Beta Amyloid Protein Alzheimer's ~ Research Papers on Beta Amyloid Protein Alzheimer's

Beta Amyloid Protein Alzheimer's ~ Research Papers on Beta Amyloid Protein Alzheimer's

Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB. beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J Biol Chem. 2000 Feb 25;275(8):5626-32.

Corrigan FM, Wienburg CL, Shore RF, Daniel SE, Mann D. Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A. 2000 Feb 25;59(4):229-34.

Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem. 2000 Feb 25;275(8):5535-44.

  

Mulnard RA, Cotman CW, Kawas C, van Dyck CH, Sano M, Doody R, Koss E, Pfeiffer E, Jin S, Gamst A, Grundman M, Thomas R, Thal LJ. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study. JAMA. 2000 Feb 23;283(8):1007-15.

    

Manly JJ, Merchant CA, Jacobs DM, Small SA, Bell K, Ferin M, Mayeux R. Endogenous estrogen levels and Alzheimer's disease among postmenopausal women. Neurology. 2000 Feb 22;54(4):833-7.

Ala TA, Beh GO, Frey WH. Pure hippocampal sclerosis: a rare cause of dementia mimicking Alzheimer's disease. Neurology. 2000 Feb 22;54(4):843-8.

Tapiola T, Pirttilä T, Mikkonen M, Mehta PD, Alafuzoff I, Koivisto K, Soininen H. Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease. Neurosci Lett. 2000 Feb 18;280(2):119-22. ,

MacManus A, Ramsden M, Murray M, Henderson Z, Pearson HA, Campbell VA. Enhancement of (45)Ca(2+) influx and voltage-dependent Ca(2+) channel activity by beta-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1beta. J Biol Chem. 2000 Feb 18;275(7):4713-8.

Kosasa T, Kuriya Y, Matsui K, Yamanishi Y. Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats. Eur J Pharmacol. 2000 Feb 18;389(2-3):173-9.

Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci. 2000 Feb 15;20(4):1386-92.

Mattson MP, Zhu H, Yu J, Kindy MS. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J Neurosci. 2000 Feb 15;20(4):1358-64.

Rockwell P, Yuan H, Magnusson R, Figueiredo-Pereira ME. Proteasome inhibition in neuronal cells induces a proinflammatory response manifested by upregulation of cyclooxygenase-2, its accumulation as ubiquitin conjugates, and production of the prostaglandin PGE(2). Arch Biochem Biophys. 2000 Feb 15;374(2):325-33.

  

Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1456-60.

Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res. 2000 Feb 15;59(4):528-33.

Panegyres PK, Zafiris-Toufexis K, Kakulas BA. Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders. J Neurol Sci. 2000 Feb 15;173(2):81-92.

Blain H, Jouzeau JY, Blain A, Terlain B, Tréchot P, Touchon J, Netter P, Jeandel C. [Non-steroidal anti-inflammatory drugs with selectivity for cyclooxygenase-2 in Alzheimer's disease. Rationale and perspectives] Presse Med. 2000 Feb 12;29(5):267-73.

Theuns J, Del-Favero J, Dermaut B, van Duijn CM, Backhovens H, Van den Broeck MV, Serneels S, Corsmit E, Van Broeckhoven CV, Cruts M. Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression. Hum Mol Genet. 2000 Feb 12;9(3):325-31. ,

Hamanaka H, Katoh-Fukui Y, Suzuki K, Kobayashi M, Suzuki R, Motegi Y, Nakahara Y, Takeshita A, Kawai M, Ishiguro K, Yokoyama M, Fujita SC. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Hum Mol Genet. 2000 Feb 12;9(3):353-61.

 

Wetterberg L. [Mental disease a heritage. New genetic knowledge can reveal "public diseases" such as autism, dyslexia, alcoholism, anorexia, schizophrenia] Lakartidningen. 2000 Feb 9;97(6):558-62, 565-7.

Aisen PS, Davis KL, Berg JD, Schafer K, Campbell K, Thomas RG, Weiner MF, Farlow MR, Sano M, Grundman M, Thal LJ. A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study. Neurology. 2000 Feb 8;54(3):588-93.

Xu W, Liu L, Emson P, Harrington CR, McKeith IG, Perry RH, Morris CM, Charles IG. The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies. Neuroreport. 2000 Feb 7;11(2):297-9. ,

Matsumoto A. The 68K protease has beta-secretase-like activity for lymphocyte precursor protein but not for brain substrate. Neuroreport. 2000 Feb 7;11(2):373-7.

Jarskog LF, Gilmore JH. Developmental expression of Bcl-2 protein in human cortex. Brain Res Dev Brain Res. 2000 Feb 7;119(2):225-30.

Evin G, Le Brocque D, Culvenor JG, Galatis D, Weidemann A, Beyreuther K, Masters CL, Cappai R. Presenilin I expression in yeast lowers secretion of the amyloid precursor protein. Neuroreport. 2000 Feb 7;11(2):405-8.

Lovell MA, Xie C, Markesbery WR. Decreased base excision repair and increased helicase activity in Alzheimer's disease brain. Brain Res. 2000 Feb 7;855(1):116-23.

Ho LH, Ratnaike RN, Zalewski PD. Involvement of intracellular labile zinc in suppression of DEVD-caspase activity in human neuroblastoma cells. Biochem Biophys Res Commun. 2000 Feb 5;268(1):148-54.

Shirotani K, Takahashi K, Araki W, Maruyama K, Tabira T. Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function. J Biol Chem. 2000 Feb 4;275(5):3681-6.

Sester M, Feuerbach D, Frank R, Preckel T, Gutermann A, Burgert HG. The amyloid precursor-like protein 2 associates with the major histocompatibility complex class I molecule K(d). J Biol Chem. 2000 Feb 4;275(5):3645-54.

Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 4;275(5):3173-8.

Romas SN, Mayeux R, Rabinowitz D, Tang MX, Zadroga HR, Lantigua R, Medrano M, Tycko B, Knowles JA. The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics. Neurosci Lett. 2000 Feb 4;279(3):133-6. ,

Ikegami S, Harada A, Hirokawa N. Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice. Neurosci Lett. 2000 Feb 4;279(3):129-32.

Roberts JS. Anticipating response to predictive genetic testing for Alzheimer's disease: a survey of first-degree relatives. Gerontologist. 2000 Feb 1;40(1):43-52.

Taylor R. National Adult Reading Test performance in established dementia. Arch Gerontol Geriatr. 2000 Feb;29(3):291-296.

Ishii H, Meguro K, Ishizaki J, Shimada M, Yamaguchi S, Sano I, Ambo H, Ohtake H, Shimada Y, Someya K, Sato M, Shibuya Y, Kato M, Sekita Y, Yamadori A. Prevalence of senile dementia in a rural community in Japan: the Tajiri project. Arch Gerontol Geriatr. 2000 Feb;29(3):249-265.

Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R. Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine. Neurobiol Dis. 2000 Feb;7(1):54-63.

Bregman DB, Pestell RG, Kidd VJ. Cell cycle regulation and RNA polymerase II. Front Biosci. 2000 Feb 1;5:D244-57.

Chui HC, Mack W, Jackson JE, Mungas D, Reed BR, Tinklenberg J, Chang FL, Skinner K, Tasaki C, Jagust WJ. Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability. Arch Neurol. 2000 Feb;57(2):191-6.

Farrer LA, Sherbatich T, Keryanov SA, Korovaitseva GI, Rogaeva EA, Petruk S, Premkumar S, Moliaka Y, Song YQ, Pei Y, Sato C, Selezneva ND, Voskresenskaya S, Golimbet V, Sorbi S, Duara R, Gavrilova S, St George-Hyslop PH, Rogaev EI. Association between angiotensin-converting enzyme and Alzheimer disease. Arch Neurol. 2000 Feb;57(2):210-4. , ,

Maruyama H, Toji H, Harrington CR, Sasaki K, Izumi Y, Ohnuma T, Arai H, Yasuda M, Tanaka C, Emson PC, Nakamura S, Kawakami H. Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease. Arch Neurol. 2000 Feb 1;57(2):236-40. ,

Gouras GK, Xu H, Gross RS, Greenfield JP, Hai B, Wang R, Greengard P. Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1202-5.

Grundman M. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr. 2000 Feb;71(2):630S-636S.

St George-Hyslop PH. Molecular genetics of Alzheimer's disease. Biol Psychiatry. 2000 Feb 1;47(3):183-99.

Schippling S, Kontush A, Arlt S, Buhmann C, Stürenburg HJ, Mann U, Müller-Thomsen T, Beisiegel U. Increased lipoprotein oxidation in Alzheimer's disease. Free Radic Biol Med. 2000 Feb 1;28(3):351-60.

Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C, Casadei V, Grimaldi LM. Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain? J Neuroimmunol. 2000 Feb 1;103(1):97-102. ,

Yamaguchi S, Tsuchiya H, Yamagata S, Toyoda G, Kobayashi S. Event-related brain potentials in response to novel sounds in dementia. Clin Neurophysiol. 2000 Feb;111(2):195-203.

Grant WB. Fish consumption, cancer, and Alzheimer disease. Am J Clin Nutr. 2000 Feb;71(2):599-600.

Altamirano CV, Bartels CF, Lockridge O. The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme. J Neurochem. 2000 Feb;74(2):869-77.

Hellström-Lindahl E, Moore H, Nordberg A. Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists. J Neurochem. 2000 Feb;74(2):777-84.

Mattson MP, Culmsee C, Yu Z, Camandola S. Roles of nuclear factor kappaB in neuronal survival and plasticity. J Neurochem. 2000 Feb;74(2):443-56.

Yasuda M, Maeda S, Kawamata T, Tamaoka A, Yamamoto Y, Kuroda S, Maeda K, Tanaka C. Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):220-3.

Pastor P, Ezquerra M, Muñoz E, Martí MJ, Blesa R, Tolosa E, Oliva R. Significant association between the tau gene A0/A0 genotype and Parkinson's disease. Ann Neurol. 2000 Feb;47(2):242-5.

Cotman SL, Halfter W, Cole GJ. Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain. Mol Cell Neurosci. 2000 Feb;15(2):183-98.

Yoshiyama Y, Asahina M, Hattori T. Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. Acta Neuropathol (Berl). 2000 Feb;99(2):91-5.

Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol. 2000 Feb;156(2):489-99.

Mizuno K, Wakai M, Takeda A, Sobue G. Medial temporal atrophy and memory impairment in early stage of Alzheimer's disease: an MRI volumetric and memory assessment study. J Neurol Sci. 2000 Feb 1;173(1):18-24.

Arlt S, Finckh B, Beisiegel U, Kontush A. Time-course of oxidation of lipids in human cerebrospinal fluid in vitro. Free Radic Res. 2000 Feb;32(2):103-14.

Shimohama S. [Changes in apoptosis-regulating proteins in Alzheimer's disease: comparison with development and aging] Tanpakushitsu Kakusan Koso. 2000 Feb;45(3 Suppl):532-6.

Ruotsalainen S, Miettinen R, MacDonald E, Koivisto E, Sirviö J. Blockade of muscarinic, rather than nicotinic, receptors impairs attention, but does not interact with serotonin depletion. Psychopharmacology (Berl). 2000 Feb;148(2):111-23.

Metzger MM. Glucose enhancement of a facial recognition task in young adults. Physiol Behav. 2000 Feb;68(4):549-53.

Hösli E, Rühl W, Hösli L. Histochemical and electrophysiological evidence for estrogen receptors on cultured astrocytes: colocalization with cholinergic receptors. Int J Dev Neurosci. 2000 Feb;18(1):101-11.

Celsis P. Age-related cognitive decline, mild cognitive impairment or preclinical Alzheimer's disease? Ann Med. 2000 Feb;32(1):6-14.

Bartolomeo AC, Morris H, Buccafusco JJ, Kille N, Rosenzweig-Lipson S, Husbands MG, Sabb AL, Abou-Gharbia M, Moyer JA, Boast CA. The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist. J Pharmacol Exp Ther. 2000 Feb;292(2):584-96.

Vickers JC, Dickson TC, Adlard PA, Saunders HL, King CE, McCormack G. The cause of neuronal degeneration in Alzheimer's disease. Prog Neurobiol. 2000 Feb 1;60(2):139-65.

Rivas-Vazquez RA, Carrazana EJ, Rey GJ, Blais MA, Racher DA. Alzheimer's disease: pharmacological treatment and management. Clin Neuropsychol. 2000 Feb;14(1):93-109.

Hugon J, Esclaire F, Terro F, Yardin C. [Apoptosis and Alzheimer disease. Contribution of cellular and transgenic models] Rev Neurol (Paris). 2000 Feb;156(2):123-5.

Fankhauser F, Ricka J, Rol P, Kwasniewska S, Niederer P. [Protein-condensation diseases--molecular basis of cataract formation] Klin Monatsbl Augenheilkd. 2000 Feb;216(2):75-8.

Schölzel-Dorenbos CJ. [Measurement of quality of life in patients with dementia of Alzheimer type and their caregivers: Schedule for the Evaluation of Individual Quality of Life (SEIQoL)] Tijdschr Gerontol Geriatr. 2000 Feb;31(1):23-6.

De Groot CJ, Montagne L, Janssen I, Ravid R, Van Der Valk P, Veerhuis R. Isolation and characterization of adult microglial cells and oligodendrocytes derived from postmortem human brain tissue. Brain Res Brain Res Protoc. 2000 Feb;5(1):85-94.

Skovronsky DM, Pijak DS, Doms RW, Lee VM. A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP. Biochemistry. 2000 Feb 1;39(4):810-7.

Williams RS, Harwood AJ. Lithium therapy and signal transduction. Trends Pharmacol Sci. 2000 Feb;21(2):61-4.

Wang Z, Natte , Berliner , van Duinen , Vinters . Toxicity of Dutch (E22Q) and Flemish (A21G) mutant amyloid beta proteins to human cerebral microvessel and aortic smooth muscle cells. Stroke. 2000 Feb;31(2):534-8. Abstract

Kwok JB, Li QX, Hallupp M, Whyte S, Ames D, Beyreuther K, Masters CL, Schofield PR. Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis. Ann Neurol. 2000 Feb;47(2):249-53.

  

Lütjohann D, Papassotiropoulos A, Björkhem I, Locatelli S, Bagli M, Oehring RD, Schlegel U, Jessen F, Rao ML, von Bergmann K, Heun R. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. J Lipid Res. 2000 Feb;41(2):195-8. ,

Gieffers J, Reusche E, Solbach W, Maass M. Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients. J Clin Microbiol. 2000 Feb;38(2):881-2.

    

Metodiewa D, Koska C. Reactive oxygen species and reactive nitrogen species: relevance to cyto(neuro)toxic events and neurologic disorders. An overview. Neurotox Res. 2000 Feb;1(3):197-233.

Shoji M, Kawarabayashi T, Matsubara E, Ikeda M, Ishiguro K, Harigaya Y, Okamoto K. Distribution of amyloid beta protein precursor in the Alzheimer's disease brain. Psychiatry Clin Neurosci. 2000 Feb;54(1):45-54.

Ishii H, Meguro K, Ishizaki J, Shimada M, Yamaguchi S, Sano I, Ambo H, Ohtake H, Shimada Y, Someya K, Sato M, Shibuya Y, Kato M, Sekita Y, Yamadori A. Prevalence of senile dementia in a rural community in Japan: the Tajiri project. Arch Gerontol Geriatr. 2000 Feb;29(3):249-65.

Londos E, Passant U, Gustafson L. Blood pressure and drug treatment in clinically diagnosed Lewy body dementia and Alzheimer's disease. Arch Gerontol Geriatr. 2000 Feb;30(1):35-46.

Clare L, Wilson BA, Carter G, Breen K, Gosses A, Hodges JR. Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. J Clin Exp Neuropsychol. 2000 Feb;22(1):132-46.

Camps P, Cusack B, Mallender WD, El Achab RE, Morral J, Muñoz-Torrero D, Rosenberry TL. Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease. Mol Pharmacol. 2000 Feb;57(2):409-17.

Ramassamy C, Averill D, Beffert U, Theroux L, Lussier-Cacan S, Cohn JS, Christen Y, Schoofs A, Davignon J, Poirier J. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain. Neurobiol Dis. 2000 Feb;7(1):23-37.

van Dyck CH, Newhouse P, Falk WE, Mattes JA. Extended-release physostigmine in Alzheimer disease: a multicenter, double-blind, 12-week study with dose enrichment. Physostigmine Study Group. Arch Gen Psychiatry. 2000 Feb;57(2):157-64.

Shimohama S. Apoptosis in Alzheimer's disease--an update. Apoptosis. 2000 Feb;5(1):9-16.

Lackey BR, Gray SL, Henricks DM. Actions and interactions of the IGF system in Alzheimer's disease: review and hypotheses. Growth Horm IGF Res. 2000 Feb;10(1):1-13.

Ribaut-Barassin C, Moussaoui S, Brugg B, Haeberlé AM, Huber G, Imperato A, Delhaye-Bouchaud N, Mariani J, Bailly YJ. Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus. Synapse. 2000 Feb;35(2):96-110.

Frederikse PH, Zigler SJ, Farnsworth PN, Carper DA. Prion protein expression in mammalian lenses. Curr Eye Res. 2000 Feb;20(2):137-43.

Walker LC, LeVine H. The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly. Mol Neurobiol. 2000 Feb-Apr;21(1-2):83-95.

Tunstall N, Owen MJ, Williams J, Rice F, Carty S, Lillystone S, Fraser L, Kehoe P, Neill D, Rudrasingham V, Sham P, Lovestone S. Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease. Br J Psychiatry. 2000 Feb;176:156-9.

Salib E. Risk factors for Alzheimer's disease. Elder Care. 2000 Feb;11(10):12-5.

McLendon BM, Chen GG, Doraiswamy PM. Current and future treatments for cognitive deficits in dementia. Curr Psychiatry Rep. 2000 Feb;2(1):20-3.

Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med. 2000 Feb;6(2):143-50.

Glabe C. Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation? Nat Med. 2000 Feb;6(2):133-4.

Kobayashi MS, Han D, Packer L. Antioxidants and herbal extracts protect HT-4 neuronal cells against glutamate-induced cytotoxicity. Free Radic Res. 2000 Feb;32(2):115-24.