Beta Amyloid Peptide: Beta Amyloid Peptide:Research Paper: Is Porphyromonas gingivalis involved in Parkinson's disease?

Beta Amyloid Peptide:Research Paper: Is Porphyromonas gingivalis involved in Parkinson's disease?

Is Porphyromonas gingivalis involved in Parkinson's disease?

Abstract

Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer's disease. In the present paper, another common neuroinflammatory disease, Parkinson's disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene.

Keywords: Amyloid formation; Cytokines; Gingipains; Hypercoagulation; LPS; Systemic inflammation.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/32564247/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.  




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