Beta Amyloid Peptide

Beta Amyloid Peptide: CONFERENCE COVERAGE: Proteostasis Consortium Seminars: Targeting Protein Folding and Stability Using Small Molecules

Proteostasis Consortium Seminars: Targeting Protein Folding and Stability Using Small Molecules

Organizers: The Proteostasis Consortium led by Richard Morimoto, Ph.D., Northwestern University
Speaker: Jason Gestwicki, PhD, University of California, San Francisco
Meeting time: 12 PM EDT
Zoom link: https://stanford.zoom.us/j/94026057431  

This article originally appeared in the "  https://www.alzforum.org/conference-calendar/1355661   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.  





Beta Amyloid Peptide: CONFERENCE COVERAGE: Proteostasis Consortium Seminars: Chaperome-Mediated Protein Connectivity Dysfunctions – From Mechanisms, To Detection and Treatment


Proteostasis Consortium Seminars: Chaperome-Mediated Protein Connectivity Dysfunctions – From Mechanisms, To Detection and Treatment


Organizers: The Proteostasis Consortium led by Richard Morimoto, Ph.D., Northwestern University
Speaker: Gabriela Chiosis, PhD, Memorial Sloan Kettering
Meeting time: 12 PM EDT
Zoom link: https://stanford.zoom.us/j/94026057431  

This article originally appeared in the "  https://www.alzforum.org/conference-calendar/1355326   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.  






Beta Amyloid Peptide: CONFERENCE COVERAGE: The Parkinson Postdoc Program "3P" Seminar Series: "The Cell Biology of Parkinson's Disease"

Organizers: The Cure Parkinson's Trust, Van Andel Institute, and World Parkinson Coalition
Speakers: Benoît Vanderperre, PhD, Edward Fon's lab, McGill University: "A Genome-Wide CRISPR Screen Identifies Genetic Modifiers of Alpha-Synuclein Aggregates Uptake" and William Hancock-Cerutti, Pietro De Camilli's lab, Yale University: "Cell Biology of VPS13C/PARK23, a Novel Lipid Transport Protein"
Meeting time: 12 PM EDT  

This article originally appeared in the "  https://www.alzforum.org/conference-calendar/1380301   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice.  




Research of Beta Amyloid Peptide: Jobs : Postdoctoral Associate

Postdoctoral Associate

Employer

Cornell University

Location

Ithaca, New York

Principal Investigator

Fenghua Hu

Contact

Interested candidates should send a copy of CV, statement of research interests and three letters of references to fenghualab@gmail.com.

Description

Postdoctoral positions are currently available in the Hu lab to study molecular and cellular mechanisms of neurodegeneration. The lab is seeking candidates who have a strong background in biochemistry, molecular biology, cell biology, or mouse genetics with interests in neurodegeneration. Please visit its website, https://hu.wicmb.cornell.edu/, for details. 

Requirements

Ph.D. in cell biology, biochemistry or neuroscience.


This article originally appeared in the " https://www.alzforum.org/jobs/postdoctoral-associate    " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 





Research of Beta Amyloid Peptide: Jobs : Director, Division of Aging Biology

Director, Division of Aging Biology

Employer

NIH, National Institute on Aging

Location

Bethesda, Maryland

Contact

Please send a cover letter, current curriculum vitae, including bibliography, a vision statement, and a statement that addresses the specific qualification requirements listed above (please limit both statements to two pages each), and three letters of reference to Cheryl Caponiti (caponitc@mail.nih.gov). NIA plans to have the position open until filled.

You may contact Cheryl Caponiti at caponitc@mail.nih.gov for more information about this vacancy.

Description

The National Institute on Aging is seeking an innovative scientific leader to serve as Director of its extramural Division of Aging Biology (DAB).  The position reports directly to the NIA director.

Over the last two decades research on the biological mechanisms of aging has expanded almost exponentially. It is now widely acknowledged that the mechanisms of aging determine the quality of health and function, as well as contributing to the pathogenesis and modulating the progression of most chronic diseases. A greater understanding of the aging process is a fundamental step toward identifying new preventive and therapeutic strategies that can improve the human life span and reduce the burden of age-related chronic diseases, with large benefits to individuals and society. The DAB has a fundamental role in the accomplishment of this goal with a focus on advancing research on aging by providing funding to support to academic institutions across the U.S. through grants and programs that investigate the basic biology of aging at the molecular, cellular, and organismal level in a variety of model systems. Through its funding programs, DAB supports and ensures continuity and stability of ongoing lines of basic research in aging biology while encouraging and facilitating the emergence of new ideas, concepts, and technologies, as well as new organizational models for aging research. The DAB portfolio is exceptionally broad, covering all research fields of basic aging biology, including fundamental genetic, molecular, and cellular mechanisms of aging, the study of aging in different model systems including comparative studies, search for mechanisms of longevity, and the testing of behavioral and pharmacological treatments in model systems for improvement of health-span and lifespan.

Because of the strong translational nature of the topic addressed, the work of DAB is strongly connected with the research conducted by other components of NIA, as well as other NIH institutes, other academic institutions and medical specialties, with many opportunities for collaborative projects and cross-fertilization of different areas of biological, behavioral, and medical research. These goals of the DAB are implemented through extramural grants, cooperative agreements, collaborative projects, contracts, and other activities.  Additional information regarding the DAB is available at the following website: https://www.nia.nih.gov/research/dab.

The division director serves as the scientific and administrative leader of the DAB and provides scientific expertise and strategic vision for the DAB portfolio, including identification of emerging new directions for basic research in aging biology, support of novel technologies, and development of collaborative programs with other NIA extramural divisions, the NIA Intramural Research Program (IRP), and other NIH Institutes. The Division Director oversees all scientific and administrative operations of the DAB and has responsibility for: (1) scientific planning and strategy, (2) operational administration of the division; (3) oversight of all the division's grants and cooperative agreement research activities; (4) budget management, and (5) working with and advising NIA senior leadership on the development and implementation of long-range strategic, scientific, facility and business plans for the division. The division director oversees approximately 17 scientific and administrative staff and an operating budget of $375,000 and oversees extramural research funding of approximately $313 million.

Salary/Benefits: This position will be filled under a Title 42 excepted service appointment.  Salary is competitive and will be commensurate with the experience of the candidate. A recruitment or relocation bonus may be available, and relocation expenses may be paid. A full package of federal Civil Service benefits is available including retirement, health and life insurance, long term care insurance, leave, and a Thrift Savings Plan (401K equivalent). The successful candidate may be subject to a background investigation and public financial disclosure requirements.  All employees of the Federal Government are subject to the conflict of interest statutes and regulations, including Standards of Ethical Conduct.

DHHS and NIH are Equal Opportunity Employers The NIH is dedicated to building a diverse community in its training and employment programs.

 

 

Requirements

The successful candidate must have an M.D. and/or Ph.D. or equivalent degree in a discipline relevant to biology and have extensive training and experience in research on the biology of aging research or related disciplines that can be applied to aging research. The successful candidate will have experience in collaborative research as documented in publications and more generally will have a history of publications that reflect experience in the requirements of the position. In addition, the candidate must have demonstrated administrative skills in supervising scientific and administrative staff, in overseeing complex research programs, and in collaborating and enhancing partnerships in the aging research community. The candidate should also have experience in developing strategic goals, managing human resources and budgetary planning and management. Eligible candidates who are also active researchers may establish a small laboratory research program in the NIA IRP.


This article originally appeared in the "  https://www.alzforum.org/jobs/director-division-aging-biology    " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






Research of Beta Amyloid Peptide: Jobs : Staff Scientist

Staff Scientist

Employer

National Institutes of Health, National Institutes of Neurological Disorders and Stroke

Location

Bethesda, Maryland

Principal Investigator

John Ngai

Contact

Application packages are to include a Curriculum Vitae with bibliography, statement of research interests and a list of three references to: Nhi Floyd, Senior Administrative Officer, NINDS at NINDSBrainJobs@nih.gov (phone: 301-443-8013). Please include a description of mentoring and outreach activities, especially those that are relevant to the specific areas of study of the Molecular Neurobiology Section. Salary is commensurate with experience and a full package of Civil Service benefits is available. All information provided by applicants will remain confidential and will not be released outside the NINDS search process without a signed release from candidates.

E-mail a single PDF document to Nhi Floyd at NINDSBrainJobs@nih.gov containing the following:

  • Curriculum Vitae with bibliography
  • One-page statement of your philosophy of successful operation of a research laboratory
  • Contact information for at least three references

All employees are subject to a background investigation.

Description

A staff scientist position is available in John Ngai's laboratory in the Molecular Neurobiology Section at the National Institutes of Health. The focus of this position is to oversee studies focused on understanding the genetic, epigenetic, and cell-signaling pathways underlying neural development and adult stem cell-mediated regeneration using the mouse peripheral olfactory system as the primary model. These studies will use a combination of approaches including single-cell transcriptomic and epigenomic analyses, mouse transgenic and other genetic approaches, viral transduction, immunohistochemistry, multiplexed RNA in situ hybridization, and confocal and other advanced light microscopy techniques. Our long-term goal is to elucidate the molecular determinants regulating the progression of cells in a developmental or regenerating pathway during the construction or repair of neural circuits.

At NIH, the staff scientist is a central member of research teams, who typically runs the scientific and teaching aspects of a Principal Investigator's research program. He/she would provide direct supervision for two or three students and/or postdocs. Together with the PI, he/she would steer the long-term direction of the research group. The opportunity also exists for the Staff Scientist to conduct his/her own studies in the above research area.

The successful candidate will be offered salary and benefits commensurate with experience and accomplishments. The appointment would be through the Title 42 mechanism - http://hr.od.nih.gov/benefits/pay/default.htm.

See https://braininitiative.nih.gov/ for further information.

Requirements

Applicants should have a Ph.D. degree (or equivalent) in molecular, cellular, and/or developmental biology, genomics, computational biology, or equivalent field and significant experience in developmental/regenerative biology. He/she should have publications demonstrating these skills, as well as expertise in the area of genomics research. Fluent command of both spoken and written English is imperative.

The applicant should have experience in supervising trainees in laboratory research and must have a track record indicative of innovative thinking.


This article originally appeared in the "  https://www.alzforum.org/jobs/staff-scientist   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






Research of Beta Amyloid Peptide: Jobs : Executive Medical Director Alzheimer's Disease, US Medical Affairs

Executive Medical Director Alzheimer's Disease, US Medical Affairs

Employer

Biogen

Contact

judy.lewallen@biogen.com

Description

This position leads and oversees all the U.S. launch and post-launch activities for Alzheimer's disease. Reporting to the VP-U.S. and Global Alzheimer Medical, the position is responsible for developing and implementing the launch strategy, including the Alzheimer's Disease Medical Science Liaison team and medical directors.

The US Medical Lead represents medical in the Alzheimer's Disease U.S. Leadership Team (US ADLT) and is an ad hoc member of the US Leadership Team (USLT) and in that capacity, has frequent interactions with Executive management. This role oversees a team currently consisting of medical directors and medical science liaisons. This individual is responsible for developing the strategy in alignment with the cross-functional partners and ensuring that the metrics and goals are met across the US AD medical organization.

  • Accountable for the development of the U.S. Launch and post-launch strategy and tactical plan, including developing measurable metrics.
  • Sits on the US ADLT and Alzheimer's Disease Medical Leadership team and she/he is the key point of contact for internal US-related interactions with senior management and externally with the key medical experts and other key stakeholders.
  • Accountable for ensuring production of highest quality local data generation plan in alignment with the cross-functional stakeholders and overall Alzheimer's Disease Medical strategy.
  • Accountable for attracting, retaining, developing and supervising a team of US medical affairs Alzheimer's Disease experts both in the Medical Director office and MSL team as business needs require.

Requirements

At least 10 years in pharmaceutical industry with experience in leading U.S. drug launch activities in medical affairs (neurology preferred).

Experience managing and developing large medical organizations.

Excellent written and oral English communication skills using common business technologies (i.e. Word, PowerPoint).

Demonstrated leadership capabilities including the ability to solve problems effectively in a highly collaborative matrix environment.

M.D., or Ph.D., ideally with training in neurology.



This article originally appeared in the " https://www.alzforum.org/jobs/executive-medical-director-alzheimers-disease-us-medical-affairs    " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






Research of Beta Amyloid Peptide: Jobs : Postdoctoral Research Fellow

Postdoctoral Research Fellow

Employer

Brigham and Women's Hospital

Location

Boston, Massachusetts

Principal Investigator

Cynthia Lemere

Contact

For consideration for this position, please send a cover letter explaining your background and motivation, detailing how you feel your skills can enrich the group's activities and whether you require sponsorship now or in the future to work in the United States, contact information for three (3) references and a full CV including contact details as a combined PDF to:

Cynthia Lemere, Ph.D.

Associate Professor of Neurology, Harvard Medical School

60 Fenwood Road

Boston, MA 02115

Email: clemere@bwh.harvard.edu

Description

A postdoctoral fellow position is available immediately in the Lemere laboratory at Brigham and Women's Hospital to utilize a novel antibody to prevent amyloidosis, inflammation, and synaptic dysfunction in Alzheimer's disease. This position is funded by an NIH RF1/R01 research grant titled "AD Immunotherapy with a Novel CDC-Mutant Anti-Pyroglutamate-3 Abeta Antibody to Avoid Vascular Side Effects" under the direction of Dr. Cynthia Lemere. The department will appoint the successful candidate to the BWH Medical Staff as a research fellow and will propose that him or her for appointment as a research fellow at the Harvard Medical School (HMS); however, final approval of this appointment rests with HMS.

The Lemere Lab has made seminal discoveries regarding active and passive anti-amyloid immunization in amyloid mouse models over the past 20 years. These findings led to the establishment of an international collaborative effort between Dr. Lemere's lab and Vivoryon Therapeutics (formerly known as Probiodrug AG) in Germany). The NIH-funded project involves in vivo immunization studies in mice including MRI brain analysis, microPET imaging, behavioral testing, and microglia single cell genomics, as well as in vitro examination of the neuroprotective effects of the antibody. The laboratory is funded by multiple NIH and NASA grants to support research studies related to testing of therapeutic treatments, understanding the role of complement in neurodegenerative diseases, and estimating the CNS and cardiovascular risks of deep space radiation. The ultimate goal of the laboratory is to discover novel therapies that are relevant to Alzheimer's disease, neurodegeneration, and radiation-induced injury.

For more information about the Lemere Lab, please visit https://www.brighamandwomens.org/research/labs-and-projects/lemere/overview.

Requirements

The lab is looking for a candidate with a strong background in mouse studies, molecular biology techniques, tissue culture, and assays to quantify gene/protein expression. Experience with mouse behavior is desirable.

Prioritized candidates should demonstrate excellent scientific productivity, evidenced by high-quality publications, and be highly motivated to conduct independent research. Additionally, candidates should display good communication and interpersonal skills. M.D., Ph.D., or equivalent is required.


This article originally appeared in the " https://www.alzforum.org/jobs/postdoctoral-research-fellow-1  " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






Research of Beta Amyloid Peptide: Jobs : Postdoctoral Scientist

Postdoctoral Scientist

Employer

Columbia University Irving Medical Center

Location

New York, New York

Principal Investigator

Abid Hussaini

Contact

sah2149@columbia.edu

Description

The Taub Institute for Research on Alzheimer's disease and the Aging Brain is seeking a Postdoctoral Scientist to join the laboratory of Dr. Abid Hussaini. The lab is focused on understanding the neurobiological underpinnings of Alzheimer's disease. Research involves studying the neuronal population in the brain that are affected by amyloid beta (Aβ) and tau pathology leading to cognitive deficits. We utilize several lines of transgenic mouse models of Alzheimer's disease to achieve our aims and routinely employ in vivo electrophysiology, behavioral testing and chemogenetics in our research. The lab is newly funded with NIH and foundation (including Alzheimer's association) grants and the position will be supported for up to 4 years.  The qualified candidate will be self-motivated, organized and able to work both independently and as part of a research team. Successful candidate will work on an independent project developing tools for in vivo electrophysiology/optogenetic experiments combined with virtual reality behavior testing in mice and analyzing large-scale extracellular single-unit, LFP and behavioral data. 

Responsibilities:

  • Develop hardware tools for electrophysiology, optogenetic and behavior experiments.
  • Analyze large-scale data pertaining to in vivo electrophysiology and behavior data.
  • Develop and maintain MATLAB, Python and C++ software and code for experiments.
  • Work with collaborators to incorporate machine learning algorithms into analysis.
  • Present findings at meetings/conferences and publish in peer-reviewed journals.
  • Train and supervise students/staff in handling hardware and software tools.

Requirements

Minimum Qualifications

  • Ph.D. in neuroscience, physics, math, or other related fields.
  • Excellent programming skills in MATLAB, Python and C# with experience in signal processing.
  • Strong understanding of experimental design and statistical analysis e.g. R.
  • Some engineering skills with experience in electronics, computer hardware and IoT.
  • Excellent communication skills (writing and verbal) in English.

Optional Qualifications

  • Experience with gaming engine and software such as Unity and Blender is highly desirable.
  • Experience with machine learning is desirable.
  • Experience handling rodents would be a plus.

This article originally appeared in the " https://www.alzforum.org/jobs/postdoctoral-scientist-1   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






Beta amyloid protein: Jobs : Postdoctoral Research Scholar, Edson Foundation

Employer

ASU-Banner Neurodegenerative Disease Research Center at Arizona State University

Location

Tempe, Arizona

Principal Investigator

Ben Readhead

Contact

Application Instructions: Applicants are responsible for including a cover letter, CV, and the names of three professional references in the application through the Interfolio website, https://apply.interfolio.com/72796. Emailed applications will not be accepted.

Applications will continue to be accepted on a rolling basis for a reserve pool.  Applications in the reserve pool may then be reviewed in the order in which they were received until the position is filled. They will continue on a biweekly basis until the position is filled.

Description

The Edson postdoctoral research scholar will have a primary mentor in the NDRC, but will have the opportunity to collaborate with other investigators. The selected candidate will work on projects utilizing highly dimensional genomic data, especially next-generation sequencing data for multilevel "omics" data analyses, with a focus on the identification of genes/drug targets implicated in neurodegenerative diseases, especially Alzheimer's disease. 

Essential Duties:

  • Write and optimize computational pipelines (scripts) for whole genome/exome sequencing, RNA-seq, and/or microarray.
  • Organize, prepare and analyze data; develop hypotheses to be tested and ways of testing it.
  • Prepare and present the results of research, in scientific conferences and journals.
  • Assist with grant preparation and reporting.
  • A background check is required for employment. Arizona State University is a VEVRAA Federal Contractor and an Equal Opportunity/Affirmative Action Employer. All qualified applicants will be considered without regard to race, color, sex, religion, national origin, disability, protected veteran status, or any other basis protected by law.

(See https://www.asu.edu/aad/manuals/acd/acd401.html and https://www.asu.edu/titleIX/.)

In compliance with federal law, ASU prepares an annual report on campus security and fire safety programs and resources.  ASU's Annual Security and Fire Safety Report is available online at https://www.asu.edu/police/PDFs/ASU-Clery-Report.pdf  Applicants may request a hard copy of the report by contacting the ASU Police Department at 480-965-3456.

Requirements

Required Qualifications:

  • Applicants must have a Ph.D. by May 31, 2020, in bioinformatics, genomics, computational biology, biostatistics, epidemiology, or related field to be considered.

Desired Qualifications:

  • Experience with Linux/Unix-based systems, developing shell scripts/command-line interface, demonstrable experience in large-scale data analysis and utilization of high-performance computing systems.
  • Formal training/experience in analyzing next-generation sequencing (NGS) or microarray data for gene expression, genotyping, or epigenetics.
  • Experience with scientific computing and data-visualization tools and scripting languages such as Python/Perl/R/Matlab, and understanding of intermediate level of statistics.
  • Excellent communication skills.
  • Experience in genomic data analysis of neurodegenerative diseases is desired but not required.

This article originally appeared in the "  https://www.alzforum.org/jobs/postdoctoral-research-scholar-edson-foundation   " and has their copyrights. We do not claim copyright on the content. This information is for research purposes only. This Blog is made available by publishers for educational purposes only as well as to give you general information and a general understanding , not to provide specific advice. By using this blog site you understand that there is no client relationship between you and the Blog publisher. The Blog should not be used as a substitute for competent research advice. 






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