Beta Amyloid Peptide: Research Paper : Behavioural change, weight loss and risk of dementia: A longitudinal study

Behavioural change, weight loss and risk of dementia: A longitudinal study

Abstract

Recent meta-analysis reported higher dementia risks associated with lower body mass index (BMI) and decreasing BMI. We examined to what extent these associations were attenuated by changes in behaviours and local environment. Multilevel discrete time-to-event models examined associations between baseline and change in BMI with dementia detected through prescription medications (source: Department of Human Services), hospitalisations and death certificates among 144,456 participants in the Sax Institute's 45 and Up Study. Models were adjusted for socioeconomic factors, lifestyles and cardiometabolic diseases, followed by measures of change in adherence to published guidelines for moderate to vigorous physical activity, sleep duration, alcohol, and fruit and vegetable consumption, as well as indicators of area-level disadvantage and rurality. Data was analysed in 2020. Higher dementia risks (albeit with imprecision) were found among participants who were underweight (Incidence Hazard Ratio (IHR) 1.30, 95%CI=0.86-1.86) and lower risks among those who were overweight (IHR=0.78, 95%CI=0.70-0.86) or obese (IHR=0.72, 95%CI=0.62-0.83) compared with 'normal' BMI. A ≥0.8 kg/m2 reduction in BMI associated with IHR=1.81 (95%CI=1.64-2.01) higher dementia risk relative to those with stable BMI. Higher dementia risk with decreasing BMI was relatively consistent relative to baseline BMI category. Adherence to physical activity and sleep duration guidelines were associated with reduced dementia risk, but neither these, nor adjustment for other behaviours and local factors, explained the BMI-dementia association. We replicated the BMI-dementia findings from a recent meta-analysis and provide further support to preventive strategies focussed on increasing physical activity and improving sleep duration. Other potential environmental risk factors warrant investigation.

Keywords: Alzheimer's disease; Australia; Cohort; Geography; Lifestyle; Obesity.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33370594/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.