Alzheimer’s Research Papers ~ April 2002 ~ Beta Amyloid Blog
Thompson VF, Saldaña S, Cong J, Luedke DM, Goll DE. The calpain system in human placenta. Life Sci. 2002 Apr 21;70(21):2493-508.
Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y. N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci. 2002 Apr 21;70(21):2567-80.
Yip CM, Darabie AA, McLaurin J. Abeta42-Peptide assembly on lipid bilayers. J Mol Biol. 2002 Apr 19;318(1):97-107.
Fidani L, Goulas A, Mirtsou V, Petersen RC, Tangalos E, Crook R, Hardy J. Interleukin-1A polymorphism is not associated with late onset Alzheimer's disease. Neurosci Lett. 2002 Apr 19;323(1):81-3. ,
D'Andrea MR, Nagele RG, Gumula NA, Reiser PA, Polkovitch DA, Hertzog BM, Andrade-Gordon P. Lipofuscin and Abeta42 exhibit distinct distribution patterns in normal and Alzheimer's disease brains. Neurosci Lett. 2002 Apr 19;323(1):45-9.
Bishop GM, Robinson SR, Smith MA, Perry G, Atwood CS. Call for Elan to publish Alzheimer's trial details. Nature. 2002 Apr 18;416(6882):677.
Münch G, Shepherd CE, McCann H, Brooks WS, Kwok JB, Arendt T, Hallupp M, Schofield PR, Martins RN, Halliday GM. Intraneuronal advanced glycation endproducts in presenilin-1 Alzheimer's disease. Neuroreport. 2002 Apr 16;13(5):601-4. ,
Evin G, Smith MJ, Tziotis A, McLean C, Canterford L, Sharples RA, Cappai R, Weidemann A, Beyreuther K, Cotton RG, Masters CL, Culvenor JG. Alternative transcripts of presenilin-1 associated with frontotemporal dementia. Neuroreport. 2002 Apr 16;13(5):719-23.
Davidsson P, Westman-Brinkmalm A, Nilsson CL, Lindbjer M, Paulson L, Andreasen N, Sjögren M, Blennow K. Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients. Neuroreport. 2002 Apr 16;13(5):611-5.
Parkin ET, Trew A, Christie G, Faller A, Mayer R, Turner AJ, Hooper NM. Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha. Biochemistry. 2002 Apr 16;41(15):4972-81.
Frenkel D, Solomon B. Filamentous phage as vector-mediated antibody delivery to the brain. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5675-9.
Perutz MF, Pope BJ, Owen D, Wanker EE, Scherzinger E. Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5596-600.
Perutz MF, Finch JT, Berriman J, Lesk A. Amyloid fibers are water-filled nanotubes. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5591-5.
Uterga Valiente JM, Rodr guez Iriarte ML, Gonz lez Garc a AI, Taramundi Arg eso S, Lvaro Gonz lez LC, Cortina Garaicorta C. [Dementia with frontal lobe atrophy: clinical study from 18 patients with cognitive impairment and frontal lobe involvement detected by structural and functional neuroimaging] Rev Neurol. 2002 Apr 16;34(8):709-14.
Akatsu H, Takahashi M, Matsukawa N, Ishikawa Y, Kondo N, Sato T, Nakazawa H, Yamada T, Okada H, Yamamoto T, Kosaka K. Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital. J Neurol Sci. 2002 Apr 15;196(1-2):63-9.
Boncristiano S, Calhoun ME, Kelly PH, Pfeifer M, Bondolfi L, Stalder M, Phinney AL, Abramowski D, Sturchler-Pierrat C, Enz A, Sommer B, Staufenbiel M, Jucker M. Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. J Neurosci. 2002 Apr 15;22(8):3234-43.
Yaffe K, Lui LY, Grady D, Stone K, Morin P. Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry. 2002 Apr 15;51(8):677-82.
Marambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 2002 Apr 15;21(8):1948-56.
Srivastava RA, Jain JC. Scavenger receptor class B type I expression and elemental analysis in cerebellum and parietal cortex regions of the Alzheimer's disease brain. J Neurol Sci. 2002 Apr 15;196(1-2):45-52.
Muñoz FJ, Opazo C, Gil-Gómez G, Tapia G, Fernández V, Valverde MA, Inestrosa NC. Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant. J Neurosci. 2002 Apr 15;22(8):3081-9.
Habeck M. New insights into Alzheimer's disease. Drug Discov Today. 2002 Apr 15;7(8):441-442.
Erkinjuntti T, Kurz A, Gauthier S, Bullock R, Lilienfeld S, Damaraju CV. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet. 2002 Apr 13;359(9314):1283-90.
Charatan F. Medicare will now cover some treatments for Alzheimer's disease. BMJ. 2002 Apr 13;324(7342):872.
Hetényi C, Szabó Z, Klement E, Datki Z, Körtvélyesi T, Zarándi M, Penke B. Pentapeptide amides interfere with the aggregation of beta-amyloid peptide of Alzheimer's disease. Biochem Biophys Res Commun. 2002 Apr 12;292(4):931-6.
Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem. 2002 Apr 12;277(15):12915-20.
Fidani L, Compton D, Hardy J, Petersen RC, Tangalos E, Mirtsou V, Goulas A, De Vrieze FW. No association between the lipoprotein lipase S447X polymorphism and Alzheimer's disease. Neurosci Lett. 2002 Apr 12;322(3):192-4. ,
Mounier N, André M, Lepage E. Nonsteroidal drugs and Alzheimer's disease. N Engl J Med. 2002 Apr 11;346(15):1171-3.
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Hüll M, Lieb K, Fiebich BL. Nonsteroidal drugs and Alzheimer's disease. N Engl J Med. 2002 Apr 11;346(15):1171-3.
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Delobel P, Flament S, Hamdane M, Delacourte A, Vilain JP, Buée L. Modelling Alzheimer-specific abnormal Tau phosphorylation independently of GSK3beta and PKA kinase activities. FEBS Lett. 2002 Apr 10;516(1-3):151-5.
Koudinov AR, Berezov TT, Koudinova NV. Cholesterol and Alzheimer's disease: is there a link? Neurology. 2002 Apr 9;58(7):1135.
Aisen PS, Schmeidler J, Pasinetti GM. Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology. 2002 Apr 9;58(7):1050-4.
Dal Forno G, Carson KA, Brookmeyer R, Troncoso J, Kawas CH, Brandt J. APOE genotype and survival in men and women with Alzheimer's disease. Neurology. 2002 Apr 9;58(7):1045-50. ,
Matsubara-Tsutsui M, Yasuda M, Yamagata H, Nomura T, Taguchi K, Kohara K, Miyoshi K, Miki T. Molecular evidence of presenilin 1 mutation in familial early onset dementia. Am J Med Genet. 2002 Apr 8;114(3):292-8.
Myllykangas L, Polvikoski T, Reunanen K, Wavrant-De Vrieze F, Ellis C, Hernandez D, Sulkava R, Kontula K, Verkkoniemi A, Notkola IL, Hardy J, Perez-Tur J, Haltia MJ, Tienari PJ. ApoE epsilon3-haplotype modulates Alzheimer beta-amyloid deposition in the brain. Am J Med Genet. 2002 Apr 8;114(3):288-91. ,
Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H. Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis. J Biol Chem. 2002 Apr 5;277(14):12128-36.
Sun W, Qureshi HY, Cafferty PW, Sobue K, Agarwal-Mawal A, Neufield KD, Paudel HK. Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules. J Biol Chem. 2002 Apr 5;277(14):11933-40.
Haas J, Storch-Hagenlocher B, Biessmann A, Wildemann B. Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with beta-amyloid 1-42 in vitro. Neurosci Lett. 2002 Apr 5;322(2):121-5.
Hauss-Wegrzyniak B, Wenk GL. Beta-amyloid deposition in the brains of rats chronically infused with thiorphan or lipopolysaccharide: the role of ascorbic acid in the vehicle. Neurosci Lett. 2002 Apr 5;322(2):75-8.
Ahn BH, Rhim H, Kim SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Lee YH, Kwon TK, Chung KC, Yoon SH, Hahn SJ, Kim MS, Jo YH, Min do S. alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem. 2002 Apr 5;277(14):12334-42.
Chou KC, Howe WJ. Prediction of the tertiary structure of the beta-secretase zymogen. Biochem Biophys Res Commun. 2002 Apr 5;292(3):702-8.
Kaplan B, Pras M. Combined use of micro-preparative gel electrophoresis and reversed-phase high-performance liquid chromatography for purification of amyloid beta peptides deposited in brains of Alzheimer's disease patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Apr 5;769(2):363-70.
Kiuchi Y, Isobe Y, Fukushima K, Kimura M. Disassembly of amyloid beta-protein fibril by basement membrane components. Life Sci. 2002 Apr 5;70(20):2421-31.
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002 Apr 4;416(6880):535-9.
Bucciantini M, Giannoni E, Chiti F, Baroni F, Formigli L, Zurdo J, Taddei N, Ramponi G, Dobson CM, Stefani M. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature. 2002 Apr 4;416(6880):507-11.
Smith AD. Imaging the progression of Alzheimer pathology through the brain. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4135-7.
Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J. 2002 Apr 2;21(7):1524-34.
Short RA, Graff-Radford NR, Adamson J, Baker M, Hutton M. Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes. Arch Neurol. 2002 Apr;59(4):611-5.
Graff-Radford NR, Green RC, Go RC, Hutton ML, Edeki T, Bachman D, Adamson JL, Griffith P, Willis FB, Williams M, Hipps Y, Haines JL, Cupples LA, Farrer LA. Association between apolipoprotein E genotype and Alzheimer disease in African American subjects. Arch Neurol. 2002 Apr;59(4):594-600.
Wang X, DeKosky ST, Luedecking-Zimmer E, Ganguli M, Kamboh I. Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease. Hum Genet. 2002 Apr;110(4):356-65. ,
Riviere GR, Riviere KH, Smith KS . Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol. 2002 Apr;17(2):113-8.
Royall DR, Palmer R, Mulroy AR, Polk MJ, Román GC, David JP, Delacourte A. Pathological determinants of the transition to clinical dementia in Alzheimer's disease. Exp Aging Res. 2002 Apr-Jun;28(2):143-62.
Casolini P, Catalani A, Zuena AR , Angelucci L. Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat. J Neurosci Res. 2002 Apr 1;68(1):59-64.
Zandi PP, Breitner JC, Anthony JC. Is pharmacological prevention of Alzheimer's a realistic goal? Expert Opin Pharmacother. 2002 Apr;3(4):365-380.
Müller U, Kins S. APP on the move. Trends Mol Med. 2002 Apr 1;8(4):152-5.
Lleó A, Rey M, Castellví M, Ferrer I, Blesa R. [Asymmetric myoclonic parietal syndrome in a patient with Alzheimer's disease mimicking corticobasal degeneration] Neurologia. 2002 Apr;17(4):223-226.
Soler T, Pujol M, Peña-Casanova J, Hernández G, Sol J, Aguilar M, Blesa R. [Adaptation and standardization of the Geriatric Evaluation of Relative's Rating Instrument (GERRI) for Spain] Neurologia. 2002 Apr;17(4):193-199.
Haan MN, Jagust WJ, Galasko D, Kaye J. Effect of extrapyramidal signs and Lewy bodies on survival in patients with Alzheimer disease. Arch Neurol. 2002 Apr;59(4):588-93.
Perini G, Della-Bianca V, Politi V, Della Valle G, Dal-Pra I, Rossi F, Armato U. Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines. J Exp Med. 2002 Apr 1;195(7):907-18.
Grön G, Bittner D, Schmitz B, Wunderlich AP, Riepe MW. Subjective memory complaints: objective neural markers in patients with Alzheimer's disease and major depressive disorder. Ann Neurol. 2002 Apr;51(4):491-8.
Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FA, Goetz CG, Mastaglia F, Stajich JM, Gibson RA, Middleton LT, Saunders AM, Scott BL, Small GW, Nicodemus KK, Reed AD, Schmechel DE, Welsh-Bohmer KA, Conneally PM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 2002 Apr 1;70(4):985-93.
Chopin P, Colpaert FC, Marien M. Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents. J Pharmacol Exp Ther. 2002 Apr;301(1):187-96.
Gander R, Eller P, Kaser S, Theurl I, Walter D, Sauper T, Ritsch A, Patsch JR, Föger B. Molecular characterization of rabbit phospholipid transfer protein. Choroid plexus and ependyma synthesize high levels of phospholipid transfer protein. J Lipid Res. 2002 Apr;43(4):636-45.
Gregory C, Lough S, Stone V, Erzinclioglu S, Martin L, Baron-Cohen S, Hodges JR. Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications. Brain. 2002 Apr;125(Pt 4):752-64.
Pickering-Brown SM, Richardson AM, Snowden JS, McDonagh AM, Burns A, Braude W, Baker M, Liu WK, Yen SH, Hardy J, Hutton M, Davies Y, Allsop D, Craufurd D, Neary D, Mann DM. Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene. Brain. 2002 Apr 1;125(Pt 4):732-51.
Gnjec A, Fonte JA, Atwood C, Martins RN. Transition metal chelator therapy--a potential treatment for Alzheimer's disease? Front Biosci. 2002 Apr 1;7:d1016-23.
Kril JJ, Patel S, Harding AJ, Halliday GM. Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation. Acta Neuropathol (Berl). 2002 Apr;103(4):370-6.
Peila R, Rodriguez BL, Launer LJ, . Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes. 2002 Apr 1;51(4):1256-62.
Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion MK, Weinberg G, Klockgether T, Feinstein DL. Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. J Neurosci. 2002 Apr 1;22(7):2434-42.
Naumann T, Casademunt E, Hollerbach E, Hofmann J, Dechant G, Frotscher M, Barde YA. Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. J Neurosci. 2002 Apr 1;22(7):2409-18.
Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S. Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins. FASEB J. 2002 Apr;16(6):601-3.
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Kovács GG, Budka H. Aging, the brain and human prion disease. Exp Gerontol. 2002 Apr;37(4):603-5.
Buxbaum JD, Cullen EI, Friedhoff LT. Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Front Biosci. 2002 Apr 1;7:a50-9.
Visser PJ, Verhey FR, Hofman PA, Scheltens P, Jolles J. Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment. J Neurol Neurosurg Psychiatry. 2002 Apr;72(4):491-7.
Yamada M, Sodeyama N, Itoh Y, Otomo E, Matsushita M, Mizusawa H. No association of paraoxonase genotype or atherosclerosis with cerebral amyloid angiopathy. Stroke. 2002 Apr;33(4):896-900. ,
Hu YY, He SS, Wang X, Duan QH, Grundke-Iqbal I, Iqbal K, Wang J. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. Am J Pathol. 2002 Apr;160(4):1269-78. ,
Münch G, Robinson SR. Alzheimer's vaccine: a cure as dangerous as the disease? J Neural Transm. 2002 Apr;109(4):537-9.
Caterini F, Della SS, Spinnler H, Stangalino C, Tumbull OH. Object recognition and object orientation in Alzheimer's disease. Neuropsychology. 2002 Apr;16(2):146-55.
Jacobson MW, Delis DC, Bondi MW, Salmon DP. Do neuropsychological tests detect preclinical Alzheimer's disease: individual-test versus cognitive-discrepancy score analyses. Neuropsychology. 2002 Apr;16(2):132-9.
Woodruff-Pak DS, Green JT, Pak JT, Heifets B, Pak MH. The effect of scopolamine in older rabbits tested in the 750 ms delay eyeblink classical conditioning procedure. Integr Physiol Behav Sci. 2002 Apr-Jun;37(2):103-13.
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Zhang S, Janciauskiene S. Multi-functional capability of proteins: alpha1-antichymotrypsin and the correlation with Alzheimer's disease. J Alzheimers Dis. 2002 Apr;4(2):115-22.
Meli M, Perier C, Ferron C, Parssegny F, Denis C, Gonthier R, Laurent B, Reynaud E, Frey J, Chamson A. Serum pentosidine as an indicator of Alzheimer's disease. J Alzheimers Dis. 2002 Apr;4(2):93-6.
Lange R, Donathan CL, Hughes LF. Assessing olfactory abilities with the University of Pennsylvania smell identification test: a Rasch scaling approach. J Alzheimers Dis. 2002 Apr;4(2):77-91.
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Tomizawa K, Ohta J, Matsushita M, Moriwaki A, Li ST, Takei K, Matsui H. Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J Neurosci. 2002 Apr 1;22(7):2590-7.
Meehan KM, Wang H, David SR, Nisivoccia JR, Jones B, Beasley CM, Feldman PD, Mintzer JE, Beckett LM, Breier A. Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: a double-blind, randomized study in acutely agitated patients with dementia. Neuropsychopharmacology. 2002 Apr;26(4):494-504.
Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. Am J Clin Nutr. 2002 Apr;75(4):616-58.
McKinnon SJ, Lehman DM, Kerrigan-Baumrind LA, Merges CA, Pease ME, Kerrigan DF, Ransom NL, Tahzib NG, Reitsamer HA, Levkovitch-Verbin H, Quigley HA, Zack DJ. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1077-87.
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Fagan AM, Watson M, Parsadanian M, Bales KR, Paul SM, Holtzman DM. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2002 Apr;9(3):305-18. ,
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Sisodia SS, St George-Hyslop PH. gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? Nat Rev Neurosci. 2002 Apr;3(4):281-90.
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Tanaka M, Fukuyama H, Yamauchi H, Narita M, Nabatame H, Yokode M, Fujimoto N, Kita T, Murakami M. Regional cerebral blood flow abnormalities in nondemented patients with memory impairment. J Neuroimaging. 2002 Apr;12(2):112-8.
Pansari K, Gupta A, Thomas P. Alzheimer's disease and vascular factors: facts and theories. Int J Clin Pract. 2002 Apr;56(3):197-203.
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Cardinali DP, Brusco LI, Liberczuk C, Furio AM. REVIEW. The use of melatonin in Alzheimer's disease. Neuroendocrinol Lett. 2002 Apr;23 Suppl 1:20-3.
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