Beta Amyloid Peptide:Research Paper: Hypoglycemia in Type 2 Diabetes exacerbates Amyloid-related proteins associated with dementia

Hypoglycemia in Type 2 Diabetes exacerbates Amyloid-related proteins associated with dementia

Abstract

Objective: Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia-induced amyloid-related protein changes would be exacerbated in T2D.

Methods: A prospective, parallel study in T2D (n=23) and controls (n=23). Subjects underwent insulin-induced hypoglycemia with blood sampling at baseline, hypoglycemia and post-hypoglycemia; proteomic analysis of amyloid-related proteins was undertaken.

Results: At baseline: Amyloid-precursor protein (APP) (p<0.01) was elevated and Alpha-synuclein (SNCA) (p<0.01) reduced in T2D. At hypoglycemia: Amyloid P-component (APCS) (p<0.01) was elevated and SNCA (p<0.05) reduced in T2D; APP (p<0.01) and Noggin (p<0.05) were elevated and SNCA (p<0.01) reduced in controls. In the post-hypoglycemia follow up period, APP and Microtubule-associated protein tau (MAPT) normalized in controls but showed a below-baseline decrease in T2D; Noggin normalized in both; SNCA normalized in T2D, with a below-baseline decrease in controls.

Conclusion: The AD-associated protein pattern found in T2D, with basal elevated APP and reduced SNCA, was exaggerated by hypoglycemia with increased APP and decreased SNCA. Additional AD-associated protein levels that changed in response to hypoglycemia, particularly in T2D, included APCS, MAPT, ApoA1, ApoE3, PAPPA and Noggin. These results are in accord with the reported detrimental effects of hypoglycemia. This article is protected by copyright. All rights reserved.

Keywords: Alzheimer's disease; Type 2 diabetes; amyloid-related proteins; dementia; hypoglycemia.

This article is protected by copyright. All rights reserved.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33026133/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.