Amyloid Beta Clearance

 

Research Paper

Abdul-Hay SO, Edirisinghe P, Thatcher GR. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. J Neurochem. 2009 Nov;111(3):683-95. Amyloid Beta Clearance

Ono M, Watanabe R, Kawashima H, Cheng Y, Kimura H, Watanabe H, Haratake M, Saji H, Nakayama M. Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of beta-amyloid plaques in Alzheimer's disease. J Med Chem. 2009 Oct 22;52(20):6394-401. Amyloid Beta Clearance

Liao MC, Ahmed M, Smith SO, Van Nostrand WE. Degradation of amyloid beta protein by purified myelin basic protein. J Biol Chem. 2009 Oct 16;284(42):28917-25. Amyloid Beta Clearance

Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P. Massive gliosis induced by interleukin-6 suppresses A{beta} deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. 2009 Oct 14; Amyloid Beta Clearance

Von Bernhardi R. Immunotherapy in Alzheimer's Disease: Where Do We Stand? Where Should We Go? J Alzheimers Dis. 2009 Oct 8; Amyloid Beta Clearance

Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, Barberger-Gateau P, Engelborghs S, De Deyn P, Mateo I, Franck A, Helisalmi S, Porcellini E, Hanon O, European Alzheimer's Disease Initiative Investigators, de Pancorbo MM, Lendon C, Dufouil C, Jaillard C, Leveillard T, Alvarez V, Bosco P, Mancuso M, Panza F, Nacmias B, Bossù P, Piccardi P, Annoni G, Seripa D, Galimberti D, Hannequin D, Licastro F, Soininen H, Ritchie K, Blanché H, Dartigues JF, Tzourio C, Gut I, Van Broeckhoven C, Alpérovitch A, Lathrop M, Amouyel P. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 2009 Oct;41(10):1094-9. Amyloid Beta Clearance,  

Antequera D, Vargas T, Ugalde C, Spuch C, Molina JA, Ferrer I, Bermejo-Pareja F, Carro E. Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Oct;36(1):42-50. Amyloid Beta Clearance

Nuutinen T, Suuronen T, Kauppinen A, Salminen A. Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev. 2009 Oct;61(2):89-104. Amyloid Beta Clearance

Sigurdsson EM. Tau-Focused Immunotherapy for Alzheimer's Disease and Related Tauopathies. Curr Alzheimer Res. 2009 Oct 1; Amyloid Beta Clearance

Ball KK, Cruz NF, Mrak RE, Dienel GA. Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes. J Cereb Blood Flow Metab. 2009 Sep 30; Amyloid Beta Clearance

Wu B, Ueno M, Onodera M, Kusaka T, Huang CL, Hosomi N, Kanenishi K, Sakamoto H. RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8. Neurosci Lett. 2009 Sep 18;461(2):100-5. Amyloid Beta Clearance

Schlachetzki JC, Hüll M. Microglial Activation in Alzheimer's Disease. Curr Alzheimer Res. 2009 Sep 13; Amyloid Beta Clearance

Boutajangout A, Goni F, Knudsen E, Schreiber F, Asuni A, Quartermain D, Frangione B, Chabalgoity A, Wisniewski T, Sigurdsson EM. Diminished Amyloid-beta Burden in Tg2576 Mice Following a Prophylactic Oral Immunization with a Salmonella-Based Amyloid-beta Derivative Vaccine. J Alzheimers Dis. 2009 Sep 11; Amyloid Beta Clearance

Arendash GW, Sanchez-Ramos J, Mori T, Mamcarz M, Lin X, Runfeldt M, Wang L, Zhang G, Sava V, Tan J, Cao C. Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice. J Alzheimers Dis. 2009 Sep 11; Amyloid Beta Clearance

Yamada K, Yabuki C, Seubert P, Schenk D, Hori Y, Ohtsuki S, Terasaki T, Hashimoto T, Iwatsubo T. Abeta immunotherapy: intracerebral sequestration of Abeta by an anti-Abeta monoclonal antibody 266 with high affinity to soluble Abeta. J Neurosci. 2009 Sep 9;29(36):11393-8. Amyloid Beta Clearance

Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J Immunol. 2009 Sep 1;183(5):3522-30. Amyloid Beta Clearance

Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage KI, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, Mizusawa H, Yokota T. Depletion of vitamin E increases Abeta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J Biol Chem. 2009 Aug 13; Amyloid Beta Clearance

Imbimbo BP. An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease. Expert Opin Investig Drugs. 2009 Aug;18(8):1147-68. Amyloid Beta Clearance

Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-beta Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Mol Ther. 2009 Jul 28; Amyloid Beta Clearance

Rosen KM, Moussa CE, Lee HK, Kumar P, Kitada T, Qin G, Fu Q, Querfurth HW. Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function. J Neurosci Res. 2009 Jul 16; Amyloid Beta Clearance

Kasturirangan S, Brune D, Sierks M. Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments. Biotechnol Prog. 2009 Jul-Aug;25(4):1054-63. Amyloid Beta Clearance

Zheng M, Wang J, Lubinski J, Flint OP, Krishna R, Yao M, Pursley JM, Thakur A, Boulton DW, Santone KS, Barten DM, Anderson JJ, Felsenstein KM, Hansel SB. Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. Xenobiotica. 2009 Jul;39(7):544-55. Amyloid Beta Clearance

Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009 Jul;118(1):103-13. Amyloid Beta Clearance

Zhang X, Luhrs KJ, Ryff KA, Malik WT, Driscoll MJ, Culver B. Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice. Neuroscience. 2009 Jun 16;161(1):53-8. Amyloid Beta Clearance

Achim CL, Adame A, Dumaop W, Everall IP, Masliah E, Neurobehavioral Research Center. Increased accumulation of intraneuronal amyloid beta in HIV-infected patients. J Neuroimmune Pharmacol. 2009 Jun;4(2):190-9. Amyloid Beta Clearance

Tai LM, Loughlin AJ, Male DK, Romero IA. P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta. J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83. Amyloid Beta Clearance

Zerovnik E. The emerging role of cystatins in Alzheimer's disease. Bioessays. 2009 Jun;31(6):597-9. Amyloid Beta Clearance

Sapra M, Kim KY. Anti-amyloid treatments in Alzheimer's disease. Recent Pat CNS Drug Discov. 2009 Jun;4(2):143-8. Amyloid Beta Clearance

Freude S, Schilbach K, Schubert M. The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer's disease: from model organisms to human disease. Curr Alzheimer Res. 2009 Jun;6(3):213-23. Amyloid Beta Clearance

Kitazawa M, Vasilevko V, Cribbs DH, Laferla FM. Immunization with amyloid-beta attenuates inclusion body myositis-like myopathology and motor impairment in a transgenic mouse model. J Neurosci. 2009 May 13;29(19):6132-41. Amyloid Beta Clearance

Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-Demotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA. Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance and Increases Brain Levels of Amyloid-beta Protein and Impairs Cognition. J Alzheimers Dis. 2009 May 11; Amyloid Beta Clearance

Masoumi A, Goldenson B, Ghirmai S, Avagyan H, Zaghi J, Abel K, Zheng X, Espinosa-Jeffrey A, Mahanian M, Liu PT, Hewison M, Mizwicki M, Cashman J, Fiala M. 1alpha,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-beta Clearance by Macrophages of Alzheimer's Disease Patients. J Alzheimers Dis. 2009 May 11; Amyloid Beta Clearance

Hung SY, Huang WP, Liou HC, Fu WM. Autophagy protects neuron from Abeta-induced cytotoxicity. Autophagy. 2009 May;5(4):502-10. Amyloid Beta Clearance

Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, Landreth GE. Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci. 2009 Apr 1;29(13):4252-62. Amyloid Beta Clearance

Vasilevko V, Head E. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. CNS Neurol Disord Drug Targets. 2009 Apr;8(2):98-113. Amyloid Beta Clearance

Tarawneh R, Holtzman DM. Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention. CNS Neurol Disord Drug Targets. 2009 Apr;8(2):144-59. Amyloid Beta Clearance

Town T. Alternative Abeta immunotherapy approaches for Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Apr;8(2):114-27. Amyloid Beta Clearance

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y. GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice. Curr Alzheimer Res. 2009 Apr;6(2):118-31. Amyloid Beta Clearance

Burgos-Ramos E, Martos-Moreno GA, López MG, Herranz R, Aguado-Llera D, Egea J, Frechilla D, Cenarruzabeitia E, León R, Arilla-Ferreiro E, Argente J, Barrios V. The N-terminal tripeptide of insulin-like growth factor-I protects against beta-amyloid-induced somatostatin depletion by calcium and glycogen synthase kinase 3 beta modulation. J Neurochem. 2009 Apr;109(2):360-70. Amyloid Beta Clearance

Fabbro S, Seeds NW. Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain. J Neurochem. 2009 Apr;109(2):303-15. Amyloid Beta Clearance

Frank S, Copanaki E, Burbach GJ, Müller UC, Deller T. Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci Lett. 2009 Mar 27;453(1):41-4. Amyloid Beta Clearance

Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, Delong C, Hale J, Liu F, Hunter JM, Paul SM. Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism. J Neurosci. 2009 Mar 18;29(11):3603-12. Amyloid Beta Clearance

Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann Neurol. 2009 Mar 18; Amyloid Beta Clearance

Thakker DR, Weatherspoon MR, Harrison J, Keene TE, Lane DS, Kaemmerer WF, Stewart GR, Shafer LL. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4501-6. Amyloid Beta Clearance

Morgan D. The role of microglia in antibody-mediated clearance of amyloid-beta from the brain. CNS Neurol Disord Drug Targets. 2009 Mar;8(1):7-15. Amyloid Beta Clearance

Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30. Amyloid Beta Clearance

Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IG. Abeta aggregation and possible implications in Alzheimer's disease pathogenesis. J Cell Mol Med. 2009 Mar;13(3):412-21. Amyloid Beta Clearance

Dasilva KA, Brown ME, McLaurin J. Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine. Vaccine. 2009 Feb 25;27(9):1365-76. Amyloid Beta Clearance

Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci. 2009 Feb 18;29(7):1977-86. Amyloid Beta Clearance

Scholtzova H, Kascsak RJ, Bates KA, Boutajangout A, Kerr DJ, Meeker HC, Mehta PD, Spinner DS, Wisniewski T. Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology. J Neurosci. 2009 Feb 11;29(6):1846-54. Amyloid Beta Clearance

Kerr E, Craig D, McGuinness B, Dynan KB, Fogarty D, Johnston JA, Passmore AP. Reduced estimated glomerular filtration rate in Alzheimer's disease. Int J Geriatr Psychiatry. 2009 Feb 4; Amyloid Beta Clearance

Bica L, Crouch PJ, Cappai R, White AR. Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease. Mol Biosyst. 2009 Feb;5(2):134-42. Amyloid Beta Clearance

Lee HJ, Jeong JM, Rai G, Lee YS, Chang YS, Kim YJ, Kim HW, Lee DS, Chung JK, Mook-Jung I, Lee MC. (18)F-Labeled benzylideneaniline derivatives as new ligands for beta-amyloid plaque imaging in Alzheimer's disease. Nucl Med Biol. 2009 Feb;36(2):107-16. Amyloid Beta Clearance

Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L. The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2009 Feb;16(2):225-33. Amyloid Beta Clearance

Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb;11(2):143-53. Amyloid Beta Clearance

Zaghi J, Goldenson B, Inayathullah M, Lossinsky AS, Masoumi A, Avagyan H, Mahanian M, Bernas M, Weinand M, Rosenthal MJ, Espinosa-Jeffrey A, de Vellis J, Teplow DB, Fiala M. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol. 2009 Feb;117(2):111-24. Amyloid Beta Clearance

Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. J Agric Food Chem. 2009 Jan 28;57(2):503-8. Amyloid Beta Clearance

Hawkes CA, McLaurin J. Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1261-6. Amyloid Beta Clearance

Huang HC, Jiang ZF. Accumulated amyloid-beta peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease. J Alzheimers Dis. 2009 Jan;16(1):15-27. Amyloid Beta Clearance

Kandimalla KK, Scott OG, Fulzele S, Davidson MW, Poduslo JF. Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS ONE. 2009;4(2):e4627. Amyloid Beta Clearance

Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener. 2009;4:17. Amyloid Beta Clearance

Luque FA, Jaffe SL. The molecular and cellular pathogenesis of dementia of the Alzheimer's type an overview. Int Rev Neurobiol. 2009;84:151-65. Amyloid Beta Clearance

Lemere CA. Developing novel immunogens for a safe and effective Alzheimer's disease vaccine. Prog Brain Res. 2009;175:83-93. Amyloid Beta Clearance

Mohandas E, Rajmohan V, Raghunath B. Neurobiology of Alzheimer's disease. Indian J Psychiatry. 2009 Jan;51(1):55-61. Amyloid Beta Clearance

Behl M, Zhang Y, Zheng W. Involvement of insulin-degrading enzyme in the clearance of beta-amyloid at the blood-CSF barrier: Consequences of lead exposure. Cerebrospinal Fluid Res. 2009;6:11. Amyloid Beta Clearance

Taguchi H, Planque S, Sapparapu G, Boivin S, Hara M, Nishiyama Y, Paul S. Exceptional Amyloid {beta} Peptide Hydrolyzing Activity of Nonphysiological Immunoglobulin Variable Domain Scaffolds. J Biol Chem. 2008 Dec 26;283(52):36724-33. Amyloid Beta Clearance

Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IG. Abeta aggregation and possible implications in Alzheimer's disease pathogenesis. J Cell Mol Med. 2008 Dec 16; Amyloid Beta Clearance

S Roriz-Filho J, Sá-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves ML, Moriguti JC, Roriz-Cruz M. (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta. 2008 Dec 16; Amyloid Beta Clearance

Nielsen HM, Veerhuis R, Holmqvist B, Janciauskiene S. Binding and uptake of Abeta1-42 by primary human astrocytes in vitro. Glia. 2008 Dec 5; Amyloid Beta Clearance

Khoury JE, Luster AD. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci. 2008 Dec;29(12):626-632. Amyloid Beta Clearance

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec;118(12):4002-13. Amyloid Beta Clearance

Sparks DL. The early and ongoing experience with the cholesterol-fed rabbit as a model of Alzheimer's disease: the old, the new and the pilot. J Alzheimers Dis. 2008 Dec;15(4):641-56. Amyloid Beta Clearance

Sevigny JJ, Ryan JM, van Dyck CH, Peng Y, Lines CR, Nessly ML, MK-677 Protocol 30 Study Group. Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial. Neurology. 2008 Nov 18;71(21):1702-8. Amyloid Beta Clearance

Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Nov 13; Amyloid Beta Clearance

Okura Y, Kohyama K, Park IK, Matsumoto Y. Nonviral DNA vaccination augments microglial phagocytosis of beta-amyloid deposits as a major clearance pathway in an Alzheimer disease mouse model. J Neuropathol Exp Neurol. 2008 Nov;67(11):1063-71. Amyloid Beta Clearance

Yan FL, Zheng Y, Zhao FD. Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia. Acta Neuropathol. 2008 Nov;116(5):529-35. Amyloid Beta Clearance

Jaya Prasanthi RP, Schommer E, Thomasson S, Thompson A, Feist G, Ghribi O. Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mech Ageing Dev. 2008 Nov;129(11):649-55. Amyloid Beta Clearance

Shimizu E, Kawahara K, Kajizono M, Sawada M, Nakayama H. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J Immunol. 2008 Nov 1;181(9):6503-13. Amyloid Beta Clearance

Matos M, Augusto E, Oliveira CR, Agostinho P. Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades. Neuroscience. 2008 Oct 28;156(4):898-910. Amyloid Beta Clearance

Foster JK, Verdile G, Bates KA, Martins RN. Immunization in Alzheimer's disease: naïve hope or realistic clinical potential? Mol Psychiatry. 2008 Oct 28; Amyloid Beta Clearance

Zhou YT, Zhang ZX, Chan P, He XM, Tang MN, Wu CB, Hong Z. Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population. Neurosci Lett. 2008 Oct 17;444(1):109-11. Amyloid Beta Clearance,  

Qu HY, Zhang T, Li XL, Zhou JP, Zhao BQ, Li Q, Sun MJ. Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. Eur J Pharmacol. 2008 Oct 10;594(1-3):93-100. Amyloid Beta Clearance

Brinton RD. Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1504-11. Amyloid Beta Clearance

Sigurdsson EM. Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies. J Alzheimers Dis. 2008 Oct;15(2):157-68. Amyloid Beta Clearance

Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase. Rejuvenation Res. 2008 Oct;11(5):891-901. Amyloid Beta Clearance

Bates KA, Verdile G, Li QX, Ames D, Hudson P, Masters CL, Martins RN. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol Psychiatry. 2008 Sep 16; Amyloid Beta Clearance

Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. J Immunol. 2008 Sep 15;181(6):3877-86. Amyloid Beta Clearance

Bacher M, Depboylu C, Du Y, Noelker C, Oertel WH, Behr T, Henriksen G, Behe M, Dodel R. Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease. Neurosci Lett. 2008 Sep 3; Amyloid Beta Clearance

Wisniewski T, Konietzko U. Amyloid-beta immunisation for Alzheimer's disease. Lancet Neurol. 2008 Sep;7(9):805-11. Amyloid Beta Clearance

Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes. J Neuropathol Exp Neurol. 2008 Sep;67(9):842-56. Amyloid Beta Clearance

Jin SM, Cho HJ, Jung ES, Shim MY, Mook-Jung I. DNA damage-inducing agents elicit gamma-secretase activation mediated by oxidative stress. Cell Death Differ. 2008 Sep;15(9):1375-84. Amyloid Beta Clearance

Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci. 2008 Aug 13;28(33):8354-60. Amyloid Beta Clearance

Van Vickle GD, Esh CL, Daugs ID, Kokjohn TA, Kalback WM, Patton RL, Luehrs DC, Walker DG, Lue LF, Beach TG, Davis J, Van Nostrand WE, Castaño EM, Roher AE. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol. 2008 Aug;173(2):483-93. Amyloid Beta Clearance

Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4. Amyloid Beta Clearance

Zeng Y, Han X. Sulfatides facilitate apolipoprotein E-mediated amyloid-beta peptide clearance through an endocytotic pathway. J Neurochem. 2008 Aug;106(3):1275-86. Amyloid Beta Clearance

Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 2008 Jul 19;372(9634):216-23. Amyloid Beta Clearance

Ono M, Haratake M, Saji H, Nakayama M. Development of novel beta-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole. Bioorg Med Chem. 2008 Jul 15;16(14):6867-72. Amyloid Beta Clearance

Schroeter S, Khan K, Barbour R, Doan M, Chen M, Guido T, Gill D, Basi G, Schenk D, Seubert P, Games D. Immunotherapy reduces vascular amyloid-beta in PDAPP mice. J Neurosci. 2008 Jul 2;28(27):6787-93. Amyloid Beta Clearance

Hashioka S, Miklossy J, Schwab C, Klegeris A, McGeer PL. Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain. J Alzheimers Dis. 2008 Jul;14(3):345-52. Amyloid Beta Clearance

Nitsch RM, Hock C. Targeting beta-amyloid pathology in Alzheimer's disease with Abeta immunotherapy. Neurotherapeutics. 2008 Jul;5(3):415-20. Amyloid Beta Clearance

Zlokovic BV. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008 Jul;5(3):409-14. Amyloid Beta Clearance

Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, Laferla FM. SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production. J Cell Biol. 2008 Jun 30;181(7):1107-16. Amyloid Beta Clearance

Jacobsen JS, Comery TA, Martone RL, Elokdah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzales C, Xu J, Zhou H, Atchison K, Wagner E, Zaleska MM, Das I, Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia M, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8754-9. Amyloid Beta Clearance

Llovera RE, de Tullio M, Alonso LG, Leissring MA, Kaufman SB, Roher AE, de Prat Gay G, Morelli L, Castaño EM. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis. J Biol Chem. 2008 Jun 20;283(25):17039-48. Amyloid Beta Clearance

Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. Amyloid Beta Clearance

Hartley DM, Zhao C, Speier AC, Woodard GA, Li S, Li Z, Walz T. Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation. J Biol Chem. 2008 Jun 13;283(24):16790-800. Amyloid Beta Clearance

Richard KL, Filali M, Préfontaine P, Rivest S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci. 2008 May 28;28(22):5784-93. Amyloid Beta Clearance

Malito E, Hulse RE, Tang WJ. Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin. Cell Mol Life Sci. 2008 May 13; Amyloid Beta Clearance

Cecarini V, Bonfili L, Amici M, Angeletti M, Keller JN, Eleuteri AM. Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes. Brain Res. 2008 May 13;1209:8-18. Amyloid Beta Clearance

El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol. 2008 May;172(5):1342-54. Amyloid Beta Clearance

Takata M, Nakashima M, Takehara T, Baba H, Machida K, Akitake Y, Ono K, Hosokawa M, Takahashi M. Detection of amyloid beta protein in the urine of Alzheimer's disease patients and healthy individuals. Neurosci Lett. 2008 Apr 18;435(2):126-30. Amyloid Beta Clearance

Solomon B. Immunological approaches for amyloid-beta clearance toward treatment for Alzheimer's disease. Rejuvenation Res. 2008 Apr;11(2):349-57. Amyloid Beta Clearance

Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol Dis. 2008 Apr;30(1):94-102. Amyloid Beta Clearance

Donahue JE, Johanson CE. Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease. J Neuropathol Exp Neurol. 2008 Apr;67(4):261-70. Amyloid Beta Clearance

Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M. Association between Deposition of Beta-Amyloid and Pathological Prion Protein in Sporadic Creutzfeldt-Jakob Disease. Neurodegener Dis. 2008 Mar 18; Amyloid Beta Clearance

Miles LA, Wun KS, Crespi GA, Fodero-Tavoletti MT, Galatis D, Bagley CJ, Beyreuther K, Masters CL, Cappai R, McKinstry WJ, Barnham KJ, Parker MW. Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol. 2008 Mar 14;377(1):181-92. Amyloid Beta Clearance

Raymond SB, Skoch J, Hills ID, Nesterov EE, Swager TM, Bacskai BJ. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S93-8. Amyloid Beta Clearance

Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB. Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models. Biochem Pharmacol. 2008 Mar 1;75(5):1093-103. Amyloid Beta Clearance

Wostyn P, Audenaert K, De Deyn PP. Alzheimer's disease-related changes in diseases characterized by elevation of intracranial or intraocular pressure. Clin Neurol Neurosurg. 2008 Feb;110(2):101-9. Amyloid Beta Clearance

Obregon D, Hou H, Bai Y, Nikolic WV, Mori T, Luo D, Zeng J, Ehrhart J, Fernandez F, Morgan D, Giunta B, Town T, Tan J. CD40L disruption enhances Abeta vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation. Neurobiol Dis. 2008 Feb;29(2):336-53. Amyloid Beta Clearance

Jaeger S, Pietrzik CU. Functional role of lipoprotein receptors in Alzheimer's disease. Curr Alzheimer Res. 2008 Feb;5(1):15-25. Amyloid Beta Clearance

Huttunen HJ, Kovacs DM. ACAT as a drug target for Alzheimer's disease. Neurodegener Dis. 2008;5(3-4):212-4. Amyloid Beta Clearance

Seubert P, Barbour R, Khan K, Motter R, Tang P, Kholodenko D, Kling K, Schenk D, Johnson-Wood K, Schroeter S, Gill D, Jacobsen JS, Pangalos M, Basi G, Games D. Antibody capture of soluble Abeta does not reduce cortical Abeta amyloidosis in the PDAPP mouse. Neurodegener Dis. 2008;5(2):65-71. Amyloid Beta Clearance

Sampson E, Jenagaratnam L, McShane R. Metal protein attenuating compounds for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2008;(1):CD005380. Amyloid Beta Clearance

Andreasen N, Zetterberg H. Amyloid-related biomarkers for Alzheimer's disease. Curr Med Chem. 2008;15(8):766-71. Amyloid Beta Clearance

Deane R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008;14(16):1601-5. Amyloid Beta Clearance

Yamin G, Ono K, Inayathullah M, Teplow DB. Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease. Curr Pharm Des. 2008;14(30):3231-46. Amyloid Beta Clearance

Bulloj A, Leal MC, Surace EI, Zhang X, Xu H, Ledesma MD, Castaño EM, Morelli L. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Mol Neurodegener. 2008;3:22. Amyloid Beta Clearance

Cashman JR, Ghirmai S, Abel KJ, Fiala M. Immune defects in Alzheimer's disease: new medications development. BMC Neurosci. 2008;9 Suppl 2:S13. Amyloid Beta Clearance

Vasilevko V, Xu F, Previti ML, Van Nostrand WE, Cribbs DH. Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. J Neurosci. 2007 Dec 5;27(49):13376-83. Amyloid Beta Clearance

Wilhelmus MM, Otte-Höller I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. Am J Pathol. 2007 Dec;171(6):1989-99. Amyloid Beta Clearance

Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB. In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 2007 Dec;28(12):2348-55. Amyloid Beta Clearance

Nixon RA. Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci. 2007 Dec 1;120(Pt 23):4081-91. Amyloid Beta Clearance

Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opin Biol Ther. 2007 Dec;7(12):1853-67. Amyloid Beta Clearance

Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis. 2007 Dec;28(3):286-292. Amyloid Beta Clearance

Ito S, Ohtsuki S, Kamiie J, Nezu Y, Terasaki T. Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J Neurochem. 2007 Dec;103(6):2482-90. Amyloid Beta Clearance

Ono M, Haratake M, Mori H, Nakayama M. Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains. Bioorg Med Chem. 2007 Nov 1;15(21):6802-9. Amyloid Beta Clearance

Findeis MA. The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol Ther. 2007 Nov;116(2):266-86. Amyloid Beta Clearance

Portelius E, Tran AJ, Andreasson U, Persson R, Brinkmalm G, Zetterberg H, Blennow K, Westman-Brinkmalm A. Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. J Proteome Res. 2007 Nov;6(11):4433-9. Amyloid Beta Clearance

Chander H, Chauhan A, Chauhan V. Binding of proteases to fibrillar amyloid-beta protein and its inhibition by Congo red. J Alzheimers Dis. 2007 Nov;12(3):261-9. Amyloid Beta Clearance

Panchal M, Lazar N, Munoz N, Fahy C, Clamagirand C, Brouard JP, Dubost L, Cohen P, Brakch N, Rholam M. Clearance of amyloid-beta peptide by neuronal and non-neuronal cells: proteolytic degradation by secreted and membrane associated proteases. Curr Neurovasc Res. 2007 Nov;4(4):240-51. Amyloid Beta Clearance

Herring A, Yasin H, Ambrée O, Sachser N, Paulus W, Keyvani K. Environmental Enrichment Counteracts Alzheimer's Neurovascular Dysfunction in TgCRND8 Mice. Brain Pathol. 2007 Oct 9; Amyloid Beta Clearance

Dal Bianco A, Bradl M, Frischer J, Kutzelnigg A, Jellinger K, Lassmann H. Multiple sclerosis and Alzheimer's disease. Ann Neurol. 2007 Oct 9; Amyloid Beta Clearance

Goldstein ME, Cao Y, Fiedler T, Toyn J, Iben L, Barten DM, Pierdomenico M, Corsa J, Prasad CV, Olson RE, Li YW, Zaczek R, Albright CF. Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. J Pharmacol Exp Ther. 2007 Oct;323(1):102-8. Amyloid Beta Clearance

Tamaki C, Ohtsuki S, Terasaki T. Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes. Mol Pharmacol. 2007 Oct;72(4):850-5. Amyloid Beta Clearance

Rockenstein E, Crews L, Masliah E. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev. 2007 Sep 30;59(11):1093-102. Amyloid Beta Clearance

Sohn JH, So JO, Kim H, Nam EJ, Ha HJ, Kim YH, Mook-Jung I. Reduced serum level of antibodies against amyloid beta peptide is associated with aging in Tg2576 mice. Biochem Biophys Res Commun. 2007 Sep 28;361(3):800-4. Amyloid Beta Clearance

Ono M, Maya Y, Haratake M, Ito K, Mori H, Nakayama M. Aurones serve as probes of beta-amyloid plaques in Alzheimer's disease. Biochem Biophys Res Commun. 2007 Sep 14;361(1):116-21. Amyloid Beta Clearance

Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep;13(9):1029-31. Amyloid Beta Clearance

Knobloch M, Konietzko U, Krebs DC, Nitsch RM. Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging. 2007 Sep 1;28(9):1297-306. Amyloid Beta Clearance

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS Med. 2007 Aug 28;4(8):e262. Amyloid Beta Clearance

Kraus B, Wolff H, Heilmann J, Elstner EF. Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells. Life Sci. 2007 Aug 23;81(11):884-94. Amyloid Beta Clearance

Wang YJ, Pollard A, Zhong JH, Dong XY, Wu XB, Zhou HD, Zhou XF. Intramuscular delivery of a single chain antibody gene reduces brain Abeta burden in a mouse model of Alzheimer's disease. Neurobiol Aging. 2007 Aug 6; Amyloid Beta Clearance

Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med. 2007 Aug 6;204(8):1999-2008. Amyloid Beta Clearance

Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Res. 2007 Aug 3;1161:116-23. Amyloid Beta Clearance

Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007 Aug;6(8):734-46. Amyloid Beta Clearance

Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12849-54. Amyloid Beta Clearance

Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Jul 25; Amyloid Beta Clearance

Kuhnke D, Jedlitschky G, Grube M, Krohn M, Jucker M, Mosyagin I, Cascorbi I, Walker LC, Kroemer HK, Warzok RW, Vogelgesang S. MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's Amyloid-beta Peptides-Implications for the Mechanisms of Abeta Clearance at the Blood-Brain Barrier. Brain Pathol. 2007 Jul 4; Amyloid Beta Clearance

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul;171(1):241-51. Amyloid Beta Clearance

Mare S, Penugonda S, Robinson SM, Dohgu S, Banks WA, Ercal N. Copper complexing decreases the ability of amyloid beta peptide to cross the BBB and enter brain parenchyma. Peptides. 2007 Jul;28(7):1424-32. Amyloid Beta Clearance

Fiala M, Cribbs DH, Rosenthal M, Bernard G. Phagocytosis of amyloid-beta and inflammation: two faces of innate immunity in Alzheimer's disease. J Alzheimers Dis. 2007 Jul;11(4):457-63. Amyloid Beta Clearance

Leo G, Genedani S, Filaferro M, Carone C, Andreoli N, Astancolle S, Davalli P, Fuxe K, Agnati LF. Hyper-homocysteinemia alters amyloid peptide-clusterin interactions and neuroglial network morphology and function in the caudate after intrastriatal injection of amyloid peptides. Curr Alzheimer Res. 2007 Jul;4(3):305-13. Amyloid Beta Clearance

Wilhelmus MM, de Waal RM, Verbeek MM. Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease. Mol Neurobiol. 2007 Jun;35(3):203-16. Amyloid Beta Clearance

Bateman RJ, Munsell LY, Chen X, Holtzman DM, Yarasheski KE. Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates. J Am Soc Mass Spectrom. 2007 Jun;18(6):997-1006. Amyloid Beta Clearance

Hirsch-Reinshagen V, Wellington CL. Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease. Curr Opin Lipidol. 2007 Jun;18(3):325-32. Amyloid Beta Clearance

Herber DL, Mercer M, Roth LM, Symmonds K, Maloney J, Wilson N, Freeman MJ, Morgan D, Gordon MN. Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice. J Neuroimmune Pharmacol. 2007 Jun;2(2):222-31. Amyloid Beta Clearance

Yamamoto M, Kiyota T, Walsh SM, Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. J Neuroimmune Pharmacol. 2007 Jun;2(2):213-21. Amyloid Beta Clearance

Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May;27(5):909-18. Amyloid Beta Clearance

Wang CY, Finstad CL, Walfield AM, Sia C, Sokoll KK, Chang TY, Fang XD, Hung CH, Hutter-Paier B, Windisch M. Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease. Vaccine. 2007 Apr 20;25(16):3041-52. Amyloid Beta Clearance

Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW. CHIP and HSPs interact with {beta}-APP in a proteasome-dependent manner and influence A{beta} metabolism. Hum Mol Genet. 2007 Apr 1;16(7):848-64. Amyloid Beta Clearance

El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med. 2007 Apr;13(4):432-8. Amyloid Beta Clearance

Ferreira ST, Vieira MN, De Felice FG. Soluble protein oligomers as emerging toxins in alzheimer's and other amyloid diseases. IUBMB Life. 2007 Apr-May;59(4-5):332-45. Amyloid Beta Clearance

Bombois S, Maurage CA, Gompel M, Deramecourt V, Mackowiak-Cordoliani MA, Black RS, Lavielle R, Delacourte A, Pasquier F. Absence of beta-amyloid deposits after immunization in Alzheimer disease with Lewy body dementia. Arch Neurol. 2007 Apr;64(4):583-7. Amyloid Beta Clearance

Koldamova R, Lefterov I. Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach. Curr Alzheimer Res. 2007 Apr;4(2):171-8. Amyloid Beta Clearance

Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007 Apr;4(2):191-7. Amyloid Beta Clearance

Cao G, Bales KR, DeMattos RB, Paul SM. Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics. Curr Alzheimer Res. 2007 Apr;4(2):179-84. Amyloid Beta Clearance

Sparks DL. Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver. Curr Alzheimer Res. 2007 Apr;4(2):165-9. Amyloid Beta Clearance

Sorrentino G, Bonavita V. Neurodegeneration and Alzheimer's disease: the lesson from tauopathies. Neurol Sci. 2007 Apr;28(2):63-71. Amyloid Beta Clearance

Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci. 2007 Feb 21;27(8):1973-80. Amyloid Beta Clearance

Tang BL, Chua CE. SIRT1 and neuronal diseases. Mol Aspects Med. 2007 Feb 16; Amyloid Beta Clearance

Smith DG, Cappai R, Barnham KJ. The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim Biophys Acta. 2007 Feb 9; Amyloid Beta Clearance

Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro S, Saeki M, Taniguchi T, Shimohama S, Tooyama I. Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. FEBS Lett. 2007 Feb 6;581(3):475-8. Amyloid Beta Clearance

Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol. 2007 Feb;170(2):680-92. Amyloid Beta Clearance

Christensen DD. Alzheimer's disease: progress in the development of anti-amyloid disease-modifying therapies. CNS Spectr. 2007 Feb;12(2):113-6, 119-23. Amyloid Beta Clearance

Chalmers KA, Love S. Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons. J Neuropathol Exp Neurol. 2007 Feb;66(2):158-67. Amyloid Beta Clearance

Weeraratna AT, Kalehua A, Deleon I, Bertak D, Maher G, Wade MS, Lustig A, Becker KG, Wood W, Walker DG, Beach TG, Taub DD. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Exp Cell Res. 2007 Feb 1;313(3):450-61. Amyloid Beta Clearance

Solomon B. Intravenous immunoglobulin and Alzheimer's disease immunotherapy. Curr Opin Mol Ther. 2007 Feb;9(1):79-85. Amyloid Beta Clearance

Woodhouse A, Dickson TC, Vickers JC. Vaccination strategies for Alzheimer's disease: A new hope? Drugs Aging. 2007;24(2):107-19. Amyloid Beta Clearance

Baron R, Harpaz I, Nemirovsky A, Cohen H, Monsonego A. Immunity and neuronal repair in the progression of Alzheimer's disease: A brief overview. Exp Gerontol. 2007 Jan-Feb;42(1-2):64-9. Amyloid Beta Clearance

Ono M, Maya Y, Haratake M, Nakayama M. Synthesis and characterization of styrylchromone derivatives as beta-amyloid imaging agents. Bioorg Med Chem. 2007 Jan 1;15(1):444-50. Amyloid Beta Clearance

Van Broeck B, van Broeckhoven C, Kumar-Singh S. Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches. Neurodegener Dis. 2007;4(5):349-65. Amyloid Beta Clearance

Lefterov I, Bookout A, Wang Z, Staufenbiel M, Mangelsdorf D, Koldamova R. Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment. Mol Neurodegener. 2007;2:20. Amyloid Beta Clearance

Shie FS, Woltjer RL. Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease. Curr Med Chem. 2007;14(27):2865-71. Amyloid Beta Clearance

Neumaier B, Deisenhofer S, Fürst D, von Arnim CA, Thees S, Buck AK, Glatting G, Landwehrmeyer GB, Krause BJ, Müller HD, Sommer C, Reske SN, Mottaghy FM. Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. Nuklearmedizin. 2007;46(6):271-80. Amyloid Beta Clearance

Park JH, Widi GA, Gimbel DA, Harel NY, Lee DH, Strittmatter SM. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. J Neurosci. 2006 Dec 20;26(51):13279-86. Amyloid Beta Clearance

Portelius E, Zetterberg H, Andreasson U, Brinkmalm G, Andreasen N, Wallin A, Westman-Brinkmalm A, Blennow K. An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal fluid. Neurosci Lett. 2006 Dec 6;409(3):215-9. Amyloid Beta Clearance

Sadowski MJ, Pankiewicz J, Scholtzova H, Mehta PD, Prelli F, Quartermain D, Wisniewski T. Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18787-92. Amyloid Beta Clearance

Golde TE, Dickson D, Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Curr Alzheimer Res. 2006 Dec;3(5):421-30. Amyloid Beta Clearance

Rogers J, Li R, Mastroeni D, Grover A, Leonard B, Ahern G, Cao P, Kolody H, Vedders L, Kolb WP, Sabbagh M. Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes. Neurobiol Aging. 2006 Dec;27(12):1733-9. Amyloid Beta Clearance

Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. J Biol Chem. 2006 Nov 24;281(47):36180-6. Amyloid Beta Clearance,  

Hellström-Lindahl E, Ravid R, Nordberg A. Age-dependent decline of neprilysin in Alzheimer's disease and normal brain: Inverse correlation with Abeta levels. Neurobiol Aging. 2006 Nov 10; Amyloid Beta Clearance,  

Asuni AA, Boutajangout A, Scholtzova H, Knudsen E, Li YS, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM. Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages. Eur J Neurosci. 2006 Nov;24(9):2530-42. Amyloid Beta Clearance

Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006 Nov;20(13):2313-20. Amyloid Beta Clearance

Tahara K, Kim HD, Jin JJ, Maxwell JA, Li L, Fukuchi K. Role of toll-like receptor signalling in Abeta uptake and clearance. Brain. 2006 Nov 1;129(Pt 11):3006-19. Amyloid Beta Clearance

Armstrong RA. Classic beta-amyloid deposits cluster around large diameter blood vessels rather than capillaries in sporadic Alzheimer's disease. Curr Neurovasc Res. 2006 Nov;3(4):289-94. Amyloid Beta Clearance

Soffer D. Cerebral amyloid angiopathy--a disease or age-related condition. Isr Med Assoc J. 2006 Nov;8(11):803-6. Amyloid Beta Clearance

Yin KJ, Cirrito JR, Yan P, Hu X, Xiao Q, Pan X, Bateman R, Song H, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism. J Neurosci. 2006 Oct 25;26(43):10939-48. Amyloid Beta Clearance

Shen Y, Joachimiak A, Rosner MR, Tang WJ. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19;443(7113):870-4. Amyloid Beta Clearance

Wang YJ, Zhou HD, Zhou XF. Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today. 2006 Oct;11(19-20):931-8. Amyloid Beta Clearance

Oide T, Kinoshita T, Arima K. Regression stage senile plaques in the natural course of Alzheimer's disease. Neuropathol Appl Neurobiol. 2006 Oct;32(5):539-56. Amyloid Beta Clearance

Miners JS, Van Helmond Z, Chalmers K, Wilcock G, Love S, Kehoe PG. Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathy. J Neuropathol Exp Neurol. 2006 Oct;65(10):1012-21. Amyloid Beta Clearance

Leal MC, Dorfman VB, Gamba AF, Frangione B, Wisniewski T, Castaño EM, Sigurdsson EM, Morelli L. Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology. J Neuropathol Exp Neurol. 2006 Oct;65(10):976-87. Amyloid Beta Clearance

Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21;1111(1):222-6. Amyloid Beta Clearance

Nakamura K, Ohya W, Funakoshi H, Sakaguchi G, Kato A, Takeda M, Kudo T, Nakamura T. Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease. J Neurosci Res. 2006 Sep;84(4):874-90. Amyloid Beta Clearance

Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7. Amyloid Beta Clearance

Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, Xiao Q, Hsu FF, Turk JW, Xu J, Hsu CY, Holtzman DM, Lee JM. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J Biol Chem. 2006 Aug 25;281(34):24566-74. Amyloid Beta Clearance

Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E. Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiol Aging. 2006 Aug 8; Amyloid Beta Clearance

Istrin G, Bosis E, Solomon B. Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-beta peptide. J Neurosci Res. 2006 Aug 1;84(2):434-43. Amyloid Beta Clearance

Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, Paulus W, Keyvani K. Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol. 2006 Aug;169(2):544-52. Amyloid Beta Clearance

Kalinin S, Gavrilyuk V, Polak PE, Heneka MT, Feinstein DL. Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease. Neurobiol Aging. 2006 Jul 10; Amyloid Beta Clearance

Helbecque N, Cottel D, Hermant X, Amouyel P. Impact of the matrix metalloproteinase MMP-3 on dementia. Neurobiol Aging. 2006 Jul 3; Amyloid Beta Clearance,  

Michaelis ML. Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice. Curr Alzheimer Res. 2006 Jul;3(3):215-9. Amyloid Beta Clearance

Bateman RJ, Munsell LY, Morris JC, Swarm R, Yarasheski KE, Holtzman DM. Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med. 2006 Jul;12(7):856-61. Amyloid Beta Clearance

Vasilevko V, Cribbs DH. Novel approaches for immunotherapeutic intervention in Alzheimer's disease. Neurochem Int. 2006 Jul;49(2):113-26. Amyloid Beta Clearance

Davis J, Xu F, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double A beta in human A betaPP transgenic mice. Neurobiol Aging. 2006 Jul 1;27(7):946-54. Amyloid Beta Clearance

Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiol Aging. 2006 Jun 30; Amyloid Beta Clearance

Moret V, Laras Y, Pietrancosta N, Garino C, Quéléver G, Rolland A, Mallet B, Norreel JC, Kraus JL. 1,1'-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: a new potential copper chelator agent for neuroprotection in Alzheimer's disease. Its comparative effects with clioquinol on rat brain copper distribution. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3298-301. Amyloid Beta Clearance

Zhao Z, Xiang Z, Haroutunian V, Buxbaum J, Stetka B, Pasinetti GM. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol Aging. 2006 Jun 10; Amyloid Beta Clearance

Masters CL, Cappai R, Barnham KJ, Villemagne VL. Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics. J Neurochem. 2006 Jun;97(6):1700-25. Amyloid Beta Clearance

Fukuchi K, Accavitti-Loper MA, Kim HD, Tahara K, Cao Y, Lewis TL, Caughey RC, Kim H, Lalonde R. Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model. Biochem Biophys Res Commun. 2006 May 26;344(1):79-86. Amyloid Beta Clearance

Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO. PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8215-20. Amyloid Beta Clearance

Kulstad JJ, Green PS, Cook DG, Watson GS, Reger MA, Baker LD, Plymate SR, Asthana S, Rhoads K, Mehta PD, Craft S. Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease. Neurology. 2006 May 23;66(10):1506-10. Amyloid Beta Clearance

Gillmore JD, Hawkins PN. Drug Insight: emerging therapies for amyloidosis. Nat Clin Pract Nephrol. 2006 May;2(5):263-70. Amyloid Beta Clearance

Standridge JB. Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease. Curr Alzheimer Res. 2006 Apr;3(2):95-108. Amyloid Beta Clearance

Brendza RP, Holtzman DM. Amyloid-beta immunotherapies in mice and men. Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2):118-23. Amyloid Beta Clearance

Miida T, Yamada T, Seino U, Ito M, Fueki Y, Takahashi A, Kosuge K, Soda S, Hanyu O, Obayashi K, Miyazaki O, Okada M. Serum amyloid A (SAA)-induced remodeling of CSF-HDL. Biochim Biophys Acta. 2006 Apr;1761(4):424-33. Amyloid Beta Clearance

Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. 2006 Apr 1;41(4):346-59. Amyloid Beta Clearance

Portelius E, Westman-Brinkmalm A, Zetterberg H, Blennow K. Determination of beta-amyloid peptide signatures in cerebrospinal fluid using immunoprecipitation-mass spectrometry. J Proteome Res. 2006 Apr;5(4):1010-6. Amyloid Beta Clearance

Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL. Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53. Amyloid Beta Clearance

Hong CS, Goins WF, Goss JR, Burton EA, Glorioso JC. Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-beta peptide in vivo. Gene Ther. 2006 Mar 16; Amyloid Beta Clearance

Thal DR, Capetillo-Zarate E, Del Tredici K, Braak H. The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ. 2006 Mar 8;2006(6):re1. Amyloid Beta Clearance

Sambamurti K, Suram A, Venugopal C, Prakasam A, Zhou Y, Lahiri DK, Greig NH. A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Curr Alzheimer Res. 2006 Feb;3(1):81-90. Amyloid Beta Clearance

Ghribi O. The role of the endoplasmic reticulum in the accumulation of beta-amyloid peptide in Alzheimer's disease. Curr Mol Med. 2006 Feb 1;6(1):119-33. Amyloid Beta Clearance

Shi J, Tian J, Pritchard A, Lendon C, Lambert JC, Iwatsubo T, Mann DM. A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases Abeta(40) load as cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathol (Berl). 2006 Jan;111(1):15-20. Amyloid Beta Clearance

Lemere CA, Maier M, Jiang L, Peng Y, Seabrook TJ. Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans. Rejuvenation Res. 2006;9(1):77-84. Amyloid Beta Clearance

Cordy JM, Hooper NM, Turner AJ. The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol. 2006 Jan-Feb;23(1):111-22. Amyloid Beta Clearance

Herzig MC, Van Nostrand WE, Jucker M. Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models. Brain Pathol. 2006 Jan;16(1):40-54. Amyloid Beta Clearance

Sigurdsson EM. Immunotherapy for conformational diseases. Curr Pharm Des. 2006;12(20):2569-85. Amyloid Beta Clearance

Levy E, Prelli F, Frangione B. Studies on the first described Alzheimer's disease amyloid beta mutant, the Dutch variant. J Alzheimers Dis. 2006;9(3 Suppl):329-39. Amyloid Beta Clearance

Das P, Smithson LA, Price RW, Holloway VM, Levites Y, Chakrabarty P, Golde TE. Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy. J Neuroinflammation. 2006;3:17. Amyloid Beta Clearance

Waldron E, Jaeger S, Pietrzik CU. Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's disease. Neurodegener Dis. 2006;3(4-5):233-8. Amyloid Beta Clearance

Wang DS, Dickson DW, Malter JS. beta-Amyloid Degradation and Alzheimer's Disease. J Biomed Biotechnol. 2006;2006(3):58406. Amyloid Beta Clearance

Sciarretta KL, Gordon DJ, Meredith SC. Peptide-based inhibitors of amyloid assembly. Methods Enzymol. 2006;413:273-312. Amyloid Beta Clearance

Dillen K, Annaert W. A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? Int Rev Cytol. 2006;254:215-300. Amyloid Beta Clearance

Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R. Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19198-203. Amyloid Beta Clearance

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Amyloid Beta Clearance

Wiseman RL, Powers ET, Kelly JW. Partitioning Conformational Intermediates between Competing Refolding and Aggregation Pathways: Insights into Transthyretin Amyloid Disease. Biochemistry. 2005 Dec 20;44(50):16612-23. Amyloid Beta Clearance

Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14;25(50):11495-503. Amyloid Beta Clearance

Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec;2(12):e355. Amyloid Beta Clearance

Tanskanen M, Lindsberg PJ, Tienari PJ, Polvikoski T, Sulkava R, Verkkoniemi A, Rastas S, Paetau A, Kiuru-Enari S. Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype. Neuropathol Appl Neurobiol. 2005 Dec;31(6):589-99. Amyloid Beta Clearance

Carro E, Spuch C, Trejo JL, Antequera D, Torres-Aleman I. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci. 2005 Nov 23;25(47):10884-93. Amyloid Beta Clearance

Okamura N, Suemoto T, Furumoto S, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Fujiwara H, Nemoto M, Maruyama M, Arai H, Yanai K, Sawada T, Kudo Y. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci. 2005 Nov 23;25(47):10857-62. Amyloid Beta Clearance

Shinall H, Song ES, Hersh LB. Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. Biochemistry. 2005 Nov 22;44(46):15345-50. Amyloid Beta Clearance

Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J Biol Chem. 2005 Nov 11;280(45):37644-50. Amyloid Beta Clearance,  

Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem. 2005 Nov 11;280(45):37377-82. Amyloid Beta Clearance

Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I. Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: New cues into the human disease? Neurobiol Aging. 2005 Nov 4; Amyloid Beta Clearance

Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathol (Berl). 2005 Nov;110(5):459-71. Amyloid Beta Clearance

Beher D, Graham SL. Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease. Expert Opin Investig Drugs. 2005 Nov;14(11):1385-409. Amyloid Beta Clearance

Harris-White ME, Frautschy SA. Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. Curr Drug Targets CNS Neurol Disord. 2005 Oct;4(5):469-80. Amyloid Beta Clearance

Vardy ER, Catto AJ, Hooper NM. Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease. Trends Mol Med. 2005 Oct;11(10):464-72. Amyloid Beta Clearance

Stratman NC, Castle CK, Taylor BM, Epps DE, Melchior GW, Carter DB. Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide. Chem Phys Lipids. 2005 Oct;137(1-2):52-61. Amyloid Beta Clearance

Moreira PI, Honda K, Liu Q, Santos MS, Oliveira CR, Aliev G, Nunomura A, Zhu X, Smith MA, Perry G. Oxidative stress: the old enemy in Alzheimer's disease pathophysiology. Curr Alzheimer Res. 2005 Oct;2(4):403-8. Amyloid Beta Clearance

Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci. 2005 Sep 7;25(36):8240-9. Amyloid Beta Clearance

Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep;11(9):959-65. Amyloid Beta Clearance

Lee M, Bard F, Johnson-Wood K, Lee C, Hu K, Griffith SG, Black RS, Schenk D, Seubert P. Abeta42 immunization in Alzheimer's disease generates Abeta N-terminal antibodies. Ann Neurol. 2005 Sep;58(3):430-5. Amyloid Beta Clearance

Rebe S, Solomon B. Deglycosylation of anti-beta amyloid antibodies inhibits microglia activation in BV-2 cellular model. Am J Alzheimers Dis Other Demen. 2005 Sep-Oct;20(5):303-13. Amyloid Beta Clearance

Oh-Hashi K, Nagai T, Tanaka T, Yu H, Hirata Y, Kiuchi K. Determination of hypoxic effect on neprilysin activity in human neuroblastoma SH-SY5Y cells using a novel HPLC method. Biochem Biophys Res Commun. 2005 Aug 26;334(2):380-5. Amyloid Beta Clearance

Strohmeyer R, Kovelowski CJ, Mastroeni D, Leonard B, Grover A, Rogers J. Microglial responses to amyloid beta peptide opsonization and indomethacin treatment. J Neuroinflammation. 2005 Aug 19;2:18. Amyloid Beta Clearance

Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR. Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies. Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):383-403. Amyloid Beta Clearance

Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochem Soc Trans. 2005 Aug;33(Pt 4):543-7. Amyloid Beta Clearance

Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C. Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol. 2005 Aug;167(2):527-43. Amyloid Beta Clearance

Roy OW, Cohen NR, Nicoll JA. Pathophysiology of dementias and implications for therapy. Indian J Pathol Microbiol. 2005 Jul;48(3):289-99. Amyloid Beta Clearance

Glatzel M, Mohajeri MH, Poirier R, Nitsch RM, Schwarz P, Lu B, Aguzzi A. No influence of amyloid-beta-degrading neprilysin activity on prion pathogenesis. J Gen Virol. 2005 Jun;86(Pt 6):1861-7. Amyloid Beta Clearance

Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, Bernard G. Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2005 Jun 1;7(3):221-32; discussion 255-62. Amyloid Beta Clearance

Yoon IS, Pietrzik CU, Kang DE, Koo EH. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem. 2005 May 20;280(20):20140-7. Amyloid Beta Clearance

Tamura Y, Hamajima K, Matsui K, Yanoma S, Narita M, Tajima N, Xin KQ, Klinman D, Okuda K. The F(ab')(2) fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain. Neurobiol Dis. 2005 May 19; Amyloid Beta Clearance

Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T. Overexpression of Monocyte Chemotactic Protein-1/CCL2 in {beta}-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse {beta}-Amyloid Deposition. Am J Pathol. 2005 May;166(5):1475-85. Amyloid Beta Clearance

Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. J Neuropathol Exp Neurol. 2005 May;64(5):378-85. Amyloid Beta Clearance,  

Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders. Neurobiol Aging. 2005 May;26(5):645-54. Amyloid Beta Clearance

Lane RM, Farlow MR. Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. J Lipid Res. 2005 May 1;46(5):949-68. Amyloid Beta Clearance

Kim HD, Cao Y, Kong FK, Van Kampen KR, Lewis TL, Ma Z, Tang DC, Fukuchi K. Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid beta-protein and GM-CSF. Vaccine. 2005 Apr 27;23(23):2977-86. Amyloid Beta Clearance

Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr 1;28(4):202-8. Amyloid Beta Clearance

Moir RD, Tanzi RE. LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP. Curr Alzheimer Res. 2005 Apr;2(2):269-73. Amyloid Beta Clearance

Moreira PI, Oliveira CR, Santos MS, Nunomura A, Honda K, Zhu X, Smith MA, Perry G. A second look into the oxidant mechanisms in Alzheimer's disease. Curr Neurovasc Res. 2005 Apr;2(2):179-84. Amyloid Beta Clearance

Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci. 2005 Mar 16;25(11):2803-10. Amyloid Beta Clearance

Floden AM, Li S, Combs CK. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. J Neurosci. 2005 Mar 9;25(10):2566-75. Amyloid Beta Clearance

Kandimalla KK, Curran GL, Holasek SS, Gilles EJ, Wengenack TM, Poduslo JF. Pharamacokinetic Analysis of the Blood-Brain Barrier Transport of 125I-A{beta}40 in Wild Type and Alzheimer's Disease Transgenic Mice (APP, PS1) and Its Implication for Amyloid Plaque Formation. J Pharmacol Exp Ther. 2005 Mar 2; Amyloid Beta Clearance

Plum L, Schubert M, Brüning JC. The role of insulin receptor signaling in the brain. Trends Endocrinol Metab. 2005 Mar;16(2):59-65. Amyloid Beta Clearance

Song ES, Hersh LB. Insulysin: An Allosteric Enzyme As a Target for Alzheimer's Disease. J Mol Neurosci. 2005 Mar;25(3):201-206. Amyloid Beta Clearance

Cam JA, Zerbinatti CV, Li Y, Bu G. Rapid endocytosis of the LDL receptor-related protein modulates cell surface distribution and processing of the beta amyloid precursors protein. J Biol Chem. 2005 Feb 10; Amyloid Beta Clearance

Chauhan V, Sheikh AM, Chauhan A, Spivack WD, Fenko MD, Malik MN. Fibrillar amyloid beta-protein inhibits the activity of high molecular weight brain protease and trypsin. J Alzheimers Dis. 2005 Feb;7(1):37-44. Amyloid Beta Clearance

Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin. J Neural Transm. 2005 Feb 1;112(2):269-82. Amyloid Beta Clearance

Rota C, Rimbach G, Minihane AM, Stoecklin E, Barella L. Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties. Nutr Neurosci. 2005 Feb;8(1):21-9. Amyloid Beta Clearance

Banks WA, Pagliari P, Nakaoke R, Morley JE. Effects of a behaviorally active antibody on the brain uptake and clearance of amyloid beta proteins. Peptides. 2005 Feb;26(2):287-94. Amyloid Beta Clearance

Gaugler MN, Tracy J, Kuhnle K, Crameri A, Nitsch RM, Mohajeri MH. Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo. FEBS Lett. 2005 Jan 31;579(3):753-6. Amyloid Beta Clearance

Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. J Cell Biol. 2005 Jan 17;168(2):291-302. Amyloid Beta Clearance

Lee EO, Kang JL, Chong YH. The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells. J Biol Chem. 2005 Jan 4; Amyloid Beta Clearance

Rossner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR. Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. J Neurochem. 2005 Jan;92(2):226-34. Amyloid Beta Clearance

Carter DB. The interaction of amyloid-beta with ApoE. Subcell Biochem. 2005;38:255-72. Amyloid Beta Clearance

Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathol. 2005 Jan;15(1):78-83. Amyloid Beta Clearance

Aisen PS. The development of anti-amyloid therapy for Alzheimer's disease : from secretase modulators to polymerisation inhibitors. CNS Drugs. 2005;19(12):989-96. Amyloid Beta Clearance

Kitazawa M, Yamasaki TR, LaFerla FM. Microglia as a Potential Bridge between the Amyloid {beta}-Peptide and Tau. Ann N Y Acad Sci. 2004 Dec;1035:85-103. Amyloid Beta Clearance

Cole GM, Morihara T, Lim GP, Yang F, Begum A, Frautschy SA. NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. Ann N Y Acad Sci. 2004 Dec 1;1035:68-84. Amyloid Beta Clearance

Ritchie CW, Bush AI, Masters CL. Metal-protein attenuating compounds and Alzheimer's disease. Expert Opin Investig Drugs. 2004 Dec;13(12):1585-92. Amyloid Beta Clearance

Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B. Peroxisome proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J Neurosci. 2004 Dec 1;24(48):10908-17. Amyloid Beta Clearance

Chauhan NB, Siegel GJ. Intracerebroventricular passive immunization in transgenic mouse models of Alzheimer's disease. Expert Rev Vaccines. 2004 Dec;3(6):717-25. Amyloid Beta Clearance

Kunjathoor VV, Tseng AA, Medeiros LA, Khan T, Moore KJ. beta-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins. J Neuroinflammation. 2004 Nov 16;1(1):23. Amyloid Beta Clearance

Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov;35(11 Suppl 1):2628-31. Amyloid Beta Clearance

Yanagisawa K. [Natural progression of Alzheimer's disease (AD): a perspective on possible therapies for advanced AD] Rinsho Shinkeigaku. 2004 Nov;44(11):921-3. Amyloid Beta Clearance

Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 2004 Sep 2;43(5):605-8. Amyloid Beta Clearance

Zetterberg H, Andreasen N, Blennow K. Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease. Neurosci Lett. 2004 Sep 2;367(2):194-6. Amyloid Beta Clearance,  

Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice. Am J Pathol. 2004 Sep 1;165(3):937-48. Amyloid Beta Clearance

Nakagawa Y, Yuzuriha T, Iwaki T. Active clearance of human amyloid beta 1-42 peptide aggregates from the rat ventricular system. Neuropathology. 2004 Sep;24(3):194-200. Amyloid Beta Clearance

Irizarry MC, Deng A, Lleo A, Berezovska O, von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem. 2004 Sep;90(5):1132-43. Amyloid Beta Clearance

Abbott NJ. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int. 2004 Sep 1;45(4):545-52. Amyloid Beta Clearance

Funalot B, Ouimet T, Claperon A, Fallet C, Delacourte A, Epelbaum J, Subkowski T, Léonard N, Codron V, David JP, Amouyel P, Schwartz JC, Helbecque N. Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease. Mol Psychiatry. 2004 Aug 31; Amyloid Beta Clearance

Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of alzheimer's Abeta 40 and Abeta 42. J Biol Chem. 2004 Aug 31; Amyloid Beta Clearance

Arendash GW, Garcia MF, Costa DA, Cracchiolo JR, Wefes IM, Potter H. Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport. 2004 Aug 6;15(11):1751-4. Amyloid Beta Clearance

Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 5;43(3):333-44. Amyloid Beta Clearance

Oddo S, Billings L, Kesslak JP, Cribbs DH, Laferla FM. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron. 2004 Aug 5;43(3):321-32. Amyloid Beta Clearance

Todd Roach J, Volmar Ch, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M. Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Res. 2004 Jul 23;1015(1-2):161-8. Amyloid Beta Clearance,  

Sigurdsson EM, Knudsen E, Asuni A, Fitzer-Attas C, Sage D, Quartermain D, Goni F, Frangione B, Wisniewski T. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J Neurosci. 2004 Jul 14;24(28):6277-82. Amyloid Beta Clearance

McGeer PL, McGeer E. Immunotherapy for Alzheimer's disease. Sci Aging Knowledge Environ. 2004 Jul 7;2004(27):pe29. Amyloid Beta Clearance

Sadowski M, Pankiewicz J, Scholtzova H, Tsai J, Li Y, Carp RI, Meeker HC, Gambetti P, Debnath M, Mathis CA, Shao L, Gan WB, Klunk WE, Wisniewski T. Targeting prion amyloid deposits in vivo. J Neuropathol Exp Neurol. 2004 Jul;63(7):775-84. Amyloid Beta Clearance

Koistinaho M, Lin S, Wu X, Esterman M, Koger D, Hanson J, Higgs R, Liu F, Malkani S, Bales KR, Paul SM. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med. 2004 Jul 1;10(7):719-26. Amyloid Beta Clearance

Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochem Res. 2004 Jun;29(6):1257-66. Amyloid Beta Clearance

Trejo JL, Carro E, Lopez-Lopez C, Torres-Aleman I. Role of serum insulin-like growth factor I in mammalian brain aging. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S39-43. Amyloid Beta Clearance

LeVine H. The Amyloid Hypothesis and the clearance and degradation of Alzheimer's beta-peptide. J Alzheimers Dis. 2004 Jun;6(3):303-14. Amyloid Beta Clearance

Maat-Schieman ML, Yamaguchi H, Hegeman-Kleinn IM, Welling-Graafland C, Natté R, Roos RA, van Duinen SG. Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Acta Neuropathol (Berl). 2004 May;107(5):389-98. Amyloid Beta Clearance,  

Vogelgesang S, Warzok RW, Cascorbi I, Kunert-Keil C, Schroeder E, Kroemer HK, Siegmund W, Walker LC, Pahnke J. The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2004 May 1;1(2):121-5. Amyloid Beta Clearance

Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Green M, Gao W, Herman MM, Ichise M, Innis RB. Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease. J Med Chem. 2004 Apr 22;47(9):2208-18. Amyloid Beta Clearance

Carro E, Torres-Aleman I. The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease. Eur J Pharmacol. 2004 Apr 19;490(1-3):127-33. Amyloid Beta Clearance

Head E, Lott IT. Down syndrome and beta-amyloid deposition. Curr Opin Neurol. 2004 Apr;17(2):95-100. Amyloid Beta Clearance

Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, Sasaki H, Kudo Y, Sawada T. Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci. 2004 Mar 10;24(10):2535-41. Amyloid Beta Clearance

Okamura N. [In vivo imaging of amyloid plaques in the brain] Nippon Ronen Igakkai Zasshi. 2004 Mar;41(2):175-8. Amyloid Beta Clearance

Schmitz A, Schneider A, Kummer MP, Herzog V. Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways. Traffic. 2004 Feb;5(2):89-101. Amyloid Beta Clearance

Fan R, Tenner AJ. Complement C1q expression induced by Abeta in rat hippocampal organotypic slice cultures. Exp Neurol. 2004 Feb;185(2):241-53. Amyloid Beta Clearance

Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC. Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J Neurosci. 2004 Jan 28;24(4):991-8. Amyloid Beta Clearance,  

Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity. J Neurosci Res. 2004 10 21; Amyloid Beta Clearance

Gregory GC, Halliday GM. What is the dominant Abeta species in human brain tissue? A review. Neurotox Res. 2004;7(1-2):29-41. Amyloid Beta Clearance

Aguilar MI, Small DH. Surface plasmon resonance for the analysis of beta-amyloid interactions and fibril formation in Alzheimer's disease research. Neurotox Res. 2004;7(1-2):17-27. Amyloid Beta Clearance

Zhang P, Yang Z, Wan CL, Zheng WD, Zhang CF, Li S, Lü ZP, Zheng CG, Jin F, Wang L. Neither the tumor necrosis factor alpha-308 A/G polymorphism nor the alpha2-macroglobulin polymorphism was associated with late-onset Alzheimer's disease in the Chinese population. Yi Chuan Xue Bao. 2004 Jan;31(1):1-6. Amyloid Beta Clearance

Holtzman DM. In Vivo Effects of ApoE and Clusterin on Amyloid-beta Metabolism and Neuropathology. J Mol Neurosci. 2004;23(3):247-54. Amyloid Beta Clearance

Manelli AM, Stine WB, Van Eldik LJ, LaDu MJ. ApoE and Abeta1-42 Interactions: Effects of Isoform and Conformation on Structure and Function. J Mol Neurosci. 2004;23(3):235-46. Amyloid Beta Clearance

Wostyn P. Can chronic increased intracranial pressure or exposure to repetitive intermittent intracranial pressure elevations raise your risk for Alzheimer's disease? Med Hypotheses. 2004;62(6):925-30. Amyloid Beta Clearance

Heppner FL, Gandy S, McLaurin J. Current concepts and future prospects for Alzheimer disease vaccines. Alzheimer Dis Assoc Disord. 2004 Jan-Mar;18(1):38-43. Amyloid Beta Clearance

Wyss-Coray T. Transforming Growth Factor-b Signaling Pathway as a Therapeutic Target in Neurodegeneration. J Mol Neurosci. 2004;24(1):149-54. Amyloid Beta Clearance

Larry Sparks D. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain. J Mol Neurosci. 2004;24(1):97-104. Amyloid Beta Clearance

Silverberg GD, Mayo M, Saul T, Carvalho J, McGuire D. Novel ventriculo-peritoneal shunt in Alzheimer's disease cerebrospinal fluid biomarkers. Expert Rev Neurother. 2004 Jan;4(1):97-107. Amyloid Beta Clearance

Rangan SK, Liu R, Brune D, Planque S, Paul S, Sierks MR. Degradation of beta-amyloid by proteolytic antibody light chains. Biochemistry. 2003 Dec 9;42(48):14328-34. Amyloid Beta Clearance

Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT. Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiol Dis. 2003 Dec;14(3):504-12. Amyloid Beta Clearance

Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. Eur J Immunol. 2003 Dec;33(12):3232-41. Amyloid Beta Clearance

Hirschfield GM, Hawkins PN. Amyloidosis: new strategies for treatment. Int J Biochem Cell Biol. 2003 Dec 1;35(12):1608-13. Amyloid Beta Clearance

Lombardo JA, Stern EA, McLellan ME, Kajdasz ST, Hickey GA, Bacskai BJ, Hyman BT. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J Neurosci. 2003 Nov 26;23(34):10879-83. Amyloid Beta Clearance

Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y, Horne P, Yang J, Sekoulidis J, Coomaraswamy J, Chishti MA, Cox DW, Mathews PM, Nixon RA, Carlson GA, St George-Hyslop P, Westaway D. In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14193-8. Amyloid Beta Clearance

Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12462-7. Amyloid Beta Clearance

Wang DS, Iwata N, Hama E, Saido TC, Dickson DW. Oxidized neprilysin in aging and Alzheimer's disease brains. Biochem Biophys Res Commun. 2003 Oct 10;310(1):236-41. Amyloid Beta Clearance,  

Melchor JP, Pawlak R, Strickland S. The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration. J Neurosci. 2003 Oct 1;23(26):8867-71. Amyloid Beta Clearance

Causevic M, Ramoz N, Haroutunian V, Davis KL, Buxbaum JD. Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype. J Neuropathol Exp Neurol. 2003 Oct;62(10):999-1005. Amyloid Beta Clearance,

Kaku M, Tsutsui K, Motokawa M, Kawata T, Fujita T, Kohno S, Tohma Y, Ohtani J, Tenjoh K, Tanne K. Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice. Brain Res Brain Res Protoc. 2003 Oct;12(2):104-8. Amyloid Beta Clearance

Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis. 2003 Oct;14(1):10-8. Amyloid Beta Clearance

Sparks DL, Schreurs BG. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11065-9. Amyloid Beta Clearance

Weller RO, Nicoll JA. Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain. Neurol Res. 2003 Sep 1;25(6):611-6. Amyloid Beta Clearance

Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn Reson Med. 2003 Aug 1;50(2):293-302. Amyloid Beta Clearance

Silverberg GD, Mayo M, Saul T, Rubenstein E, McGuire D. Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol. 2003 Aug;2(8):506-11. Amyloid Beta Clearance

Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug;112(3):415-22. Amyloid Beta Clearance

Abe K, Misawa M. The extracellular signal-regulated kinase cascade suppresses amyloid beta protein-induced promotion of glutamate clearance in cultured rat cortical astrocytes. Brain Res. 2003 Jul 25;979(1-2):179-87. Amyloid Beta Clearance

Dickerson TJ, Janda KD. Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8182-7. Amyloid Beta Clearance

Mitrasinovic OM, Vincent VA, Simsek D, Murphy GM. Macrophage colony stimulating factor promotes phagocytosis by murine microglia. Neurosci Lett. 2003 Jul 3;344(3):185-8. Amyloid Beta Clearance

Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. J Neurosci. 2003 Jul 2;23(13):5645-9. Amyloid Beta Clearance

Saric T, Müller D, Seitz HJ, Pavelic K. Non-covalent interaction of ubiquitin with insulin-degrading enzyme. Mol Cell Endocrinol. 2003 Jun 30;204(1-2):11-20. Amyloid Beta Clearance

Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S. Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo. Neurosci Lett. 2003 Jun 26;344(2):87-90. Amyloid Beta Clearance

James AP, Pal S, Gennat HC, Vine DF, Mamo JC. The incorporation and metabolism of amyloid-beta into chylomicron-like lipid emulsions. J Alzheimers Dis. 2003 Jun;5(3):179-88. Amyloid Beta Clearance

Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S. Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1 - 42) in rat microglia. J Pharmacol Sci. 2003 Jun;92(2):115-23. Amyloid Beta Clearance

Davis J, Wagner MR, Zhang W, Xu F, Van Nostrand WE. Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells. J Biol Chem. 2003 May 23;278(21):19054-61. Amyloid Beta Clearance

Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci. 2003 May 1;23(9):3745-51. Amyloid Beta Clearance,  

Serot JM, Bene MC, Faure GC. Choroid plexus, ageing of the brain, and Alzheimer's disease. Front Biosci. 2003 May 1;8:S515-21. Amyloid Beta Clearance

Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med. 2003 Apr;9(4):448-52. Amyloid Beta Clearance

Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci. 2003 Apr;6(4):345-51. Amyloid Beta Clearance

Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med. 2003 Apr;9(4):453-7. Amyloid Beta Clearance

Dodel RC, Hampel H, Du Y. Immunotherapy for Alzheimer's disease. Lancet Neurol. 2003 Apr;2(4):215-20. Amyloid Beta Clearance

Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci. 2003 Mar 15;23(6):1992-6. Amyloid Beta Clearance

Lesne S, Docagne F, Gabriel C, Liot G, Lahiri DK, Buee L, Plawinski L, Delacourte A, MacKenzie ET, Buisson A, Vivien D. TGF-beta1 potentiates amyloid-beta generation in astrocytes and in transgenic mice. J Biol Chem. 2003 Mar 7; Amyloid Beta Clearance

Bard F, Barbour R, Cannon C, Carretto R, Fox M, Games D, Guido T, Hoenow K, Hu K, Johnson-Wood K, Khan K, Kholodenko D, Lee C, Lee M, Motter R, Nguyen M, Reed A, Schenk D, Tang P, Vasquez N, Seubert P, Yednock T. Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2023-8. Amyloid Beta Clearance

Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S. Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis. Biochem Biophys Res Commun. 2003 Feb 14;301(3):699-703. Amyloid Beta Clearance

Hone E, Martins IJ, Fonte J, Martins RN. Apolipoprotein E influences amyloid-beta clearance from the murine periphery. J Alzheimers Dis. 2003 Feb;5(1):1-8. Amyloid Beta Clearance

Kung MP, Skovronsky DM, Hou C, Zhuang ZP, Gur TL, Zhang B, Trojanowski JQ, Lee VM, Kung HF. Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients. J Mol Neurosci. 2003 Feb;20(1):15-24. Amyloid Beta Clearance

Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB. Alzheimer's Disease beta -Amyloid Peptide Is Increased in Mice Deficient in Endothelin-converting Enzyme. J Biol Chem. 2003 Jan 24;278(4):2081-4. Amyloid Beta Clearance

Sánchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 2003 Jan 23;421(6921):373-9. Amyloid Beta Clearance

Hersh LB. Peptidases, Proteases and Amyloid beta-Peptide Catabolism. Curr Pharm Des. 2003;9(6):449-54. Amyloid Beta Clearance

Conway KA, Baxter EW, Felsenstein KM, Reitz AB. Emerging beta-Amyloid Therapies for the Treatment of Alzheimer's Disease. Curr Pharm Des. 2003;9(6):427-47. Amyloid Beta Clearance

Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci. 2003 Jan 1;23(1):29-33. Amyloid Beta Clearance

Abe K, Misawa M. Amyloid beta protein enhances the clearance of extracellular L-glutamate by cultured rat cortical astrocytes. Neurosci Res. 2003 Jan;45(1):25-31. Amyloid Beta Clearance

Janus C. Vaccines for Alzheimer's disease: how close are we? CNS Drugs. 2003;17(7):457-74. Amyloid Beta Clearance

Kowalska A. Amyloid precursor protein gene mutations responsible for early-onset autosomal dominant Alzheimer's disease. Folia Neuropathol. 2003;41(1):35-40. Amyloid Beta Clearance

Petanceska SS, DeRosa S, Sharma A, Diaz N, Duff K, Tint SG, Refolo LM, Pappolla M. Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. J Mol Neurosci. 2003;20(3):395-406. Amyloid Beta Clearance

Guénette SY. Mechanisms of Abeta clearance and catabolism. Neuromolecular Med. 2003;4(3):147-60. Amyloid Beta Clearance

Sparks DL, Lochhead J, Horstman D, Wagoner T, Martin T. Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain. J Alzheimers Dis. 2002 Dec 1;4(6):523-9. Amyloid Beta Clearance

Sparks DL, Lochhead J, Horstman D, Wagoner T, Martin T. Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain. J Alzheimers Dis. 2002 Dec;4(6):523-529. Amyloid Beta Clearance

Banks WA, Terrell B, Farr SA, Robinson SM, Nonaka N, Morley JE. Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease. Peptides. 2002 Dec;23(12):2223-6. Amyloid Beta Clearance

De Felice FG, Ferreira ST. Beta-amyloid production, aggregation, and clearance as targets for therapy in Alzheimer's disease. Cell Mol Neurobiol. 2002 Dec;22(5-6):545-63. Amyloid Beta Clearance

Sparks DL, Lochhead J, Horstman D, Wagoner T, Martin T. Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain. J Alzheimers Dis. 2002 Dec;4(6):523-9. Amyloid Beta Clearance

Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I. Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med. 2002 Dec 1;8(12):1390-7. Amyloid Beta Clearance

Yamauchi K, Tozuka M, Hidaka H, Nakabayashi T, Sugano M, Katsuyama T. Isoform-specific effect of apolipoprotein E on endocytosis of beta-amyloid in cultures of neuroblastoma cells. Ann Clin Lab Sci. 2002 Winter;32(1):65-74. Amyloid Beta Clearance

de Leon MJ, Segal S, Tarshish CY, DeSanti S, Zinkowski R, Mehta PD, Convit A, Caraos C, Rusinek H, Tsui W, Saint Louis LA, DeBernardis J, Kerkman D, Qadri F, Gary A, Lesbre P, Wisniewski T, Poirier J, Davies P. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neurosci Lett. 2002 Nov 29;333(3):183-6. Amyloid Beta Clearance,  

Lazarov O, Lee M, Peterson DA, Sisodia SS. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci. 2002 Nov 15;22(22):9785-93. Amyloid Beta Clearance

Lue LF, Walker DG. Modeling Alzheimer's disease immune therapy mechanisms: interactions of human postmortem microglia with antibody-opsonized amyloid beta peptide. J Neurosci Res. 2002 Nov 15;70(4):599-610. Amyloid Beta Clearance

Van Uden E, Mallory M, Veinbergs I, Alford M, Rockenstein E, Masliah E. Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. J Neurosci. 2002 Nov 1;22(21):9298-304. Amyloid Beta Clearance

de Leon MJ, Segal S, Tarshish CY, DeSanti S, Zinkowski R, Mehta PD, Convit A, Caraos C, Rusinek H, Tsui W. Longitudinal cerebrospinal fluid tau load increases in mild cognitive impairment. Neurosci Lett. 2002 Nov;333(3):183-6. Abstract

Sigurdsson EM, Wisniewski T, Frangione B. A safer vaccine for Alzheimer's disease? Neurobiol Aging. 2002 Nov-Dec;23(6):1001-8. Amyloid Beta Clearance

Friedland RP. Lipid metabolism, epidemiology, and the mechanisms of Alzheimer's disease. Ann N Y Acad Sci. 2002 Nov;977:387-90. Amyloid Beta Clearance

Yanagisawa K, Matsuzaki K. Cholesterol-dependent aggregation of amyloid beta-protein. Ann N Y Acad Sci. 2002 Nov;977:384-6. Amyloid Beta Clearance

Rogers J, Strohmeyer R, Kovelowski CJ, Li R. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia. 2002 Nov;40(2):260-9. Amyloid Beta Clearance

Tabira T. [Progress in developing anti-Alzheimer drugs] Nippon Yakurigaku Zasshi. 2002 Nov;120(1):34P-36P. Amyloid Beta Clearance

Morelli L, Llovera R, Ibendahl S, Castaño EM. The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses. Neurochem Res. 2002 Nov;27(11):1387-99. Amyloid Beta Clearance

Chauhan NB. Trafficking of intracerebroventricularly injected antisense oligonucleotides in the mouse brain. Antisense Nucleic Acid Drug Dev. 2002 Oct;12(5):353-7. Amyloid Beta Clearance

Mukherjee A, Hersh LB. Regulation of amyloid beta-peptide levels by enzymatic degradation. J Alzheimers Dis. 2002 Oct;4(5):341-8. Amyloid Beta Clearance

Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, Warzok RW. Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics. 2002 Oct 1;12(7):535-41. Amyloid Beta Clearance

Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002 Sep 15;22(18):7873-8. Amyloid Beta Clearance

Boussaha M, Hannequin D, Verpillat P, Brice A, Frebourg T, Campion D. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. Neurosci Lett. 2002 Aug 23;329(1):121. Amyloid Beta Clearance, ,  

Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10837-42. Amyloid Beta Clearance

Wisniewski T, Brown DR, Sigurdsson EM. Therapeutics in Alzheimer's and prion diseases. Biochem Soc Trans. 2002 Aug;30(4):574-8. Amyloid Beta Clearance

Goto JJ, Tanzi RE. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. J Mol Neurosci. 2002 Aug-Oct;19(1-2):37-41. Amyloid Beta Clearance

Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA. Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease. J Mol Neurosci. 2002 Aug-Oct;19(1-2):11-6. Amyloid Beta Clearance

Kamino K, Tanaka T, Kida T, Ohkochi M, Tanii H, Kudo T, Takeda M. [The role of lipid metabolism in Alzheimer's disease] Nihon Shinkei Seishin Yakurigaku Zasshi. 2002 Aug;22(4):103-10. Amyloid Beta Clearance

Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002 Jul 19;297(5580):353-6. Amyloid Beta Clearance

Arélin K, Kinoshita A, Whelan CM, Irizarry MC, Rebeck GW, Strickland DK, Hyman BT. LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes. Brain Res Mol Brain Res. 2002 Jul 15;104(1):38-46. Amyloid Beta Clearance

Evin G, Weidemann A. Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides. Peptides. 2002 Jul;23(7):1285-97. Amyloid Beta Clearance

Dominguez DI, Strooper BD. Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease. Trends Pharmacol Sci. 2002 Jul;23(7):324-30. Amyloid Beta Clearance

Ikegaya Y, Matsuura S, Ueno S, Baba A, Yamada MK, Nishiyama N, Matsuki N. beta-Amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy. J Biol Chem. 2002 Jun 17; Amyloid Beta Clearance

Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun 1;38(6):303-13. Amyloid Beta Clearance

Palmblad M, Westlind-Danielsson A, Bergquist J. Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers. J Biol Chem. 2002 May 31;277(22):19506-10. Amyloid Beta Clearance

Bentley NM, LaDu MJ, Rajan C, Getz GS, Reardon CA. Apoprotein E Structural Requirements for SDS-stable complex formation with beta-amyloid(1-40). The Role of Salt Bridges. Biochem J. 2002 May 17;Pt Amyloid Beta Clearance

Dodart JC, Bales KR, Gannon KS, Greene SJ, Demattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci. 2002 May;5(5):452-7. Amyloid Beta Clearance

Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun;23(3):405-12. Amyloid Beta Clearance

Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J. 2002 Apr;16(6):601-3. Amyloid Beta Clearance

Buxbaum JD, Cullen EI, Friedhoff LT. Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Front Biosci. 2002 Apr 1;7:a50-9. Amyloid Beta Clearance

Barrow CJ. Advances in the Development of Abeta-Related Therapeutic Strategies for Alzheimer's Disease. Drug News Perspect. 2002 Mar;15(2):102-109. Amyloid Beta Clearance

Gau JT, Steinhilb ML, Kao TC, D'Amato CJ, Gaut JR, Frey KA, Turner RS. Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice. Am J Pathol. 2002 Feb 1;160(2):731-8. Amyloid Beta Clearance

Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):24-35. Amyloid Beta Clearance

Sánchez-Guerra M, Combarros O, Infante J, Llorca J, Berciano J, Fontalba A, Fernández-Luna JL, Peña N, Fernández-Viadero C. Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease. Neurosci Lett. 2001 Dec 4;316(1):17-20. Amyloid Beta Clearance,  

Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC. Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons. J Biochem. 2001 Dec;130(6):721-6. Amyloid Beta Clearance

Sjögren M, Gisslén M, Vanmechelen E, Blennow K. Low cerebrospinal fluid beta-amyloid 42 in patients with acute bacterial meningitis and normalization after treatment. Neurosci Lett. 2001 Nov 13;314(1-2):33-6. Amyloid Beta Clearance

Abraham CR. Reactive astrocytes and alpha1-antichymotrypsin in Alzheimer's disease. Neurobiol Aging. 2001 Nov-Dec;22(6):931-6. Amyloid Beta Clearance

Harris-White ME, Chu T, Miller SA, Simmons M, Teter B, Nash D, Cole GM, Frautschy SA. Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo. Neurochem Int. 2001 Nov-Dec;39(5-6):435-48. Amyloid Beta Clearance

Rogers J, Lue LF. Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem Int. 2001 Nov-Dec;39(5-6):333-40. Amyloid Beta Clearance

Wilcock DM, Gordon MN, Ugen KE, Gottschall PE, DiCarlo G, Dickey C, Boyett KW, Jantzen PT, Connor KE, Melachrino J, Hardy J, Morgan D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA Cell Biol. 2001 Nov;20(11):731-6. Amyloid Beta Clearance

Vehmas AK, Borchelt DR, Price DL, McCarthy D, Wills-Karp M, Peper MJ, Rudow G, Luyinbazi J, Siew LT, Troncoso JC. beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. DNA Cell Biol. 2001 Nov;20(11):713-21. Amyloid Beta Clearance

Golde TE, Eckman CB. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discov Today. 2001 Oct 15;6(20):1049-1055. Amyloid Beta Clearance

Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct;8(5):792-806. Amyloid Beta Clearance

Holtzman DM. Role of apoe/Abeta interactions in the pathogenesis of Alzheimer's disease and cerebral amyloid angiopathy. J Mol Neurosci. 2001 Oct;17(2):147-55. Amyloid Beta Clearance

Galasko D. Biological markers and the treatment of Alzheimer's disease. J Mol Neurosci. 2001 Oct;17(2):119-25. Amyloid Beta Clearance

Schenk D, Games D, Seubert P. Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Abeta immunization. J Mol Neurosci. 2001 Oct;17(2):259-67. Amyloid Beta Clearance

Du Y, Dodel R, Hampel H, Buerger K, Lin S, Eastwood B, Bales K, Gao F, Moeller HJ, Oertel W, Farlow M, Paul S. Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology. 2001 Sep 11;57(5):801-5. Amyloid Beta Clearance,  

Kuo YM, Beach TG, Sue LI, Scott S, Layne KJ, Kokjohn TA, Kalback WM, Luehrs DC, Vishnivetskaya TA, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Weller RO, Roher AE. The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease. Mol Med. 2001 Sep 1;7(9):609-18. Amyloid Beta Clearance

Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 2001 Aug 17;69(13):1471-84. Amyloid Beta Clearance,  

Demattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5. Amyloid Beta Clearance

Lauderback CM, Hackett JM, Huang FF, Keller JN, Szweda LI, Markesbery WR, Butterfield DA. The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42. J Neurochem. 2001 Jul;78(2):413-6. Amyloid Beta Clearance

Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol. 2001 Jun 15;166(12):7496-503. Amyloid Beta Clearance

Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends Mol Med. 2001 Jun;7(6):264-9. Amyloid Beta Clearance

Barnes H, Larsen B, Tyers M, van Der Geer P. Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells. J Biol Chem. 2001 Jun 1;276(22):19119-25. Amyloid Beta Clearance

Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med. 2001 May;7(5):612-8. Amyloid Beta Clearance

Puglielli L, Kovacs DM. Alzheimer disease: 100 years later. Rev Med Chil. 2001 May;129(5):569-75. Amyloid Beta Clearance

Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med. 2001 Mar;7(3):369-72. Amyloid Beta Clearance

Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ. Bip/GRP78-induced production of cytokines and uptake of amyloid-beta(1-42) peptide in microglia. Biochem Biophys Res Commun. 2001 Feb 16;281(1):6-10. Amyloid Beta Clearance

Lauer D, Reichenbach A, Birkenmeier G. Alpha 2-macroglobulin-mediated degradation of amyloid beta 1--42: a mechanism to enhance amyloid beta catabolism. Exp Neurol. 2001 Feb;167(2):385-92. Amyloid Beta Clearance

Christie RH, Bacskai BJ, Zipfel WR, Williams RM, Kajdasz ST, Webb WW, Hyman BT. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci. 2001 Feb 1;21(3):858-64. Amyloid Beta Clearance

Ji Y, Permanne B, Sigurdsson EM, Holtzman DM, Wisniewski T. Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice. J Alzheimers Dis. 2001 Feb;3(1):23-30. Amyloid Beta Clearance

Sánchez L, Alvarez V, González P, González I, Alvarez R, Coto E. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. Am J Med Genet. 2001 Jan 8;105(1):76-8. Amyloid Beta Clearance,  

Chodobski A, Szmydynger-Chodobska J. Choroid plexus: target for polypeptides and site of their synthesis. Microsc Res Tech. 2001 Jan 1;52(1):65-82. Amyloid Beta Clearance

Hoozemans JJ, Rozemuller AJ, Veerhuis R, Eikelenboom P. Immunological aspects of alzheimer's disease: therapeutic implications. BioDrugs. 2001;15(5):325-37. Amyloid Beta Clearance

Munson GW, Roher AE, Kuo YM, Gilligan SM, Reardon CA, Getz GS, LaDu MJ. SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides. Biochemistry. 2000 Dec 26;39(51):16119-24. Amyloid Beta Clearance

Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP, Pyrek JS, Estus S, Hersh LB. Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques. J Neurosci. 2000 Dec 1;20(23):8745-9. Amyloid Beta Clearance

Yamauchi K, Tozuka M, Hidaka H, Nakabayashi T, Sugano M, Kondo Y, Nakagawara A, Katsuyama T. Effect of apolipoprotein AII on the interaction of apolipoprotein E with beta-amyloid: some apo(E-AII) complexes inhibit the internalization of beta-amyloid in cultures of neuroblastoma cells. J Neurosci Res. 2000 Nov 15;62(4):608-14. Amyloid Beta Clearance

Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest. 2000 Nov;106(9):1159-66. Amyloid Beta Clearance

Irizarry MC, Cheung BS, Rebeck GW, Paul SM, Bales KR, Hyman BT. Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice. Acta Neuropathol. 2000 Nov;100(5):451-8. Amyloid Beta Clearance

Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. Biochem J. 2000 Oct 15;351 Pt 2:509-16. Amyloid Beta Clearance

Dewachter I, Van Dorpe J, Spittaels K, Tesseur I, Van den Haute C, Moechars D, Van Leuven F. Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice. Exp Gerontol. 2000 Sep;35(6-7):831-41. Amyloid Beta Clearance

Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000 Aug;6(8):916-9. Amyloid Beta Clearance,  

Fukuchi K, Li L, Hart M, Lindsey JR. Accumulation of amyloid-beta protein in exocrine glands of transgenic mice overexpressing a carboxyl terminal portion of amyloid protein precursor. Int J Exp Pathol. 2000 Aug 1;81(4):231-9. Amyloid Beta Clearance

Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul;6(7):718-9. Amyloid Beta Clearance

Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7609-14. Amyloid Beta Clearance

Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, LaDu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 1;348 Pt 2:359-65. Amyloid Beta Clearance

Hyman BT, Strickland D, Rebeck GW. Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease. Arch Neurol. 2000 May;57(5):646-50. Amyloid Beta Clearance

Prior R, Wihl G, Urmoneit B. Apolipoprotein E, smooth muscle cells and the pathogenesis of cerebral amyloid angiopathy: the potential role of impaired cerebrovascular A beta clearance. Ann N Y Acad Sci. 2000 Apr;903:180-6. Amyloid Beta Clearance

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 1;20(5):1657-65. Amyloid Beta Clearance