurosci Res. 2005 Aug 1;81(3):412-25.
PMID: 15957156
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15957156
Zohar O, Pick CG, Cavallaro S, Chapman J, Katzav A, Milman A, Alkon DL
Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice.
Neurobiol Aging. 2005 Aug-Sep;26(8):1167-75.
PMID: 15917100
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15917100
Höglund K, Syversen S, Lewczuk P, Wallin A, Wiltfang J, Blennow K
Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease.
Exp Brain Res. 2005 Jul;164(2):205-14.
PMID: 15937702
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15937702
Pluta R
Pathological opening of the blood-brain barrier to horseradish peroxidase and amyloid precursor protein following ischemia-reperfusion brain injury.
Chemotherapy. 2005 Jul;51(4):223-6.
PMID: 16006769
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16006769
Ballard CG, Greig NH, Guillozet-Bongaarts AL, Enz A, Darvesh S
Cholinesterases: roles in the brain during health and disease.
Curr Alzheimer Res. 2005 Jul;2(3):307-18.
PMID: 15974896
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15974896
Lafay-Chebassier C, Paccalin M, Page G, Barc-Pain S, Perault-Pochat MC, Gil R, Pradier L, Hugon J
mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease.
J Neurochem. 2005 Jul;94(1):215-25.
PMID: 15953364
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15953364
Askanas V, Engel WK
Molecular pathology and pathogenesis of inclusion-body myositis.
Microsc Res Tech. 2005 Jul;67(3-4):114-20.
PMID: 16104000
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16104000
Nitrini R
The cure of one of the most frequent types of dementia: a historical parallel.
Alzheimer Dis Assoc Disord. 2005 Jul-Sep;19(3):156-8.
PMID: 16118533
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16118533
Marchesi VT
An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease.
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9093-8.
PMID: 15967987
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15967987
Craft JM, Watterson DM, Hirsch E, Van Eldik LJ
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.
J Neuroinflammation. 2005 Jun 20;2:15.
PMID: 15967035
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15967035
Anderluh G, Gutierrez-Aguirre I, Rabzelj S, Ceru S, Kopitar-Jerala N, Macek P, Turk V, Zerovnik E
Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity.
FEBS J. 2005 Jun;272(12):3042-51.
PMID: 15955063
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15955063
Maynard CJ, Bush AI, Masters CL, Cappai R, Li QX
Metals and amyloid-beta in Alzheimer's disease.
Int J Exp Pathol. 2005 Jun;86(3):147-59.
PMID: 15910549
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15910549
Ueberham U, Arendt T
The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease.
Curr Drug Targets CNS Neurol Disord. 2005 Jun;4(3):293-306.
PMID: 15975031
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15975031
Bolognesi ML, Andrisano V, Bartolini M, Cavalli A, Minarini A, Recanatini M, Rosini M, Tumiatti V, Melchiorre C
Heterocyclic inhibitors of AChE acylation and peripheral sites.
Farmaco. 2005 Jun-Jul;60(6-7):465-73.
PMID: 15878569
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15878569
Reichard RR, Smith C, Graham DI
The significance of beta-APP immunoreactivity in forensic practice.
Neuropathol Appl Neurobiol. 2005 Jun;31(3):304-13.
PMID: 15885067
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15885067
Cribbs DH, David H, Agadjanyan MG
Immunotherapy for Alzheimer's Disease: Potential Problems and Possible Solutions
Current Immunology Reviews. 2005 June 1;1(2):139-155.
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=56186
Yoon IS, Pietrzik CU, Kang DE, Koo EH
Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling.
J Biol Chem. 2005 May 20;280(20):20140-7.
PMID: 15772078
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15772078
Elesber AA, Bonetti PO, Woodrum JE, Zhu XY, Lerman LO, Younkin SG, Lerman A
Bosentan preserves endothelial function in mice overexpressing APP.
Neurobiol Aging. 2005 May 12;
PMID: 15894408
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15894408
Brunkan AL, Goate AM
Presenilin function and gamma-secretase activity.
J Neurochem. 2005 May;93(4):769-92.
PMID: 15857382
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15857382
Woltjer RL, Nghiem W, Maezawa I, Milatovic D, Vaisar T, Montine KS, Montine TJ
Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity.
J Neurochem. 2005 May;93(4):1047-56.
PMID: 15857408
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15857408
Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.
J Biol Chem. 2005 Apr 29;280(17):17294-300.
PMID: 15722360
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15722360
Joshi G, Sultana R, Perluigi M, Allan Butterfield D
In vivo protection of synaptosomes from oxidative stress mediated by Fe(2+)/H(2)O(2) or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate.
Free Radic Biol Med. 2005 Apr 15;38(8):1023-31.
PMID: 15780760
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15780760
Zlokovic BV
Neurovascular mechanisms of Alzheimer's neurodegeneration.
Trends Neurosci. 2005 Apr 1;28(4):202-8.
PMID: 15808355
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15808355
Bartha JL, Soothill PW
Plasma amyloid beta protein 1-42 levels in fetuses with Down syndrome.
Early Hum Dev. 2005 Apr;81(4):351-4.
PMID: 15814219
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15814219
Michaelis ML, Seyb KI, Ansar S
Cytoskeletal integrity as a drug target.
Curr Alzheimer Res. 2005 Apr;2(2):227-9.
PMID: 15974922
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15974922
Liu HC, Chi CW, Ko SY, Wang HC, Hong CJ, Lin KN, Wang PN, Liu TY
Cholinesterase Inhibitor Affects the Amyloid Precursor Protein Isoforms in Patients with Alzheimer's Disease.
Dement Geriatr Cogn Disord. 2005 Mar 22;19(5-6):345-348.
PMID: 15785036
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15785036
Floden AM, Li S, Combs CK
Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.
J Neurosci. 2005 Mar 9;25(10):2566-75.
PMID: 15758166
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15758166
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ
Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.
J Neurosci. 2005 Mar 9;25(10):2455-62.
PMID: 15758153
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15758153
Green DA, Masliah E, Vinters HV, Beizai P, Moore DJ, Achim CL
Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients.
AIDS. 2005 Mar 4;19(4):407-11.
PMID: 15750394
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15750394
Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
J Neurosci. 2005 Mar 2;25(9):2386-95.
PMID: 15745965
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15745965
Huitrón-Reséndiz S, Sánchez-Alavez M, Criado JR
Sleep-wake states in transgenic mouse models overexpressing the human beta-amyloid precursor protein.
Am J Alzheimers Dis Other Demen. 2005 Mar-Apr;20(2):87-90.
PMID: 15844754
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15844754
Elsisi NS, Darling-Reed S, Lee EY, Oriaku ET, Soliman KF
Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia.
Neurosci Lett. 2005 Feb 28;375(2):91-6.
PMID: 15670648
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15670648
Tanzi RE, Bertram L
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective.
Cell. 2005 Feb 25;120(4):545-55.
PMID: 15734686
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15734686
Conti L, Cattaneo E
Controlling neural stem cell division within the adult subventricular zone: an APPealing job.
Trends Neurosci. 2005 Feb;28(2):57-9.
PMID: 15667924
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15667924
Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen RL, Smith MA
Evidence for the role of gonadotropin hormones in the development of Alzheimer disease.
Cell Mol Life Sci. 2005 Feb 1;62(3):293-8.
PMID: 15723165
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15723165
Christoforidis M, Schober R, Krohn K
Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy.
Neuropathol Appl Neurobiol. 2005 Feb;31(1):11-9.
PMID: 15634227
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15634227
Ognibene E, Middei S, Daniele S, Adriani W, Ghirardi O, Caprioli A, Laviola G
Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer's disease.
Behav Brain Res. 2005 Jan 30;156(2):225-32.
PMID: 15582108
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15582108
Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH
The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.
J Neurosci. 2005 Jan 26;25(4):823-9.
PMID: 15673661
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Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM
Ibuprofen Suppresses Interleukin-1beta Induction of Pro-Amyloidogenic alpha(1)-Antichymotrypsin to Ameliorate beta-Amyloid (Abeta) Pathology in Alzheimer's Models.
Neuropsychopharmacology. 2005 Jan 26;
PMID: 15688088
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15688088
James VJ, Richardson JC, Robertson TA, Papadimitriou JM, Dutton NS, Maley MA, Berstein LM, Lantseva OE, Martins RN
Fibre diffraction of hair can provide a screening test for Alzheimer's Disease: a human and animal model study.
Med Sci Monit. 2005 Jan 24;11(2):CR53-57.
PMID: 15668631
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15668631
Iqbal K, Grundke-Iqbal I
Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies.
Acta Neuropathol (Berl). 2005 Jan 11;
PMID: 15645264
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15645264
Pedrini S, Carter TL, Prendergast G, Petanceska S, Ehrlich ME, Gandy S
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.
PLoS Med. 2005 Jan;2(1):e18.
PMID: 15647781
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15647781
Chauhan NB, Siegel GJ, Feinstein DL
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.
Neuropharmacology. 2005 Jan;48(1):93-104.
PMID: 15617731
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15617731
Walker ES, Martinez M, Brunkan AL, Goate A
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
J Neurochem. 2005 Jan;92(2):294-301.
PMID: 15663477
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15663477
Carter DB
The interaction of amyloid-beta with ApoE.
Subcell Biochem. 2005;38:255-72.
PMID: 15709483
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15709483
Exley C
The aluminium-amyloid cascade hypothesis and Alzheimer's disease.
Subcell Biochem. 2005;38:225-34.
PMID: 15709481
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15709481
Kojro E, Fahrenholz F
The non-amyloidogenic pathway: structure and function of alpha-secretases.
Subcell Biochem. 2005;38:105-27.
PMID: 15709475
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15709475
Golde TE
The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease.
Brain Pathol. 2005 Jan;15(1):84-7.
PMID: 15779241
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15779241
Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM
Neurovascular pathways and Alzheimer amyloid beta-peptide.
Brain Pathol. 2005 Jan;15(1):78-83.
PMID: 15779240
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15779240
Ceru S, Rabzelj S, Kopitar-Jerala N, Turk V, Zerovnik E
Protein aggregation as a possible cause for pathology in a subset of familial Unverricht-Lundborg disease.
Med Hypotheses. 2005;64(5):955-9.
PMID: 15780491
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15780491
Yamagishi S, Nakamura K, Inoue H, Kikuchi S, Takeuchi M
Serum or cerebrospinal fluid levels of glyceraldehyde-derived advanced glycation end products (AGEs) may be a promising biomarker for early detection of Alzheimer's disease.
Med Hypotheses. 2005;64(6):1205-7.
PMID: 15823718
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15823718
Roy S, Rauk A
Alzheimer's disease and the 'ABSENT' hypothesis: mechanism for amyloid beta endothelial and neuronal toxicity.
Med Hypotheses. 2005 Jan;65(1):123-37.
PMID: 15893129
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15893129
Hama E, Saido TC
Etiology of sporadic Alzheimer's disease: somatostatin, neprilysin, and amyloid beta peptide.
Med Hypotheses. 2005;65(3):498-500.
PMID: 15921860
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15921860
Bohr IJ
Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease?
Lipids Health Dis. 2005;4:13.
PMID: 15949039
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15949039
Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribé E, Dalfó E, Avila J
Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies.
Curr Alzheimer Res. 2005 Jan;2(1):3-18.
PMID: 15977985
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15977985
Sjögren M, Blennow K
The link between cholesterol and Alzheimer's disease.
World J Biol Psychiatry. 2005;6(2):85-97.
PMID: 16156481
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16156481
Aisen PS
The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors.
CNS Drugs. 2005;19(12):989-96.
PMID: 16332141
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16332141
Pluta R
From brain ischemia-reperfusion injury to possible sporadic Alzheimer's disease.
Curr Neurovasc Res. 2004 Dec;1(5):441-53.
PMID: 16181092
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16181092
Stuerenburg HJ, Ganzer S, Müller-Thomsen T
5-hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer"s disease, depression and mild cognitive impairment.
Neuro Endocrinol Lett. 2004 Dec;25(6):435-7.
PMID: 15665806
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15665806
Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, Montine KS
Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity.
J Neurochem. 2004 Dec;91(6):1312-21.
PMID: 15584908
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15584908
Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
J Neurochem. 2004 Dec;91(6):1249-59.
PMID: 15584902
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15584902
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL
Synaptic targeting by Alzheimer's-related amyloid beta oligomers.
J Neurosci. 2004 Nov 10;24(45):10191-200.
PMID: 15537891
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Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15537891
Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F
beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice.
Am J Pathol. 2004 Nov 1;165(5):1621-31.
PMID: 15509532
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15509532
Wirths O, Multhaup G, Bayer TA
A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.
J Neurochem. 2004 Nov;91(3):513-20.
PMID: 15485483
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15485483
Götz J, Schild A, Hoerndli F, Pennanen L
Amyloid-induced neurofibrillary tangle formation in Alzheimer's disease: insight from transgenic mouse and tissue-culture models.
Int J Dev Neurosci. 2004 Nov;22(7):453-65.
PMID: 15465275
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15465275
Lee JY, Friedman JE, Angel I, Kozak A, Koh JY
The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice.
Neurobiol Aging. 2004 Nov-Dec;25(10):1315-21.
PMID: 15465629
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15465629
Rossner S
New players in old amyloid precursor protein-processing pathways.
Int J Dev Neurosci. 2004 Nov;22(7):467-74.
PMID: 15465276
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15465276
Pillay NS, Kellaway LA, Kotwal GJ
Molecular mechanisms, emerging etiological insights and models to test potential therapeutic interventions in Alzheimer's disease.
Curr Alzheimer Res. 2004 Nov;1(4):295-306.
PMID: 15975058
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15975058
Hayashi Y, Ueda Y, Nakajima A, Mitsuyama Y
EPR evidence of hydroxyl radical generation as an initiator of lipid peroxidation in amyloid beta-protein-stimulated PC12 cells.
Brain Res. 2004 Oct 29;1025(1-2):29-34.
PMID: 15464741
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15464741
Bellingham SA, Ciccotosto GD, Needham BE, Fodero LR, White AR, Masters CL, Cappai R, Camakaris J
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.
J Neurochem. 2004 Oct;91(2):423-8.
PMID: 15447675
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15447675
Schenk D, Hagen M, Seubert P
Current progress in beta-amyloid immunotherapy.
Curr Opin Immunol. 2004 Oct;16(5):599-606.
PMID: 15342006
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15342006
Verdile G, Fuller S, Atwood CS, Laws SM, Gandy SE, Martins RN
The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught?
Pharmacol Res. 2004 Oct;50(4):397-409.
PMID: 15304237
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15304237
Love R
Mouse model provides support for amyloid-cascade hypothesis.
Lancet Neurol. 2004 Oct;3(10):576.
PMID: 15461989
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15461989
Clementi ME, Martorana GE, Pezzotti M, Giardina B, Misiti F
Methionine 35 oxidation reduces toxic effects of the amyloid beta-protein fragment (31-35) on human red blood cell.
Int J Biochem Cell Biol. 2004 Oct;36(10):2076-86.
PMID: 15203119
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15203119
Walsh DM, Selkoe DJ
Deciphering the molecular basis of memory failure in Alzheimer's disease.
Neuron. 2004 Sep 30;44(1):181-93.
PMID: 15450169
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15450169
Sodhi CP, Rampalli S, Perez RG, Koo EH, Quinn B, Gottardi-Littell NR
The endocytotic pathway is required for increased Abeta42 secretion during apoptosis.
Brain Res Mol Brain Res. 2004 Sep 28;128(2):201-11.
PMID: 15363895
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15363895
Tanzi RE, Moir RD, Wagner SL
Clearance of Alzheimer's Abeta peptide: the many roads to perdition.
Neuron. 2004 Sep 2;43(5):605-8.
PMID: 15339642
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15339642
Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.
J Neurosci. 2004 Sep 1;24(35):7707-17.
PMID: 15342738
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15342738
Barger SW
An unconventional hypothesis of oxidation in alzheimer s disease: intersections with excitotoxicity.
Front Biosci. 2004 Sep 1;9:3286-95.
PMID: 15353358
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15353358
Gutierrez-Zepeda A, Luo Y
Testing the amyloid toxicity hypothesis of alzheimer's disease in transgenic Caenorhabditis elegans model.
Front Biosci. 2004 Sep 1;9:3333-8.
PMID: 15353361
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15353361
de Leon MJ, DeSanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Clark C, Kerkman D, DeBernardis J, Li J, Lair L, Reisberg B, Tsui W, Rusinek H
MRI and CSF studies in the early diagnosis of Alzheimer's disease.
J Intern Med. 2004 Sep;256(3):205-23.
PMID: 15324364
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15324364
Rabacchi SA, Friedman WJ, Shelanski ML, Troy CM
Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein.
Neurobiol Aging. 2004 Sep;25(8):1057-66.
PMID: 15212831
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15212831
Ye C, Walsh DM, Selkoe DJ, Hartley DM
Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation.
Neurosci Lett. 2004 Aug 19;366(3):320-5.
PMID: 15288443
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15288443
Bartzokis G, Sultzer D, Lu PH, Nuechterlein KH, Mintz J, Cummings JL
Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease.
Neurobiol Aging. 2004 Aug;25(7):843-51.
PMID: 15212838
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15212838
Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
J Neurochem. 2004 Aug;90(4):1011-8.
PMID: 15287908
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15287908
Lopez EM, Bell KF, Ribeiro-da-Silva A, Cuello AC
Early changes in neurons of the hippocampus and neocortex in transgenic rats expressing intracellular human a-beta.
J Alzheimers Dis. 2004 Aug;6(4):421-31.
PMID: 15345813
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15345813
Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA
Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease.
Curr Drug Targets CNS Neurol Disord. 2004 Aug 1;3(4):281-5.
PMID: 15379604
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15379604
Toledano A, Alvarez MI
Lesions and dysfunctions of the nucleus basalis as Alzheimer's disease models: general and critical overview and analysis of the long-term changes in several excitotoxic models.
Curr Alzheimer Res. 2004 Aug;1(3):189-214.
PMID: 15975067
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15975067
Solomon B
Alzheimer's disease and immunotherapy.
Curr Alzheimer Res. 2004 Aug;1(3):149-63.
PMID: 15975063
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15975063
Tong L, Balazs R, Thornton PL, Cotman CW
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.
J Neurosci. 2004 Jul 28;24(30):6799-809.
PMID: 15282285
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15282285
Lacombe P, Mathews PM, Schmidt SD, Breidert T, Heneka MT, Landreth GE, Feinstein DL, Galea E
Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised.
J Neuroinflammation. 2004 Jul 2;1(1):11.
PMID: 15285804
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15285804
Rossner S, Fuchsbrunner K, Lange-Dohna C, Hartlage-Rübsamen M, Bigl V, Betz A, Reim K, Brose N
Munc13-1-mediated Vesicle Priming Contributes to Secretory Amyloid Precursor Protein Processing.
J Biol Chem. 2004 Jul 2;279(27):27841-4.
PMID: 15123597
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15123597
Streit WJ
Microglia and Alzheimer's disease pathogenesis.
J Neurosci Res. 2004 Jul 1;77(1):1-8.
PMID: 15197750
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15197750
Schönheit B, Zarski R, Ohm TG
Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology.
Neurobiol Aging. 2004 Jul;25(6):697-711.
PMID: 15165691
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15165691
Alvarez AR, Godoy JA, Mullendorff K, Olivares GH, Bronfman M, Inestrosa NC
Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.
Exp Cell Res. 2004 Jul 1;297(1):186-96.
PMID: 15194435
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15194435
Reid SJ, van Roon-Mom WM, Wood PC, Rees MI, Owen MJ, Faull RL, Dragunow M, Snell RG
TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease.
Brain Res Mol Brain Res. 2004 Jun 18;125(1-2):120-8.
PMID: 15193429
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15193429
Haglund M, Sjöbeck M, Englund E
Severe Cerebral Amyloid Angiopathy Characterizes an Underestimated Variant of Vascular Dementia.
Dement Geriatr Cogn Disord. 2004 Jun 18;18(2):132-137.
PMID: 15211067
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15211067
Lahdo R, Bessueille LD
Insertion of the amyloid protein precursor into lipid monolayers: effect of cholesterol and apolipoprotein E.
Biochem J. 2004 Jun 15;Pt
PMID: 15202933
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15202933
Delatour B, Blanchard V, Pradier L, Duyckaerts C
Alzheimer pathology disorganizes cortico-cortical circuitry: direct evidence from a transgenic animal model.
Neurobiol Dis. 2004 Jun 1;16(1):41-7.
PMID: 15207260
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15207260
LeVine H
The Amyloid Hypothesis and the clearance and degradation of Alzheimer's beta-peptide.
J Alzheimers Dis. 2004 Jun;6(3):303-14.
PMID: 15201485
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15201485
Bobich JA, Zheng Q, Campbell A
Incubation of nerve endings with a physiological concentration of Abeta1-42 activates CaV2.2(N-Type)-voltage operated calcium channels and acutely increases glutamate and noradrenaline release.
J Alzheimers Dis. 2004 Jun;6(3):243-55.
PMID: 15201479
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15201479
Mobley DL, Cox DL, Singh RR, Maddox MW, Longo ML
Modeling amyloid beta-peptide insertion into lipid bilayers.
Biophys J. 2004 Jun;86(6):3585-97.
PMID: 15189856
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15189856
Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA
Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease.
Ann N Y Acad Sci. 2004 Jun 1;1019:1-4.
PMID: 15246983
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15246983
Goldfarb LG, Cervenakova L, Gajdusek DC
Genetic studies in relation to kuru: an overview.
Curr Mol Med. 2004 Jun;4(4):375-84.
PMID: 15354868
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15354868
Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW
Increased beta-secretase activity and expression in rats following transient cerebral ischemia.
Brain Res. 2004 May 29;1009(1-2):1-8.
PMID: 15120577
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15120577
Lin S, Rhodes PG, Lei M, Zhang F, Cai Z
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain.
Brain Res. 2004 May 8;1007(1-2):132-41.
PMID: 15064144
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15064144
Ray SS, Nowak RJ, Strokovich K, Brown RH, Walz T, Lansbury PT
An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.
Biochemistry. 2004 May 4;43(17):4899-905.
PMID: 15109247
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15109247
Kim JR, Murphy RM
Mechanism of accelerated assembly of beta-amyloid filaments into fibrils by KLVFFK(6).
Biophys J. 2004 May;86(5):3194-203.
PMID: 15111432
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15111432
Zlokovic BV
Clearing amyloid through the blood-brain barrier.
J Neurochem. 2004 May;89(4):807-11.
PMID: 15140180
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15140180
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, Van Leuven F, Fahrenholz F
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.
J Clin Invest. 2004 May;113(10):1456-64.
PMID: 15146243
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15146243
Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.
FASEB J. 2004 May;18(7):902-4.
PMID: 15033922
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15033922
Kawahara M
Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases.
Curr Alzheimer Res. 2004 May;1(2):87-95.
PMID: 15975072
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15975072
Dima RI, Thirumalai D
Proteins associated with diseases show enhanced sequence correlation between charged residues.
Bioinformatics. 2004 Apr 8;
PMID: 15073020
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15073020
Tomimoto H, Lin JX, Matsuo A, Ihara M, Ohtani R, Shibata M, Miki Y, Shibasaki H
Different mechanisms of corpus callosum atrophy in Alzheimer's disease and vascular dementia.
J Neurol. 2004 Apr;251(4):398-406.
PMID: 15083283
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15083283
Schmitz C, Rutten BP, Pielen A, Schäfer S, Wirths O, Tremp G, Czech C, Blanchard V, Multhaup G, Rezaie P, Korr H, Steinbusch HW, Pradier L, Bayer TA
Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
Am J Pathol. 2004 Apr 1;164(4):1495-502.
PMID: 15039236
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15039236
Rodero L, Infante J, Palacio E, Llorca J, Berciano J, Combarros O
Polymorphism at codon 469 of the intercellular adhesion molecule-1 gene is not associated with sporadic Alzheimer's disease.
Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126(1):66-8.
PMID: 15048650
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15048650
Lee HG, Casadesus G, Zhu X, Joseph JA, Perry G, Smith MA
Perspectives on the amyloid-beta cascade hypothesis.
J Alzheimers Dis. 2004 Apr 1;6(2):137-45.
PMID: 15096697
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15096697
Price JM, Hellermann A, Hellermann G, Sutton ET
Aging enhances vascular dysfunction induced by the Alzheimer's peptide beta-amyloid.
Neurol Res. 2004 Apr;26(3):305-11.
PMID: 15142324
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15142324
Xu BG, Wu X
[Advances in molecular biology and clinical study of amyloid precursor protein for Alzheimer's disease]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Apr;26(2):201-9.
PMID: 15171563
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15171563
Heo HJ, Kim DO, Shin SC, Kim MJ, Kim BG, Shin DH
Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection.
J Agric Food Chem. 2004 Mar 24;52(6):1520-5.
PMID: 15030205
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15030205
Tanaka M, Chien P, Naber N, Cooke R, Weissman JS
Conformational variations in an infectious protein determine prion strain differences.
Nature. 2004 Mar 18;428(6980):323-8.
PMID: 15029196
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15029196
Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ
Amyloid precursor protein mRNA levels in Alzheimer's disease brain.
Brain Res Mol Brain Res. 2004 Mar 17;122(1):1-9.
PMID: 14992810
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14992810
Otto M, Cepek L, Ratzka P, Doehlinger S, Boekhoff I, Wiltfang J, Irle E, Pergande G, Ellers-Lenz B, Windl O, Kretzschmar HA, Poser S, Prange H
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.
Neurology. 2004 Mar 9;62(5):714-8.
PMID: 15007119
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15007119
Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE
Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function.
Arch Neurol. 2004 Mar;61(3):378-84.
PMID: 15023815
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15023815
Kowalska A
Genetic basis of neurodegeneration in familial Alzheimer's disease.
Pol J Pharmacol. 2004 Mar-Apr;56(2):171-8.
PMID: 15156067
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15156067
Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J
Copper depletion down-regulates expression of Alzheimer's disease Amyloid-beta precursor protein gene.
J Biol Chem. 2004 Feb 25;
PMID: 14985339
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14985339
Chartier-Harlin MC, Araria-Goumidi L, Lambert JC
[Genetic complexity of Alzheimer's disease]
Rev Neurol (Paris). 2004 Feb;160(2):251-5.
PMID: 15034485
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15034485
Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Praticò D
Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.
FASEB J. 2004 Feb 1;18(2):323-5.
PMID: 14656990
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14656990
Craner MJ, Hains BC, Lo AC, Black JA, Waxman SG
Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.
Brain. 2004 Feb;127(Pt 2):294-303.
PMID: 14662515
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14662515
Fukumoto H, Rosene DL, Moss MB, Raju S, Hyman BT, Irizarry MC
Beta-secretase activity increases with aging in human, monkey, and mouse brain.
Am J Pathol. 2004 Feb;164(2):719-25.
PMID: 14742275
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14742275
Janson J, Laedtke T, Parisi JE, O'Brien P, Petersen RC, Butler PC
Increased risk of type 2 diabetes in Alzheimer disease.
Diabetes. 2004 Feb;53(2):474-81.
PMID: 14747300
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14747300
Citron M
Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge.
Trends Pharmacol Sci. 2004 Feb;25(2):92-7.
PMID: 15102495
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15102495
Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S
High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity.
J Neurosci Res. 2004 10 21;
PMID: 15499593
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15499593
Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Hum Mol Genet. 2004 Jan 15;13(2):159-70.
PMID: 14645205
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14645205
Arispe N
Architecture of the Alzheimer's A beta P ion channel pore.
J Membr Biol. 2004 Jan 1;197(1):33-48.
PMID: 15014916
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15014916
Bour A, Little S, Dodart JC, Kelche C, Mathis C
A secreted form of the beta-amyloid precursor protein (sAPP695) improves spatial recognition memory in OF1 mice.
Neurobiol Learn Mem. 2004 Jan;81(1):27-38.
PMID: 14670356
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14670356
Kim HS, Kim EM, Kim NJ, Chang KA, Choi Y, Ahn KW, Lee JH, Kim S, Park CH, Suh YH
Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein.
J Neurosci Res. 2004 Jan 1;75(1):117-24.
PMID: 14689454
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14689454
Hegde ML, Anitha S, Latha KS, Mustak MS, Stein R, Ravid R, Rao KS
First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.
J Mol Neurosci. 2004;22(1-2):19-31.
PMID: 14742907
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14742907
Henderson ST
High carbohydrate diets and Alzheimer's disease.
Med Hypotheses. 2004;62(5):689-700.
PMID: 15082091
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15082091
Kowalska A, Pruchnik-Wolinska D, Florczak J, Modestowicz R, Szczech J, Kozubski W, Rossa G, Wender M
Genetic study of familial cases of Alzheimer's disease.
Acta Biochim Pol. 2004;51(1):245-52.
PMID: 15094846
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15094846
Wostyn P
Can chronic increased intracranial pressure or exposure to repetitive intermittent intracranial pressure elevations raise your risk for Alzheimer's disease?
Med Hypotheses. 2004;62(6):925-30.
PMID: 15142650
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15142650
Scheibel T
Amyloid formation of a yeast prion determinant.
J Mol Neurosci. 2004;23(1-2):13-22.
PMID: 15126688
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15126688
Lane RM, Kivipelto M, Greig NH
Acetylcholinesterase and Its Inhibition in Alzheimer Disease.
Clin Neuropharmacol. 2004 May-Jun;27(3):141-149.
PMID: 15190239
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15190239
Trzesniewska K, Brzyska M, Elbaum D
Neurodegenerative aspects of protein aggregation.
Acta Neurobiol Exp (Wars). 2004;64(1):41-52.
PMID: 15190679
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15190679
Tappel A, Tappel A
Oxidant free radical initiated chain polymerization of protein and other biomolecules and its relationship to diseases.
Med Hypotheses. 2004;63(1):98-9.
PMID: 15193357
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15193357
Swerdlow RH, Khan SM
A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease.
Med Hypotheses. 2004;63(1):8-20.
PMID: 15193340
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15193340
Manelli AM, Stine WB, Van Eldik LJ, LaDu MJ
ApoE and Abeta1-42 Interactions: Effects of Isoform and Conformation on Structure and Function.
J Mol Neurosci. 2004;23(3):235-46.
PMID: 15181252
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15181252
Misiti F, Martorana GE, Nocca G, Di Stasio E, Giardina B, Clementi ME
Methionine 35 oxidation reduces toxic and pro-apoptotic effects of the amyloid beta-protein fragment (31-35) on isolated brain mitochondria.
Neuroscience. 2004;126(2):297-303.
PMID: 15207347
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15207347
Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL
Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats.
Mol Med. 2004 Jan-Jun;10(1-6):36-44.
PMID: 15502881
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15502881
Pluta R
Alzheimer lesions after ischemia-reperfusion brain injury.
Folia Neuropathol. 2004;42(3):181-6.
PMID: 15535038
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15535038
Recanatini M, Valenti P
Acetylcholinesterase inhibitors as a starting point towards improved Alzheimer's disease therapeutics.
Curr Pharm Des. 2004;10(25):3157-66.
PMID: 15544505
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15544505
Kim JR, Muresan A, Lee KY, Murphy RM
Urea modulation of {beta}-amyloid fibril growth: Experimental studies and kinetic models.
Protein Sci. 2004 11;13(11):2888-2898.
PMID: 15459334
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15459334
Ferrer I
Stress kinases involved in tau phosphorylation in Alzheimer's disease, tauopathies and APP transgenic mice.
Neurotox Res. 2004;6(6):469-75.
PMID: 15658002
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15658002
Nawrot B
Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?.
Acta Biochim Pol. 2004;51(2):431-44.
PMID: 15218540
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15218540
Marques MA, Owens PA, Crutcher KA
Progress toward identification of protease activity involved in proteolysis of apolipoprotein e in human brain.
J Mol Neurosci. 2004;24(1):73-80.
PMID: 15314253
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15314253
Olsson T, Nygren J, Håkansson K, Lundblad C, Grubb A, Smith ML, Wieloch T
Gene deletion of cystatin C aggravates brain damage following focal ischemia but mitigates the neuronal injury after global ischemia in the mouse.
Neuroscience. 2004;128(1):65-71.
PMID: 15450354
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15450354
Bozzo C, Lombardi G, Santoro C, Canonico PL
Involvement of beta(1) integrin in betaAP-induced apoptosis in human neuroblastoma cells.
Mol Cell Neurosci. 2004 Jan;25(1):1-8.
PMID: 14962735
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14962735
Bell KF, de Kort GJ, Steggerda S, Shigemoto R, Ribeiro-da-Silva A, Cuello AC
Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology.
Neurosci Lett. 2003 Dec 19;353(2):143-7.
PMID: 14664921
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14664921
Woltjer RL, Maezawa I, Ou JJ, Montine KS, Montine TJ
Advanced glycation endproduct precursor alters intracellular amyloid-beta/A beta PP carboxy-terminal fragment aggregation and cytotoxicity.
J Alzheimers Dis. 2003 Dec 1;5(6):467-76.
PMID: 14757937
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14757937
Mandelkow EM, Stamer K, Vogel R, Thies E, Mandelkow E
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.
Neurobiol Aging. 2003 Dec;24(8):1079-85.
PMID: 14643379
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14643379
Oddo S, Caccamo A, Kitazawa M, Tseng BP, Laferla FM
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.
Neurobiol Aging. 2003 Dec;24(8):1063-70.
PMID: 14643377
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14643377
Kay A, Petzold A, Kerr M, Keir G, Thompson E, Nicoll J
Temporal alterations in cerebrospinal fluid amyloid beta-protein and apolipoprotein E after subarachnoid hemorrhage.
Stroke. 2003 Dec;34(12):e240-3.
PMID: 14605321
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14605321
Huff ME, Page LJ, Balch WE, Kelly JW
Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type.
J Mol Biol. 2003 Nov 14;334(1):119-27.
PMID: 14596804
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14596804
Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL
Self-assembly of Abeta(1-42) into globular neurotoxins.
Biochemistry. 2003 Nov 11;42(44):12749-60.
PMID: 14596589
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14596589
Fujiwara Y, Takahashi M, Tanaka M, Hoshi T, Someya T, Shinkai S
Relationships between plasma beta-amyloid peptide 1-42 and atherosclerotic risk factors in community-based older populations.
Gerontology. 2003 Nov-Dec;49(6):374-9.
PMID: 14624066
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14624066
Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ
Androgens modulate beta-amyloid levels in male rat brain.
J Neurochem. 2003 Nov;87(4):1052-5.
PMID: 14622134
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14622134
Selkoe DJ
Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman.
Neurochem Res. 2003 Nov;28(11):1705-13.
PMID: 14584824
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14584824
Mattson MP
Adventures in neural plasticity, aging, and neurodegenerative disorders aboard the CWC beagle.
Neurochem Res. 2003 Nov;28(11):1631-7.
PMID: 14584817
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14584817
Hook VY, Reisine TD
Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
J Neurosci Res. 2003 Nov 1;74(3):393-405.
PMID: 14598316
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14598316
Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
J Biol Chem. 2003 Oct 31;278(44):43430-6.
PMID: 12885769
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12885769
Kanski J, Sultana R, Klunk W, Butterfield DA
Antioxidant activity of X-34 in synaptosomal and neuronal systems.
Brain Res. 2003 Oct 24;988(1-2):173-9.
PMID: 14519539
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14519539
Kim JR, Gibson TJ, Murphy RM
Targeted Control of Kinetics of {beta}-Amyloid Self-association by Surface Tension-modifying Peptides.
J Biol Chem. 2003 Oct 17;278(42):40730-40735.
PMID: 12917437
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12917437
Rees T, Hammond PI, Soreq H, Younkin S, Brimijoin S
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex.
Neurobiol Aging. 2003 Oct;24(6):777-87.
PMID: 12927760
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12927760
Melton LM, Keith AB, Davis S, Oakley AE, Edwardson JA, Morris CM
Chronic glial activation, neurodegeneration, and APP immunoreactive deposits following acute administration of double-stranded RNA.
Glia. 2003 Oct;44(1):1-12.
PMID: 12951652
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12951652
Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM
Cyclooxygenase (COX)-2 and COX-1 potentiate beta -amyloid peptid generation through mechanisms that involve gamma -secretase activity.
J Biol Chem. 2003 Sep 24;
PMID: 14507922
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14507922
Lleo A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT
Notch1 competes with the amyloid precursor protein for gamma -secretase and downregulates presenilin-1 gene expression.
J Biol Chem. 2003 Sep 5;
PMID: 12960155
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12960155
McKinnon SJ
Glaucoma: ocular Alzheimer's disease?
Front Biosci. 2003 Sep 1;8:s1140-56.
PMID: 12957857
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12957857
Blass JP
Cerebrometabolic abnormalities in Alzheimer's disease.
Neurol Res. 2003 Sep;25(6):556-66.
PMID: 14503009
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14503009
McLaurin J, Darabie AA, Morrison MR
Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis.
Pharmacopsychiatry. 2003 Sep;36 Suppl 2:S130-5.
PMID: 14574627
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14574627
Nordberg A
Toward an early diagnosis and treatment of Alzheimer's disease.
Int Psychogeriatr. 2003 Sep;15(3):223-37.
PMID: 14756159
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14756159
Butler AE, Janson J, Soeller WC, Butler PC
Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.
Diabetes. 2003 Sep 1;52(9):2304-14.
PMID: 12941770
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12941770
Koudinov AR, Koudinova NV
Amyloid beta protein restores hippocampal long term potentiation: a central role for cholesterol?
Neurobiology of Lipids. 2003 Sep;1(8):46-56.
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=40667
Scola L, Licastro F, Chiappelli M, Franceschi C, Grimaldi LM, Crivello A, Colonna-Romano G, Candore G, Lio D, Caruso C
Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients.
Aging Clin Exp Res. 2003 Aug;15(4):292-5.
PMID: 14661818
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14661818
Smith JV, Luo Y
Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761.
J Alzheimers Dis. 2003 Aug;5(4):287-300.
PMID: 14624024
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14624024
Allain H, Bentué-Ferrer D, Tribut O, Gauthier S, Michel BF, Drieu-La Rochelle C
Alzheimer's disease: the pharmacological pathway.
Fundam Clin Pharmacol. 2003 Aug;17(4):419-28.
PMID: 12914543
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12914543
Gilgun-Sherki Y, Melamed E, Offen D
Antioxidant treatment in Alzheimer's disease: current state.
J Mol Neurosci. 2003 Aug;21(1):1-12.
PMID: 14500988
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14500988
Petanceska S, Pappolla M, Refolo LM
Modulation of Alzheimer's amyloidosis by statins: Mechanisms of action.
Curr Med Chem Immun Endoc & Metab Agents. 2003 Aug;3(1):1-7.
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=30478
Morgan D, Jantzen P, Wilcock D, DiCarlo G, Ugen K, Gordon M
The association of microglial activation and amyloid reduction in APP+PS1 transgenic mice.
Curr Med Chem Immun Endoc & Metab Agents. 2003 Aug;3(1):27-32.
Alzforum: http://www.alzforum.org/pap/annotation.asp?powid=30480
Perry EK, Kilford L, Lees AJ, Burn DJ, Perry RH
Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs.
Ann Neurol. 2003 Aug;54(2):235-8.
PMID: 12891676
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12891676
Silverberg GD, Mayo M, Saul T, Rubenstein E, McGuire D
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis.
Lancet Neurol. 2003 Aug;2(8):506-11.
PMID: 12878439
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12878439
Chauhan NB, Siegel GJ
Effect of PPF and ALCAR on the Induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain.
Neurochem Int. 2003 Aug;43(3):225-33.
PMID: 12689602
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12689602
Volles MJ, Lansbury PT
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease.
Biochemistry. 2003 Jul 8;42(26):7871-8.
PMID: 12834338
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12834338
Kuperstein F, Yavin E
Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity.
J Neurochem. 2003 Jul;86(1):114-25.
PMID: 12807431
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12807431
Speciale L, Ruzzante S, Calabrese E, Saresella M, Taramelli D, Mariani C, Bava L, Longhi R, Ferrante P
1-40 Beta-amyloid protein fragment modulates the expression of CD44 and CD71 on the astrocytoma cell line in the presence of IL1beta and TNFalpha.
J Cell Physiol. 2003 Jul;196(1):190-5.
PMID: 12767055
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12767055
Zhang S, Yao T
[Estrogen: regulation of amyloid-beta protein metabolism and attenuation of amyloid-beta protein neurotoxicity]
Sheng Li Ke Xue Jin Zhan. 2003 Jul;34(3):197-201.
PMID: 14628462
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14628462
Sjögren M, Andreasen N, Blennow K
Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers.
Clin Chim Acta. 2003 Jun;332(1-2):1-10.
PMID: 12763273
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12763273
Bimonte-Nelson HA, Singleton RS, Nelson ME, Eckman CB, Barber J, Scott TY, Granholm AC
Testosterone, but not nonaromatizable dihydrotestosterone, improves working memory and alters nerve growth factor levels in aged male rats.
Exp Neurol. 2003 Jun;181(2):301-12.
PMID: 12782002
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12782002
Manuelidis L
Transmissible encephalopathies: speculations and realities.
Viral Immunol. 2003 Summer;16(2):123-39.
PMID: 12828865
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12828865
Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE
Overexpression of nicastrin increases Abeta production.
FASEB J. 2003 Jun;17(9):1138-40.
PMID: 12692078
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12692078
Bigl V, Rossner S
Amyloid precursor protein processing in vivo - insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.
Curr Med Chem. 2003 May;10(10):871-82.
PMID: 12678689
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12678689
Levites Y, Amit T, Mandel S, Youdim MB
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate.
FASEB J. 2003 May;17(8):952-4.
PMID: 12670874
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12670874
Pomara N, Murali Doraiswamy P
Does increased platelet release of Abeta peptide contribute to brain abnormalities in individuals with depression?
Med Hypotheses. 2003 May;60(5):640-3.
PMID: 12710895
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12710895
Drake J, Link CD, Butterfield DA
Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.
Neurobiol Aging. 2003 May-Jun;24(3):415-20.
PMID: 12600717
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12600717
Turner PR, O'Connor K, Tate WP, Abraham WC
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory.
Prog Neurobiol. 2003 May;70(1):1-32.
PMID: 12927332
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12927332
Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease.
Lancet. 2003 Apr 12;361(9365):1258-65.
PMID: 12699953
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12699953
Russo A, Palumbo M, Aliano C, Lempereur L, Scoto G, Renis M
Red wine micronutrients as protective agents in Alzheimer-like induced insult.
Life Sci. 2003 Apr 11;72(21):2369-79.
PMID: 12639702
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12639702
Quinn J, Montine T, Morrow J, Woodward WR, Kulhanek D, Eckenstein F
Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease.
J Neuroimmunol. 2003 Apr;137(1-2):32-41.
PMID: 12667645
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12667645
Lee MS, Tsai LH
Cdk5: One of the links between senile plaques and neurofibrillary tangles?
J Alzheimers Dis. 2003 Apr;5(2):127-37.
PMID: 12719630
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12719630
Dodel RC, Hampel H, Du Y
Immunotherapy for Alzheimer's disease.
Lancet Neurol. 2003 Apr;2(4):215-20.
PMID: 12849209
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12849209
Goodman AB, Pardee AB
Evidence for defective retinoid transport and function in late onset Alzheimer's disease.
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2901-5.
PMID: 12604774
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12604774
Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW
Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets.
J Proteome Res. 2003 Mar-Apr;2(2):199-205.
PMID: 12716134
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12716134
Kubo T, Kumagae Y, Miller CA, Kaneko I
Beta-amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease.
J Neuropathol Exp Neurol. 2003 Mar;62(3):248-59.
PMID: 12638729
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12638729
Laws SM, Hone E, Gandy S, Martins RN
Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription.
J Neurochem. 2003 Mar;84(6):1215-36.
PMID: 12614323
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12614323
Vagnucci AH, Li WW
Alzheimer's disease and angiogenesis.
Lancet. 2003 Feb 15;361(9357):605-8.
PMID: 12598159
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12598159
Parvathenani LK, Tertyshnikova S, Greco CR, Roberts SB, Robertson B, Posmantur R
P2X7 mediates superoxide production in primary microglia and is upregulated in a transgenic mouse model of Alzheimer's disease.
J Biol Chem. 2003 Jan 27;
PMID: 12551918
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12551918
Mingeot-Leclercq MP, Lins L, Bensliman M, Thomas A, Van Bambeke F, Peuvot J, Schanck A, Brasseur R
Piracetam inhibits the lipid-destabilising effect of the amyloid peptide Abeta C-terminal fragment.
Biochim Biophys Acta. 2003 Jan 10;1609(1):28-38.
PMID: 12507755
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12507755
Conway KA, Baxter EW, Felsenstein KM, Reitz AB
Emerging beta-Amyloid Therapies for the Treatment of Alzheimer's Disease.
Curr Pharm Des. 2003;9(6):427-47.
PMID: 12570807
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12570807
Wang G, Zhang Y, Chen B, Cheng J
Preliminary studies on Alzheimer's disease using cDNA microarrays.
Mech Ageing Dev. 2003 Jan;124(1):115-24.
PMID: 12618014
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12618014
Vidal J, Bruce Verchere C, Andrikopoulos S, Wang F, Hull RL, Cnop M, Olin KL, LeBoeuf RC, O'Brien KD, Chait A, Kahn SE
The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice.
Diabetologia. 2003 Jan;46(1):71-9.
PMID: 12637985
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12637985
Cantarella G, Uberti D, Carsana T, Lombardo G, Bernardini R, Memo M
Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity.
Cell Death Differ. 2003 Jan;10(1):134-41.
PMID: 12655302
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12655302
Kvetnoi IM, Kvetnaia TV, Riadnova IIu, Fursov BB, Ernandes-Jago H, Blesa JR
[Expression of beta-amyloid and tau-protein in mastocytes in Alzheimer disease]
Arkh Patol. 2003 Jan-Feb;65(1):36-9.
PMID: 12669611
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12669611
Austen BM, Sidera C, Liu C, Frears E
The role of intracellular cholesterol on the processing of the -amyloid precursor protein.
J Nutr Health Aging. 2003;7(1):452-7.
PMID: 12679838
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12679838
Cooper J
Dietary lipids in the aetiology of Alzheimer's disease: implications for therapy.
Drugs Aging. 2003;20(6):399-418.
PMID: 12710861
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12710861
Kim HC, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo WK, Im DH, Shin EJ, Hjelle OP, Ottersen OP, Park SC, Kato K, Mirault ME, Nabeshima T
Immunocytochemical evidence that amyloid beta (1-42) impairs endogenous antioxidant systems in vivo.
Neuroscience. 2003;119(2):399-419.
PMID: 12770555
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12770555
Kowalska A
Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease.
Folia Neuropathol. 2003;41(1):35-40.
PMID: 12862394
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12862394
Torp R, Ottersen OP, Cotman CW, Head E
Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing.
Neuroscience. 2003;120(2):291-300.
PMID: 12890502
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12890502
Petanceska SS, DeRosa S, Sharma A, Diaz N, Duff K, Tint SG, Refolo LM, Pappolla M
Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.
J Mol Neurosci. 2003;20(3):395-406.
PMID: 14501024
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14501024
Marlow L, Cain M, Pappolla MA, Sambamurti K
Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).
J Mol Neurosci. 2003;20(3):233-9.
PMID: 14501002
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14501002
Banks WA, Robinson SM, Verma S, Morley JE
Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease.
Neuroscience. 2003;121(2):487-92.
PMID: 14522007
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14522007
van Roon-Mom WM, Reid SJ, Jones AL, MacDonald ME, Faull RL, Snell RG
Insoluble TATA-binding protein accumulation in Huntington's disease cortex.
Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):1-10.
PMID: 12531510
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12531510
Gold M
Tau therapeutics for Alzheimer's disease: the promise and the challenges.
J Mol Neurosci. 2002 Dec;19(3):331-4.
PMID: 12540060
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12540060
Wolfe MS
APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.
Int Immunopharmacol. 2002 Dec;2(13-14):1919-29.
PMID: 12489805
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12489805
Solomon B
Immunological approaches as therapy for Alzheimer's disease.
Expert Opin Biol Ther. 2002 Dec;2(8):907-17.
PMID: 12517269
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12517269
Melo JB, Agostinho P, Oliveira CR
Amyloid beta-peptide 25-35 reduces [3H]acetylcholine release in retinal neurons. Involvement of metabolic dysfunction.
Amyloid. 2002 Dec;9(4):221-8.
PMID: 12557749
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12557749
Butterfield DA
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review.
Free Radic Res. 2002 Dec;36(12):1307-13.
PMID: 12607822
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12607822
Lalonde R, Dumont M, Fukuchi K, Strazielle C
Transgenic mice expressing the human C99 terminal fragment of betaAPP: effects on spatial learning, exploration, anxiety, and motor coordination.
Exp Gerontol. 2002 Dec 1;37(12):1401-12.
PMID: 12559409
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12559409
Rojas-Fernandez CH, Chen M, Fernandez HL
Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's disease.
Pharmacotherapy. 2002 Dec;22(12):1547-63.
PMID: 12495166
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12495166
Prasad KN, Cole WC, Prasad KC
Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment.
J Am Coll Nutr. 2002 Dec;21(6):506-22.
PMID: 12480796
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12480796
Hartman RE, Laurer H, Longhi L, Bales KR, Paul SM, McIntosh TK, Holtzman DM
Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.
J Neurosci. 2002 Dec 1;22(23):10083-7.
PMID: 12451108
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12451108
D'Andrea MR, Nagele RG, Wang HY, Lee DH
Consistent immunohistochemical detection of intracellular beta-amyloid42 in pyramidal neurons of Alzheimer's disease entorhinal cortex.
Neurosci Lett. 2002 Nov 29;333(3):163-6.
PMID: 12429373
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12429373
Orlacchio A, Kawarai T, Polidoro M, Stefani A, Orlacchio A, St George-Hyslop PH, Bernardi G
Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms.
Neurosci Lett. 2002 Nov 22;333(2):115-8.
PMID: 12419494
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12419494
Sheng JG, Price DL, Koliatsos VE
Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis.
J Neurosci. 2002 Nov 15;22(22):9794-9.
PMID: 12427835
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12427835
Lazarov O, Lee M, Peterson DA, Sisodia SS
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
J Neurosci. 2002 Nov 15;22(22):9785-93.
PMID: 12427834
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12427834
Cecchi C, Fiorillo C, Sorbi S, Latorraca S, Nacmias B, Bagnoli S, Nassi P, Liguri G
Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients.
Free Radic Biol Med. 2002 Nov 15;33(10):1372-9.
PMID: 12419469
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12419469
Gatta LB, Albertini A, Ravid R, Finazzi D
Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus.
Neuroreport. 2002 Nov 15;13(16):2031-3.
PMID: 12438920
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12438920
Infante J, Llorca J, Rodero L, Palacio E, Berciano J, Combarros O
Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease.
Neurosci Lett. 2002 Nov 8;332(3):213-5.
PMID: 12399017
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12399017
de Jong D, Jansen RW, Verbeek MM, Kremer HP
[In Process Citation]
Ned Tijdschr Geneeskd. 2002 Nov 2;146(44):2074-8.
PMID: 12448960
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12448960
Xing Y, Higuchi K
Amyloid fibril proteins.
Mech Ageing Dev. 2002 Nov;123(12):1625-36.
PMID: 12470900
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12470900
Bishop GM, Robinson SR
The amyloid hypothesis: let sleeping dogmas lie?
Neurobiol Aging. 2002 Nov-Dec;23(6):1101-5.
PMID: 12470810
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12470810
Blass JP
Alzheimer's disease and Alzheimer's dementia: distinct but overlapping entities.
Neurobiol Aging. 2002 Nov-Dec;23(6):1077-84.
PMID: 12470805
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12470805
Robinson SR, Bishop GM
Abeta as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease.
Neurobiol Aging. 2002 Nov-Dec;23(6):1051-72.
PMID: 12470802
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12470802
McLaurin J, Darabie AA, Morrison MR
Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis.
Ann N Y Acad Sci. 2002 Nov;977:376-83.
PMID: 12480775
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12480775
Sparks DL, Martins R, Martin T
Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits.
Ann N Y Acad Sci. 2002 Nov;977:356-66.
PMID: 12480773
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12480773
Weller RO, Yow HY, Preston SD, Mazanti I, Nicoll JA
Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the aging human brain: implications for therapy of Alzheimer's disease.
Ann N Y Acad Sci. 2002 Nov 1;977:162-8.
PMID: 12480747
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12480747
Tabira T
[Progress in developing anti-Alzheimer drugs]
Nippon Yakurigaku Zasshi. 2002 Nov;120(1):34P-36P.
PMID: 12491773
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12491773
Iwatsubo T
[The mechanism of A beta production and its inhibition as a therapeutic strategy for the prevention of Alzheimer's disease]
Nippon Yakurigaku Zasshi. 2002 Nov;120(1):30P-33P.
PMID: 12491772
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12491772
Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST
Selective neuronal degeneration induced by soluble oligomeric amyloid beta-protein.
FASEB J. 2002 Nov 1;
PMID: 12424218
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12424218
Kubo T, Nishimura S, Kumagae Y, Kaneko I
In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.
J Neurosci Res. 2002 Nov 1;70(3):474-83.
PMID: 12391608
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12391608
Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M
Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade.
J Neurosci Res. 2002 Nov 1;70(3):438-46.
PMID: 12391604
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12391604
Rutten BP, Steinbusch HW, Korr H, Schmitz C
Antioxidants and Alzheimer's disease: from bench to bedside (and back again).
Curr Opin Clin Nutr Metab Care. 2002 Nov;5(6):645-51.
PMID: 12394639
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12394639
Dewachter I, Van Leuven F
Secretases as targets for the treatment of Alzheimer's disease: the prospects.
Lancet Neurol. 2002 Nov 1;1(7):409-16.
PMID: 12849363
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12849363
Leclercq PD, Stephenson MS, Murray LS, McIntosh TK, Graham DI, Gentleman SM
Simple morphometry of axonal swellings cannot be used in isolation for dating lesions after traumatic brain injury.
J Neurotrauma. 2002 Oct;19(10):1183-92.
PMID: 12427327
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12427327
Echeverria V, Cuello AC
Intracellular A-beta amyloid, a sign for worse things to come?
Mol Neurobiol. 2002 Oct-Dec;26(2-3):299-316.
PMID: 12428762
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12428762
Mazzola JL, Sirover MA
Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?
Neurotoxicology. 2002 Oct;23(4-5):603-9.
PMID: 12428732
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12428732
Togo T, Dickson DW
Tau accumulation in astrocytes in progressive supranuclear palsy is a degenerative rather than a reactive process.
Acta Neuropathol (Berl). 2002 Oct;104(4):398-402.
PMID: 12200627
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12200627
Askanas V, Engel WK
Newest Pathogenetic Considerations in Inclusion-body Myositis: Possible Role of Amyloid-beta, Cholesterol, Relation to Aging and to Alzheimer's Disease.
Curr Rheumatol Rep. 2002 Oct;4(5):427-33.
PMID: 12217248
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12217248
Askanas V, Engel WK
Inclusion-body myositis and myopathies: different etiologies, possibly similar pathogenic mechanisms.
Curr Opin Neurol. 2002 Oct;15(5):525-31.
PMID: 12351995
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12351995
Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
J Biol Chem. 2002 Sep 27;277(39):36521-6.
PMID: 12119298
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12119298
Gosavi N, Lee HJ, Lee JS, Patel S, Lee SJ
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion.
J Biol Chem. 2002 Sep 25;
PMID: 12351643
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12351643
Reches M, Porat Y, Gazit E
Amyloid fibril formation by pentapeptide and tetrapeptide fragments of human calcitonin.
J Biol Chem. 2002 Sep 20;277(38):35475-80.
PMID: 12095997
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12095997
Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH
The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11830-5.
PMID: 12189211
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12189211
Suh YH, Checler F
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.
Pharmacol Rev. 2002 Sep;54(3):469-525.
PMID: 12223532
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12223532
Fukumoto H, Cheung BS, Hyman BT, Irizarry MC
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
Arch Neurol. 2002 Sep;59(9):1381-9.
PMID: 12223024
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12223024
Kourie JI, Henry CL
Ion channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: The role of dangerous unchaperoned molecules.
Clin Exp Pharmacol Physiol. 2002 Sep;29(9):741-53.
PMID: 12165037
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12165037
Bastianetto S, Quirion R
Natural extracts as possible protective agents of brain aging.
Neurobiol Aging. 2002 Sep-Oct;23(5):891.
PMID: 12392793
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12392793
Lashuel HA, Hartley DM, Balakhaneh D, Aggarwal A, Teichberg S, Callaway DJ
New class of inhibitors of amyloid-beta (Abeta ) fibril formation: Implications for the mechanism of pathogenesis in alzheimer's disease.
J Biol Chem. 2002 Aug 6;
PMID: 12167652
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12167652
Boutaud O, Ou JJ, Chaurand P, Caprioli RM, Montine TJ, Oates JA
Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers.
J Neurochem. 2002 Aug 1;82(4):1003-6.
PMID: 12358806
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12358806
Tun H, Marlow L, Pinnix I, Kinsey R, Sambamurti K
Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway.
J Mol Neurosci. 2002 Aug-Oct;19(1-2):31-5.
PMID: 12212790
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12212790
Di Rosa G, Odrijin T, Nixon RA, Arancio O
Calpain inhibitors: a treatment for Alzheimer's disease.
J Mol Neurosci. 2002 Aug-Oct;19(1-2):135-41.
PMID: 12212771
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12212771
Seiler N
Ammonia and Alzheimer's disease.
Neurochem Int. 2002 Aug-Sep;41(2-3):189-207.
PMID: 12020619
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12020619
Tamagno E, Bardini P, Obbili A, Vitali A, Borghi R, Zaccheo D, Pronzato MA, Danni O, Smith MA, Perry G, Tabaton M
Oxidative stress increases expression and activity of BACE in NT2 neurons.
Neurobiol Dis. 2002 Aug;10(3):279-88.
PMID: 12270690
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12270690
Fezoui Y, Teplow DB
Kinetic studies of amyloid beta -protein fibril assembly: Differential effects of alpha -helix stabilization.
J Biol Chem. 2002 Jul 30;
PMID: 12149256
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12149256
Hardy J, Selkoe DJ
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.
Science. 2002 Jul 19;297(5580):353-6.
PMID: 12130773
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12130773
Das A, Smalheiser NR, Markaryan A, Kaplan A
Evidence for binding of the ectodomain of amyloid precursor protein 695 and activated high molecular weight kininogen.
Biochim Biophys Acta. 2002 Jul 3;1571(3):225-38.
PMID: 12090937
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12090937
Arias C, Montiel T, Quiroz-Báez R, Massieu L
beta-Amyloid Neurotoxicity Is Exacerbated during Glycolysis Inhibition and Mitochondrial Impairment in the Rat Hippocampus in Vivo and in Isolated Nerve Terminals: Implications for Alzheimer's Disease.
Exp Neurol. 2002 Jul;176(1):163-74.
PMID: 12093093
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12093093
Chauhan NB, Siegel GJ
Reversal of amyloid beta toxicity in Alzheimer's disease model Tg2576 by intraventricular antiamyloid beta antibody.
J Neurosci Res. 2002 Jul 1;69(1):10-23.
PMID: 12111811
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12111811
Dominguez DI, Strooper BD
Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease.
Trends Pharmacol Sci. 2002 Jul;23(7):324-30.
PMID: 12119153
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12119153
Massi F, Klimov D, Thirumalai D, Straub JE
Charge states rather than propensity for beta-structure determine enhanced fibrillogenesis in wild-type Alzheimer's beta-amyloid peptide compared to E22Q Dutch mutant.
Protein Sci. 2002 Jul;11(7):1639-47.
PMID: 12070316
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12070316
Kagan BL, Hirakura Y, Azimov R, Azimova R, Lin MC
The channel hypothesis of Alzheimer's disease: current status.
Peptides. 2002 Jul;23(7):1311-5.
PMID: 12128087
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12128087
Josien H
Recent advances in the development of gamma-secretase inhibitors.
Curr Opin Drug Discov Devel. 2002 Jul;5(4):513-25.
PMID: 12197309
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12197309
Praticò D, Uryu K, Sung S, Tang S, Trojanowski JQ, Lee VM
Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice.
FASEB J. 2002 Jul 1;16(9):1138-40.
PMID: 12039845
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12039845
EDELSTEIN-KESHET L, SPIROS A
Exploring the Formation of Alzheimer's Disease Senile Plaques in Silico.
J Theor Biol. 2002 Jun 7;216(3):301.
PMID: 12183120
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12183120
Alvarez G, Muñoz-Montaño JR, Satrústegui J, Avila J, Bogónez E, Díaz-Nido J
Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease.
Bipolar Disord. 2002 Jun;4(3):153-65.
PMID: 12180271
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12180271
Lahiri DK, Nall C, Chen D, Zaphiriou M, Morgan C, Nurnberger JI
Developmental Expression of the beta-Amyloid Precursor Protein and Heat-Shock Protein 70 in the Cerebral Hemisphere Region of the Rat Brain.
Ann N Y Acad Sci. 2002 Jun;965:324-33.
PMID: 12105108
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12105108
Morgan D, Keller RK
What evidence would prove the amyloid hypothesis? Towards rational drug treatments for Alzheimer's disease.
J Alzheimers Dis. 2002 Jun;4(3):257-60.
PMID: 12226546
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12226546
Blass JP, Gibson GE, Hoyer S
The role of the metabolic lesion in Alzheimer's disease.
J Alzheimers Dis. 2002 Jun;4(3):225-32.
PMID: 12226541
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12226541
Grammas P, Yamada M, Zlokovic B
The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease.
J Alzheimers Dis. 2002 Jun 1;4(3):217-23.
PMID: 12226540
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12226540
Kanski J, Aksenova M, Schöneich C, Butterfield DA
Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide (1-42).
Free Radic Biol Med. 2002 Jun 1;32(11):1205-11.
PMID: 12031904
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12031904
Tarkowski E
Cytokines in dementias.
Curr Drug Targets Inflamm Allergy. 2002 Jun;1(2):193-200.
PMID: 14561200
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=14561200
J M Hoozemans J, Veerhuis R, J M Rozemuller A, Eikelenboom P
The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications.
Drugs Today (Barc). 2002 Jun;38(6):429-43.
PMID: 12532179
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12532179
Kanski J, Aksenova M, Butterfield DA
The hydrophobic environment of Met35 of Alzheimer's Abeta(1-42) is important for the neurotoxic and oxidative properties of the peptide.
Neurotox Res. 2002 May;4(3):219-23.
PMID: 12829402
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12829402
Dhenain M, Privat N, Duyckaerts C, Jacobs RE
Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images.
NMR Biomed. 2002 May;15(3):197-203.
PMID: 11968135
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11968135
Frölich L, Hoyer S
[In Process Citation]
Nervenarzt. 2002 May;73(5):422-7.
PMID: 12078019
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12078019
Domenici MR, Paradisi S, Sacchetti B, Gaudi S, Balduzzi M, Bernardo A, Ajmone-Cat MA, Minghetti L, Malchiodi-Albedi F
The presence of astrocytes enhances beta amyloid-induced neurotoxicity in hippocampal cell cultures.
J Physiol Paris. 2002 May-Aug;96(3-4):313-6.
PMID: 12445911
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12445911
Yip CM, Darabie AA, McLaurin J
Abeta42-Peptide assembly on lipid bilayers.
J Mol Biol. 2002 Apr 19;318(1):97-107.
PMID: 12054771
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12054771
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Nature. 2002 Apr 4;416(6880):535-9.
PMID: 11932745
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11932745
Jacobsen JS
Alzheimer s disease: an overview of current and emerging therapeutic strategies.
Curr Top Med Chem. 2002 Apr;2(4):343-52.
PMID: 11966458
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11966458
Yow HY, Weller RO
A role for cerebrovascular disease in determining the pattern of beta-amyloid deposition in Alzheimer's disease.
Neuropathol Appl Neurobiol. 2002 Apr;28(2):149.
PMID: 11972804
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11972804
Hashimoto K, Iyo M
[Amyloid cascade hypothesis of Alzheimer's disease and alpha 7 nicotinic receptor]
Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Apr;22(2):49-53.
PMID: 12050852
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12050852
Scacchi R, Ruggeri M, Gambina G, Martini MC, Corbo RM
Alpha2-macroglobulin deletion polymorphism and plasma levels in late onset Alzheimer's disease.
Clin Chem Lab Med. 2002 Apr;40(4):333-6.
PMID: 12059070
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12059070
Morais Cardoso S, Swerdlow RH, Oliveira CR
Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria.
Brain Res. 2002 Mar 29;931(2):117-25.
PMID: 11897097
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11897097
Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, Gilchrest BA
Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling.
J Biol Chem. 2002 Mar 8;277(10):7720-5.
PMID: 11756426
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11756426
Wang W, Hecht MH
Rationally designed mutations convert de novo amyloid-like fibrils into monomeric beta-sheet proteins.
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2760-5.
PMID: 11880628
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11880628
Kruman II, Kumaravel TS, Lohani A, Pedersen WA, Cutler RG, Kruman Y, Haughey N, Lee J, Evans M, Mattson MP
Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.
J Neurosci. 2002 Mar 1;22(5):1752-62.
PMID: 11880504
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11880504
Rosenblum WI
Structure and location of amyloid beta peptide chains and arrays in Alzheimer's disease: new findings require reevaluation of the amyloid hypothesis and of tests of the hypothesis.
Neurobiol Aging. 2002 Mar-Apr;23(2):225-30.
PMID: 11804706
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11804706
Pogocki D, Schöneich C
Redox Properties of Met(35) in Neurotoxic beta-Amyloid Peptide. A Molecular Modeling Study.
Chem Res Toxicol. 2002 Mar;15(3):408-18.
PMID: 11896689
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11896689
Hatters DM, Howlett GJ
The structural basis for amyloid formation by plasma apolipoproteins: a review.
Eur Biophys J. 2002 Mar;31(1):2-8.
PMID: 12046894
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12046894
Kay AD, Nicoll JA
Decreased concentration of apolipoprotein E in the cerebrospinal fluid after acute brain injury.
Neuropathol Appl Neurobiol. 2002 Mar;28(2):152.
PMID: 11972812
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11972812
Sommer B
Alzheimer's disease and the amyloid cascade hypothesis: ten years on.
Curr Opin Pharmacol. 2002 Feb;2(1):87-92.
PMID: 11786314
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11786314
Head E, Torp R
Insights into Abeta and presenilin from a canine model of human brain aging.
Neurobiol Dis. 2002 Feb;9(1):1-10.
PMID: 11848680
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11848680
Katona G, Berglund GI, Hajdu J, Gráf L, Szilágyi L
Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.
J Mol Biol. 2002 Feb 1;315(5):1209-18.
PMID: 11827488
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11827488
Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.
Neurobiol Dis. 2002 Feb 1;9(1):61-8.
PMID: 11848685
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11848685
Yong W, Lomakin A, Kirkitadze MD, Teplow DB, Chen SH, Benedek GB
Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering.
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):150-4.
PMID: 11756677
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11756677
Mudher A, Lovestone S
Alzheimer's disease-do tauists and baptists finally shake hands?
Trends Neurosci. 2002 Jan;25(1):22-6.
PMID: 11801334
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11801334
Kratzsch T, Peters J, Frölich L
[Etiology and pathogenesis of Alzheimer dementia]
Wien Med Wochenschr. 2002;152(3-4):72-6.
PMID: 11925775
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11925775
Gazit E
A possible role for pi-stacking in the self-assembly of amyloid fibrils.
FASEB J. 2002 Jan;16(1):77-83.
PMID: 11772939
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11772939
Annaert W, De Strooper B
A cell biological perspective on Alzheimer's disease.
Annu Rev Cell Dev Biol. 2002;18:25-51.
PMID: 12142279
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12142279
Wolozin B
Cholesterol and Alzheimer's disease.
Biochem Soc Trans. 2002;30(4):525-9.
PMID: 12196129
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12196129
Sparks DL, Connor DJ, Browne PJ, Lopez JE, Sabbagh MN
HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier.
J Nutr Health Aging. 2002;6(5):324-31.
PMID: 12474023
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12474023
Terwel D, Dewachter I, Van Leuven F
Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease.
Neuromolecular Med. 2002;2(2):151-65.
PMID: 12428809
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12428809
Haglund M, Englund E
Cerebral amyloid angiopathy, white matter lesions and Alzheimer encephalopathy - a histopathological assessment.
Dement Geriatr Cogn Disord. 2002;14(3):161-6.
PMID: 12218260
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12218260
Basun H, Nilsberth C, Eckman C, Lannfelt L, Younkin S
Plasma Levels of Abeta42 and Abeta40 in Alzheimer Patients during Treatment with the Acetylcholinesterase Inhibitor Tacrine.
Dement Geriatr Cogn Disord. 2002;14(3):156-60.
PMID: 12218259
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12218259
Hu J, Igarashi A, Kamata M, Nakagawa H
Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.
J Biol Chem. 2001 Dec 21;276(51):47863-8.
PMID: 11604391
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11604391
McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL
beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations.
Brain Res Mol Brain Res. 2001 Dec 16;97(1):103-13.
PMID: 11744168
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11744168
Tabner B J, Turnbull S, El-Agnaf O, Allsop D
Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.
Curr Top Med Chem. 2001 Dec;1(6):507-17.
PMID: 11895127
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11895127
Engidawork E, Lubec G
Protein expression in Down syndrome brain.
Amino Acids. 2001 Dec;21(4):331-61.
PMID: 11858695
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11858695
Dhitavat S, Rivera ER, Rogers E, Shea TB
Differential efficacy of lipophilic and cytosolic antioxidants on generation of reactive oxygen species by amyloid-beta.
J Alzheimers Dis. 2001 Dec;3(6):525-529.
PMID: 12214018
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12214018
Iwatsubo T
[Beta-amyloid protein: recent progress in basic research and therapeutic approaches]
Rinsho Shinkeigaku. 2001 Dec;41(12):1198-200.
PMID: 12235837
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12235837
Tacnet-Delorme P, Chevallier S, Arlaud GJ
Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions.
J Immunol. 2001 Dec 1;167(11):6374-81.
PMID: 11714802
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11714802
Ceciliani F, Pergami P
Infective proteins: the prion puzzle.
Curr Protein Pept Sci. 2001 Dec;2(4):191-204.
PMID: 12369924
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12369924
Jaikaran ET, Clark A
Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.
Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203.
PMID: 11731221
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11731221
Koudinov AR, Berezov TT, Koudinova NV
The levels of soluble amyloid beta in different high density lipoprotein subfractions distinguish Alzheimer's and normal aging cerebrospinal fluid: implication for brain cholesterol pathology?
Neurosci Lett. 2001 Nov 16;314(3):115-8.
PMID: 11704297
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11704297
Tominaga-Yoshino K, Uetsuki T, Yoshikawa K, Ogura A
Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA.
Brain Res. 2001 Nov 9;918(1-2):121-30.
PMID: 11684050
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11684050
Gunawardena S, Goldstein LS
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.
Neuron. 2001 Nov 8;32(3):389-401.
PMID: 11709151
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11709151
Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL
Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.
J Neurochem. 2001 Nov;79(3):595-605.
PMID: 11701763
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11701763
Harris-White ME, Chu T, Miller SA, Simmons M, Teter B, Nash D, Cole GM, Frautschy SA
Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo.
Neurochem Int. 2001 Nov-Dec;39(5-6):435-48.
PMID: 11578779
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11578779
Guo L, Sawkar A, Zasadzki M, Watterson DM, Van Eldik LJ
Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands.
Neurobiol Aging. 2001 Nov-Dec;22(6):975-81.
PMID: 11755006
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11755006
DiCarlo G, Wilcock D, Henderson D, Gordon M, Morgan D
Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice.
Neurobiol Aging. 2001 Nov-Dec;22(6):1007-12.
PMID: 11755009
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11755009
Sisodia S S, Annaert W, Kim S H, De Strooper B
Gamma-secretase: never more enigmatic.
Trends Neurosci. 2001 Nov;24(11 Suppl):S2-6.
PMID: 11881741
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11881741
Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
J Biol Chem. 2001 Oct 26;276(43):40288-92.
PMID: 11544248
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11544248
Nicolaou M, Song YQ, Sato CA, Orlacchio A, Kawarai T, Medeiros H, Liang Y, Sorbi S, Richard E, Rogaev EI, Moliaka Y, Bruni AC, Jorge R, Percy M, Duara R, Farrer LA, St Georg-Hyslop P, Rogaeva EA
Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.
Neurogenetics. 2001 Oct;3(4):203-6.
PMID: 11714100
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11714100
Schenk D, Games D, Seubert P
Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization.
J Mol Neurosci. 2001 Oct;17(2):259-67.
PMID: 11816797
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11816797
Forsell C, Enmark E, Axelman K, Blomberg M, Wahlund LO, Gustafsson JA, Lannfelt L
Investigations of a CA repeat in the oestrogen receptor beta gene in patients with Alzheimer's disease.
Eur J Hum Genet. 2001 Oct;9(10):802-4.
PMID: 11781694
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11781694
Morris RG
Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease.
Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1453-65.
PMID: 11571036
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11571036
Hammarström P, Schneider F, Kelly JW
Trans-suppression of misfolding in an amyloid disease.
Science. 2001 Sep 28;293(5539):2459-62.
PMID: 11577236
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11577236
Waschuk SA, Elton EA, Darabie AA, Fraser PE, McLaurin JA
Cellular membrane composition defines A beta-lipid interactions.
J Biol Chem. 2001 Sep 7;276(36):33561-8.
PMID: 11438533
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11438533
Xia W
Amyloid metabolism and secretases in Alzheimer's disease.
Curr Neurol Neurosci Rep. 2001 Sep;1(5):422-7.
PMID: 11898552
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11898552
Castro A, Martinez A
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
Mini Rev Med Chem. 2001 Sep;1(3):267-72.
PMID: 12369973
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12369973
Roth KA
Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion.
J Neuropathol Exp Neurol. 2001 Sep 1;60(9):829-38.
PMID: 11556539
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11556539
Martín D, Salinas M, López-Valdaliso R, Serrano E, Recuero M, Cuadrado A
Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells.
J Neurochem. 2001 Sep;78(5):1000-8.
PMID: 11553674
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11553674
Heo HJ, Cho HY, Hong B, Kim HK, Kim EK, Kim BG, Shin DH
Protective effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica against Abeta-induced oxidative stress in PC12 cells.
Amyloid. 2001 Sep;8(3):194-201.
PMID: 11676296
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11676296
Liou YJ, Lai IC, Hong CJ, Liu HC, Liu TY, Tsai SJ
Association analysis of the partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant and Alzheimer's disease.
Dement Geriatr Cogn Disord. 2001 Sep-Oct;12(5):301-4.
PMID: 11455129
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11455129
Kallijärvi J, Haltia M, Baumann MH
Amphoterin includes a sequence motif which is homologous to the Alzheimer's beta-amyloid peptide (Abeta), forms amyloid fibrils in vitro, and binds avidly to Abeta.
Biochemistry. 2001 Aug 28;40(34):10032-7.
PMID: 11513581
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11513581
Götz J, Chen F, Van Dorpe J, Nitsch RM
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.
Science. 2001 Aug 24;293(5534):1491-5.
PMID: 11520988
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11520988
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science. 2001 Aug 24;293(5534):1487-91.
PMID: 11520987
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11520987
Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W
The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
J Cell Biol. 2001 Aug 20;154(4):731-40.
PMID: 11502763
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11502763
Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
J Biol Chem. 2001 Aug 10;276(32):30018-23.
PMID: 11408475
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11408475
Chochina SV, Avdulov NA, Igbavboa U, Cleary JP, O'Hare EO, Wood WG
Amyloid beta-peptide1-40 increases neuronal membrane fluidity: role of cholesterol and brain region.
J Lipid Res. 2001 Aug;42(8):1292-7.
PMID: 11483631
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11483631
Kremer JJ, Sklansky DJ, Murphy RM
Profile of changes in lipid bilayer structure caused by beta-amyloid peptide.
Biochemistry. 2001 Jul 24;40(29):8563-71.
PMID: 11456496
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11456496
Ramirez MJ, Heslop KE, Francis PT, Rattray M
Expression of amyloid precursor protein, tau and presenilin RNAs in rat hippocampus following deafferentation lesions.
Brain Res. 2001 Jul 13;907(1-2):222-32.
PMID: 11430905
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11430905
Schönknecht P, Pantel J, Klinga K, Jensen M, Hartmann T, Salbach B, Schröder J
Reduced cerebrospinal fluid estradiol levels are associated with increased beta-amyloid levels in female patients with Alzheimer's disease.
Neurosci Lett. 2001 Jul 13;307(2):122-4.
PMID: 11427315
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11427315
Pappolla MA, Omar RA, Chyan YJ, Ghiso J, Hsiao K, Bozner P, Perry G, Smith MA, Cruz-Sanchez F
Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".
J Neurochem. 2001 Jul;78(1):121-8.
PMID: 11432979
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11432979
Olson RE, Copeland RA, Seiffert D
Progress towards testing the amyloid hypothesis: inhibitors of APP processing.
Curr Opin Drug Discov Devel. 2001 Jul;4(4):390-401.
PMID: 11727304
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11727304
El-Agnaf OM, Nagala S, Patel BP, Austen BM
Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils.
J Mol Biol. 2001 Jun 29;310(1):157-68.
PMID: 11419943
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11419943
Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L
Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.
J Biol Chem. 2001 Jun 8;276(23):20267-79.
PMID: 11278337
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11278337
Rossner S, Apelt J, Schliebs R, Perez-Polo JR, Bigl V
Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
J Neurosci Res. 2001 Jun 1;64(5):437-46.
PMID: 11391698
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11391698
Pedersen WA, McCullers D, Culmsee C, Haughey NJ, Herman JP, Mattson MP
Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease.
Neurobiol Dis. 2001 Jun;8(3):492-503.
PMID: 11442356
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11442356
Dominguez DI, De Strooper B, Annaert W
Secretases as therapeutic targets for the treatment of Alzheimer's disease.
Amyloid. 2001 Jun;8(2):124-42.
PMID: 11409035
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11409035
Darvesh S, Kumar R, Roberts S, Walsh R, Martin E
Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin.
Cell Mol Neurobiol. 2001 Jun;21(3):285-96.
PMID: 11569538
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11569538
Citron M
Human beta-secretase and Alzheimer's disease.
Expert Opin Ther Targets. 2001 Jun;5(3):341-348.
PMID: 12540269
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12540269
Hirakura Y, Kagan BL
Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis.
Amyloid. 2001 Jun 1;8(2):94-100.
PMID: 11409039
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11409039
Turnbull S, Tabner BJ, El-Agnaf OM, Twyman LJ, Allsop D
New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.
Free Radic Biol Med. 2001 May 15;30(10):1154-62.
PMID: 11369506
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11369506
Shukla C, Bridges LR
Tau, beta-amyloid and beta-amyloid precursor protein distribution in the entorhinal-hippocampal alvear and perforant pathways in the Alzheimer's brain.
Neurosci Lett. 2001 May 11;303(3):193-7.
PMID: 11323118
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11323118
Schupf N, Patel B, Silverman W, Zigman WB, Zhong N, Tycko B, Mehta PD, Mayeux R
Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.
Neurosci Lett. 2001 Apr 6;301(3):199-203.
PMID: 11257432
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11257432
Gerlai R
Alzheimer's disease: beta-amyloid hypothesis strengthened!
Trends Neurosci. 2001 Apr;24(4):199.
PMID: 11249992
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11249992
Jhee S, Shiovitz T, Crawford AW, Cutler NR
Beta-amyloid therapies in Alzheimer's disease.
Expert Opin Investig Drugs. 2001 Apr;10(4):593-605.
PMID: 11281811
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11281811
Campbell A
beta-amyloid: friend or foe.
Med Hypotheses. 2001 Mar;56(3):388-91.
PMID: 11359367
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11359367
Armstrong RA, Cairns NJ, Lantos PL
Spatial pattern of prion protein deposits in patients with sporadic Creutzfeldt-Jakob disease.
Neuropathology. 2001 Mar;21(1):19-24.
PMID: 11304038
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11304038
Lambert JC, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon C, Chartier-Harlin MC
Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.
Lancet. 2001 Feb 24;357(9256):608-9.
PMID: 11558492
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11558492
Rodrigues CM, Solá S, Brito MA, Brondino CD, Brites D, Moura JJ
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.
Biochem Biophys Res Commun. 2001 Feb 23;281(2):468-74.
PMID: 11181071
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11181071
Kuperstein F, Reiss N, Koudinova N, Yavin E
Biphasic modulation of protein kinase C and enhanced cell toxicity by amyloid beta peptide and anoxia in neuronal cultures.
J Neurochem. 2001 Feb;76(3):758-67.
PMID: 11158247
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11158247
Parks JK, Smith TS, Trimmer PA, Bennett JP, Parker WD
Neurotoxic Abeta peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro.
J Neurochem. 2001 Feb;76(4):1050-6.
PMID: 11181824
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11181824
Seo J, Kim S, Kim H, Park CH, Jeong S, Lee J, Choi SH, Chang K, Rah J, Koo J, Kim E, Suh Y
Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity.
Biol Psychiatry. 2001 Feb 1;49(3):240-7.
PMID: 11230875
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11230875
Shimohama S, Kihara T
Nicotinic receptor-mediated protection against beta-amyloid neurotoxicity.
Biol Psychiatry. 2001 Feb 1;49(3):233-9.
PMID: 11230874
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11230874
Ji Y, Permanne B, Sigurdsson EM, Holtzman DM, Wisniewski T
Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.
J Alzheimers Dis. 2001 Feb;3(1):23-30.
PMID: 12214069
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12214069
Sasaki N, Toki S, Chowei H, Saito T, Nakano N, Hayashi Y, Takeuchi M, Makita Z
Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease.
Brain Res. 2001 Jan 12;888(2):256-262.
PMID: 11150482
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11150482
Pettit DL, Shao Z, Yakel JL
beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.
J Neurosci. 2001 Jan 1;21(1):RC120.
PMID: 11150356
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11150356
Dovey HF, John V, Anderson JP, Chen LZ, de Saint Andrieu P, Fang LY, Freedman SB, Folmer B, Goldbach E, Holsztynska EJ, Hu KL, Johnson-Wood KL, Kennedy SL, Kholodenko D, Knops JE, Latimer LH, Lee M, Liao Z, Lieberburg IM, Motter RN, Mutter LC, Nietz J, Quinn KP, Sacchi KL, Seubert PA, Shopp GM, Thorsett ED, Tung JS, Wu J, Yang S, Yin CT, Schenk DB, May PC, Altstiel LD, Bender MH, Boggs LN, Britton TC, Clemens JC, Czilli DL, Dieckman-McGinty DK, Droste JJ, Fuson KS, Gitter BD, Hyslop PA, Johnstone EM, Li WY, Little SP, Mabry TE, Miller FD, Audia JE
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.
J Neurochem. 2001 Jan;76(1):173-81.
PMID: 11145990
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11145990
Joseph J, Shukitt-Hale B, Denisova NA, Martin A, Perry G, Smith MA
Copernicus revisited: amyloid beta in Alzheimer's disease.
Neurobiol Aging. 2001 Jan-Feb;22(1):131-46.
PMID: 11164287
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11164287
Chodobski A, Szmydynger-Chodobska J
Choroid plexus: target for polypeptides and site of their synthesis.
Microsc Res Tech. 2001 Jan 1;52(1):65-82.
PMID: 11135450
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11135450
Brion JP, Anderton BH, Authelet M, Dayanandan R, Leroy K, Lovestone S, Octave JN, Pradier L, Touchet N, Tremp G
Neurofibrillary tangles and tau phosphorylation.
Biochem Soc Symp. 2001;(67):81-8.
PMID: 11447842
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11447842
Neve RL, McPhie DL, Chen Y
Alzheimer's disease: dysfunction of a signalling pathway mediated by the amyloid precursor protein?
Biochem Soc Symp. 2001;(67):37-50.
PMID: 11447838
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11447838
O'Neill C, Cowburn RF, Bonkale WL, Ohm TG, Fastbom J, Carmody M, Kelliher M
Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease.
Biochem Soc Symp. 2001;(67):177-94.
PMID: 11447834
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11447834
Yan SD, Schmidt AM, Stern D
Alzheimer's disease: inside, outside, upside down.
Biochem Soc Symp. 2001;(67):15-22.
PMID: 11447831
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11447831
Allsop D, Twyman LJ, Davies Y, Moore S, York A, Swanson L, Soutar I
Modulation of beta-amyloid production and fibrillization.
Biochem Soc Symp. 2001;(67):1-14.
PMID: 11447825
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11447825
Lee VM, Goedert M, Trojanowski JQ
Neurodegenerative tauopathies.
Annu Rev Neurosci. 2001;24:1121-59.
PMID: 11520930
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11520930
Ramirez MJ, Ridley RM, Baker HF, Maclean CJ, Honer WG, Francis PT
Chronic elevation of amyloid precursor protein in the neocortex or hippocampus of marmosets with selective cholinergic lesions.
J Neural Transm. 2001;108(7):809-26.
PMID: 11515747
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11515747
Guan ZZ, Miao H, Tian JY, Unger C, Nordberg A, Zhang X
Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells.
J Neural Transm. 2001;108(12):1417-33.
PMID: 11810405
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11810405
Pepeu G
Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint.
Prog Neuropsychopharmacol Biol Psychiatry. 2001 Jan;25(1):193-209.
PMID: 11263752
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11263752
Askanas V, Engel WK
Inclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.
J Neuropathol Exp Neurol. 2001 Jan;60(1):1-14.
PMID: 11202170
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11202170
Hoozemans JJ, Rozemuller AJ, Veerhuis R, Eikelenboom P
Immunological aspects of alzheimer's disease: therapeutic implications.
BioDrugs. 2001;15(5):325-37.
PMID: 11437695
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11437695
Munson GW, Roher AE, Kuo YM, Gilligan SM, Reardon CA, Getz GS, LaDu MJ
SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides.
Biochemistry. 2000 Dec 26;39(51):16119-24.
PMID: 11123940
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11123940
Schmidt AM, Yan SD, Yan SF, Stern DM
The biology of the receptor for advanced glycation end products and its ligands.
Biochim Biophys Acta. 2000 Dec 20;1498(2-3):99-111.
PMID: 11108954
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11108954
Mueller HT, Borg JP, Margolis B, Turner RS
Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.
J Biol Chem. 2000 Dec 15;275(50):39302-6.
PMID: 11010978
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11010978
Hoyer S
Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update.
Exp Gerontol. 2000 Dec;35(9-10):1363-72.
PMID: 11113614
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11113614
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Nature. 2000 Dec 21-28;408(6815):979-82.
PMID: 11140685
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11140685
Butcher J
Alzheimer's amyloid hypothesis gains support.
Lancet. 2000 Dec 23-30;356(9248):2161.
PMID: 11191550
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11191550
Iwatsubo T
[beta-amyloid cascade: current status and future directions]
Rinsho Shinkeigaku. 2000 Dec;40(12):1228-30.
PMID: 11464463
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11464463
Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.
Prog Neurobiol. 2000 Dec 1;62(6):633-48.
PMID: 10880853
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10880853
Gamblin TC, King ME, Kuret J, Berry RW, Binder LI
Oxidative regulation of fatty acid-induced tau polymerization.
Biochemistry. 2000 Nov 21;39(46):14203-10.
PMID: 11087369
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11087369
Praticò D, Delanty N
Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease.
Am J Med. 2000 Nov;109(7):577-85.
PMID: 11063960
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11063960
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.
Nat Cell Biol. 2000 Nov;2(11):848-51.
PMID: 11056541
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11056541
Kawahara M, Kuroda Y
Molecular mechanism of neurodegeneration induced by Alzheimer's beta-amyloid protein: channel formation and disruption of calcium homeostasis.
Brain Res Bull. 2000 Nov 1;53(4):389-97.
PMID: 11136994
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11136994
Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ
Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.
Ann Neurol. 2000 Oct;48(4):567-79.
PMID: 11026440
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11026440
Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van den Haute C, Mercken M, Moechars D, Laenen I, Kuiperi C, Bruynseels K, Tesseur I, Loos R, Vanderstichele H, Checler F, Sciot R, Van Leuven F
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.
Am J Pathol. 2000 Oct 1;157(4):1283-98.
PMID: 11021833
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11021833
Hirakura Y, Yiu WW, Yamamoto A, Kagan BL
Amyloid peptide channels: blockade by zinc and inhibition by Congo red (amyloid channel block).
Amyloid. 2000 Sep 1;7(3):194-9.
PMID: 11019860
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11019860
Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuipéri C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, Van Leuven F
Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
J Neurosci. 2000 Sep 1;20(17):6452-8.
PMID: 10964951
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10964951
Shibata N, Ohnuma T, Takahashi T, Ohtsuka E, Ueki A, Nagao M, Arai H
No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease.
Neurosci Lett. 2000 Aug 25;290(2):154-6.
PMID: 10936700
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10936700
Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Neurobiol Dis. 2000 Aug;7(4):321-31.
PMID: 10964604
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10964604
Huse JT, Doms RW
Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease.
Mol Neurobiol. 2000 Aug-Dec;22(1-3):81-98.
PMID: 11414282
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11414282
De Ferrari GV, Inestrosa NC
Wnt signaling function in Alzheimer's disease.
Brain Res Brain Res Rev. 2000 Aug;33(1):1-12.
PMID: 10967351
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10967351
Golde TE, Eckman CB, Younkin SG
Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease.
Biochim Biophys Acta. 2000 Jul 26;1502(1):172-87.
PMID: 10899442
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10899442
Anderson AJ, Ruehl WW, Fleischmann LK, Stenstrom K, Entriken TL, Cummings BJ
DNA damage and apoptosis in the aged canine brain: relationship to Abeta deposition in the absence of neuritic pathology.
Prog Neuropsychopharmacol Biol Psychiatry. 2000 Jul;24(5):787-99.
PMID: 11191713
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11191713
Cacabelos R, Alvarez A, Lombardi V, Fernandez-Novoa L, Corzo L, Perez P, Laredo M, Pichel V, Hernandez A, Varela M, Figueroa J, Prous J, Windisch M, Vigo C
Pharmacological treatment of Alzheimer disease: From psychotropic drugs and cholinesterase inhibitors to pharmacogenomics.
Drugs Today (Barc). 2000 Jul;36(7):415-99.
PMID: 12861345
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12861345
Yatin SM, Varadarajan S, Butterfield DA
Vitamin E Prevents Alzheimer's Amyloid beta-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production.
J Alzheimers Dis. 2000 Jun;2(2):123-131.
PMID: 12214102
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12214102
Andorn AC, Kalaria RN
Factors Affecting Pro- and Anti-Oxidant Properties of Fragments of the b-Protein Precursor (bPP): Implication for Alzheimer's Disease.
J Alzheimers Dis. 2000 Jun;2(2):69-78.
PMID: 12214091
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=12214091
Zhang S, Iwata K, Lachenmann MJ, Peng JW, Li S, Stimson ER, Lu Y, Felix AM, Maggio JE, Lee JP
The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J Struct Biol. 2000 Jun;130(2-3):130-41.
PMID: 10940221
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10940221
Danysz W, Parsons CG, Mobius HJ, Stoffler A, Quack G
Neuroprotective and symptomatological action of memantine relevant for Alzheimer's disease - a unified glutamatergic hypothesis on the mechanism of action.
Neurotox Res. 2000 May;2(2-3):85-97.
PMID: 16787834
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=16787834
Drouet B, Pinçon-Raymond M, Chambaz J, Pillot T
Molecular basis of Alzheimer's disease.
Cell Mol Life Sci. 2000 May 1;57(5):705-15.
PMID: 10892337
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10892337
Suo Z, Su G, Placzek A, Kundtz A, Humphrey J, Crawford F, Mullan M
A beta vasoactivity in vivo.
Ann N Y Acad Sci. 2000 Apr;903:156-63.
PMID: 10818502
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10818502
Weller RO, Massey A, Kuo YM, Roher AE
Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease.
Ann N Y Acad Sci. 2000 Apr 1;903:110-7.
PMID: 10818495
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10818495
Tsuzuki K, Fukatsu R, Yamaguchi H, Tateno M, Imai K, Fujii N, Yamauchi T
Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration.
Neurosci Lett. 2000 Mar 10;281(2-3):171-4.
PMID: 10704770
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10704770
Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
J Biol Chem. 2000 Mar 10;275(10):7410-5.
PMID: 10702315
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10702315
Panegyres PK, Zafiris-Toufexis K, Kakulas BA
Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders.
J Neurol Sci. 2000 Feb 15;173(2):81-92.
PMID: 10675649
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10675649
Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM
Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
J Biol Chem. 2000 Jan 28;275(4):2568-75.
PMID: 10644715
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10644715
Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, Danscher G, Frederickson CJ
Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains.
Brain Res. 2000 Jan 10;852(2):274-8.
PMID: 10678753
[ARF Recommends]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10678753
Guo ZH, Mattson MP
Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function.
Cereb Cortex. 2000 Jan;10(1):50-7.
PMID: 10639395
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10639395
Poirier J
Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism.
Ann N Y Acad Sci. 2000;924:81-90.
PMID: 11193807
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11193807
Mesulam MM
A plasticity-based theory of the pathogenesis of Alzheimer's disease.
Ann N Y Acad Sci. 2000;924:42-52.
PMID: 11193801
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11193801
Selkoe DJ
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.
Ann N Y Acad Sci. 2000;924:17-25.
PMID: 11193794
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11193794
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Ann N Y Acad Sci. 2000;920:223-6.
PMID: 11193154
[ARF Recommends] [Milestone Paper]
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11193154
Annaert W, Cupers P, Saftig P, De Strooper B
Presenilin function in APP processing.
Ann N Y Acad Sci. 2000;920:158-64.
PMID: 11193144
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11193144
Pluta R, Misicka A, Barcikowska M, Spisacka S, Lipkowski AW, Januszewski S
Possible reverse transport of beta-amyloid peptide across the blood-brain barrier.
Acta Neurochir Suppl. 2000;76:73-7.
PMID: 11450095
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=11450095
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
J Biol Chem. 1999 Dec 17;274(51):36801-7.
PMID: 10593990
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10593990
Di Iorio A, Zito M, Lupinetti M, Abate G
Are vascular factors involved in Alzheimer's disease? Facts and theories.
Aging (Milano). 1999 Dec;11(6):345-52.
PMID: 10738848
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10738848
Kanfer JN, Sorrentino G, Sitar DS
Amyloid beta peptide membrane perturbation is the basis for its biological effects.
Neurochem Res. 1999 Dec;24(12):1621-30.
PMID: 10591414
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10591414
Yao ZX, Drieu K, Szweda LI, Papadopoulos V
Free radicals and lipid peroxidation do not mediate beta-amyloid-induced neuronal cell death.
Brain Res. 1999 Nov 20;847(2):203-10.
PMID: 10575089
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10575089
Cecchi C, Latorraca S, Sorbi S, Iantomasi T, Favilli F, Vincenzini MT, Liguri G
Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease.
Neurosci Lett. 1999 Nov 12;275(2):152-4.
PMID: 10568522
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10568522
Rogaev EI
[Genetic factors and a polygenic model of Alzheimer's disease]
Genetika. 1999 Nov;35(11):1558-71.
PMID: 10624576
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10624576
Clarke MS, Prendergast MA, Terry AV
Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats.
Learn Mem. 1999 Nov-Dec;6(6):634-49.
PMID: 10641767
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10641767
Hashimoto M, Masliah E
Alpha-synuclein in Lewy body disease and Alzheimer's disease.
Brain Pathol. 1999 Oct;9(4):707-20.
PMID: 10517509
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10517509
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
Neurobiol Dis. 1999 Oct 1;6(5):440-9.
PMID: 10527810
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10527810
Saito H, Shultz LD, Sinha M, Papaconstantinou J
Induction of the alpha(1)-antichymotrypsin gene in the brain associated with TGF-beta1 deficiency or systemic administration of endotoxin.
Biochem Biophys Res Commun. 1999 Sep 24;263(2):270-5.
PMID: 10491283
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10491283
Varadarajan S, Yatin S, Kanski J, Jahanshahi F, Butterfield DA
Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.
Brain Res Bull. 1999 Sep 15;50(2):133-41.
PMID: 10535332
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10535332
Garcia C, Pinho e Melo T, Rocha L, Lechner MC
Cerebral hemorrhage and apoE.
J Neurol. 1999 Sep;246(9):830-4.
PMID: 10525983
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10525983
Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
J Comp Neurol. 1999 Aug 30;411(3):390-8.
PMID: 10413774
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10413774
Hirakura Y, Lin MC, Kagan BL
Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.
J Neurosci Res. 1999 Aug 15;57(4):458-66.
PMID: 10440895
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10440895
Petronis A
Alzheimer's disease and down syndrome: from meiosis to dementia.
Exp Neurol. 1999 Aug;158(2):403-13.
PMID: 10415146
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10415146
García de Yébenes E, Ho A, Damani T, Fillit H, Blum M
Regulation of the heparan sulfate proteoglycan, perlecan, by injury and interleukin-1alpha.
J Neurochem. 1999 Aug;73(2):812-20.
PMID: 10428080
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10428080
Durkin JT, Murthy S, Husten EJ, Trusko SP, Savage MJ, Rotella DP, Greenberg BD, Siman R
Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
J Biol Chem. 1999 Jul 16;274(29):20499-504.
PMID: 10400678
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10400678
Cathcart ES, Elliott-Bryant R
Diet, amyloid enhancing factor (AEF) and amyloidogenesis: an hypothesis.
Amyloid. 1999 Jun;6(2):107-13.
PMID: 10439116
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10439116
Miyata S, Koshikawa N, Higashi S, Miyagi Y, Nagashima Y, Yanoma S, Kato Y, Yasumitsu H, Miyazaki K
Expression of trypsin in human cancer cell lines and cancer tissues and its tight binding to soluble form of Alzheimer amyloid precursor protein in culture.
J Biochem (Tokyo). 1999 Jun;125(6):1067-76.
PMID: 10348909
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10348909
Tomimoto H, Akiguchi I, Akiyama H, Ikeda K, Wakita H, Lin JX, Budka H
Vascular changes in white matter lesions of Alzheimer's disease.
Acta Neuropathol (Berl). 1999 Jun;97(6):629-34.
PMID: 10378382
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10378382
Behl C
Vitamin E and other antioxidants in neuroprotection.
Int J Vitam Nutr Res. 1999 May;69(3):213-9.
PMID: 10389030
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10389030
Papassotiropoulos A, Bagli M, Jessen F, Bayer TA, Maier W, Rao ML, Heun R
A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease.
Ann Neurol. 1999 May;45(5):666-8.
PMID: 10319892
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10319892
Paris D, Town T, Parker TA, Tan J, Humphrey J, Crawford F, Mullan M
Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism.
Exp Neurol. 1999 May;157(1):211-21.
PMID: 10222124
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10222124
Yamada K, Ren X, Nabeshima T
Perspectives of pharmacotherapy in Alzheimer's disease.
Jpn J Pharmacol. 1999 May;80(1):9-14.
PMID: 10446751
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10446751
Yatin SM, Varadarajan S, Link CD, Butterfield DA
In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)
Neurobiol Aging. 1999 May-Jun;20(3):325-30; discussion 339-42.
PMID: 10588580
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10588580
Garlind A, Brauner A, Höjeberg B, Basun H, Schultzberg M
Soluble interleukin-1 receptor type II levels are elevated in cerebrospinal fluid in Alzheimer's disease patients.
Brain Res. 1999 Apr 24;826(1):112-6.
PMID: 10216202
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10216202
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry. 1999 Apr 13;38(15):4720-7.
PMID: 10200159
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10200159
Castillo GM, Lukito W, Wight TN, Snow AD
The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation.
J Neurochem. 1999 Apr;72(4):1681-7.
PMID: 10098877
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10098877
Möller HJ
Reappraising neurotransmitter-based strategies.
Eur Neuropsychopharmacol. 1999 Apr;9 Suppl 2:S53-9.
PMID: 10332935
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10332935
Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.
Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):150-62.
PMID: 10095087
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10095087
Zubenko GS, Stiffler JS, Hughes HB, Martinez AJ
Reductions in brain phosphatidylinositol kinase activities in Alzheimer's disease.
Biol Psychiatry. 1999 Mar 15;45(6):731-6.
PMID: 10188002
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10188002
Papassotiropoulos A, Bagli M, Feder O, Jessen F, Maier W, Rao ML, Ludwig M, Schwab SG, Heun R
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.
Neurosci Lett. 1999 Mar 12;262(3):171-4.
PMID: 10218883
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10218883
Mazur-Kolecka B, Frackowiak J, Krzeslowska J, Ramakrishna N, Haske T, Emmerling MR, Zhang W, Kim KS, Wisniewski HM
Apolipoprotein E alters metabolism of AbetaPP in cells engaged in beta-amyloidosis.
J Neuropathol Exp Neurol. 1999 Mar;58(3):288-95.
PMID: 10197820
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10197820
Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC
The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.
Diabetes. 1999 Mar 1;48(3):491-8.
PMID: 10078548
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10078548
Yatin SM, Aksenov M, Butterfield DA
The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease.
Neurochem Res. 1999 Mar;24(3):427-35.
PMID: 10215518
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10215518
Calingasan NY, Uchida K, Gibson GE
Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer's disease.
J Neurochem. 1999 Feb;72(2):751-6.
PMID: 9930749
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9930749
Ivins KJ, Ivins JK, Sharp JP, Cotman CW
Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid.
J Biol Chem. 1999 Jan 22;274(4):2107-12.
PMID: 9890971
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9890971
Carroll RT, Lust MR, Emmerling MR
Beta-amyloid levels predict cholinesterase activity in human cerebrospinal fluid.
Neuroreport. 1999 Jan 18;10(1):127-30.
PMID: 10094147
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10094147
Shastry BS, Giblin FJ
Genes and susceptible loci of Alzheimer's disease.
Brain Res Bull. 1999 Jan 15;48(2):121-7.
PMID: 10230703
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10230703
Bugiani O
Pathogenesis of Alzheimer's disease and dementia.
Rev Neurol (Paris). 1999;155 Suppl 4:S28-32.
PMID: 10637935
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10637935
Yoo BC, Seidl R, Cairns N, Lubec G
Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease.
J Neural Transm Suppl. 1999;57:315-22.
PMID: 10666686
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10666686
Nagy Z
Mechanisms of neuronal death in Down's syndrome.
J Neural Transm Suppl. 1999;57:233-45.
PMID: 10666679
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10666679
Sawa A
Neuronal cell death in Down's syndrome.
J Neural Transm Suppl. 1999;57:87-97.
PMID: 10666670
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10666670
Larner AJ
Hypothesis: amyloid beta-peptides truncated at the N-terminus contribute to the pathogenesis of Alzheimer's disease.
Neurobiol Aging. 1999 Jan-Feb;20(1):65-9.
PMID: 10466895
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10466895
Teplow DB
Truncating the amyloid cascade hypothesis: the role of C-terminal Abeta peptides in Alzheimer's disease.
Neurobiol Aging. 1999 Jan-Feb;20(1):71-3; discussion 87.
PMID: 10466896
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10466896
Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H, Jucker M
No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.
Neuroscience. 1999;90(4):1207-16.
PMID: 10338291
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10338291
Brusco LI, Márquez M, Cardinali DP
Monozygotic twins with Alzheimer's disease treated with melatonin: Case report.
J Pineal Res. 1998 Dec 1;25(4):260-3.
PMID: 9885996
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9885996
Knowles RB, Gomez-Isla T, Hyman BT
Abeta associated neuropil changes: correlation with neuronal loss and dementia.
J Neuropathol Exp Neurol. 1998 Dec;57(12):1122-30.
PMID: 9862634
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9862634
Suo Z, Humphrey J, Kundtz A, Sethi F, Placzek A, Crawford F, Mullan M
Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo.
Neurosci Lett. 1998 Nov 27;257(2):77-80.
PMID: 9865931
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9865931
Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, Staehelin H, Growdon JH, Tanzi RE, Hyman BT
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Hum Mol Genet. 1998 Nov;7(12):1953-6.
PMID: 9811940
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9811940
Prasad KN, Hovland AR, La Rosa FG, Hovland PG
Prostaglandins as putative neurotoxins in Alzheimer's disease.
Proc Soc Exp Biol Med. 1998 Nov;219(2):120-5.
PMID: 9790168
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9790168
Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12956-60.
PMID: 9789022
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9789022
Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M
Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40.
Brain Res. 1998 Oct 5;807(1-2):110-7.
PMID: 9757011
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9757011
Averback P
Spherons as a drug target in Alzheimer's disease.
Drug News Perspect. 1998 Oct;11(8):469-79.
PMID: 15616675
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=15616675
Hu Q, Kukull WA, Bressler SL, Gray MD, Cam JA, Larson EB, Martin GM, Deeb SS
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
Hum Genet. 1998 Sep 1;103(3):295-303.
PMID: 9799084
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9799084
Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE
Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease.
Am J Pathol. 1998 Sep;153(3):725-33.
PMID: 9736023
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9736023
Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nat Neurosci. 1998 Sep;1(5):355-8.
PMID: 10196523
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10196523
McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain Res. 1998 Aug 31;804(1):45-51.
PMID: 9729270
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9729270
Querfurth HW, Haughey NJ, Greenway SC, Yacono PW, Golan DE, Geiger JD
Expression of ryanodine receptors in human embryonic kidney (HEK293) cells.
Biochem J. 1998 Aug 15;334 ( Pt 1):79-86.
PMID: 9693105
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9693105
Bradt BM, Kolb WP, Cooper NR
Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide.
J Exp Med. 1998 Aug 3;188(3):431-8.
PMID: 9687521
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9687521
van de Nes JA, Kamphorst W, Ravid R, Swaab DF
Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently.
Acta Neuropathol (Berl). 1998 Aug;96(2):129-38.
PMID: 9705127
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9705127
Takashima A, Honda T, Yasutake K, Michel G, Murayama O, Murayama M, Ishiguro K, Yamaguchi H
Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.
Neurosci Res. 1998 Aug 1;31(4):317-23.
PMID: 9809590
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9809590
Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Neurobiol Dis. 1998 Aug 1;5(2):107-16.
PMID: 9746908
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9746908
Yu SP, Farhangrazi ZS, Ying HS, Yeh CH, Choi DW
Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death.
Neurobiol Dis. 1998 Aug;5(2):81-8.
PMID: 9746905
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9746905
Paris D, Parker TA, Town T, Suo Z, Fang C, Humphrey J, Crawford F, Mullan M
Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide.
Exp Neurol. 1998 Jul;152(1):116-22.
PMID: 9682018
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9682018
Decout A, Labeur C, Goethals M, Brasseur R, Vandekerckhove J, Rosseneu M
Enhanced efficiency of a targeted fusogenic peptide.
Biochim Biophys Acta. 1998 Jun 24;1372(1):102-16.
PMID: 9651495
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9651495
Ross SL, Martin F, Simonet L, Jacobsen F, Deshpande R, Vassar R, Bennett B, Luo Y, Wooden S, Hu S, Citron M, Burgess TL
Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells.
J Biol Chem. 1998 Jun 19;273(25):15309-12.
PMID: 9624107
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9624107
Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM
The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation.
Brain Res Mol Brain Res. 1998 Jun 1;57(1):63-72.
PMID: 9630519
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9630519
Teplow DB
Structural and kinetic features of amyloid beta-protein fibrillogenesis.
Amyloid. 1998 Jun;5(2):121-42.
PMID: 9686307
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9686307
Chen M
The Alzheimer's plaques, tangles and memory deficits may have a common origin; part I; a calcium deficit hypothesis.
Front Biosci. 1998 May 11;3:a27-31.
PMID: 9576681
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9576681
Shastry BS
Molecular genetics of familial Alzheimer disease.
Am J Med Sci. 1998 Apr;315(4):266-72.
PMID: 9537642
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9537642
Pappolla MA, Chyan YJ, Omar RA, Hsiao K, Perry G, Smith MA, Bozner P
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
Am J Pathol. 1998 Apr 1;152(4):871-7.
PMID: 9546346
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9546346
Tolar M, Scott SA, Crutcher KA
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Brain Res. 1998 Mar 16;787(1):49-58.
PMID: 9518548
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9518548
Prasher VP, Farrer MJ, Kessling AM, Fisher EM, West RJ, Barber PC, Butler AC
Molecular mapping of Alzheimer-type dementia in Down's syndrome.
Ann Neurol. 1998 Mar 1;43(3):380-3.
PMID: 9506555
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9506555
Gustafson L, Brun A, Englund E, Hagnell O, Nilsson K, Stensmyr M, Ohlin AK, Abrahamson M
A 50-year perspective of a family with chromosome-14-linked Alzheimer's disease.
Hum Genet. 1998 Mar;102(3):253-7.
PMID: 9544835
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9544835
Sunderland T
Alzheimer's disease. Cholinergic therapy and beyond.
Am J Geriatr Psychiatry. 1998 Spring;6(2 Suppl 1):S56-63.
PMID: 9581222
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9581222
Behl C, Holsboer F
[Oxidative stress in the pathogenesis of Alzheimer's disease and antioxidant neuroprotection]
Fortschr Neurol Psychiatr. 1998 Mar;66(3):113-21.
PMID: 9565761
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9565761
Almkvist O, Basun H, Bäckman L, Herlitz A, Lannfelt L, Small B, Viitanen M, Wahlund LO, Winblad B
Mild cognitive impairment--an early stage of Alzheimer's disease?
J Neural Transm Suppl. 1998;54:21-9.
PMID: 9850912
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9850912
Haass C, Baumeister R
What do we learn from a few familial Alzheimer's disease cases?
J Neural Transm Suppl. 1998;54:137-45.
PMID: 9850922
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9850922
Retz W, Gsell W, Münch G, Rösler M, Riederer P
Free radicals in Alzheimer's disease.
J Neural Transm Suppl. 1998;54:221-36.
PMID: 9850931
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9850931
Terry RD
The cytoskeleton in Alzheimer disease.
J Neural Transm Suppl. 1998;53:141-5.
PMID: 9700652
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9700652
Masliah E
Mechanisms of synaptic pathology in Alzheimer's disease.
J Neural Transm Suppl. 1998;53:147-58.
PMID: 9700653
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9700653
Saido TC
Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid.
Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S69-75.
PMID: 9562472
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9562472
Hutton M, Pérez-Tur J, Hardy J
Genetics of Alzheimer's disease.
Essays Biochem. 1998;33:117-31.
PMID: 10488446
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10488446
Neve RL, Robakis NK
Alzheimer's disease: a re-examination of the amyloid hypothesis.
Trends Neurosci. 1998 Jan;21(1):15-9.
PMID: 9464679
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9464679
Hoyer S
Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis.
J Neural Transm. 1998;105(4-5):415-22.
PMID: 9720971
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9720971
Mjöberg B, Hellquist E, Mallmin H, Lindh U
Aluminum, Alzheimer's disease and bone fragility.
Acta Orthop Scand. 1997 Dec;68(6):511-4.
PMID: 9462346
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9462346
Emmerling MR, Spiegel K, Watson MD
Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide.
Immunopharmacology. 1997 Dec;38(1-2):101-9.
PMID: 9476121
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9476121
Behl C
Amyloid beta-protein toxicity and oxidative stress in Alzheimer's disease.
Cell Tissue Res. 1997 Dec;290(3):471-80.
PMID: 9369525
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9369525
Keller JN, Germeyer A, Begley JG, Mattson MP
17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron.
J Neurosci Res. 1997 Nov 15;50(4):522-30.
PMID: 9404714
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9404714
Teasdale GM, Nicoll JA, Murray G, Fiddes M
Association of apolipoprotein E polymorphism with outcome after head injury.
Lancet. 1997 Oct 11;350(9084):1069-71.
PMID: 10213549
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=10213549
Kato A, Fukunari A, Sakai Y, Nakajima T
Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse.
J Pharmacol Exp Ther. 1997 Oct 1;283(1):328-35.
PMID: 9336340
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9336340
Giannakopoulos P, Hof PR, Michel JP, Guimon J, Bouras C
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts.
Brain Res Brain Res Rev. 1997 Oct;25(2):217-45.
PMID: 9403139
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9403139
Subramaniam R, Roediger F, Jordan B, Mattson MP, Keller JN, Waeg G, Butterfield DA
The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins.
J Neurochem. 1997 Sep;69(3):1161-9.
PMID: 9282939
Alzforum: http://www.alzforum.org/pap/annotation.asp?pmid=9282939
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[ARF Recommends] [Milestone Paper]
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