Alzheimer's Research Updates ~ November 2010

Lee KH, Park JH, Won R, Lee H, Nam TS, Lee BH. Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture. J Neurosci Res. 2011 Jan;89(1):96-107. PubMed Abstract
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Michalke B, Nischwitz V. Review on metal speciation analysis in cerebrospinal fluid-current methods and results: A review. Anal Chim Acta. 2010 Dec 3;682(1-2):23-36. PubMed Abstract
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Saxena U. Alzheimer's disease amyloid hypothesis at crossroads: where do we go from here? Expert Opin Ther Targets. 2010 Dec;14(12):1273-7. PubMed Abstract
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Cumming T, Brodtmann A. Dementia and stroke: the present and future epidemic. Int J Stroke. 2010 Dec;5(6):453-4. PubMed Abstract
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Maheshwari M, Roberts JK, Desutter B, Duong KT, Tingling J, Fawver JN, Schall HE, Kahle M, Murray IV. Hydralazine Modifies Aß Fibril Formation and Prevents Modification by Lipids in Vitro. Biochemistry. 2010 Nov 17; PubMed Abstract
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Womack KB, Diaz-Arrastia R, Aizenstein HJ, Arnold SE, Barbas NR, Boeve BF, Clark CM, Decarli CS, Jagust WJ, Leverenz JB, Peskind ER, Turner RS, Zamrini EY, Heidebrink JL, Burke JR, Dekosky ST, Farlow MR, Gabel MJ, Higdon R, Kawas CH, Koeppe RA, Lipton AM, Foster NL. Temporoparietal Hypometabolism in Frontotemporal Lobar Degeneration and Associated Imaging Diagnostic Errors. Arch Neurol. 2010 Nov 12; PubMed Abstract
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Hong XP, Peng CX, Wei W, Tian Q, Liu YH, Cao FY, Wang Q, Wang JZ. Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3ß Activity in Subventricular Zone. Neurochem Res. 2010 Nov 9; PubMed Abstract
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Craik FI, Bialystok E, Freedman M. Delaying the onset of Alzheimer disease: Bilingualism as a form of cognitive reserve. Neurology. 2010 Nov 9;75(19):1726-9. PubMed Abstract

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Rodríguez-Rodríguez C, Rimola A, Alí-Torres J, Sodupe M, González-Duarte P. In silico strategies for the selection of chelating compounds with potential application in metal-promoted neurodegenerative diseases. J Comput Aided Mol Des. 2010 Nov 9; PubMed Abstract
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Robins Wahlin TB, Byrne GJ. Personality changes in Alzheimer's disease: a systematic review. Int J Geriatr Psychiatry. 2010 Nov 9; PubMed Abstract
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Takahashi RH, Tobiume M, Sato Y, Sata T, Gouras GK, Takahashi H. Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain. Neuropathology. 2010 Nov 9; PubMed Abstract
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Smith P, Al Hashimi A, Girard J, Delay C, Hébert SS. In vivo regulation of Amyloid precursor protein neuronal splicing by microRNAs. J Neurochem. 2010 Nov 9; PubMed Abstract
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Ludwig J, Höffle-Maas A, Samochocki M, Luttmann E, Albuquerque EX, Fels G, Maelicke A. Localization by site-directed mutagenesis of a galantamine binding site on a7 nicotinic acetylcholine receptor extracellular domain. J Recept Signal Transduct Res. 2010 Nov 9; PubMed Abstract
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Chen J, Armstrong AH, Koehler AN, Hecht MH. Small Molecule Microarrays Enable the Discovery of Compounds That Bind the Alzheimer's Aß Peptide and Reduce its Cytotoxicity. J Am Chem Soc. 2010 Nov 9; PubMed Abstract
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Sato Y, Nakamura T, Aoshima K, Oda Y. Quantitative and Wide-Ranging Profiling of Phospholipids in Human Plasma by Two-dimensional Liquid Chromatography/Mass Spectrometry. Anal Chem. 2010 Nov 9; PubMed Abstract
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García-Macia M, Vega-Naredo I, De Gonzalo-Calvo D, Rodríguez-González SM, Camello PJ, Camello-Almaraz C, Martín-Cano FE, Rodríguez-Colunga MJ, Pozo MJ, Coto-Montes AM. Melatonin induces neural SOD2 expression independent of the NF-kappaB pathway and improves the mitochondrial population and function in old mice. J Pineal Res. 2010 Nov 9; PubMed Abstract
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Nagaishi M, Yokoo H, Nakazato Y. Tau-positive glial cytoplasmic granules in multiple system atrophy. Neuropathology. 2010 Nov 9; PubMed Abstract
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Wu UI, Mai FD, Sheu JN, Chen LY, Liu YT, Huang HC, Chang HM. Melatonin inhibits microglial activation, reduces pro-inflammatory cytokine levels, and rescues hippocampal neurons of adult rats with acute Klebsiella pneumoniae meningitis. J Pineal Res. 2010 Nov 9; PubMed Abstract
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Brady OA, Meng P, Zheng Y, Mao Y, Hu F. Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1. J Neurochem. 2010 Nov 9; PubMed Abstract
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Fiala M, Chattopadhay M, La Cava A, Tse E, Liu G, Lourenco E, Eskin A, Liu PT, Magpantay L, Tse S, Mahanian M, Weitzman R, Tong J, Nguyen C, Cho T, Koo P, Sayre J, Martinez-Maza O, Rosenthal MJ, Wiedau-Pazos M. IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients. J Neuroinflammation. 2010 Nov 9;7(1):76. PubMed Abstract
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Rhodes SL, Sinsheimer JS, Bordelon Y, Bronstein JM, Ritz B. Replication of GWAS Associations for GAK and MAPT in Parkinson's Disease. Ann Hum Genet. 2010 Nov 8; PubMed Abstract
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Frye CA, Paris JJ. Progesterone turnover to its 5alpha-reduced metabolites in the ventral tegmental area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female rats. J Endocrinol Invest. 2010 Nov 8; PubMed Abstract

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Bilsland LG, Sahai E, Kelly G, Golding M, Greensmith L, Schiavo G. Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A. 2010 Nov 8; PubMed Abstract
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Magill ST, Cambronne XA, Luikart BW, Lioy DT, Leighton BH, Westbrook GL, Mandel G, Goodman RH. microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus. Proc Natl Acad Sci U S A. 2010 Nov 8; PubMed Abstract
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Campbell GR, Ziabreva I, Reeve AK, Krishnan KJ, Reynolds R, Howell O, Lassmann H, Turnbull DM, Mahad DJ. Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis. Ann Neurol. 2010 Nov 8; PubMed Abstract
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Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. {beta}-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J. 2010 Nov 8; PubMed Abstract
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Lee JH, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, Jiménez-Velazquez IZ, Rogaeva E, St George-Hyslop PH, Mayeux R. Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals. Arch Neurol. 2010 Nov 8; PubMed Abstract
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Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA. Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol. 2010 Nov 8; PubMed Abstract

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Shearer J, Callan PE, Tran T, Szalai VA. Cu K-edge X-ray absorption spectroscopy reveals differential copper coordination within amyloid-ß oligomers compared to amyloid-ß monomers. Chem Commun (Camb). 2010 Nov 8; PubMed Abstract
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Lasagna-Reeves CA, Castillo-Carranza DL, Guerrero-Mun~oz MJ, Jackson GR, Kayed R. Preparation and Characterization of Neurotoxic Tau Oligomers. Biochemistry. 2010 Nov 8; PubMed Abstract
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Dadon-Nachum M, Melamed E, Offen D. The "Dying-Back" Phenomenon of Motor Neurons in ALS. J Mol Neurosci. 2010 Nov 7; PubMed Abstract
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van Tijn P, Hobo B, Verhage MC, Oitzl MS, Van Leeuwen FW, Fischer DF. Alzheimer-associated mutant ubiquitin impairs spatial reference memory. Physiol Behav. 2010 Nov 6; PubMed Abstract
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Terry AV, Kutiyanawalla A, Pillai A. Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats. Physiol Behav. 2010 Nov 6; PubMed Abstract
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Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M. Amyloid Fibril Recognition with the Conformational B10 Antibody Fragment Depends on Electrostatic Interactions. J Mol Biol. 2010 Nov 6; PubMed Abstract
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Mievis S, Blum D, Ledent C. A(2A) receptor knockout worsens survival and motor behavior in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2010 Nov 6; PubMed Abstract
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Xing YY, Yu JT, Yan WJ, Chen W, Zhong XL, Jiang H, Wang P, Tan L. NEDD9 is genetically associated with Alzheimer's disease in a Han Chinese population. Brain Res. 2010 Nov 5; PubMed Abstract
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Legradi A, Varszegi S, Szigeti C, Gulya K. Adult rat hippocampal slices as in vitro models for neurodegeneration: Studies on cell viability and apoptotic processes. Brain Res Bull. 2010 Nov 5; PubMed Abstract
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Baek SB, Bahn G, Moon SJ, Lee J, Kim KH, Ko IG, Kim SE, Sung YH, Kim BK, Kim TS, Kim CJ, Shin MS. The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances cell proliferation in the hippocampus of maternal-separated rat pups. Neurosci Lett. 2010 Nov 5; PubMed Abstract
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Fujioka A, Fujioka T, Tsuruta R, Izumi T, Kasaoka S, Maekawa T. Effects of a constant light environment on hippocampal neurogenesis and memory in mice. Neurosci Lett. 2010 Nov 5; PubMed Abstract
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Bauereis B, Haskins WE, Lebaron RG, Renthal R. Proteomic insights into the protective mechanisms of an in vitro oxidative stress model of early stage Parkinson's disease. Neurosci Lett. 2010 Nov 5; PubMed Abstract
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Greene JG. Current status and future directions of gene expression profiling in Parkinson's disease. Neurobiol Dis. 2010 Nov 5; PubMed Abstract
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Hsieh HM, Wu WM, Hu ML. Genistein attenuates D-galactose-induced oxidative damage through decreased reactive oxygen species and NF-?B binding activity in neuronal PC12 cells. Life Sci. 2010 Nov 5; PubMed Abstract
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Chow KM, Guan H, Hersh LB. Aminopeptidases do not directly degrade tau protein. Mol Neurodegener. 2010 Nov 5;5(1):48. PubMed Abstract
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Lange C, Mix E, Frahm J, Glass A, Müller J, Schmitt O, Schmöle AC, Klemm K, Ortinau S, Hübner R, Frech MJ, Wree A, Rolfs A. Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells. Neurosci Lett. 2010 Nov 5; PubMed Abstract
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Park HJ, Bang G, Lee BR, Kim HO, Lee PH. Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy-parkinsonism. Cell Transplant. 2010 Nov 5; PubMed Abstract
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Motawaj M, Burban A, Davenas E, Arrang JM. ACTIVATION OF BRAIN HISTAMINERGIC NEUROTRANSMISSION: A MECHANISM FOR COGNITIVE EFFECTS OF MEMANTINE IN ALZHEIMER'S DISEASE. J Pharmacol Exp Ther. 2010 Nov 5; PubMed Abstract
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Lewis KA, Su Y, Jou O, Ritchie C, Foong C, Hynan LS, White CL, Thomas PJ, Hatanpaa KJ. Abnormal Neurites Containing C-Terminally Truncated {alpha}-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology. Am J Pathol. 2010 Nov 5; PubMed Abstract
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Sankari Z, Adeli H, Adeli A. Intrahemispheric, interhemispheric, and distal EEG coherence in Alzheimer's disease. Clin Neurophysiol. 2010 Nov 5; PubMed Abstract
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Toyn JH, Lin XA, Thompson MW, Guss V, Meredith JE, Sankaranarayanan S, Barrezueta N, Corradi J, Majumdar A, Small DL, Hansard M, Lanthorn T, Westphal RS, Albright CF. Viable mouse gene ablations that robustly alter brain Abeta levels are rare. BMC Neurosci. 2010 Nov 5;11(1):143. PubMed Abstract
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McCampbell A, Wessner K, Marlatt MW, Wolffe C, Toolan D, Podtelezhnikov A, Yeh S, Zhang R, Szczerba P, Tanis KQ, Majercak J, Ray WJ, Savage M. Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine. J Neurochem. 2010 Nov 5; PubMed Abstract
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Salminen A, Ojala J, Kaarniranta K, Hiltunen M, Soininen H. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog Neurobiol. 2010 Nov 5; PubMed Abstract
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van Tijn P, Kamphuis W, Marlatt MW, Hol EM, Lucassen PJ. Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis. Prog Neurobiol. 2010 Nov 5; PubMed Abstract
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Hatipoglu MG, Kabay SC, Güven G. The clinical evaluation of the oral status in Alzheimer-type dementia patients. Gerodontology. 2010 Nov 5; PubMed Abstract
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Hidalgo C, Carrasco MA. Redox Control of Brain Calcium in Health and Disease. Antioxid Redox Signal. 2010 Nov 5; PubMed Abstract
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Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han YH, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G. Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes. J Biol Chem. 2010 Nov 4; PubMed Abstract

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Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn D. Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies. Curr Top Med Chem. 2010 Nov 4; PubMed Abstract
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Pascual B, Prieto E, Arbizu J, Marti-Climent J, Olier J, Masdeu JC. Brain Glucose Metabolism in Vascular White Matter Disease With Dementia. Differentiation From Alzheimer Disease. Stroke. 2010 Nov 4; PubMed Abstract
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Galanakis PA, Bazoti FN, Bergquist J, Markides K, Spyroulias GA, Tsarbopoulos A. Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by NMR spectroscopy. Biopolymers. 2010 Nov 4; PubMed Abstract
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Rahman A, Brew BJ, Guillemin GJ. Lead Dysregulates Serine/Threonine Protein Phosphatases in Human Neurons. Neurochem Res. 2010 Nov 4; PubMed Abstract
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Cordner Z, Blass DM, Rabins PV, Black BS. Quality of Life in Nursing Home Residents with Advanced Dementia. J Am Geriatr Soc. 2010 Nov 4; PubMed Abstract
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Sgourakis NG, Merced-Serrano M, Boutsidis C, Drineas P, Du Z, Wang C, Garcia AE. Atomic-level characterization of the ensemble of the Aß(1-42) monomer in water using unbiased Molecular Dynamics simulations and spectral algorithms. J Mol Biol. 2010 Nov 4; PubMed Abstract
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Bohic S, Ghersi-Egea JF, Gibon J, Paoletti P, Arnaud J, Hunot S, Boom A, Bouron A. [Biological roles of trace elements in the brain with special focus on Zn and Fe.] Rev Neurol (Paris). 2010 Nov 4; PubMed Abstract
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Kaleem A, Hoessli DC, Ul-Haq I, Walker-Nasir E, Butt A, Iqbal Z, Zamani Z, Shakoori AR, Ud-Din N. CREB in long term potentiation in hippocampus: Role of post-translational modifications - studies In silico. J Cell Biochem. 2010 Nov 4; PubMed Abstract
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McQuiston AR. Mu opioid receptor activation normalizes temporo-ammonic pathway driven inhibition in hippocampal CA1. Neuropharmacology. 2010 Nov 4; PubMed Abstract
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Klöppel C, Michels C, Zimmer J, Herrmann JM, Riemer J. In yeast redistribution of Sod1 to the mitochondrial intermembrane space provides protection against respiration derived oxidative stress. Biochem Biophys Res Commun. 2010 Nov 4; PubMed Abstract
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Ferland CL, Schrader LA. Regulation of histone acetylation in the hippocampus of chronically stressed rats: A potential role of sirtuins. Neuroscience. 2010 Nov 4; PubMed Abstract
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Small G, Bullock R. Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease. Alzheimers Dement. 2010 Nov 3; PubMed Abstract
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Matsuoka T, Narumoto J, Shibata K, Okamura A, Nakamura K, Nakamae T, Yamada K, Nishimura T, Fukui K. Neural correlates of performance on the different scoring systems of the clock drawing test. Neurosci Lett. 2010 Nov 3; PubMed Abstract
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Li L, Ding J, Marshall C, Gao J, Hu G, Xiao M. Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice. Behav Brain Res. 2010 Nov 3; PubMed Abstract
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Hedskog L, Petersen CA, Svensson AI, Welander H, Tjernberg LO, Karlström H, Ankarcrona M. Gamma-secretase Complexes Containing Caspase-cleaved Presenilin-1 Increase Intracellular Aß42/Aß40 Ratio. J Cell Mol Med. 2010 Nov 3; PubMed Abstract
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Kim YH, Lussier S, Rane A, Choi SW, Andersen JK. Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction. Neuroscience. 2010 Nov 3; PubMed Abstract
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Baltanás FC, Casafont I, Weruaga E, Alonso JR, Berciano MT, Lafarga M. Nucleolar disruption and Cajal body disassembly are nuclear hallmarks of DNA damage-induced neurodegeneration in Purkinje cells. Brain Pathol. 2010 Nov 3; PubMed Abstract
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Polvikoski TM, van Straaten EC, Barkhof F, Sulkava R, Aronen HJ, Niinistö L, Oinas M, Scheltens P, Erkinjuntti T, Kalaria RN. Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old. Neurology. 2010 Nov 3; PubMed Abstract
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Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology. 2010 Nov 3; PubMed Abstract
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Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. J Neurosci. 2010 Nov 3;30(44):14915-24. PubMed Abstract
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Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem. 2010 Nov 3; PubMed Abstract
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Torpy JM, Lynm C, Glass RM. JAMA patient page. Dementia. JAMA. 2010 Nov 3;304(17):1972. PubMed Abstract
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Winker MA. Themes of aging: preserving function, improving care. JAMA. 2010 Nov 3;304(17):1954-5. PubMed Abstract
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Serem WK, Bett CK, Ngunjiri JN, Garno JC. Studies of the growth, evolution, and self-aggregation of ß-amyloid fibrils using tapping-mode atomic force microscopy. Microsc Res Tech. 2010 Nov 3; PubMed Abstract
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Mulugeta E, Londos E, Ballard C, Alves G, Zetterberg H, Blennow K, Skogseth R, Minthon L, Aarsland D. CSF amyloid {beta}38 as a novel diagnostic marker for dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2010 Nov 3; PubMed Abstract
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Zhang H, Trollor JN, Wen W, Zhu W, Crawford JD, Kochan NA, Slavin MJ, Brodaty H, Reppermund S, Kang K, Mather KA, Sachdev PS. Grey matter atrophy of basal forebrain and hippocampus in mild cognitive impairment. J Neurol Neurosurg Psychiatry. 2010 Nov 3; PubMed Abstract
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Head MW, Lowrie S, Chohan G, Knight R, Scoones DJ, Ironside JW. Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, a synuclein and Aß pathology. Acta Neuropathol. 2010 Nov 3; PubMed Abstract
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Trexler AJ, Rhoades E. Single molecule characterization of a-synuclein in aggregation-prone states. Biophys J. 2010 Nov 3;99(9):3048-55. PubMed Abstract
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Krave U, Al-Olama M, Hansson HA. Rotational acceleration closed head flexion trauma generates more extensive diffuse brain injury than extension. J Neurotrauma. 2010 Nov 3; PubMed Abstract
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Chen L, Chatterjee M, Li JY. The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci. 2010 Nov 3;30(44):14824-34. PubMed Abstract
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Eadie BD, Cushman J, Kannangara TS, Fanselow MS, Christie BR. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus. 2010 Nov 3; PubMed Abstract
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Sivaswamy S, Neafsey EJ, Collins MA. Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector heat shock proteins. Eur J Neurosci. 2010 Nov 3; PubMed Abstract
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Steele ML, Robinson SR. Reactive astrocytes give neurons less support: implications for Alzheimer's disease. Neurobiol Aging. 2010 Nov 2; PubMed Abstract
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Schuitemaker A, van der Doef TF, Boellaard R, van der Flier WM, Yaqub M, Windhorst AD, Barkhof F, Jonker C, Kloet RW, Lammertsma AA, Scheltens P, van Berckel BN. Microglial activation in healthy aging. Neurobiol Aging. 2010 Nov 2; PubMed Abstract

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Han LC, Zhang H, Wang W, Wei YY, Sun XX, Yanagawa Y, Li YQ, Xu LX, Wu SX. The Effect of Sevoflurane Inhalation on Gabaergic Neurons Activation: Observation on the GAD67-GFP Knock-In Mouse. Anat Rec (Hoboken). 2010 Nov 2; PubMed Abstract
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Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frankl M, Rothstein JD. Molecular comparison of GLT1(+) and ALDH1L1(+) astrocytes in vivo in astroglial reporter mice. Glia. 2010 Nov 2; PubMed Abstract
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Tarantino P, De Marco EV, Annesi G, Rocca FE, Annesi F, Civitelli D, Provenzano G, Scornaienchi V, Greco V, Colica C, Nicoletti G, Quattrone A. Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2010 Nov 2; PubMed Abstract
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Parga JA, Rodríguez-Pallares J, Joglar B, Diaz-Ruiz C, Guerra MJ, Labandeira-Garcia JL. Effect of inhibitors of NADPH oxidase complex and mitochondrial ATP-sensitive potassium channels on generation of dopaminergic neurons from neurospheres of mesencephalic precursors. Dev Dyn. 2010 Nov 2; PubMed Abstract
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Wang P, Jiang S, Cui Y, Yue Z, Su C, Sun J, Sheng S, Tian J. The N-Terminal 5-Mer Peptide Analogue P165 Of App Exerts Protective Effects On SH-SY5Y Cells And Rat Hippocampus Neuronal Synapses. Neuroscience. 2010 Nov 2; PubMed Abstract
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Li X, Zhang X, Cmarik JL, Ruscetti S. Importance of macrophage inflammatory protein-1a and splenic macrophages in neurodegeneration induced by PVC-211 murine leukemia virus. Virology. 2010 Nov 2; PubMed Abstract
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Liu Y, Zhu L, Plössl K, Choi SR, Qiao H, Sun X, Li S, Zha Z, Kung HF. Optimization of automated radiosynthesis of [(18)F]AV-45: a new PET imaging agent for Alzheimer's disease. Nucl Med Biol. 2010 Nov;37(8):917-25. PubMed Abstract
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Carmichael O, Schwarz C, Drucker D, Fletcher E, Harvey D, Beckett L, Jack CR, Weiner M, Decarli C, for the Alzheimer's Disease Neuroimaging Initiative. Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative. Arch Neurol. 2010 Nov;67(11):1370-1378. PubMed Abstract

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Storandt M, Morris JC. Ascertainment bias in the clinical diagnosis of Alzheimer disease. Arch Neurol. 2010 Nov;67(11):1364-9. PubMed Abstract

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Mata IF, Shi M, Agarwal P, Chung KA, Edwards KL, Factor SA, Galasko DR, Ginghina C, Griffith A, Higgins DS, Kay DM, Kim H, Leverenz JB, Quinn JF, Roberts JW, Samii A, Snapinn KW, Tsuang DW, Yearout D, Zhang J, Payami H, Zabetian CP. SNCA Variant Associated With Parkinson Disease and Plasma {alpha}-Synuclein Level. Arch Neurol. 2010 Nov;67(11):1350-6. PubMed Abstract
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Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M. A ß-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nat Commun. 2010 Nov;1(8):110. PubMed Abstract

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Hsiung GY, Fok A, Feldman HH, Rademakers R, Mackenzie IR. rs5848 polymorphism and serum progranulin level. J Neurol Sci. 2010 Nov 1; PubMed Abstract
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Avila J. Alzheimer disease: Caspases first. Nat Rev Neurol. 2010 Nov;6(11):587-8. PubMed Abstract
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Phillips LJ, Reid-Arndt SA, Pak Y. Effects of a creative expression intervention on emotions, communication, and quality of life in persons with dementia. Nurs Res. 2010 Nov-Dec;59(6):417-25. PubMed Abstract
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Verhovshek T, Sengelaub DR. Trophic effects of brain-derived neurotrophic factor blockade in an androgen-sensitive neuromuscular system. Endocrinology. 2010 Nov;151(11):5337-48. PubMed Abstract
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Gaxatte C, Daroux M, Bloch J, Puisieux F, Deramecourt V, Boulanger E. [Cognitive impairment and chronic kidney disease: Which links?] Nephrol Ther. 2010 Nov 1; PubMed Abstract
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Lang AE. Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future. Nat Med. 2010 Nov;16(11):1223-6. PubMed Abstract

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Blennow K. Biomarkers in Alzheimer's disease drug development. Nat Med. 2010 Nov;16(11):1218-22. PubMed Abstract

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Finkbeiner S. Bridging the Valley of Death of therapeutics for neurodegeneration. Nat Med. 2010 Nov;16(11):1227-32. PubMed Abstract

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Lo EH. Degeneration and repair in central nervous system disease. Nat Med. 2010 Nov;16(11):1205-9. PubMed Abstract

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Jeynes B, Provias J. An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis. Neurosci Lett. 2010 Oct 31; PubMed Abstract
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Scuteri A, Ravasi M, Pasini S, Bossi M, Tredici G. Mesenchymal stem cells support dorsal root ganglion neurons survival by inhibiting the metalloproteinase pathway. Neuroscience. 2010 Oct 31; PubMed Abstract
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Nishino Y, Ando M, Makino R, Ueda K, Okamoto Y, Kojima N. Different Mechanisms Between Copper and Iron in Catecholamines-Mediated Oxidative DNA Damage and Disruption of Gene Expression In Vitro. Neurotox Res. 2010 Oct 30; PubMed Abstract
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Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol. 2010 Oct 30; PubMed Abstract
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Miyazaki T, Yamasaki M, Uchigashima M, Matsushima A, Watanabe M. Cellular expression and subcellular localization of secretogranin II in the mouse hippocampus and cerebellum. Eur J Neurosci. 2010 Oct 29; PubMed Abstract
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Fleisch VC, Fraser B, Allison WT. Investigating regeneration and functional integration of CNS neurons: Lessons from zebrafish genetics and other fish species. Biochim Biophys Acta. 2010 Oct 28; PubMed Abstract
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Becklenberg MA. Early-stage Alzheimer's. "This disease requires that you lower expectations of yourself". Time. 2010 Oct 25;176(17):59. PubMed Abstract
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Davis P. One woman's travels with Alzheimer's. "The experience is solitary and personal". Time. 2010 Oct 25;176(17):55. PubMed Abstract
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Park A. Alzheimer's unlocked. Time. 2010 Oct 25;176(17):53-9. PubMed Abstract
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Hardy J. Genetic analysis of pathways to Parkinson disease. Neuron. 2010 Oct 21;68(2):201-6. PubMed Abstract
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Diamond J. Social science. The benefits of multilingualism. Science. 2010 Oct 15;330(6002):332-3. PubMed Abstract
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Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Ninomiya T, Tsukada M, Yanagawa Y, Fukai T, Takada M. Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons. J Neurosci. 2010 Oct 13;30(41):13679-89. PubMed Abstract
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Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu MT, Elgersma Y, De Zeeuw CI, Jörntell H, Hansel C. Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells. J Neurosci. 2010 Oct 13;30(41):13630-43. PubMed Abstract
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Melø T, Bigini P, Sonnewald U, Balosso S, Cagnotto A, Barbera S, Uboldi S, Vezzani A, Mennini T. Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation. J Neurochem. 2010 Oct 12; PubMed Abstract
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Wilson RS, Barral S, Lee JH, Leurgans SE, Foroud TM, Sweet RA, Graff-Radford N, Bird TD, Mayeux R, Bennett DA, For The National Institute On Aging Late-Onset Alz . Heritability of Different Forms of Memory in the Late Onset Alzheimer's Disease Family Study. J Alzheimers Dis. 2010 Oct 7; PubMed Abstract
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Kang KS, Wen Y, Yamabe N, Fukui M, Bishop SC, Zhu BT. Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies. PLoS One. 2010;5(8):e11951. PubMed Abstract
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Akaneya Y, Sohya K, Kitamura A, Kimura F, Washburn C, Zhou R, Ninan I, Tsumoto T, Ziff EB. Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development. PLoS One. 2010;5(8):e12486. PubMed Abstract
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Kermen F, Sultan S, Sacquet J, Mandairon N, Didier A. Consolidation of an olfactory memory trace in the olfactory bulb is required for learning-induced survival of adult-born neurons and long-term memory. PLoS One. 2010;5(8):e12118. PubMed Abstract
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Buchman AS, Boyle PA, Wilson RS, James BD, Leurgans SE, Arnold SE, Bennett DA. Loneliness and the rate of motor decline in old age: the rush memory and aging project, a community-based cohort study. BMC Geriatr. 2010;10:77. PubMed Abstract
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Pollen DA, Baker S, Hinerfeld D, Swearer J, Evans BA, Evans JE, Caselli R, Rogaeva E, St George-Hyslop P, Moonis M. Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4. Alzheimers Res Ther. 2010;2(5):31. PubMed Abstract
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Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 Enhances a-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner. PLoS One. 2010;5(10):e13700. PubMed Abstract
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Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010;15(11):7792-814. PubMed Abstract