Beta Amyloid Peptide: Research Paper : Interactions of α-synuclein oligomers with lipid membranes

Interactions of α-synuclein oligomers with lipid membranes

Abstract

Parkinson's disease is an increasingly prevalent and currently incurable neurodegenerative disorder. At the molecular level, this disease is characterized by the formation of aberrant intracellular protein deposits known as Lewy bodies. Oligomeric forms of the protein α-synuclein (αS), which are believed to be both intermediates and by-products of Lewy body formation, are considered to be the main pathogenic species. Interactions of such oligomers with membranes are increasingly emerging as a major molecular pathway underpinning their toxicity. Here we review recent progress in our understanding of the interactions of αS oligomers with lipid membranes. We highlight key structural and biophysical features of αS oligomers, their effects on αS oligomer membrane binding properties, and resultant implications for understanding the etiology of Parkinson's disease. We discuss mechanistic modes of αS oligomer-lipid membrane interactions, the contribution of environmental factors, and provide an overview of the current understanding of the main molecular determinants of αS oligomer toxicity in vivo.

Keywords: Aggregation; Alpha-synuclein; Lipids; Membranes; Oligomers; Parkinson's disease.

Copyright © 2018. Published by Elsevier B.V.

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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