Dementia-Alzheimer’s Research Papers

Dementia-Alzheimer’s Research Papers

Camandola S, Poli G, Mattson MP. The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):53-60.

Lopez OL, Becker JT, Klunk W, Saxton J, Hamilton RL, Kaufer DI, Sweet RA, Cidis Meltzer C, Wisniewski S, Kamboh MI, DeKosky ST. Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I. Neurology. 2000 Dec 26;55(12):1854-62.

Munson GW, Roher AE, Kuo YM, Gilligan SM, Reardon CA, Getz GS, LaDu MJ. SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides. Biochemistry. 2000 Dec 26;39(51):16119-24.

Lopez OL, Becker JT, Klunk W, Saxton J, Hamilton RL, Kaufer DI, Sweet RA, Cidis Meltzer C, Wisniewski S, Kamboh MI, DeKosky ST. Research evaluation and diagnosis of possible Alzheimer's disease over the last two decades: II. Neurology. 2000 Dec 26;55(12):1863-9.

Yasojima K, Schwab C, McGeer EG, McGeer PL. Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Res. 2000 Dec 22;887(1):80-9.

  

Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, DeVrieze FW, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 2000 Dec 22;290(5500):2304-5.

 

  

Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 2000 Dec 22;290(5500):2303-4.

 

  

Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 2000 Dec 22;290(5500):2302-3.

 

Zemlyak I, Furman S, Brenneman DE, Gozes I. A novel peptide prevents death in enriched neuronal cultures. Regul Pept. 2000 Dec 22;96(1-2):39-43.

 

Schmidt AM, Yan SD, Yan SF, Stern DM. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta. 2000 Dec 20;1498(2-3):99-111.

Ravaglia G, Forti P, Maioli F, Vettori C, Grossi G, Bargossi AM, Caldarera M, Franceschi C, Facchini A, Mariani E, Cavalli G. Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment. Mech Ageing Dev. 2000 Dec 20;121(1-3):251-61. ,

Shanavas A, Papasozomenos SC. tau kinases in the rat heat shock model: possible implications for Alzheimer disease. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14139-44.

Wen C, Levitan D, Li X, Greenwald I. spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14524-9.

Boyle CD, Chackalamannil S, Chen LY, Dugar S, Pushpavanam P, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Duffy RA, Ruperto V, Lachowicz JE. Benzylidene ketal derivatives as M2 muscarinic receptor antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2727-30.

Masel J, Jansen VA. Designing drugs to stop the formation of prion aggregates and other amyloids. Biophys Chem. 2000 Dec 15;88(1-3):47-59.

 

Jafferali S, Dumont Y, Sotty F, Robitaille Y, Quirion R, Kar S. Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains. Synapse. 2000 Dec 15;38(4):450-9.

Neve RL, McPhie DL, Chen Y. Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). Brain Res. 2000 Dec 15;886(1-2):54-66.

Mattson MP. Neuroprotective signaling and the aging brain: take away my food and let me run. Brain Res. 2000 Dec 15;886(1-2):47-53.

Schroeter H, Williams RJ, Matin R, Iversen L, Rice-Evans CA. Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radic Biol Med. 2000 Dec 15;29(12):1222-33.

Yamamoto M, Götz ME, Ozawa H, Luckhaus C, Saito T, Rösler M, Riederer P. Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease. Biochim Biophys Acta. 2000 Dec 15;1535(1):60-8.

Grippa E, Pavone F, Gatto MT, Petrucci R, Marrosu G, Silvestrini B, Saso L. In vitro evaluation of antioxidant activity by electrophoresis and high performance liquid chromatography. Biochim Biophys Acta. 2000 Dec 15;1524(2-3):171-7.

Gulesserian T, Engidawork E, Cairns N, Lubec G. Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome. Neurosci Lett. 2000 Dec 15;296(1):53-7.

Goodenough S, Engert S, Behl C. Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway. Neurosci Lett. 2000 Dec 15;296(1):49-52.

 

Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci Lett. 2000 Dec 15;296(1):17-20. ,

Mueller HT, Borg JP, Margolis B, Turner RS. Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. J Biol Chem. 2000 Dec 15;275(50):39302-6.

Saito Y, Murayama S. Expression of tau immunoreactivity in the spinal motor neurons of Alzheimer's disease. Neurology. 2000 Dec 12;55(11):1727-9.

Wang JC, Kwon JM, Shah P, Morris JC, Goate A. Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease. Neurology. 2000 Dec 12;55(11):1644-9. , ,

 

Csernansky JG, Wang L, Joshi S, Miller JP, Gado M, Kido D, McKeel D, Morris JC, Miller MI. Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type. Neurology. 2000 Dec 12;55(11):1636-43.

Jolly-Tornetta C, Wolf BA. Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells. Biochemistry. 2000 Dec 12;39(49):15282-90.

 

Nakamura S. [Current status of the treatment of Alzheimer's disease] Nippon Naika Gakkai Zasshi. 2000 Dec 10;89(12):2534-40.

  

Wilcock GK, Lilienfeld S, Gaens E. Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomised controlled trial. Galantamine International-1 Study Group. BMJ. 2000 Dec 9;321(7274):1445-9.

Jackson T. Drugs for Alzheimer's disease BMJ. 2000 Dec 9;321(7274):1478B.

Lee KF, Chan JY, Lau KF, Lee WC, Miller CC, Anderton BH, Shaw PC. Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter. Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):150-7.

Szot P, Leverenz JB, Peskind ER, Kiyasu E, Rohde K, Miller MA, Raskind MA. Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease. Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):135-40.

Seiffert D, Mitchell T, Stern AM, Roach A, Zhan Y, Grzanna R. Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing. Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):115-26.

Grossman M. An Atlas of Alzheimer's Disease. Ann Intern Med. 2000 Dec 5;133(11):932.

Kheterpal I, Zhou S, Cook KD, Wetzel R. Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13597-601.

Rodriguez G, Vitali P, Calvini P, Bordoni C, Girtler N, Taddei G, Mariani G, Nobili F. Hippocampal perfusion in mild Alzheimer's disease. Psychiatry Res. 2000 Dec 4;100(2):65-74.

Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC. Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative. Am J Med Genet. 2000 Dec 4;96(6):823-30. ,

Bagli M, Papassotiropoulos A, Jessen F, Schmitz S, Rao ML, Maier W, Heun R. Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population. Am J Med Genet. 2000 Dec 4;96(6):775-7. , ,

Flory JD, Manuck SB, Ferrell RE, Ryan CM, Muldoon MF. Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults. Am J Med Genet. 2000 Dec 4;96(6):707-11.

  

Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec;106(12):1489-99.

 

Kumar A. Alzheimer's disease: amyloid beta-peptide antibody vaccine as plaque remover. J Biosci. 2000 Dec;25(4):315-6.

Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD. No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls. Ann Neurol. 2000 Dec;48(6):950.

Knauber J, Müller WE. Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the alpha(1b)-adrenoceptor. Eur Neuropsychopharmacol. 2000 Dec;10(6):423-7.

Farber NB, Rubin EH, Newcomer JW, Kinscherf DA, Miller JP, Morris JC, Olney JW, McKeel DW. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch Gen Psychiatry. 2000 Dec;57(12):1165-73.

Devenny DA, Krinsky-McHale SJ, Sersen G, Silverman WP. Sequence of cognitive decline in dementia in adults with Down's syndrome. J Intellect Disabil Res. 2000 Dec;44 ( Pt 6):654-65.

Sudo H, Jiang H, Yasukawa T, Hashimoto Y, Niikura T, Kawasumi M, Matsuda S, Takeuchi Y, Aiso S, Matsuoka M, Murayama Y, Nishimoto I. Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein. Mol Cell Neurosci. 2000 Dec 1;16(6):708-23.

Sweet RA, Hamilton RL, Lopez OL, Klunk WE, Wisniewski SR, Kaufer DI, Healy MT, DeKosky ST. Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features. Int Psychogeriatr. 2000 Dec;12(4):547-58.

Spigset O, Wilhelmsson C, Mjörndal T, Eriksson S. Serotonin 5-HT2A receptor binding in platelets from patients with Alzheimer's disease or vascular dementia. Int Psychogeriatr. 2000 Dec;12(4):537-45.

Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H. The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei. Neuropathol Appl Neurobiol. 2000 Dec;26(6):553-67.

Veinbergs I, Mallory M, Sagara Y, Masliah E. Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice. Eur J Neurosci. 2000 Dec;12(12):4541-6.

Mileusnic R, Lancashire CL, Johnston AN, Rose SP. APP is required during an early phase of memory formation. Eur J Neurosci. 2000 Dec;12(12):4487-95.

Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B. Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis. 2000 Dec;7(6 Pt B):682-9.

Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec;7(6 Pt B):673-81.

 

Banerjee C, Nyengaard JR, Wevers A, de Vos RA, Jansen Steur EN, Lindstrom J, Pilz K, Nowacki S, Bloch W, Schröder H. Cellular expression of alpha7 nicotinic acetylcholine receptor protein in the temporal cortex in Alzheimer's and Parkinson's disease--a stereological approach. Neurobiol Dis. 2000 Dec;7(6 Pt B):666-72.

Busiguina S, Fernandez AM, Barrios V, Clark R, Tolbert DL, Berciano J, Torres-Aleman I. Neurodegeneration is associated to changes in serum insulin-like growth factors. Neurobiol Dis. 2000 Dec;7(6 Pt B):657-65.

Sommer B, Barbieri S, Hofele K, Wiederhold K, Probst A, Mistl C, Danner S, Kauffmann S, Spooren W, Tolnay M, Bilbe G, van der Putten H , Kafmann S, Caromi P, Ruegg MA. Mouse models of alpha-synucleinopathy and Lewy pathology. Exp Gerontol. 2000 Dec;35(9-10):1389-403.

Umegaki H, Tamaya N, Shinkai T, Iguchi A. The metabolism of plasma glucose and catecholamines in Alzheimer's disease. Exp Gerontol. 2000 Dec;35(9-10):1373-82.

Hoyer S. Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update. Exp Gerontol. 2000 Dec;35(9-10):1363-72.

Bertram L, Blacker D, Crystal A, Mullin K, Keeney D, Jones J, Basu S, Yhu S, Guénette S, McInnis M, Go R, Tanzi R. Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies. Exp Gerontol. 2000 Dec;35(9-10):1353-61. ,

Pericak-Vance MA, Grubber J, Bailey LR, Hedges D, West S, Santoro L, Kemmerer B, Hall JL, Saunders AM, Roses AD, Small GW, Scott WK, Conneally PM, Vance JM, Haines JL. Identification of novel genes in late-onset Alzheimer's disease. Exp Gerontol. 2000 Dec;35(9-10):1343-52.

Brewer GJ. Neuronal plasticity and stressor toxicity during aging. Exp Gerontol. 2000 Dec 1;35(9-10):1165-83.

de la Torre JC, Stefano GB. Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide. Brain Res Brain Res Rev. 2000 Dec 1;34(3):119-36.

Huang P, Miao S, Fan H, Sheng Q, Yan Y, Wang L, Koide SS. Expression and characterization of the human YWK-II gene, encoding a sperm membrane protein related to the alzheimer betaA4-amyloid precursorprotein. Mol Hum Reprod. 2000 Dec;6(12):1069-78.

Mitchell TW, Nissanov J, Han LY, Mufson EJ, Schneider JA, Cochran EJ, Bennett DA, Lee VM, Trojanowski JQ, Arnold SE. Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. J Histochem Cytochem. 2000 Dec 1;48(12):1627-38.

Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. Am J Pathol. 2000 Dec;157(6):2093-9.

 

Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. Am J Pathol. 2000 Dec;157(6):2003-10. ,

Ding XL, Husseman J, Tomashevski A, Nochlin D, Jin LW, Vincent I. The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol. 2000 Dec;157(6):1983-90.

Hu CJ, Sung SM, Liu HC, Hsu WC, Lee LS, Lee CC, Tsai CH, Chang JG. Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. J Neurol Sci. 2000 Dec 1;181(1-2):127-31. ,

Singleton AB, Hall R, Ballard CG, Perry RH, Xuereb JH, Rubinsztein DC, Tysoe C, Matthews P, Cordell B, Kumar-Singh S, de Jonghe C, Cruts M, van Broeckhoven C, Morris CM. Pathology of early-onset Alzheimer's disease cases bearing the Thr113-114ins presenilin-1 mutation. Brain. 2000 Dec;123 Pt 12:2467-74.

Lee JM. Alzheimer disease Arch Pathol Lab Med. 2000 Dec;124(12):1851.

Barbanti P, Fabbrini G, Ricci A, Bruno G, Cerbo R, Bronzetti E, Amenta F, Luigi Lenzi G. Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's disease. Mech Ageing Dev. 2000 Dec 1;120(1-3):65-75.

da Silva AM, Payão SL, Borsatto B, Bertolucci PH, Smith MA. Quantitative evaluation of the rRNA in Alzheimer's disease. Mech Ageing Dev. 2000 Dec 1;120(1-3):57-64.

Harwood DG, Barker WW, Ownby RL, Bravo M, Aguero H, Duara R. Depressive symptoms in Alzheimer's disease. An examination among community-dwelling Cuban American patients. Am J Geriatr Psychiatry. 2000 Winter;8(1):84-91.

Magai C, Kennedy G, Cohen CI, Gomberg D. A controlled clinical trial of sertraline in the treatment of depression in nursing home patients with late-stage Alzheimer's disease. Am J Geriatr Psychiatry. 2000 Winter;8(1):66-74.

Sands LP, Phinney A, Katz IR. Monitoring Alzheimer's patients for acute changes in cognitive functioning. Am J Geriatr Psychiatry. 2000 Winter;8(1):47-56.

Jeste DV, Finkel SI. Psychosis of Alzheimer's disease and related dementias. Diagnostic criteria for a distinct syndrome. Am J Geriatr Psychiatry. 2000 Winter;8(1):29-34.

Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability. J Neurosci. 2000 Dec 1;20(23):8717-26.

 

Shoji M. [The progress of Alzheimer's disease research biomarkers--sensitivity and specificity] Rinsho Shinkeigaku. 2000 Dec;40(12):1234-6.

Ohta S. [Roles of mitochondrial dysfunctions in Alzheimer's disease--contribution of deficiency of ALDH 2] Rinsho Shinkeigaku. 2000 Dec;40(12):1231-3.

Iwatsubo T. [beta-amyloid cascade: current status and future directions] Rinsho Shinkeigaku. 2000 Dec;40(12):1228-30.

Yanagisawa K. [Risk factors for Alzheimer's disease] Rinsho Shinkeigaku. 2000 Dec;40(12):1225-7.

Lambat Z, Conrad N, Anoopkumar-Dukie S, Walker RB, Daya S. An investigation into the neuroprotective properties of ibuprofen. Metab Brain Dis. 2000 Dec;15(4):249-56.

van Rensburg SJ, Berman PA, Potocnik FC, Taljaard JJ. Glycosylation of transferrin in Alzheimer's disease and alcohol-induced dementia. Metab Brain Dis. 2000 Dec;15(4):243-7.

Negrón AE, Reichman WE. Risperidone in the treatment of patients with Alzheimer's disease with negative symptoms. Int Psychogeriatr. 2000 Dec;12(4):527-36.

Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG. Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. EMBO Rep. 2000 Dec;1(6):530-5.

 

Periz G, Fortini ME. Proteolysis in Alzheimer's disease. Can plasmin tip the balance? EMBO Rep. 2000 Dec;1(6):477-8.

Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nat Rev Mol Cell Biol. 2000 Dec;1(3):217-24.

Halbreich U, Kahn LS. Selective oestrogen receptor modulators--current and future brain and behaviour applications. Expert Opin Pharmacother. 2000 Dec;1(7):1385-98.

Lücking CB, Brice A. Alpha-synuclein and Parkinson's disease. Cell Mol Life Sci. 2000 Dec;57(13-14):1894-908.

Primot A, Baratte B, Gompel M, Borgne A, Liabeuf S, Romette JL, Jho EH, Costantini F, Meijer L. Purification of GSK-3 by affinity chromatography on immobilized axin. Protein Expr Purif. 2000 Dec;20(3):394-404.

Ikonomovic MD, Nocera R, Mizukami K, Armstrong DM. Age-related loss of the AMPA receptor subunits GluR2/3 in the human nucleus basalis of Meynert. Exp Neurol. 2000 Dec;166(2):363-75.

Zhang J, Johnson GV. Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells. J Neurochem. 2000 Dec;75(6):2346-57.

Pillot T, Drouet B, Pinçon-Raymond M, Vandekerckhove J, Rosseneu M, Chambaz J. A nonfibrillar form of the fusogenic prion protein fragment [118-135] induces apoptotic cell death in rat cortical neurons. J Neurochem. 2000 Dec;75(6):2298-308.

Toliver-Kinsky T, Wood T, Perez-Polo JR. Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells. J Neurochem. 2000 Dec;75(6):2241-51.

Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol. 2000 Dec 1;279(6):C1772-81.

Kok CC, Boyt A, Gaudieri S, Martins R, Askanas V, Dalakas M, Kiers L, Mastaglia F, Garlepp M. Mitochondrial DNA variants in inclusion body myositis. Neuromuscul Disord. 2000 Dec;10(8):604-11.

Liu Z, Chen J. [The research advance of brain derived neurotrophic factor] Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2000 Dec;17(4):454-6, 460.

Giannetti AM, Lindwall G, Chau MF, Radeke MJ, Feinstein SC, Kohlstaedt LA. Fibers of tau fragments, but not full length tau, exhibit a cross beta-structure: implications for the formation of paired helical filaments. Protein Sci. 2000 Dec;9(12):2427-35.

Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids. 2000 Dec;35(12):1305-12.

Uchihara T, Nakamura A, Nagaoka U, Yamazaki M, Mori O. Dual enhancement of double immunofluorescent signals by CARD: participation of ubiquitin during formation of neurofibrillary tangles. Histochem Cell Biol. 2000 Dec;114(6):447-51.

Okamura N, Shinkawa M, Arai H, Matsui T, Nakajo K, Maruyama M, Hu XS, Sasaki H. [Prediction of progression in patients with mild cognitive impairment using IMP-SPECT] Nippon Ronen Igakkai Zasshi. 2000 Dec;37(12):974-8.

Almkvist O. Functional brain imaging as a looking-glass into the degraded brain: reviewing evidence from Alzheimer disease in relation to normal aging. Acta Psychol (Amst). 2000 Dec;105(2-3):255-77.

Baladi JF, Bailey PA, Black S, Bouchard RW, Farcnik KD, Gauthier S, Kertesz A, Mohr E, Robillard A. Rivastigmine for Alzheimer's disease: Canadian interpretation of intermediate outcome measures and cost implications. Clin Ther. 2000 Dec;22(12):1549-61.

Butcher J. Alzheimer's amyloid hypothesis gains support. Lancet. 2000 Dec 23-30;356(9248):2161.

Peinado MA, del Moral ML, Esteban FJ, Martínez-Lara E, Siles E, Jiménez A, Hernández-Cobo R, Blanco S, Rodrigo J, Pedrosa JA. [Aging and neurodegeneration: molecular and cellular bases] Rev Neurol. 2000 Dec 1-15;31(11):1054-65.

Issa AM, Keyserlingk EW. Apolipoprotein E genotyping for pharmacogenetic purposes in Alzheimer's disease: emerging ethical issues. Can J Psychiatry. 2000 Dec;45(10):917-22.

Daniel PT. Dissecting the pathways to death. Leukemia. 2000 Dec;14(12):2035-44.

Court JA, Martin-Ruiz C, Graham A, Perry E. Nicotinic receptors in human brain: topography and pathology. J Chem Neuroanat. 2000 Dec;20(3-4):281-98.

Dick MB, Hsieh S, Dick-Muehlke C, Davis DS, Cotman CW. The variability of practice hypothesis in motor learning: does it apply to Alzheimer's disease? Brain Cogn. 2000 Dec;44(3):470-89.

St George-Hyslop PH. Piecing together Alzheimer's. Sci Am. 2000 Dec;283(6):76-83.

Goldstein S, Lestage P. Chemical and pharmacological aspects of heteroaryl-nitrones. Curr Med Chem. 2000 Dec;7(12):1255-67.

McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. FASEB J. 2000 Dec;14(15):2383-6.

Villeponteau B, Cockrell R, Feng J. Nutraceutical interventions may delay aging and the age-related diseases. Exp Gerontol. 2000 Dec;35(9-10):1405-17.

Petanceska SS, Nagy V, Frail D, Gandy S. Ovariectomy and 17beta-estradiol modulate the levels of Alzheimer's amyloid beta peptides in brain. Exp Gerontol. 2000 Dec;35(9-10):1317-25.

Ferrari E, Arcaini A, Gornati R, Pelanconi L, Cravello L, Fioravanti M, Solerte SB, Magri F. Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. Exp Gerontol. 2000 Dec;35(9-10):1239-50.

Vanderstichele H, Van Kerschaver E, Hesse C, Davidsson P, Buyse MA, Andreasen N, Minthon L, Wallin A, Blennow K, Vanmechelen E. Standardization of measurement of beta-amyloid(1-42) in cerebrospinal fluid and plasma. Amyloid. 2000 Dec;7(4):245-58.

Nicholson SJ, Witherden AS, Hafezparast M, Martin JE, Fisher EM. Mice, the motor system, and human motor neuron pathology. Mamm Genome. 2000 Dec;11(12):1041-52.

Bae CY, Cho CY, Cho K, Hoon Oh B, Choi KG, Lee HS, Jung SP, Kim DH, Lee S, Choi GD, Cho H, Lee H. A double-blind, placebo-controlled, multicenter study of Cerebrolysin for Alzheimer's disease. J Am Geriatr Soc. 2000 Dec 1;48(12):1566-71.

Brotman DJ, Eberhart CG, Burger PC, McArthur JC, Hellmann DB. Primary angiitis of the central nervous system and Alzheimer's disease: clinically and pathologically evident in a single patient. J Rheumatol. 2000 Dec;27(12):2935-7.

Demers L, Oremus M, Perrault A, Champoux N, Wolfson C. Review of outcome measurement instruments in Alzheimer's disease drug trials: psychometric properties of functional and quality of life scales. J Geriatr Psychiatry Neurol. 2000 Winter;13(4):170-80.

Alvarez-Arcaya A, Combarros O, Llorca J, Sánchez-Guerra M, Berciano J, Fernández-Viadero C, Peña N. The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women. Acta Neurol Scand. 2000 Dec;102(6):350-3. ,

Ihara Y, Hayabara T, Sasaki K, Kawada R, Nakashima Y, Kuroda S. Relationship between oxidative stress and apoE phenotype in Alzheimer's disease. Acta Neurol Scand. 2000 Dec;102(6):346-9.

Konsman JP, Blond D, Vigues S. Neurobiology of interleukin-1 receptors: getting the message. Eur Cytokine Netw. 2000 Dec;11(4):699-702.

Burt T. Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents. Curr Psychiatry Rep. 2000 Dec;2(6):473-8.

Chung YH, Shin C, Kim MJ, Lee B, Park KH, Cha CI. Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat. Brain Res. 2000 Dec 1;885(1):137-41.

Togo T, Akiyama H, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res. 2000 Dec 1;885(1):117-21.

Nitsch RM, Deng M, Tennis M, Schoenfeld D, Growdon JH. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol. 2000 Dec 1;48(6):913-8.

    

Ballard C, Piggott M, Johnson M, Cairns N, Perry R, McKeith I, Jaros E, O'Brien J, Holmes C, Perry E. Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Ann Neurol. 2000 Dec;48(6):868-76.

Sumi N, Nan'no H, Fujimoto O, Ohta Y, Takeda M. Interpeak latency of auditory event-related potentials (P300) in senile depression and dementia of the Alzheimer type. Psychiatry Clin Neurosci. 2000 Dec;54(6):679-84.

Asada T, Motonaga T, Kinoshita T. Predictors of severity of behavioral disturbance among community-dwelling elderly individuals with Alzheimer's disease: a 6-year follow-up study. Psychiatry Clin Neurosci. 2000 Dec;54(6):673-7.

Shinosaki K, Nishikawa T, Takeda M. Neurobiological basis of behavioral and psychological symptoms in dementia of the Alzheimer type. Psychiatry Clin Neurosci. 2000 Dec;54(6):611-20.

Feinberg AW. Statins & Alzheimer's. Health News. 2000 Dec;6(12):1.

Geldmacher DS. Conflicting priorities in Alzheimer's care, primary care, and managed care: who pays the price? Am J Manag Care. 2000 Dec;6(22 Suppl):S1161-4.

Fillit HM. Managed care decisions in Alzheimer's disease. Am J Manag Care. 2000 Dec;6(22 Suppl):S1149-55; discussion S1156-60.

Fillit HM. The pharmacoeconomics of Alzheimer's disease. Am J Manag Care. 2000 Dec;6(22 Suppl):S1139-44; discussion S1145-8.

Reichman WE. Alzheimer's disease: clinical treatment options. Am J Manag Care. 2000 Dec;6(22 Suppl):S1125-32; discussion S1133-8.

Relkin N. Screening and early diagnosis of dementia. Am J Manag Care. 2000 Dec;6(22 Suppl):S1111-8; discussion S1119-24.

  

Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):982-5.

    

  

Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):979-82. ,

    

  

Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 2000 Dec 21-28;408(6815):975-9.

 

Terry RD. Cell death or synaptic loss in Alzheimer disease. J Neuropathol Exp Neurol. 2000 Dec;59(12):1118-9.

Takeuchi M, Bucala R, Suzuki T, Ohkubo T, Yamazaki M, Koike T, Kameda Y, Makita Z. Neurotoxicity of advanced glycation end-products for cultured cortical neurons. J Neuropathol Exp Neurol. 2000 Dec;59(12):1094-105.

Rothwell NJ, Luheshi GN. Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 2000 Dec;23(12):618-25.

Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC. The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease. Prog Neurobiol. 2000 Dec 1;62(6):633-48.

Ptok U, Papassotiropoulos A, Maier W, Heun R. Advanced parental age: a risk factor for Alzheimer's disease or depression in the elderly? Int Psychogeriatr. 2000 Dec;12(4):445-51.

Zou J, Sugimoto N. Complexation of peptide with Cu2+ responsible to inducing and enhancing the formation of alpha-helix conformation. Biometals. 2000 Dec;13(4):349-59.

Kaplan M, Henderson AR. Solomon Carter Fuller, M.D. (1872-1953): American pioneer in Alzheimer's disease research. J Hist Neurosci. 2000 Dec;9(3):250-61.

Satoh J, Kuroda Y. Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors. Neuropathology. 2000 Dec;20(4):289-96.

Otsuka M. [Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia] Nippon Ronen Igakkai Zasshi. 2000 Dec;37(12):970-3.

Umegaki H. [The changes of peripheral-central nervous system interaction in Alzheimer's disease] Nippon Ronen Igakkai Zasshi. 2000 Dec;37(12):966-9.

Sakurai T, Yang B, Takata T, Yokono K. [Exogenous lactate sustains synaptic activity and neuronal viability, but fails to induce long-term potentiation (LTP)] Nippon Ronen Igakkai Zasshi. 2000 Dec;37(12):962-5.

Forman MS, Lee VM, Trojanowski JQ. New insights into genetic and molecular mechanisms of brain degeneration in tauopathies. J Chem Neuroanat. 2000 Dec;20(3-4):225-44.

Durany N, Michel T, Kurt J, Cruz-Sánchez FF, Cervás-Navarro J, Riederer P. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. Int J Dev Neurosci. 2000 Dec;18(8):807-13.

Ortiz Alonso T, Martínez Castillo E, Fernández Lucas A, Arrazola García J, Maestú Unturbe F, López-Ibor JJ. Callosal atrophy and associated electromyographic responses in Alzheimer's disease and aging. Electromyogr Clin Neurophysiol. 2000 Dec;40(8):465-75.

Kalmijn S, Mehta KM, Pols HA, Hofman A, Drexhage HA, Breteler MM. Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin Endocrinol (Oxf). 2000 Dec;53(6):733-7.

Yao FS, Caserta MT, Wyrwicz AM. In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development. Int J Dev Neurosci. 2000 Dec;18(8):833-41.

Algotsson A, Nordberg A, Winblad B. Apolipoprotein E varepsilon4 allele has an impact on vascular reactivity in Alzheimer's disease. Arch Gerontol Geriatr. 2000 Dec;31(3):221-231.

Hoffmann J, Twiesselmann C, Kummer MP, Romagnoli P, Herzog V. A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. Eur J Cell Biol. 2000 Dec 1;79(12):905-14.

Gurd JM, Herzberg L, Joachim C, Marshall JC, Jobst K, McShane RH, Hindley NJ, King EE. Dementia with Lewy bodies: a pure case. Brain Cogn. 2000 Dec;44(3):307-23.

Yang JD, Feng G, Zhang J, Lin ZX, Shen T, Breen G, St Clair D, He L. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese. Neurosci Lett. 2000 Dec 1;295(1-2):41-4. ,

Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP, Pyrek JS, Estus S, Hersh LB. Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. J Neurosci. 2000 Dec 1;20(23):8745-9.

 

McCurry SM, Reynolds CF, Ancoli-Israel S, Teri L, Vitiello MV. Treatment of sleep disturbance in Alzheimer's disease. Sleep Med Rev. 2000 Dec;4(6):603-628.

Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase. J Biol Chem. 2000 Dec 1;275(48):37712-7.

Kumar VB, Farr SA, Flood JF, Kamlesh V, Franko M, Banks WA, Morley JE. Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice. Peptides. 2000 Dec 1;21(12):1769-75.

Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2000 Dec;2(12):863-70.

 

Rafael H, Mego R, Moromizato P, Espinoza M. Omental transplantation for Alzheimer's disease. Neurol India. 2000 Dec;48(4):319-21.

Niwa K, Carlson GA, Iadecola C. Exogenous A beta1-40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. J Cereb Blood Flow Metab. 2000 Dec;20(12):1659-68.