Beta Amyloid Peptide: Research Paper : Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

Abstract

Objectives: Early diagnosis in Alzheimer's disease (AD) is crucial in order to implement new therapeutic strategies. The retina is embryologically related to the brain. Thus, the possible usefulness of optical coherence tomography (OCT) in the early detection of AD is currently being studied. Our aim was to study the relationship between retinal nerve fiber layer (RNFL) thickness and AD.

Methods: We undertook an observational, analytical, cross-sectional study with consecutive sampling of 32 patients with AD or mild cognitive impairment (MCI) and a group of healthy controls (C). The total number of eyes studied was 64. An ophthalmological and a comprehensive neuropsychological evaluation were performed in all participants. Quantification of white matter lesions and study of atrophy of the hippocampus by cerebral magnetic resonance were also performed.

Results: We observed a significant linear trend towards a thinning of RNFL as the degree of cognitive deterioration increased, in the superior and temporal quadrants of the retina. A significant correlation was also noted between the mean thickness of the RNFL of the left temporal quadrant and occipital white matter lesions (r = -0.579, p = 0.038).

Conclusions: OCT could be a safe, rapid non-invasive tool providing useful biomarkers in the early detection of cognitive deterioration and AD. This article is protected by copyright. All rights reserved.

Keywords: Alzheimer disease; mild cognitive impairment; optical coherence tomography; retinal nerve fiber layer thickness; white matter lesions.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33387372/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.