Beta Amyloid Antibody:: Abeta Antibodies

Beta Amyloid Antibody

Lambracht-Washington D, Qu BX, Fu M, Eagar TN, Stüve O, Rosenberg RN. DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model. JAMA. 2009 Oct 28;302(16):1796-802. Beta Amyloid Antibody

Boussert S, Diez-Perez I, Kogan MJ, de Oliveira E, Giralt E. An intramolecular O-N migration reaction on gold surfaces: toward the preparation of well-defined amyloid surfaces. ACS Nano. 2009 Oct 27;3(10):3091-7. Beta Amyloid Antibody

Zhang Y, Xiong M, Yan RQ, Sun FY. Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats. J Cereb Blood Flow Metab. 2009 Oct 21; Beta Amyloid Antibody

Klaver AC, Finke JM, Digambaranath J, Balasubramaniam M, Loeffler DA.Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigen-dissociated intravenous immunoglobulin preparations. Int Immunopharmacol. 2009 Oct 17; Beta Amyloid Antibody

Manczak M, Mao P, Nakamura K, Bebbington C, Park B, Reddy PH.Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet. 2009 Oct 15;18(20):3876-93. Beta Amyloid Antibody

Simpson ER, Herold EM, Buchner J. The folding pathway of the antibody V(L) domain. J Mol Biol. 2009 Oct 9;392(5):1326-38. Beta Amyloid Antibody

Gustaw-Rothenberg KA, Siedlak SL, Bonda DJ, Lerner A, Tabaton M, Perry G, Smith MA. Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: A population-based study. Exp Gerontol. 2009 Oct 9; Beta Amyloid Antibody

Ying Z, Xin W, Jin-Sheng H, Fu-Xiang B, Wei-Min S, Xin-Xian D, Xiao-Bo W, Yi-Qin L, Xian-Xian Z, Hong-Gang H, Xiang-Lei P, Yan-Peng Z, Ling-Ling H, Tao H. Preparation and characterization of a monoclonal antibody with high affinity for soluble Abeta oligomers. Hybridoma (Larchmt). 2009 Oct;28(5):349-54. Beta Amyloid Antibody

Ali AK, Banks WA, Kumar VB, Shah GN, Lynch JL, Farr SA, Fleegal-DeMotta MA, Morley JE. Nitric oxide activity and isoenzyme expression in the senescence-accelerated mouse p8 model of Alzheimer's disease: effects of anti-amyloid antibody and antisense treatments. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1025-30. Beta Amyloid Antibody

Boridy S, Takahashi H, Akiyoshi K, Maysinger D. The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity. Biomaterials. 2009 Oct;30(29):5583-91. Beta Amyloid Antibody

Song H, Ritz S, Knoll W, Sinner EK. Conformation and topology of amyloid beta-protein adsorbed on a tethered artificial membrane probed by surface plasmon field-enhanced fluorescence spectroscopy. J Struct Biol. 2009 Oct;168(1):117-24. Beta Amyloid Antibody

Beta Amyloid: Videio on Beta Amyloid

What causes neuronal death in Alzheimer's disease.

Tau Antibody AT8: HT7 Tau Antibody:MC1 Tau Antibody

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Tau Antibody at8

Ichihara K, Uchihara T, Nakamura A, Suzuki Y, Mizutani T. Selective deposition of 4-repeat tau in cerebral infarcts. J Neuropathol Exp Neurol. 2009 Sep;68(9):1029-36. Tau Antibody at8

Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21;4(8):673-84. Tau Antibody at8

Pham CT, de Silva R, Haïk S, Verny M, Sachet A, Forette B, Lees A, Hauw JJ, Duyckaerts C. Tau-positive grains are constant in centenarians' hippocampus. Neurobiol Aging. 2009 Aug 18; Tau Antibody at8

Thangavel R, Sahu SK, Van Hoesen GW, Zaheer A. Loss of nonphosphorylated neurofilament immunoreactivity in temporal cortical areas in Alzheimer's disease. Neuroscience. 2009 May 5;160(2):427-33.Tau Antibody at8

Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS. Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 2009 May;132(Pt 5):1324-34. Tau Antibody at8

Guerrero R, Navarro P, Gallego E, Garcia-Cabrero AM, Avila J, Sanchez MP.Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene. Acta Neuropathol. 2009 Feb;117(2):159-68. Tau Antibody at8

Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, Mandelkow E. Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation. J Biol Chem. 2008 Nov 14;283(46):32066-76. Tau Antibody at8

Hu M, Waring JF, Gopalakrishnan M, Li J. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7. Tau Antibody at8

Thangavel R, Van Hoesen GW, Zaheer A. The Abnormally Phosphorylated Tau Lesion of Early Alzheimer's Disease. Neurochem Res. 2008 Apr 25;Tau Antibody at8

Muntané G, Dalfó E, Martinez A, Ferrer I. Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies. Neuroscience. 2008 Apr 9;152(4):913-23. Tau Antibody at8

Arima K. Ultrastructural characteristics of tau filaments in tauopathies: immuno-electron microscopic demonstration of tau filaments in tauopathies. Neuropathology. 2006 Oct;26(5):475-83. Tau Antibody at8

Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zolo P, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday G, Mackenzie J, Khan N, Ravid R, Dickson D, Wszolek Z. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathol Appl Neurobiol. 2006 Aug;32(4):374-87. Tau Antibody at8

Ding ZT, Wang Y, Jiang YP, Yoshida M, Mimuro M, Inagaki T, Iwase T, Hashizume Y. Argyrophilic grain disease: frequency and neuropathology in centenarians. Acta Neuropathol (Berl). 2006 Apr;111(4):320-8. Tau Antibody at8

van de Nes JA, Konermann S, Nafe R, Swaab DF. beta-Protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients. Acta Neuropathol (Berl). 2006 Feb;111(2):126-138. Tau Antibody at8

Jin C, Katayama S, Hiji M, Watanabe C, Noda K, Nakamura S, Matsumoto M. Relationship between neuronal loss and tangle formation in neurons and oligodendroglia in progressive supranuclear palsy. Neuropathology. 2006 Feb;26(1):50-6. Tau Antibody at8

Härtig W, Oklejewicz M, Strijkstra AM, Boerema AS, Stieler J, Arendt T.Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain Res. 2005 Sep 14;1056(1):100-4. Tau Antibody at8, 

Uchihara T, Tsuchiya K, Nakamura A, Akiyama H. Argyrophilic grains are not always argyrophilic-Distinction from neurofibrillary tangles of diffuse neurofibrillary tangles with calcification revealed by comparison between Gallyas and Campbell-Switzer methods. Acta Neuropathol (Berl). 2005 Aug;110(2):158-64. Tau Antibody at8

Rankin CA, Sun Q, Gamblin TC. Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation. Brain Res Mol Brain Res. 2005 Jul 29;138(1):84-93. Tau Antibody at8

Dalfó E, Albasanz JL, Rodríguez A, Martín M, Ferrer I. Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease. J Neuropathol Exp Neurol. 2005 Jul;64(7):638-47.Tau Antibody at8

Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 2005 May;26(5):749-63. Tau Antibody at8

Uchihara T, Tsuchiya K, Nakamura A, Akiyama H. Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: comparison between Gallyas and Campbell-Switzer methods. Acta Neuropathol (Berl). 2005 Mar 10; Tau Antibody at8

Uchihara T, Shibuya K, Nakamura A, Yagishita S. Silver stains distinguish tau-positive structures in corticobasal degeneration/progressive supranuclear palsy and in Alzheimer's disease-Comparison between Gallyas and Campbell-Switzer methods. Acta Neuropathol (Berl). 2004 Dec 24; Tau Antibody at8

Beach TG, Sue L, Scott S, Layne K, Newell A, Walker D, Baker M, Sahara N, Yen SH, Hutton M, Caselli R, Adler C, Connor D, Sabbagh M.Hippocampal sclerosis dementia with tauopathy. Brain Pathol. 2003 Jul;13(3):263-78. Tau Antibody at8

Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K.Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathol (Berl). 2003 Apr 1;105(4):381-92. Tau Antibody at8,

Chang RC, Wong AK, Ng HK, Hugon J. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport. 2002 Dec 20;13(18):2429-32. Tau Antibody at8

Phf1 Tau Antibody

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Phf1 Tau Antibody

Guerrero R, Navarro P, Gallego E, Garcia-Cabrero AM, Avila J, Sanchez MP.Hyperphosphorylated tau aggregates in the cortex and hippocampus of transgenic mice with mutant human FTDP-17 Tau and lacking the PARK2 gene. Acta Neuropathol. 2009 Feb;117(2):159-68. Phf1 Tau Antibody

Jeganathan S, Hascher A, Chinnathambi S, Biernat J, Mandelkow EM, Mandelkow E. Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation. J Biol Chem. 2008 Nov 14;283(46):32066-76. Phf1 Tau Antibody

Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM.Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci. 2007 Aug 22;27(34):9115-29. Phf1 Tau Antibody

Otth C, Concha II, Arendt T, Stieler J, Schliebs R, González-Billault C, Maccioni RB. AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. J Alzheimers Dis. 2002 Oct;4(5):417-30.Phf1 Tau Antibody

Beta Amyloid Aggregation

Beta Amyloid Aggregation

Davis CH, Berkowitz ML. Structure of the Amyloid-beta (1-42) Monomer Absorbed To Model Phospholipid Bilayers: A Molecular Dynamics Study.J Phys Chem B. 2009 Oct 29;113(43):14480-6. Beta Amyloid Aggregation

Motamedi-Shad N, Monsellier E, Torrassa S, Relini A, Chiti F. Kinetic analysis of amyloid formation in the presence of heparan sulfate: faster unfolding and change of pathway. J Biol Chem. 2009 Oct 23;284(43):29921-34. Beta Amyloid Aggregation

Mancino AM, Hindo SS, Kochi A, Lim MH. Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited. Inorg Chem. 2009 Oct 19;48(20):9596-8. Beta Amyloid Aggregation

Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity. Proc Natl Acad Sci U S A. 2009 Oct 19; Beta Amyloid Aggregation

Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain. Proc Natl Acad Sci U S A. 2009 Oct 16; Beta Amyloid Aggregation

Veloso AJ, Hung VW, Sindhu G, Constantinof A, Kerman K.Electrochemical Oxidation of Benzothiazole Dyes for Monitoring Amyloid Formation Related to the Alzheimer's Disease. Anal Chem. 2009 Oct 15;Beta Amyloid Aggregation

Kanekiyo T, Bu G. RECEPTOR-ASSOCIATED PROTEIN (RAP) INTERACTS WITH AMYLOID-{beta} (A{beta}) PEPTIDE AND PROMOTES ITS CELLULAR UPTAKE. J Biol Chem. 2009 Oct 13;Beta Amyloid Aggregation

Ouberai M, Dumy P, Chierici S, Garcia J. Synthesis and Biological Evaluation of Clicked Curcumin and Clicked KLVFFA Conjugates as Inhibitors of beta-Amyloid Fibril Formation. Bioconjug Chem. 2009 Oct 12; Beta Amyloid Aggregation

Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Exp Neurol. 2009 Oct 6; Beta Amyloid Aggregation

Surguchev A, Surguchov A. Conformational diseases: Looking into the eyes. Brain Res Bull. 2009 Oct 4; Beta Amyloid Aggregation

Taniguchi A. [Development of click peptide: stimuli-responsive precursor producing Alzheimer's disease-related amyloid beta peptide] Yakugaku Zasshi. 2009 Oct;129(10):1227-32. Beta Amyloid Aggregation

Yadav A, Sonker M. Perspectives in designing anti aggregation agents as Alzheimer disease drugs. Eur J Med Chem. 2009 Oct;44(10):3866-73.Beta Amyloid Aggregation

Crews L, Tsigelny I, Hashimoto M, Masliah E. Role of synucleins in Alzheimer's disease. Neurotox Res. 2009 Oct;16(3):306-17. Beta Amyloid Aggregation

D'Arrigo C, Tabaton M, Perico A. N-terminal truncated pyroglutamyl beta amyloid peptide Abetapy3-42 shows a faster aggregation kinetics than the full-length Abeta1-42. Biopolymers. 2009 Oct;91(10):861-73. Beta Amyloid Aggregation

Ahmad A, Muzaffar M, Ingram VM. Ca(2+), within the physiological concentrations, selectively accelerates Abeta42 fibril formation and not Abeta40 in vitro. Biochim Biophys Acta. 2009 Oct;1794(10):1537-48.Beta Amyloid Aggregation

Beta Amyloid Binding

Beta Amyloid Binding:: Papers of Amyloid Beta Binding

Protas HD, Huang SC, Kepe V, Hayashi K, Klunder A, Braskie MN, Ercoli L, Bookheimer S, Thompson PM, Small GW, Barrio JR. FDDNP binding using MR derived cortical surface maps. Neuroimage. 2010 Jan 1;49(1):240-8. Beta Amyloid Binding

Arrázola MS, Varela-Nallar L, Colombres M, Toledo EM, Cruzat F, Pavez L, Assar R, Aravena A, González M, Montecino M, Maass A, Martínez S, Inestrosa NC. Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. J Cell Physiol. 2009 Dec;221(3):658-67. Beta Amyloid Binding

Milton NG, Harris JR. Polymorphism of amyloid-beta fibrils and its effects on human erythrocyte catalase binding. Micron. 2009 Dec;40(8):800-10. Beta Amyloid Binding

Xu YX, Wang HQ, Yan J, Sun XB, Guo JC, Zhu CQ. Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins. Neurosci Lett. 2009 Nov 20;465(3):276-81. Beta Amyloid Binding

Weissmann C, Reyher HJ, Gauthier A, Steinhoff HJ, Junge W, Brandt R. Microtubule binding and trapping at the tip of neurites regulate tau motion in living neurons. Traffic. 2009 Nov;10(11):1655-68. Beta Amyloid Binding

Bierhaus A, Nawroth PP. Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications. Diabetologia. 2009 Nov;52(11):2251-63. Beta Amyloid Binding

Davis CH, Berkowitz ML. Structure of the Amyloid-beta (1-42) Monomer Absorbed To Model Phospholipid Bilayers: A Molecular Dynamics Study. J Phys Chem B. 2009 Oct 29;113(43):14480-6. Beta Amyloid Binding

Morita M, Osoda K, Yamazaki M, Shirai F, Matsuoka N, Arakawa H, Nishimura S. Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans. Brain Res. 2009 Oct 27;1295:186-91. Beta Amyloid Binding

Ono M, Watanabe R, Kawashima H, Cheng Y, Kimura H, Watanabe H, Haratake M, Saji H, Nakayama M. Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of beta-amyloid plaques in Alzheimer's disease. J Med Chem. 2009 Oct 22;52(20):6394-401. Beta Amyloid Binding

Li Q, Zhao HF, Zhang ZF, Liu ZG, Pei XR, Wang JB, Li Y. Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus. Neuroscience. 2009 Oct 20;163(3):741-9. Beta Amyloid Binding

Eggert S, Midthune B, Cottrell B, Koo EH. Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-{beta} Protein Production. J Biol Chem. 2009 Oct 16;284(42):28943-28952. Beta Amyloid Binding

Choi SR, Golding G, Zhuang Z, Zhang W, Lim N, Hefti F, Benedum TE, Kilbourn MR, Skovronsky D, Kung HF. Preclinical Properties of 18F-AV-45: A PET Agent for A{beta} Plaques in the Brain. J Nucl Med. 2009 Oct 16; Beta Amyloid Binding

Klaver AC, Finke JM, Digambaranath J, Balasubramaniam M, Loeffler DA. Antibody concentrations to Abeta1-42 monomer and soluble oligomers in untreated and antibody-antigen-dissociated intravenous immunoglobulin preparations. Int Immunopharmacol. 2009 Oct 16; Beta Amyloid Binding

Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U. Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway. J Cell Sci. 2009 Oct 15;122(Pt 20):3703-14. Beta Amyloid Binding

Kanekiyo T, Bu G. RECEPTOR-ASSOCIATED PROTEIN (RAP) INTERACTS WITH AMYLOID-{beta} (A{beta}) PEPTIDE AND PROMOTES ITS CELLULAR UPTAKE. J Biol Chem. 2009 Oct 13; Beta Amyloid Binding

Ouberai M, Dumy P, Chierici S, Garcia J. Synthesis and Biological Evaluation of Clicked Curcumin and Clicked KLVFFA Conjugates as Inhibitors of beta-Amyloid Fibril Formation. Bioconjug Chem. 2009 Oct 12; Beta Amyloid Binding

Ramakrishnan M, Kandimalla KK, Wengenack TM, Howell KG, Poduslo JF. Surface Plasmon Resonance Binding Kinetics of Alzheimer's Disease Amyloid beta Peptide-Capturing and Plaque-Binding Monoclonal Antibodies. Biochemistry. 2009 Oct 9; Beta Amyloid Binding

Elsinghorst PW, Härtig W, Goldhammer S, Grosche J, Gütschow M. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6. Beta Amyloid Binding

Atamna H. Amino acids variations in Amyloid-beta peptides, mitochondrial dysfunction, and new therapies for Alzheimer's disease. J Bioenerg Biomembr. 2009 Oct 6; Beta Amyloid Binding

Ono M, Hayashi S, Kimura H, Kawashima H, Nakayama M, Saji H. Push-pull benzothiazole derivatives as probes for detecting beta-amyloid plaques in Alzheimer's brains. Bioorg Med Chem. 2009 Oct 1;17(19):7002-7. Beta Amyloid Binding

Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB. Role of the macrophage inflammatory protein-1alpha/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid peptide. Am J Pathol. 2009 Oct;175(4):1586-97. Beta Amyloid Binding

Kristofiková Z, Bocková M, Hegnerová K, Bartos A, Klaschka J, Rícný J, Rípová D, Homola J. Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. Mol Biosyst. 2009 Oct;5(10):1174-9. Beta Amyloid Binding

Nuutinen T, Suuronen T, Kauppinen A, Salminen A. Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev. 2009 Oct;61(2):89-104. Beta Amyloid Binding

Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R. Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain. Int J Dev Neurosci. 2009 Oct;27(6):517-23. Beta Amyloid Binding

Antequera D, Vargas T, Ugalde C, Spuch C, Molina JA, Ferrer I, Bermejo-Pareja F, Carro E. Cytoplasmic gelsolin increases mitochondrial activity and reduces Abeta burden in a mouse model of Alzheimer's disease. Neurobiol Dis. 2009 Oct;36(1):42-50. Beta Amyloid Binding

Boridy S, Takahashi H, Akiyoshi K, Maysinger D. The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity. Biomaterials. 2009 Oct;30(29):5583-91. Beta Amyloid Binding

Song H, Ritz S, Knoll W, Sinner EK. Conformation and topology of amyloid beta-protein adsorbed on a tethered artificial membrane probed by surface plasmon field-enhanced fluorescence spectroscopy. J Struct Biol. 2009 Oct;168(1):117-24. Beta Amyloid Binding

Leskovjan AC, Lanzirotti A, Miller LM. Amyloid plaques in PSAPP mice bind less metal than plaques in human Alzheimer's disease. Neuroimage. 2009 Oct 1;47(4):1215-20. Beta Amyloid Binding

Bencherif M, Lippiello PM. Alpha7 neuronal nicotinic receptors: The missing link to understanding Alzheimer's etiopathology? Med Hypotheses. 2009 Sep 30; Beta Amyloid Binding

Damante CA, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, So´va´go´ I. Metal Loading Capacity of Abeta N-Terminus: a Combined Potentiometric and Spectroscopic Study of Zinc(II) Complexes with Abeta(1-16), Its Short or Mutated Peptide Fragments and Its Polyethylene Glycol-ylated Analogue. Inorg Chem. 2009 Sep 25; Beta Amyloid Binding

Hernández F, Gómez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J. GSK3: A possible link between beta amyloid peptide and tau protein. Exp Neurol. 2009 Sep 24; Beta Amyloid Binding

Boussert S, Diez-Perez I, Kogan MJ, de Oliveira E, Giralt E. An Intramolecular O-N Migration Reaction on Gold Surfaces: Toward the Preparation of Well-Defined Amyloid Surfaces. ACS Nano. 2009 Sep 22; Beta Amyloid Binding

Qi W, Zhang A, Good TA, Fernandez EJ. Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability. Biochemistry. 2009 Sep 22;48(37):8908-19. Beta Amyloid Binding

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16505-10. Beta Amyloid Binding

Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu SI, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima YI, Kakita A, Imahori K, Hoshi M. Isolation and characterization of patient-derived, toxic, high-mass amyloid {beta}-protein (A{beta}) assembly from Alzheimer's disease brains. J Biol Chem. 2009 Sep 15; Beta Amyloid Binding

Zhu YY, Ni DF, Xu CM. Gene Expression Profiles in the Olfactory Bulb from a Rat Model of Alzheimer's Disease. J Alzheimers Dis. 2009 Sep 11; Beta Amyloid Binding

Pani A, Dessì S, Diaz G, La Colla P, Abete C, Mulas C, Angius F, Cannas MD, Orru CD, Cocco PL, Mandas A, Putzu P, Laurenzana A, Cellai C, Costanza AM, Bavazzano A, Mocali A, Paoletti F. Altered Cholesterol Ester Cycle in Skin Fibroblasts from Patients with Alzheimer's Disease. J Alzheimers Dis. 2009 Sep 11; Beta Amyloid Binding

Morley JE, Farr SA, Banks WA, Johnson SN, Yamada KA, Xu L. A Physiological Role for Amyloid-beta Protein: Enhancement of Learning and Memory. J Alzheimers Dis. 2009 Sep 11; Beta Amyloid Binding

House E, Mold M, Collingwood J, Baldwin A, Goodwin S, Exley C. Copper Abolishes the beta-Sheet Secondary Structure of Preformed Amyloid Fibrils of Amyloid-beta_{42} J Alzheimers Dis. 2009 Sep 11; Beta Amyloid Binding

Camps P, Formosa X, Galdeano C, Muñoz-Torrero D, Ramírez L, Gómez E, Isambert N, Lavilla R, Badia A, Clos MV, Bartolini M, Mancini F, Andrisano V, Arce MP, Rodríguez-Franco MI, Huertas O, Dafni T, Luque FJ. Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79. Beta Amyloid Binding

Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL. (3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a Novel Neuroprotective Agent ( perpendicular). J Med Chem. 2009 Sep 3; Beta Amyloid Binding

Wang HY, Stucky A, Liu J, Shen C, Trocme-Thibierge C, Morain P. Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. J Neurosci. 2009 Sep 2;29(35):10961-73. Beta Amyloid Binding

Tolboom N, van der Flier WM, Yaqub M, Boellaard R, Verwey NA, Blankenstein MA, Windhorst AD, Scheltens P, Lammertsma AA, van Berckel BN. Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding. J Nucl Med. 2009 Sep;50(9):1464-70. Beta Amyloid Binding

Watanabe H, Ono M, Ikeoka R, Haratake M, Saji H, Nakayama M. Synthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting beta-amyloid plaques in the brain. Bioorg Med Chem. 2009 Sep 1;17(17):6402-6. Beta Amyloid Binding

Hureau C, Balland V, Coppel Y, Solari PL, Fonda E, Faller P. Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes. J Biol Inorg Chem. 2009 Sep;14(7):995-1000. Beta Amyloid Binding

Tõugu V, Karafin A, Zovo K, Chung RS, Howells C, West AK, Palumaa P. Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. J Neurochem. 2009 Sep;110(6):1784-95. Beta Amyloid Binding

Fodero-Tavoletti MT, Mulligan RS, Okamura N, Furumoto S, Rowe CC, Kudo Y, Masters CL, Cappai R, Yanai K, Villemagne VL. In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies. Eur J Pharmacol. 2009 Sep 1;617(1-3):54-8. Beta Amyloid Binding

Hayley M, Perspicace S, Schulthess T, Seelig J. Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction. Biochim Biophys Acta. 2009 Sep;1788(9):1933-8. Beta Amyloid Binding

Bulgarelli I, Tamiazzo L, Bresciani E, Rapetti D, Caporali S, Lattuada D, Locatelli V, Torsello A. Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. J Neurosci Res. 2009 Sep;87(12):2718-27. Beta Amyloid Binding

Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB. Amino acid position-specific contributions to amyloid beta-protein oligomerization. J Biol Chem. 2009 Aug 28;284(35):23580-91. Beta Amyloid Binding

Roostaee A, Cote S, Roucou X. Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions. J Biol Chem. 2009 Aug 26; Beta Amyloid Binding

Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD. Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14670-5. Beta Amyloid Binding

Jiang D, Li X, Williams R, Patel S, Men L, Wang Y, Zhou F. Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease. Biochemistry. 2009 Aug 25;48(33):7939-47. Beta Amyloid Binding

Groenning M. Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status. J Chem Biol. 2009 Aug 20; Beta Amyloid Binding

Rosen RF, Ciliax BJ, Wingo TS, Gearing M, Dooyema J, Lah JJ, Ghiso JA, Levine H, Walker LC. Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol. 2009 Aug 19; Beta Amyloid Binding

Furlan S, La Penna G. Modeling of the Zn2+ binding in the 1-16 region of the amyloid beta peptide involved in Alzheimer's disease. Phys Chem Chem Phys. 2009 Aug 14;11(30):6468-81. Beta Amyloid Binding

Mazzucchelli S, De Palma A, Riva M, D'Urzo A, Pozzi C, Pastori V, Comelli F, Fusi P, Vanoni M, Tortora P, Mauri P, Regonesi ME. Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin. Int J Biochem Cell Biol. 2009 Aug 8; Beta Amyloid Binding

Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y. Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons. J Alzheimers Dis. 2009 Aug 3; Beta Amyloid Binding

Olofsson A, Lindhagen-Persson M, Vestling M, Sauer-Eriksson AE, Ohman A. Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+. FEBS J. 2009 Aug;276(15):4051-60. Beta Amyloid Binding

Arslan PE, Chakrabartty A. Probing Alzheimer amyloid peptide aggregation using a cell-free fluorescent protein refolding method. Biochem Cell Biol. 2009 Aug;87(4):631-9. Beta Amyloid Binding

Bettens K, Brouwers N, Engelborghs S, van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C. APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease. Hum Mutat. 2009 Aug;30(8):1207-13. Beta Amyloid Binding,

Bamburg JR, Bloom GS. Cytoskeletal pathologies of Alzheimer disease. Cell Motil Cytoskeleton. 2009 Aug;66(8):635-49. Beta Amyloid Binding

Chen TJ, Wang DC, Chen SS. Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons. J Neurosci Res. 2009 Aug 1;87(10):2297-307. Beta Amyloid Binding

Zheng H, Youdim MB, Fridkin M. Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. J Med Chem. 2009 Jul 23;52(14):4095-8. Beta Amyloid Binding

Takahashi T, Ohta K, Mihara H. Rational design of amyloid beta peptide-binding proteins: Pseudo-Abeta beta-sheet surface presented in green fluorescent protein binds tightly and preferentially to structured Abeta. Proteins. 2009 Jul 20; Beta Amyloid Binding

Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric A{beta}. J Biol Chem. 2009 Jul 10;284(28):18742-53. Beta Amyloid Binding

Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J Neurosci. 2009 Jul 8;29(27):8805-15. Beta Amyloid Binding

Mi W, Jung SS, Yu H, Schmidt SD, Nixon RA, Mathews PM, Tagliavini F, Levy E. Complexes of Amyloid-beta and Cystatin C in the Human Central Nervous System. J Alzheimers Dis. 2009 Jul 7; Beta Amyloid Binding

Taru H, Suzuki T. Regulation of the Physiological Function and Metabolism of AbetaPP by AbetaPP Binding Proteins. J Alzheimers Dis. 2009 Jul 7; Beta Amyloid Binding

Kubo K, Nakao S, Jomura S, Sakamoto S, Miyamoto E, Xu Y, Tomimoto H, Inada T, Shingu K. Edaravone, a free radical scavenger, mitigates both gray and white matter damages after global cerebral ischemia in rats. Brain Res. 2009 Jul 7;1279:139-46. Beta Amyloid Binding

Salminen A, Kaarniranta K. Siglec receptors and hiding plaques in Alzheimer's disease. J Mol Med. 2009 Jul;87(7):697-701. Beta Amyloid Binding

Kozikowski AP, Chen Y, Subhasish T, Lewin NE, Blumberg PM, Zhong Z, D'Annibale MA, Wang WL, Shen Y, Langley B. Searching for disease modifiers-PKC activation and HDAC inhibition - a dual drug approach to Alzheimer's disease that decreases Abeta production while blocking oxidative stress. ChemMedChem. 2009 Jul;4(7):1095-105. Beta Amyloid Binding

Holzmann J, Rossmanith W. tRNA recognition, processing, and disease: hypotheses around an unorthodox type of RNase P in human mitochondria. Mitochondrion. 2009 Jul;9(4):284-8. Beta Amyloid Binding

Atamna H, Frey WH, Ko N. Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease. Arch Biochem Biophys. 2009 Jul 1;487(1):59-65. Beta Amyloid Binding

Lee JH, Kang DY, Kim SU, Yea CH, Oh BK, Choi JW. Electrical detection of beta-amyloid (1-40) using scanning tunneling microscopy. Ultramicroscopy. 2009 Jul;109(8):923-8. Beta Amyloid Binding

Garai K, Crick SL, Mustafi SM, Frieden C. Expression and purification of amyloid-beta peptides from Escherichia coli. Protein Expr Purif. 2009 Jul;66(1):107-12. Beta Amyloid Binding

Tanaka M, Yamazaki M, Chiba K. Neuroprotective action of genipin on tunicamycin-induced cytotoxicity in neuro2a cells. Biol Pharm Bull. 2009 Jul;32(7):1220-3. Beta Amyloid Binding

Liu RT, Zou LB, Lü QJ. Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons. Acta Pharmacol Sin. 2009 Jul;30(7):899-906. Beta Amyloid Binding

Salajegheh M, Pinkus JL, Taylor JP, Amato AA, Nazareno R, Baloh RH, Greenberg SA. Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle Nerve. 2009 Jul;40(1):19-31. Beta Amyloid Binding

Douraghi-Zadeh D, Matharu B, Razvi A, Austen B. The Protective Effects of the Nutraceutical, Colostrinin, against Alzheimer's Disease, is Mediated via Prevention of Apoptosis in Human Neurones Induced by Aggregated beta-Amyloid. J Nutr Health Aging. 2009 Jul;13(6):522-7. Beta Amyloid Binding

Marques AT, Fernandes PA, Ramos MJ. ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease. Mini Rev Med Chem. 2009 Jul;9(8):1002-8. Beta Amyloid Binding

Walsh P, Yau J, Simonetti K, Sharpe S. Morphology and secondary structure of stable beta-oligomers formed by amyloid peptide PrP(106-126). Biochemistry. 2009 Jun 30;48(25):5779-81. Beta Amyloid Binding

Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, Zhang H, Feng Y, Palmeri A, Landry DW, Arancio O. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci. 2009 Jun 24;29(25):8075-86. Beta Amyloid Binding

Vega L, Arroyo AA, Tabernero A, Medina JM. Albumin-Blunted Deleterious Effect of Amyloid-beta by Preventing the Internalization of the Peptide into Neurons. J Alzheimers Dis. 2009 Jun 19; Beta Amyloid Binding

Nanga RP, Brender JR, Xu J, Hartman K, Subramanian V, Ramamoorthy A. Three-dimensional structure and orientation of rat islet amyloid polypeptide protein in a membrane environment by solution NMR spectroscopy. J Am Chem Soc. 2009 Jun 17;131(23):8252-61. Beta Amyloid Binding

Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T, Kim HC. Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Jun 16; Beta Amyloid Binding

Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE. APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes. J Biol Chem. 2009 Jun 12;284(24):16298-307. Beta Amyloid Binding

Matsuda S, Matsuda Y, D'Adamio L. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem. 2009 Jun 5;284(23):15815-25. Beta Amyloid Binding

Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T. Inhibition of gamma-secretase activity by helical beta-peptide foldamers. J Am Chem Soc. 2009 Jun 3;131(21):7353-9. Beta Amyloid Binding

Liu ML, Liu MJ, Shen YF, Ryu H, Kim HJ, Klupsch K, Downward J, Hong ST. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta. J Cell Sci. 2009 Jun 1;122(Pt 11):1917-26. Beta Amyloid Binding

Yamazaki M, Chiba K, Yoshikawa C. Genipin suppresses A23187-induced cytotoxicity in neuro2a cells. Biol Pharm Bull. 2009 Jun;32(6):1043-6. Beta Amyloid Binding

Tai LM, Loughlin AJ, Male DK, Romero IA. P-glycoprotein and breast cancer resistance protein restrict apical-to-basolateral permeability of human brain endothelium to amyloid-beta. J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83. Beta Amyloid Binding

Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol Cell Neurosci. 2009 Jun;41(2):166-74. Beta Amyloid Binding

Lee JY, Lee SA, Kim JK, Chae CB, Kim Y. Interaction models of substrate peptides and beta-secretase studied by NMR spectroscopy and molecular dynamics simulation. Mol Cells. 2009 Jun;27(6):651-6. Beta Amyloid Binding

Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R, Ferreira ST. Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity. Int J Biochem Cell Biol. 2009 Jun;41(6):1361-70. Beta Amyloid Binding

Yamin G. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. J Neurosci Res. 2009 Jun;87(8):1729-36. Beta Amyloid Binding

Gralle M, Botelho MG, Wouters FS. Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem. 2009 May 29;284(22):15016-25. Beta Amyloid Binding

Sarell CJ, Syme CD, Rigby SE, Viles JH. Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form. Biochemistry. 2009 May 26;48(20):4388-402. Beta Amyloid Binding

Fernández A, Llacuna L, Fernández-Checa JC, Colell A. Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci. 2009 May 20;29(20):6394-405. Beta Amyloid Binding

Ma X, Liu L, Mao X, Niu L, Deng K, Wu W, Li Y, Yang Y, Wang C. Amyloid beta (1-42) folding multiplicity and single-molecule binding behavior studied with STM. J Mol Biol. 2009 May 15;388(4):894-901. Beta Amyloid Binding