Beta Amyloid Peptide: Research Paper : Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

Abstract

Purpose of review: The term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems with speech and language. They present considerable challenges to clinicians and researchers.

Recent findings: Here, we review critical issues around diagnosis of the three major PPA variants (semantic variant PPA, nonfluent/agrammatic variant PPA, logopenic variant PPA), as well as considering 'fragmentary' syndromes. We next consider issues around assessing disease stage, before discussing physiological phenotyping of proteinopathies across the PPA spectrum. We also review evidence for core central auditory impairments in PPA, outline critical challenges associated with treatment, discuss pathophysiological features of each major PPA variant, and conclude with thoughts on key challenges that remain to be addressed. New findings elucidating the pathophysiology of PPA represent a major step forward in our understanding of these diseases, with implications for diagnosis, care, management, and therapies.

Keywords: Alzheimer's disease; Frontotemporal dementia; Logopenic aphasia; Physiology; Primary progressive aphasia; Progressive nonfluent aphasia; Semantic dementia.

This article originally appeared in the "https://pubmed.ncbi.nlm.nih.gov/33543347/" and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.