Beta Amyloid Peptide: Research Paper : β-Amyloid may accumulate in the human brain after focal bacterial infection: a 18F-flutemetamol positron emission tomography study

β-Amyloid may accumulate in the human brain after focal bacterial infection: a 18F-flutemetamol positron emission tomography study

Abstract

Background and purpose: β-Amyloid formation has been suggested to form part of the brain's response to bacterial infection. This hypothesis has been based on experimental animal studies and autopsy studies in humans. We asked if β-amyloid accumulates locally around a bacterial brain abscess in living human patients. Further, because brain abscess patients may suffer from chronic cognitive symptoms after abscess treatment, we also asked if a brain abscess precipitates accumulation of β-amyloid in the neocortex in a manner that could explain abscess-related cognitive complaints.

Methods: In a prospective study, we investigated 17 brain abscess patients (age 24-72 years) with 18 F-flutemetamol positron emission tomography on one occasion 1-10 months after brain abscess treatment to visualize β-amyloid accumulation.

Results: 18 F-flutemetamol uptake was reduced in the edematous brain tissue that surrounded the abscess remains. On this background of reduced 18 F-flutemetamol signal, three out of 17 patients showed a distinctly increased 18 F-flutemetamol uptake in the tissue immediately surrounding the abscess remains, suggesting accumulation of β-amyloid. These three patients underwent 18 F-flutemetamol positron emission tomography significantly earlier after neurosurgical treatment (p=0.042), and they had larger abscesses (p=0.027) than the rest of the patients. All 17 patients suffered from mental fatigue or some subjective cognitive symptom, such as attention difficulties or memory problems, but in none of the patients was there an increase in neocortical 18 F-flutemetamol signal.

Conclusion: β-Amyloid may accumulate locally around the abscess remains in some patients with brain abscess.

Keywords: 18F-flutemetamol-positron emission tomography; brain abscess; β-amyloid.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33131195/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.