Beta Amyloid Peptide: Beta Amyloid Peptide: Jobs: Postdoctoral Fellow (three opportunities)

Beta Amyloid Peptide: Jobs: Postdoctoral Fellow (three opportunities)

Postdoctoral Fellow (three opportunities)


Employer

UCSF Memory and Aging Center

Location

San Francisco, California

Principal Investigator

Possin, Kramer, Casaletto

Contact

Informal inquiries are welcome. Please submit a cover letter, CV, and three letters of recommendation to Nina Djukic (nina.djukic@ucsf.edu).

For more information, please review the MAC website (http://memory.ucsf.edu/) and/or email Drs. Possin, Kramer, or Casaletto.

Description

The University of California, San Francisco Memory and Aging Center (MAC) is offering several neuropsychology postdoctoral fellowships for 2021-2023. It is looking for candidates invested in a scientist-practitioner model. It has flexibility to design the fellowship around the individual fellow's training needs and goals. Applicants from diverse backgrounds are encouraged. Postdoctoral fellows typically spend approximately 60-80 percent of their time engaged in research activities, 20-30 percent in clinical activities, and the rest of their time in training, supervision, supervising predoctoral trainees, and a wide variety of didactic opportunities.

The MAC is dedicated to providing the highest quality of care for individuals with cognitive problems, conducting research on causes and cures for degenerative brain diseases, and educating health professionals, patients and their families. Multidisciplinary clinical opportunities will range from healthy cognitive aging to typical (e.g., Alzheimer's disease) and atypical (e.g., frontotemporal dementia, primary progressive aphasias, corticobasal syndrome, prion disease) neurodegenerative syndromes. Research opportunities will be related to specific openings in the Possin, Kramer, and Casaletto labs (see below), though fellows are encouraged to collaborate across labs and PIs. Please indicate which lab(s) you are applying to in your cover letter.

The Possin lab is focused on improving detection, diagnosis, and care for people with neurodegenerative disease. This work includes developing and validating novel cognitive assessments and care models in controlled research settings, real-world clinical settings, and with diverse populations including medically underserved minorities and with large, multidisciplinary, and sometimes international datasets. The postdoctoral fellow will contribute to ongoing research studies and pursue self-directed projects that align with the lab's area of investigation and provide clinical neuropsychology services through the Memory and Aging Center's Clinic and research projects. (Katherine.Possin@ucsf.edu)

The Kramer lab leads the Longitudinal Brain Aging Program, which aims to understand the complex biological, genetic, and lifestyle factors that underlie differential aging trajectories. It has large, deeply phenotyped research cohorts with an extensive research infrastructure that supports standard and experimental neuropsychological and neurological measures, structural and functional MRI, amyloid and tau PET, and biofluid proteomics (e.g., inflammatory markers). The overarching goals are to gain a better understanding of what healthy aging is and identify the earliest changes associated with degenerative brain disease. (joel.kramer@ucsf.eduwww.https://healthyaging.ucsf.edu)

The Casaletto lab aims to understand factors that underlie cognitive resilience to brain aging. Her lab works closely with the Longitudinal Brain Aging Program and takes several approaches to tackling these questions. The lab identifies and deeply phenotypes older adults who demonstrate abnormally successful aging trajectories, relative to their age, risk profile, or neuropathology markers. It also examines how lifestyle behaviors can be used to shape brain health, with a focus on the underlying biological mechanisms driving these relationships. The work includes an ongoing randomized controlled trial of lifestyle behaviors (ActAN Study), actigraphy monitoring (Fitbit), and often leverages advanced biofluid markers (plasma, CSF, exosome) to identify novel biological targets. Active areas of work focus on in-vivo markers of synaptic health as a bridging biology between lifestyle and resilience. The postdoctoral fellow is encouraged to contribute to ongoing work and pursue related areas of his/her own focus. Applicants with interest and/or experience working with wearable data are encouraged. (Kaitlin.casaletto@ucsf.edu)

Requirements

The ideal candidate: a) has clinical and research experience and demonstrated research productivity; b) is interested in specializing in cognitive aging and neurodegenerative diseases; c) is committed to clinical excellence; and d) is eager to develop an independent scientist-practitioner academic career. The fellowship is a full-time, two-year commitment.


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